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ES2072548T3 - Derivados de pirimidina. - Google Patents

Derivados de pirimidina.

Info

Publication number
ES2072548T3
ES2072548T3 ES91306488T ES91306488T ES2072548T3 ES 2072548 T3 ES2072548 T3 ES 2072548T3 ES 91306488 T ES91306488 T ES 91306488T ES 91306488 T ES91306488 T ES 91306488T ES 2072548 T3 ES2072548 T3 ES 2072548T3
Authority
ES
Spain
Prior art keywords
sub
alcoxi
elevated
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91306488T
Other languages
English (en)
Inventor
Mitsunori Hiratsuka
Naonori Hirata
Kazuo Saitoh
Hideyuki Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Application granted granted Critical
Publication of ES2072548T3 publication Critical patent/ES2072548T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN DERIVADO DE PIRIMIDINA TIENE LA FORMULA, EN DONDE CADA R ELEVADO 1 Y R (AL CUADRADO) , QUE PUEDEN SER IGUALES O DIFERENTES, ES ALQUILO C SUB 1-6, ALCOXI C SUB 1-6, HALOALCOXI C SUB 1-6 O HALOGENO; R ELEVADO 3 ES HIDROGENO O ALQUILO C SUB 1-C SUB 6; R ELEVADO 4 ES ALQUILO C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, BENZILO, FENILO O FENILO SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6, NITRO Y HALOGENO; X ES OXIGENO O AZUFRE; Z ES NITROGENO O CY ELEVADO 4; CADA Y ELEVADO 1, Y (AL CUADRADO) E Y ELEVADO 3, QUE PUEDEN SER IGUALES O DIFERENTES, ES HIDROGENO, HALOGENO, ALQUILO C SUB 1-C SUB 6 O ALCOXI C SUB 1-C SUB 6; E Y ELEVADO 4 ES HIDROGENO, HIDROXILO, MERCAPTO, NITRO, HALOGENO, ALQUILO C SUB 1-C SUB 6, ALQUENILO C SUB 2-C SUB 6, ALQUINILO C SUB 2-C SUB 6, ALCOXI C SUB 1-C SUB 6, ALQUENILOXI C SUB 3-C SUB 6, ALQUINILOXI C SUB 3-C SUB 6, HALOALQUILOC SUB 1-C SUB 6, HALOALQUENILO C SUB 2-C SUB 6, HALOALQUINILO C SUB 2-C SUB 6, HALOALCOXI C SUB 1-C SUB 6, HALOALQUENILOXI C SUB 3-C SUB 6, HALOALQUINILOXI C SUB 3-C SUB 6, ALCOXI C SUB 1-C SUB 6 ALQUILO C SUB 1-C SUB 6, ALQUENILOXI C SUB 3-C SUB 6 ALQUILO C SUB 1-C SUB 6, ALQUINILOXI C SUB 3-C SUB 6 ALQUILO C SUB 1-C SUB 6, CIANO, FORMILO, CARBOXILO, ALCOXICARBONILO C SUB 1-C SUB 6, ALQUENILOXICARBONILO C SUB 3-C SUB 6, ALQUINILOXICARBONILO C SUB 3-C SUB 6, FENILO, FENILO SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, FENOXI, FENOXI SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, FENILTIO, FENILTIO SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, BENZILOXI, BENZILOXI SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, BENZILOXI, BENZILOXI SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, BENZILOXI, BENZILOXI SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, BENZILTIO, BENZILTIO SUSTITUIDO POR UN MIEMBRO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN ALQUILO C SUB 1-C SUB 6, ALCOXI C SUB 1-C SUB 6, HALOALQUILO C SUB 1-C SUB 6, ALCOXICARBONILO C SUB 1-C SUB 6 Y HALOGENO, EN DONDE CADAR ELEVADO 5 Y R ELEVADO 6, QUE PUEDEN SER IGUALES O DIFERENTES, ES HIDROGENO, ALQUILO C SUB 1-C SUB 6, ALQUENILO C SUB 3-C SUB 6 O ALQUINILO C SUB 3-C SUB 6, EN DONDE R ELEVADO 5 Y R ELEVADO 6 SON COMO SE HA DEFINIDO ARRIBA, EN DONDE R ELEVADO 7 ES ALQUILO C SUB 1-C SUB 6, ALQUENILO C SUB 3-C SUB 6 O ALQUINILO C SUB 3-C SUB 6 Y M ES UN ENTERO QUE PUEDE SER 0, 1 O 2, EN DONDE X ELEVADO 1 ES HIDROGENO O AZUFRE, Y R ELEVADO 7 ES COMO SE HA DEFINIDO ARRIBA, O EN DONDE R ELEVADO 7 Y M SON COMO SE HAN DEFINIDO ARRIBA Y N ES UN ENTERO DE 1 A 4.
ES91306488T 1990-07-26 1991-07-17 Derivados de pirimidina. Expired - Lifetime ES2072548T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19976390 1990-07-26
JP3125495A JPH04235171A (ja) 1990-07-26 1991-04-25 スルホヒドロキサム酸誘導体、その製造法およびそれを有効成分とする除草剤

