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ES2064324T3 - Adn que codifica para un polipeptido con actividades anticoagulantes. - Google Patents

Adn que codifica para un polipeptido con actividades anticoagulantes.

Info

Publication number
ES2064324T3
ES2064324T3 ES88102468T ES88102468T ES2064324T3 ES 2064324 T3 ES2064324 T3 ES 2064324T3 ES 88102468 T ES88102468 T ES 88102468T ES 88102468 T ES88102468 T ES 88102468T ES 2064324 T3 ES2064324 T3 ES 2064324T3
Authority
ES
Spain
Prior art keywords
polypeptide
dna coding
anticoagulant activities
anticoagulant
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88102468T
Other languages
English (en)
Inventor
Yushi Saino
Akio Iwasaki
Makoto Suda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of ES2064324T3 publication Critical patent/ES2064324T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBE UN POLIPEPTIDO QUE TIENE UNA SECUENCIA DE AMINOACIDOS ESPECIFICA. TAMBIEN SE DESCRIBE UN NUEVO ADN QUE CODIFICA EL POLIPEPTIDO, UN PLASMIDO RECOMBINANTE QUE CONTIENE EL ADN, UN TRANSFORMANTE QUE CONTIENE EL PLASMIDO RECOMBINANTE, UN ANTICOAGULANTE QUE CONTIENE EL POLIPEPTIDO COMO INGREDIENTE EFECTIVO Y UN PROICEDIMIENTO PARA LA OBTENCION DEL POLIPEPTIDO.
ES88102468T 1987-02-20 1988-02-19 Adn que codifica para un polipeptido con actividades anticoagulantes. Expired - Lifetime ES2064324T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3722787 1987-02-20
JP62184428A JP2660514B2 (ja) 1987-02-20 1987-07-23 抗血液凝固作用を有するポリペプチド

Publications (1)

Publication Number Publication Date
ES2064324T3 true ES2064324T3 (es) 1995-02-01

Family

ID=26376346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88102468T Expired - Lifetime ES2064324T3 (es) 1987-02-20 1988-02-19 Adn que codifica para un polipeptido con actividades anticoagulantes.

Country Status (7)

Country Link
US (1) US5591633A (es)
EP (1) EP0279459B1 (es)
JP (1) JP2660514B2 (es)
KR (1) KR960013386B1 (es)
CA (1) CA1339992C (es)
DE (1) DE3851645T2 (es)
ES (1) ES2064324T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3843513A1 (de) * 1988-12-23 1990-07-05 Behringwerke Ag Fuer das plazentaprotein 11 (pp11) kodierende cdna, ihre isolierung und verwendung
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
DE4003773A1 (de) * 1990-02-08 1991-08-14 Behringwerke Ag Verfahren zur reinigung von lipocortinen
EP0558751B1 (en) * 1990-11-20 2000-02-02 Kowa Co. Ltd. Therapeutic agent for the treatment of wounds
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US6323313B1 (en) * 1999-06-01 2001-11-27 The University Of Washington Annexin derivative with endogenous chelation sites
CN1250567C (zh) * 2000-07-21 2006-04-12 财团法人化学及血清疗法研究所 钙离子结合蛋白的提纯方法
US7635680B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US7635676B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
DE60219611T2 (de) * 2001-02-21 2007-12-27 Alavita Pharmaceuticals, Inc., Mountain View Modifizierte annexin-proteine und verhinderung und behandlung von thrombose
US7645739B2 (en) * 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US6982154B2 (en) * 2002-02-21 2006-01-03 Surromed, Inc. Modified annexin proteins and methods for treating vaso-occlusive sickle-cell disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
AU1299788A (en) * 1987-02-06 1988-08-24 Board Of Regents Of The University Of Washington, The Human proteins having anticoagulant and anti-inflammatory activity
PT87083B (pt) * 1987-03-28 1992-07-31 Boehringer Ingelheim Int Processo para a preparacao de uma proteina anticoagulante vascular, de adn que codifica para esta proteina e de composicoes farmaceuticas que a contem

Also Published As

Publication number Publication date
EP0279459A3 (en) 1990-06-27
KR960013386B1 (ko) 1996-10-04
DE3851645D1 (de) 1994-11-03
EP0279459A2 (en) 1988-08-24
EP0279459B1 (en) 1994-09-28
CA1339992C (en) 1998-08-11
KR880009991A (ko) 1988-10-06
US5591633A (en) 1997-01-07
JPS6420095A (en) 1989-01-24
DE3851645T2 (de) 1995-05-04
JP2660514B2 (ja) 1997-10-08

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