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ES2091820T3 - 5-amino-carbonil-5h-dibenzo(a,d)ciclo-hepten-5.10-iminas para tratamiento de la epilepsia y la adiccion a la cocaina. - Google Patents

5-amino-carbonil-5h-dibenzo(a,d)ciclo-hepten-5.10-iminas para tratamiento de la epilepsia y la adiccion a la cocaina.

Info

Publication number
ES2091820T3
ES2091820T3 ES90905307T ES90905307T ES2091820T3 ES 2091820 T3 ES2091820 T3 ES 2091820T3 ES 90905307 T ES90905307 T ES 90905307T ES 90905307 T ES90905307 T ES 90905307T ES 2091820 T3 ES2091820 T3 ES 2091820T3
Authority
ES
Spain
Prior art keywords
treatment
epilepsy
cocaine
iminas
hepten
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905307T
Other languages
English (en)
Inventor
James A Monn
Andrew Thurkauf
Shunichi Yamaguchi
Michael A Rogawski
Kenneth C Rice
Mariena V Mattson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
US Department of Commerce
Original Assignee
US Department of Health and Human Services
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, US Department of Commerce filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of ES2091820T3 publication Critical patent/ES2091820T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION ESTA EN EL CAMPO DE LA NEUROLOGIA CLINICA Y SE REFIERE ESPECIFICAMENTE A LOS COMPUESTOS, Y METODOS PARA EL TRATAMIENTO DE PACIENTES CON EPILEPSIA GENERAL O PARCIAL (SINTOMATICA), UTILIZANDO COMPUESTOS DE LA FORMULA (I). ESTA INVENCION SE REFIERE TAMBIEN A LOS COMPUESTOS Y METODOS PARA EL TRATAMIENTO DEL SINDROME DE ABSTINENCIA DE LAS DROGAS EN LOS PACIENTES ADICTOS A LA COCAINA.
ES90905307T 1989-05-09 1990-03-23 5-amino-carbonil-5h-dibenzo(a,d)ciclo-hepten-5.10-iminas para tratamiento de la epilepsia y la adiccion a la cocaina. Expired - Lifetime ES2091820T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34918789A 1989-05-09 1989-05-09

Publications (1)

Publication Number Publication Date
ES2091820T3 true ES2091820T3 (es) 1996-11-16

Family

ID=23371261

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905307T Expired - Lifetime ES2091820T3 (es) 1989-05-09 1990-03-23 5-amino-carbonil-5h-dibenzo(a,d)ciclo-hepten-5.10-iminas para tratamiento de la epilepsia y la adiccion a la cocaina.

Country Status (9)

Country Link
EP (1) EP0472526B1 (es)
JP (2) JPH07119224B2 (es)
AT (1) ATE137752T1 (es)
AU (1) AU637364B2 (es)
CA (1) CA2053247C (es)
DE (1) DE69026936T2 (es)
DK (1) DK0472526T3 (es)
ES (1) ES2091820T3 (es)
WO (1) WO1990013297A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4540193A (en) * 1992-06-17 1994-01-04 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Method of treating and protecting against central nervous system ischemia, hypoxia, degeneration, and trauma with a 5-aminocarbonyl-sh-dibenzo{a,d}cyclohepten-5,10-imine
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
AU6765598A (en) * 1997-03-20 1998-10-12 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo(3.2.1.) octanes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
US4399141A (en) * 1977-09-19 1983-08-16 Merck & Co., Inc. 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof
NZ221626A (en) * 1986-09-08 1989-11-28 Merck & Co Inc Dibenzo(a,d cycloheptene derivatives and pharmaceutical compositions
NZ225634A (en) * 1987-08-10 1991-03-26 Merck & Co Inc 10,11-dihydro-5h-dibenzo(a,d)cyclohepten-5,10-imine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
ATE137752T1 (de) 1996-05-15
WO1990013297A1 (en) 1990-11-15
CA2053247C (en) 1996-01-02
EP0472526A1 (en) 1992-03-04
JPH08157474A (ja) 1996-06-18
AU637364B2 (en) 1993-05-27
DE69026936T2 (de) 1997-01-16
JP2798628B2 (ja) 1998-09-17
EP0472526B1 (en) 1996-05-08
JPH04503216A (ja) 1992-06-11
DK0472526T3 (da) 1996-07-29
DE69026936D1 (de) 1996-06-13
JPH07119224B2 (ja) 1995-12-20
EP0472526A4 (en) 1992-05-20
AU5339690A (en) 1990-11-29
CA2053247A1 (en) 1990-11-10

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