ES2082971T3 - Esteres de fosfato de acilo y modificacion de proteinas con los mismos. - Google Patents
Esteres de fosfato de acilo y modificacion de proteinas con los mismos.Info
- Publication number
- ES2082971T3 ES2082971T3 ES91905433T ES91905433T ES2082971T3 ES 2082971 T3 ES2082971 T3 ES 2082971T3 ES 91905433 T ES91905433 T ES 91905433T ES 91905433 T ES91905433 T ES 91905433T ES 2082971 T3 ES2082971 T3 ES 2082971T3
- Authority
- ES
- Spain
- Prior art keywords
- phosphate esters
- acil
- image
- alkenyl
- protein modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003014 phosphoric acid esters Chemical class 0.000 title 1
- 230000009145 protein modification Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- -1 acyl phosphate esters Chemical class 0.000 abstract 1
- 125000005018 aryl alkenyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/095—Compounds containing the structure P(=O)-O-acyl, P(=O)-O-heteroatom, P(=O)-O-CN
- C07F9/096—Compounds containing the structure P(=O)-O-C(=X)- (X = O, S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
SE PRESENTA UN PROCESO PARA LA PREPARACION DE ESTERES DE FOSFATO DE ACIL DE LA FORMULA (I) O LAS SALES DE LOS MISMOS, EN DONDE R Y R1 SON LO MISMO O DIFERENTE Y REPRESENTAN UN GRUPO ALQUIL LINEAL O RAMIFICADO QUE TIENE HASTA 4 ATOMOS DE CARBONO, FENIL O BENZIL; N ES UN ENTERO; CUANDO N ES 1, R2 REPRESENTA EL GRUPO ((ALFA)) EN DONDE R4 ES UN ALQUIL, ALQUENIL O ALQUINIL LINEAL O RAMIFICADO, UN CICLOALQUIL, UN ALQUENIL O ARIL CICLICO QUE PUEDE ESTAR SUSTITUIDO POR ALQUIL, ALQUENIL, ALQUINIL, ARIL, ARILALQUIL, ARILQUENIL O CUANDO N ES AL MENOS 1 R2 REPRESENTA EL GRUPO ((BETA)) EN EL QUE R4 ES SEGUN SE DEFINIO ANTERIORMENTE; EL PROCESO COMPRENDE A) LA REACCION DE UN COMPUESTO DE LA FORMULA (II) O UNA SAL DEL MISMO, EN DONDE R Y R1 SON SEGUN SE DEFINIERON ANTERIORMENTE Y R3 ES UN CONTRA ION, (I) CON UN COMPUESTO DE LA FORMULA (III), EN DONDE R4 ES SEGUN SE DEFINIO ANTERIORMENTE Y R5 ES UN GRUPO SALIENTE QUE ES CONOCIDO GENERALMENTE PARA REACCIONES DE ESTERIFICACION, EN LA PRESENCIA DE UN SOLVENTEDE ETER, CUANDO UN COMPUESTO DE LA FORMULA (I) LO REQUIERA O, II) CON UNA CANTIDAD ESTOICOMETRICA DE UN COMPUESTO DE LA FORMULA (IV), EN DONDE N ES AL MENOS 2, Y R4 Y R5 SON SEGUN SE DEFINIERON ANTERIORMENTE, EN LA PRESENCIA DE UN SOLVENTE DE ETER, CUANDO UN COMPUESTO DE LA FORMULA (I) EN DONDE N ES AL MENOS 2 SE REQUIERA, Y B) SI SE REQUIRIESE, LOS ESTERES DE FOSFATO DE ACIL DE LA FORMULA (I) ASI OBTENIDOS SE CONVIERTEN EN SALES DE LOS MISMOS. TAMBIEN SE PRESENTAN NUEVOS COMPUESTOS DE LA FORMULA (I) EN DONDE N ES AL MENOS 2, Y PROTEINAS MODIFICADAS OBTENIDAS USANDO LOS NUEVOS COMPUESTOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49352490A | 1990-03-14 | 1990-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2082971T3 true ES2082971T3 (es) | 1996-04-01 |
Family
ID=23960593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91905433T Expired - Lifetime ES2082971T3 (es) | 1990-03-14 | 1991-03-12 | Esteres de fosfato de acilo y modificacion de proteinas con los mismos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5334707A (es) |
| EP (1) | EP0519953B1 (es) |
| JP (1) | JP3021041B2 (es) |
| AT (1) | ATE133955T1 (es) |
| AU (1) | AU658821B2 (es) |
| CA (1) | CA2078141C (es) |
| DE (1) | DE69117054T2 (es) |
| DK (1) | DK0519953T3 (es) |
| ES (1) | ES2082971T3 (es) |
| WO (1) | WO1991013891A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
| EP1042334B1 (en) * | 1997-12-24 | 2002-05-22 | Methylgene, Inc. | Acyl phosph(on)ate inhibitors of beta-lactamase |
