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ES2095207T3 - Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn. - Google Patents

Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn.

Info

Publication number
ES2095207T3
ES2095207T3 ES88403229T ES88403229T ES2095207T3 ES 2095207 T3 ES2095207 T3 ES 2095207T3 ES 88403229 T ES88403229 T ES 88403229T ES 88403229 T ES88403229 T ES 88403229T ES 2095207 T3 ES2095207 T3 ES 2095207T3
Authority
ES
Spain
Prior art keywords
dna
hap
retinoic acid
hepatoma
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88403229T
Other languages
English (en)
Inventor
Pierre Tiollais
Anne Dejean
De The Hugues Blaudin
Agnes Marchio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Original Assignee
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/134,130 external-priority patent/US5223606A/en
Priority claimed from US07/209,009 external-priority patent/US5149781A/en
Application filed by Institut Pasteur de Lille filed Critical Institut Pasteur de Lille
Application granted granted Critical
Publication of ES2095207T3 publication Critical patent/ES2095207T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE EMPLEA LA INTEGRACION DE UN VIRUS DE HEPATITIS B (VHB) PREVIAMENTE AISLADO, EN UN FRAGMENTO DE DNA CELULAR 147 BP LIGADO AL CARCINOMA HEPATOCELULAR, COMO SONDA PARA CLONAR EL CORRESPONDIENTE DNA COMPLEMENTARIO DE UNA BIBLIOTECA DE CDNA DEL HIGADO HUMANO. EL ANALISIS DE LA SECUENCIA NUCLEOTIDICA REVELA QUE LA ESTRUCTURA TOTAL DEL GEN CELULAR, DESIGNADA HAP, ES SIMILAR A LA DE LOS RECEPTORES DE LA HORMONA QUE SE UNE AL DNA. 6 DE CADA 7 LINEAS CELULARES DEL HEPATOMA Y DERIVADAS DEL HEPATOMA EXPRESAN 2.5 KB DE ESPECIES DE MRNA HAP, INDETECTABLE ENEL HIGADO DE ADULTOS Y FETOS NORMALES, PERO PRESENTES EN TODOS LOS TEJIDOS NO - PEPTIDICOS ANALIZADOS. LAS EXPERIENCIAS DE HIBRIDACION DE POCA RIGUROSIDAD REVELAN LA EXISTENCIA DE GENES RELACIONADOS CON HAP EN EL GENOMA HUMANO. LA SECUENCIA DE DNA CLONADA ES UTIL EN LA PREPARACION DE PROTEINA HAP PURA Y COMO SONDA PARA LA DETECCION Y AISLAMIENTO DE SECUENCIAS COMPLEMENTARIAS DE DNA Y RNA. LA PROTEINA HAP ES UN RECEPTOR DE ACIDO RETINOICO (AR) IDENTIFICADO COMO RAR - BETA.
ES88403229T 1987-12-16 1988-12-16 Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn. Expired - Lifetime ES2095207T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13368787A 1987-12-16 1987-12-16
US07/134,130 US5223606A (en) 1987-12-16 1987-12-17 Steroid/thyroid hormone receptor-related protein inappropriately expressed in human hepatocellular carcinoma
US07/209,009 US5149781A (en) 1987-12-16 1988-06-20 Steroid/thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma
US27813688A 1988-11-30 1988-11-30

Publications (1)

Publication Number Publication Date
ES2095207T3 true ES2095207T3 (es) 1997-02-16

Family

ID=27495052

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88403229T Expired - Lifetime ES2095207T3 (es) 1987-12-16 1988-12-16 Receptor de acido retinoico y derivados del mismo, adn que codifica cualquiera de las dos sustancias y uso de las proteinas y del adn.

Country Status (8)

Country Link
US (3) US6531585B1 (es)
EP (1) EP0321362B1 (es)
AT (1) ATE143413T1 (es)
CA (1) CA1320161C (es)
DE (1) DE3855577T2 (es)
ES (1) ES2095207T3 (es)
GR (1) GR3021954T3 (es)
WO (1) WO1989005854A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4035889A (en) * 1988-06-16 1990-01-12 La Jolla Cancer Research Foundation Retinoic acid receptor
US6335159B1 (en) 1988-06-16 2002-01-01 The Burnham Institute Retinoic acid receptor ε(rarε)
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
EP0411323A3 (en) * 1989-06-30 1991-08-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Human and mouse retinoic acid receptors and genes encoding for them
FR2658204A1 (fr) * 1990-02-12 1991-08-16 Inst Nat Sante Rech Med Nouvelles compositions de cycline a humaine, sequence nucleotidique correspondante, et agents de detection ou de diagnostic de mutations hepatocellulaires induites par le virus hbv.
US5922596A (en) * 1990-12-10 1999-07-13 Bristol-Myers Squibb Co. Promoter of the retinoic acid receptor gene for directing gene expression
AU2001236589A1 (en) * 2000-02-04 2001-08-14 Aeomica, Inc. Methods and apparatus for high-throughput detection and characterization of alternatively spliced genes
US9585857B2 (en) 2013-01-18 2017-03-07 Cornell University Methods of treating diseases associated with high-fat diet and vitamin A deficiency using retinoic acid receptor agonists
WO2021113290A1 (en) 2019-12-03 2021-06-10 Alamar Biosciences, Inc. Nucleic acid linked immune-sandwich assay (nulisa)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034114A (en) * 1976-09-15 1977-07-05 Yu Ruey J Treatment of skin keratoses with retinal
US4310546A (en) * 1978-07-31 1982-01-12 Johnson & Johnson Novel retinoids and their use in preventing carcinogenesis
US4323581A (en) * 1978-07-31 1982-04-06 Johnson & Johnson Method of treating carcinogenesis
US4385175A (en) * 1982-03-22 1983-05-24 Bristol-Myers Company Esters of retinoic acid and azetidinone derivatives
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US5171671A (en) * 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5571692A (en) * 1987-12-02 1996-11-05 The Salk Institute For Biological Studies Retinoic acid receptor α, vectors and cells comprising the same DNA encoding

Also Published As

Publication number Publication date
US20030153740A1 (en) 2003-08-14
DE3855577T2 (de) 1997-04-17
US6531585B1 (en) 2003-03-11
WO1989005854A1 (en) 1989-06-29
CA1320161C (en) 1993-07-13
EP0321362B1 (en) 1996-09-25
GR3021954T3 (en) 1997-03-31
US7622266B2 (en) 2009-11-24
ATE143413T1 (de) 1996-10-15
US20060189798A1 (en) 2006-08-24
DE3855577D1 (de) 1996-10-31
EP0321362A1 (en) 1989-06-21

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