Publications (1)

Publication Number Publication Date
ES2072548T3 true ES2072548T3 (es) 1995-07-16

Family

ID=26461925

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91306488T Expired - Lifetime ES2072548T3 (es) 1990-07-26 1991-07-17 Derivados de pirimidina.

Country Status (9)

Country Link
US (1) US5129938A (es)
EP (1) EP0468690B1 (es)
JP (1) JPH04235171A (es)
KR (1) KR920002556A (es)
AU (2) AU636234B2 (es)
BR (1) BR9103188A (es)
CA (1) CA2047770A1 (es)
DE (1) DE69110093T2 (es)
ES (1) ES2072548T3 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5125957A (en) * 1989-11-01 1992-06-30 Sumitomo Chemical Company, Limited Pyrimidine derivatives
US5232897A (en) * 1990-05-15 1993-08-03 Sumitomo Chemical Company, Limited Herbicidal pyrimidine compounds, compositions containing the same and method of use
US5298632A (en) * 1990-05-15 1994-03-29 Sumitomo Chemical Company, Limited Herbicidal pyrimidine compounds, compositions containing the same and method of use
GB9112566D0 (en) * 1991-06-11 1991-07-31 Shell Int Research Sulphonamide herbicides
CA2107748A1 (en) * 1992-10-16 1994-04-17 Mitsunori Hiratsuka Biphenyl derivative, a method for producing the same and its use as herbicides
PT1390040E (pt) 2001-05-18 2007-04-30 Pantarhei Bioscience Bv Composição farmacêutica para ser utilizado na terapia hormonal de substituição.
DE60234515D1 (de) 2001-05-23 2010-01-07 Pantarhei Bioscience Bv Tetrahydroxylierte estrogen enthaltendes arzneistoffverabreichungssystem zur verwendung in hormonalen kontrazeption
WO2002094279A1 (en) 2001-05-23 2002-11-28 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception
EP1446128B1 (en) 2001-11-15 2006-12-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
ES2399423T3 (es) 2002-06-11 2013-04-01 Pantarhei Bioscience B.V. Método para tratar la piel humana y una composición para el cuidado de la piel para su uso en tal método
ATE340579T1 (de) 2002-06-11 2006-10-15 Pantarhei Bioscience Bv Methode zur behandlung oder prävention immunologischer erkrankungen und pharmazeutische zusammensetzung zur solchen anwendung
CN100374116C (zh) 2002-07-12 2008-03-12 潘塔希生物科学股份有限公司 用于癌症治疗的含有雌四醇衍生物的药物组合物
DK1556058T3 (da) 2002-10-23 2008-03-03 Pantarhei Bioscience Bv Farmaceutiske præparater omfattende östetrolderivater til anvendelse i cancerterapi
US8236785B2 (en) 2007-01-08 2012-08-07 Pantarhei Bioscience B.V. Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method
ES2719101T3 (es) * 2009-12-07 2019-07-08 Univ Johns Hopkins Derivados de hidroxilamina N-acilados y derivados de hidroxilamina o-acilados
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives

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NZ191078A (en) * 1978-08-08 1982-05-31 Ici Australia Ltd Bis(pyrimidyloxy) benzenes bis(pyrimidylthio)benzenes and prymidyloxy-pyrimidyl thiobenzens and herbicidal compositions
EP0223406B1 (en) * 1985-10-15 1990-08-29 Kumiai Chemical Industry Co., Ltd. Pyrimidine derivatives and herbicidal uses thereof
DE3602016A1 (de) * 1985-12-05 1987-06-11 Bayer Ag Pyri(mi)dyl-oxy- und thio-benzoesaeure-derivate
JPH082883B2 (ja) * 1986-06-06 1996-01-17 クミアイ化学工業株式会社 ２−フエノキシピリミジン誘導体および除草剤
ES2039369T3 (es) * 1986-06-14 1993-10-01 Kumiai Chemical Industry Co., Ltd. Un procedimiento para la produccion de nuevos derivados de acido picolinico.
JPS63258462A (ja) * 1987-04-14 1988-10-25 Kumiai Chem Ind Co Ltd ２−フエノキシピリミジン誘導体及び除草剤
US4946495A (en) * 1987-04-14 1990-08-07 Kumiai Chemical Industry Co., Ltd. 2-phenoxypyrimidine derivative and herbicidal composition
EP0287079B1 (en) * 1987-04-14 1994-10-12 Kumiai Chemical Industry Co., Ltd. 2-Phenoxypyrimidine derivatives and herbicidal compositions
JPS63258463A (ja) * 1987-04-14 1988-10-25 Kumiai Chem Ind Co Ltd ２−フエノキシピリミジン誘導体及び除草剤
JPS63258467A (ja) * 1987-04-14 1988-10-25 Kumiai Chem Ind Co Ltd ２−フエノキシトリアジン誘導体及び除草剤
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JPH0256469A (ja) * 1987-12-08 1990-02-26 Kumiai Chem Ind Co Ltd ピリミジン誘導体及び除草剤
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GB8808071D0 (en) * 1988-04-07 1988-05-11 Shell Int Research Triazine herbicides
JPH01290671A (ja) * 1988-05-16 1989-11-22 Kumiai Chem Ind Co Ltd ピリミジン誘導体及び除草剤
EP0346789B1 (de) * 1988-06-16 1994-04-20 BASF Aktiengesellschaft Salicylsäurederivate und deren Schwefelanaloge
EP0347811B1 (en) * 1988-06-20 1994-03-30 Kumiai Chemical Industry Co., Ltd. Alkanoic acid derivatives and herbicidal compositions
DE3832237A1 (de) * 1988-09-22 1990-03-29 Basf Ag Aromatische carbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als herbizide
JPH03128362A (ja) * 1988-12-01 1991-05-31 Nissan Chem Ind Ltd ピリミジン誘導体及び除草剤
US4973354A (en) * 1988-12-01 1990-11-27 Nissan Chemical Industries, Ltd. Pyrimidine derivatives and herbicide containing the same
DE3841432A1 (de) * 1988-12-09 1990-06-21 Basf Ag Pyridinderivate und ihre verwendung als herbizide
JPH02262565A (ja) * 1988-12-19 1990-10-25 Mitsui Toatsu Chem Inc ピリミジン誘導体、その製造法およびこれらを含有する除草剤ならびに除草剤組成物
DE3910635A1 (de) * 1989-04-01 1990-10-04 Basf Ag Pyridinderivate und ihre verwendung als herbizide
DE3919435A1 (de) * 1989-06-14 1990-12-20 Basf Ag Salicylaldehyd- und salicylsaeurederivate sowie deren schwefelanaloge, verfahren zu ihrer herstellung als herbizide und bioregulatoren
JPH0331266A (ja) * 1989-06-27 1991-02-12 Nissan Chem Ind Ltd ピリミジン誘導体及び除草剤
JPH0352873A (ja) * 1989-07-19 1991-03-07 Hokko Chem Ind Co Ltd ２―オキシベンジルアルコール誘導体および除草剤
DE3927382A1 (de) * 1989-08-19 1991-02-21 Basf Ag Carbonsaeurederivate
GB8924465D0 (en) * 1989-10-31 1989-12-20 Ici Plc Herbicides

Also Published As

Publication number Publication date
AU636234B2 (en) 1993-04-22
EP0468690B1 (en) 1995-05-31
DE69110093T2 (de) 1995-10-19
BR9103188A (pt) 1992-02-11
US5129938A (en) 1992-07-14
CA2047770A1 (en) 1992-01-27
AU3538393A (en) 1993-05-20
JPH04235171A (ja) 1992-08-24
EP0468690A1 (en) 1992-01-29
AU8033891A (en) 1992-01-30
DE69110093D1 (de) 1995-07-06
KR920002556A (ko) 1992-02-28
AU649917B2 (en) 1994-06-02

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