| US6599889B2 (en) | 1997-12-24 | 2003-07-29 | Methylgere, Inc. | Acyl phosphonate inhibitors of β-lactamases |
| JP5514973B2 (ja) * | 2010-04-30 | 2014-06-04 | 独立行政法人産業技術総合研究所 | ホスホン酸ジエステル誘導体の製造方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2625536A (en) * | 1951-05-05 | 1953-01-13 | Du Pont | Neutral esters of dicarboxylic acid orthophosphoric acid mixed anhydrides and condensation polymerization process utilizing the same |
| US2748153A (en) * | 1951-05-05 | 1956-05-29 | Du Pont | Preparation of acyl phosphoric esters |
| DE1044073B (de) * | 1957-03-20 | 1958-11-20 | Basf Ag | Verfahren zur Herstellung von O, O-Dialkylphosphorsaeure- bzw. -thiophosphorsaeureverbindungen |
| US3835203A (en) * | 1970-11-10 | 1974-09-10 | Us Agriculture | Phosphoric-carboxylic acid anhydrides |
| US4061736A (en) * | 1975-02-02 | 1977-12-06 | Alza Corporation | Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin |
| US4001401A (en) * | 1975-02-02 | 1977-01-04 | Alza Corporation | Blood substitute and blood plasma expander comprising polyhemoglobin |
| US4001200A (en) * | 1975-02-27 | 1977-01-04 | Alza Corporation | Novel polymerized, cross-linked, stromal-free hemoglobin |
| US4053590A (en) * | 1975-02-27 | 1977-10-11 | Alza Corporation | Compositions of matter comprising macromolecular hemoglobin |
| US4473496A (en) * | 1981-09-14 | 1984-09-25 | The United States Of America As Represented By The Secretary Of The Army | Intramolecularly crosslinked hemoglobin |
| DE3144705C2 (de) * | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
| US4529719A (en) * | 1983-05-04 | 1985-07-16 | Tye Ross W | Modified crosslinked stroma-free tetrameric hemoglobin |
| GB8328917D0 (en) * | 1983-10-28 | 1983-11-30 | Fisons Plc | Blood substitute |
| US4600531A (en) * | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| US4598064A (en) * | 1984-06-27 | 1986-07-01 | University Of Iowa Research Foundation | Alpha-alpha cross-linked hemoglobins |
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| GB8712240D0 (en) * | 1987-05-23 | 1987-07-01 | Fisons Plc | Pharmaceutical formulation |
| IL87708A (en) * | 1988-09-08 | 1994-04-12 | Technion Inst For Research And | Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof |
-
1991
- 1991-03-12 CA CA002078141A patent/CA2078141C/en not_active Expired - Fee Related
- 1991-03-12 WO PCT/CA1991/000073 patent/WO1991013891A1/en active IP Right Grant
- 1991-03-12 EP EP91905433A patent/EP0519953B1/en not_active Expired - Lifetime
- 1991-03-12 AT AT91905433T patent/ATE133955T1/de not_active IP Right Cessation
- 1991-03-12 DE DE69117054T patent/DE69117054T2/de not_active Expired - Fee Related
- 1991-03-12 DK DK91905433.8T patent/DK0519953T3/da active
- 1991-03-12 AU AU74477/91A patent/AU658821B2/en not_active Ceased
- 1991-03-12 ES ES91905433T patent/ES2082971T3/es not_active Expired - Lifetime
- 1991-03-12 JP JP3505262A patent/JP3021041B2/ja not_active Expired - Fee Related
-
1992
- 1992-09-15 US US07/944,914 patent/US5334707A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5334707A (en) | 1994-08-02 |
| JP3021041B2 (ja) | 2000-03-15 |
| CA2078141C (en) | 1996-10-08 |
| WO1991013891A1 (en) | 1991-09-19 |
| ATE133955T1 (de) | 1996-02-15 |
| DE69117054D1 (de) | 1996-03-21 |
| EP0519953A1 (en) | 1992-12-30 |
| EP0519953B1 (en) | 1996-02-07 |
| AU7447791A (en) | 1991-10-10 |
| CA2078141A1 (en) | 1991-09-15 |
| JPH05505604A (ja) | 1993-08-19 |
| DK0519953T3 (da) | 1996-07-01 |
| DE69117054T2 (de) | 1996-06-27 |
| AU658821B2 (en) | 1995-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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