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ES2087812B1 - DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. - Google Patents

DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Info

Publication number
ES2087812B1
ES2087812B1 ES9301493A ES9301493A ES2087812B1 ES 2087812 B1 ES2087812 B1 ES 2087812B1 ES 9301493 A ES9301493 A ES 9301493A ES 9301493 A ES9301493 A ES 9301493A ES 2087812 B1 ES2087812 B1 ES 2087812B1
Authority
ES
Spain
Prior art keywords
decahydroisokinoline
antagonists
derivatives
useful
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9301493A
Other languages
Spanish (es)
Other versions
ES2087812A1 (en
Inventor
Brian Arnold Macklin
Nancy Kay Augenstein
Carl Franklin Bertsch
Marvin Martin Housen
Allen Robert Harkness
Bret Eugene Huff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to ES9301493A priority Critical patent/ES2087812B1/en
Publication of ES2087812A1 publication Critical patent/ES2087812A1/en
Application granted granted Critical
Publication of ES2087812B1 publication Critical patent/ES2087812B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVADOS DE DECAHIDROISOQUINOLINA UTILES COMO ANTAGONISTAS DE LOS RECEPTORES DE LOS AMINOACIDOS EXCITADORES. LOS DERIVADOS DE DECAHIDROISOQUINOLINA DE FORMULA (I) DONDE R1 ES H, ALQUILO, ARILALQUILO, ALCOXICARBONILO O ACILO, R2 ES H, ALQUILO, OPCIONALMENTE SUSTITUIDO, CICLOALQUILO O ARILAQUILO, R3 ES CO2H, SO3H, CONHSO2R8, O UN ANILLO DE 5 MIEMBROS QUE CONTIENE DE 1 A 4 ATOMOS DE N, Y, OPCIONALMENTE 1 ATOMO DE O O S, OPCIONALMENTE SUSTITUIDO, W ES (CH2)N, S, SO, SO2, Y ES CHR7, NR4, O, S, SO, O SO2, Z ES NR6, CHR7, CH, O W E Y JUNTOS SON HC=CH O CIGUC, O Y Y Z JUNTOS SON HC=CH O CIGUC, SON UTILES COMO ANTAGONISTAS DE LOS AMINOACIDOS EXCITADORES, POR LO QUE PUEDEN SER UTILIZADOS EN EL TRATAMIENTO DE DESORDENES NEUROLOGICOS Y EN LA PRODUCCION DE ANALGESIA.DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. THE DECAHYDROISOKINOLINE DERIVATIVES OF FORMULA (I) WHERE R1 IS H, ALKYL, ARYALKYL, ALCOXYCARBONYL OR ACIL, R2 IS H, ALKYL, OPTIONALLY SUBSTITUTED, CYCLOALKYL OR ARYLAHYL, R3 IS CO2 CONTAINS 1 TO 4 ATOMS OF N, Y, OPTIONALLY 1 ATOM OF OOS, OPTIONALLY SUBSTITUTED, W ES (CH2) N, S, SO, SO2, Y ES CHR7, NR4, O, S, SO, O SO2, Z ES NR6, CHR7, CH, OWEY TOGETHER ARE HC = CH O CIGUC, OYYZ TOGETHER ARE HC = CH OR CIGUC, THEY ARE USEFUL AS ANTAGONISTS OF EXCITING AMINO ACIDS, SO THEY CAN BE USED IN THE TREATMENT OF NEUROLOGICAL DISORDERS AND IN THE PRODUCTION OF ANALGESIA.

ES9301493A 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS. Expired - Fee Related ES2087812B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301493A ES2087812B1 (en) 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301493A ES2087812B1 (en) 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Publications (2)

Publication Number Publication Date
ES2087812A1 ES2087812A1 (en) 1996-07-16
ES2087812B1 true ES2087812B1 (en) 1997-03-16

Family

ID=8282429

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301493A Expired - Fee Related ES2087812B1 (en) 1993-07-02 1993-07-02 DERIVATIVES OF DECAHYDROISOKINOLINE USEFUL AS ANTAGONISTS OF THE RECEPTORS OF THE EXCITING AMINO ACIDS.

Country Status (1)

Country Link
ES (1) ES2087812B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists

Also Published As

Publication number Publication date
ES2087812A1 (en) 1996-07-16

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Legal Events

Date Code Title Description
EC2A Search report published

Effective date: 19960716

FD1A Patent lapsed

Effective date: 20040503