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ES2068361T3 - Procedimiento para la preparacion de (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r), los (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r) asi obtenidos y las composiciones farmaceuticas que les contienen. - Google Patents

Procedimiento para la preparacion de (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r), los (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r) asi obtenidos y las composiciones farmaceuticas que les contienen.

Info

Publication number
ES2068361T3
ES2068361T3 ES90403061T ES90403061T ES2068361T3 ES 2068361 T3 ES2068361 T3 ES 2068361T3 ES 90403061 T ES90403061 T ES 90403061T ES 90403061 T ES90403061 T ES 90403061T ES 2068361 T3 ES2068361 T3 ES 2068361T3
Authority
ES
Spain
Prior art keywords
tetrahidrotiopiranocarbotioamida
oxidos
piridil
pharmaceutical compositions
los
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90403061T
Other languages
English (en)
Inventor
Jean-Claude Aloup
Claude James
Rodolphe Margraff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Application granted granted Critical
Publication of ES2068361T3 publication Critical patent/ES2068361T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCESO DE PREPARACION DE (PIRIDIL-3)-2 TETRAHIDROTIOPIRANOCARBOTIOAMIDA-2 -OXIDOS-1-(1R, 2R) CUYA FORMULA GENERAL ES: (R SUB 1 = ALQUILO QUE CONTIENE 1 A 4 ATOMOS DE CARBONO) POR ACCION DE UN ISOTIOCIANATO DE ALQUILO SOBRE LOS SULFOXIDOS 1R, 2R Y 1R, 2S CUYA FORMULA ES: TOMADOS SOLOS O EN MEZCLA, LOS (PIRIDIL-3)-2 TETRAHIDROTIOPIRANOCARBOTIOMIDA-2 R) ASI OBTENIDOS Y LAS OBTENIDOS Y LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. LOS (PIRIDIL-3)-2 TETRAHIDROTIOPIRENOCARBOTIOMIDA-2 OXIDOS-1 MO ANTI-HIPERTENSORES.
ES90403061T 1989-10-31 1990-10-30 Procedimiento para la preparacion de (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r), los (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r) asi obtenidos y las composiciones farmaceuticas que les contienen. Expired - Lifetime ES2068361T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8914273A FR2653770B1 (fr) 1989-10-31 1989-10-31 Procede de preparation de (pyridyl-3)-2 tetrahydrothiopyrannecarbothioamide-2-oxydes-1-(1r,2r), les (pyridyl-3)-2 tetrhydrothiopyrannecarbothioamide-2-oxydes-1-(1r,2r) ainsi obtenus et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2068361T3 true ES2068361T3 (es) 1995-04-16

Family

ID=9386963

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90403061T Expired - Lifetime ES2068361T3 (es) 1989-10-31 1990-10-30 Procedimiento para la preparacion de (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r), los (piridil-3)-2-tetrahidrotiopiranocarbotioamida-2-oxidos-1-(1r,2r) asi obtenidos y las composiciones farmaceuticas que les contienen.

Country Status (25)

Country Link
US (1) US5120852A (es)
EP (1) EP0426557B1 (es)
JP (1) JPH03153684A (es)
KR (1) KR910007921A (es)
AT (1) ATE118773T1 (es)
AU (1) AU641950B2 (es)
CA (1) CA2028985A1 (es)
DE (1) DE69017146T2 (es)
DK (1) DK0426557T3 (es)
ES (1) ES2068361T3 (es)
FI (1) FI905358A0 (es)
FR (1) FR2653770B1 (es)
GR (1) GR3015159T3 (es)
HU (1) HU212501B (es)
IE (1) IE66252B1 (es)
IL (1) IL96160A (es)
MA (1) MA21989A1 (es)
NO (1) NO177707C (es)
NZ (1) NZ235872A (es)
OA (1) OA09324A (es)
PL (1) PL164269B1 (es)
PT (1) PT95758A (es)
RU (1) RU1838311C (es)
TN (1) TNSN90128A1 (es)
ZA (1) ZA908679B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9001327D0 (en) * 1990-01-19 1990-03-21 May & Baker Ltd New compositions of matter
FR2702213B1 (fr) * 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Procédé de préparation de N-méthyl (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2-oxyde-1-(1R,2R).
GB9314133D0 (en) * 1993-07-08 1993-08-18 Rhone Poulenc Rorer Ltd New process
GB9321939D0 (en) * 1993-10-25 1993-12-15 Rhone Poulenc Rorer Ltd New process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395142A (en) * 1963-11-27 1968-07-30 Rohm & Haas Aminoethylene compositions
IE49570B1 (en) * 1979-03-30 1985-10-30 Rhone Poulenc Ind 2-(pyrid-2-yl)tetrahydrothiophene derivatives
FR2488609A1 (fr) * 1980-08-18 1982-02-19 Rhone Poulenc Ind Nouveaux derives de la thioformamide, leur preparation et les medicaments qui les contiennent
AU543387B2 (en) * 1981-05-27 1985-04-18 Rhone-Poulenc Sante Thioformamide derivatives
FR2528849B1 (fr) * 1982-06-17 1985-06-21 Rhone Poulenc Sante Nouveaux derives de la thioformamide, leur preparation et les medicaments qui les contiennent
ATE23577T1 (de) * 1983-06-16 1986-11-15 Rhone Poulenc Sante Verfahren zur elektrochemischen herstellung von sulfoxyden von thioformamid-derivaten,die als arzneimittel anwendung finden.

Also Published As

Publication number Publication date
IE66252B1 (en) 1995-12-27
PL164269B1 (pl) 1994-07-29
TNSN90128A1 (fr) 1991-03-05
DE69017146T2 (de) 1995-07-06
AU6554890A (en) 1991-05-09
ATE118773T1 (de) 1995-03-15
NO904708L (no) 1991-05-02
ZA908679B (en) 1991-08-28
GR3015159T3 (en) 1995-05-31
KR910007921A (ko) 1991-05-30
EP0426557B1 (fr) 1995-02-22
HUT59397A (en) 1992-05-28
MA21989A1 (fr) 1991-07-01
NZ235872A (en) 1992-05-26
IL96160A0 (en) 1991-07-18
RU1838311C (ru) 1993-08-30
HU906945D0 (en) 1991-05-28
AU641950B2 (en) 1993-10-07
FR2653770B1 (fr) 1992-01-03
OA09324A (fr) 1992-09-15
DK0426557T3 (da) 1995-03-27
NO177707B (no) 1995-07-31
JPH03153684A (ja) 1991-07-01
CA2028985A1 (fr) 1991-05-01
PL287557A1 (en) 1991-12-16
IE903902A1 (en) 1991-05-08
IL96160A (en) 1995-12-31
FI905358A0 (fi) 1990-10-30
US5120852A (en) 1992-06-09
DE69017146D1 (de) 1995-03-30
NO177707C (no) 1995-11-08
PT95758A (pt) 1991-09-13
EP0426557A1 (fr) 1991-05-08
NO904708D0 (no) 1990-10-30
FR2653770A1 (fr) 1991-05-03
HU212501B (en) 1996-07-29

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