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ES2059396T3 - Derivados de indeno y metodos. - Google Patents

Derivados de indeno y metodos.

Info

Publication number
ES2059396T3
ES2059396T3 ES87309996T ES87309996T ES2059396T3 ES 2059396 T3 ES2059396 T3 ES 2059396T3 ES 87309996 T ES87309996 T ES 87309996T ES 87309996 T ES87309996 T ES 87309996T ES 2059396 T3 ES2059396 T3 ES 2059396T3
Authority
ES
Spain
Prior art keywords
derivatives
methods
indeno
indenous
indano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87309996T
Other languages
English (en)
Inventor
Klaus Peter Bogeso
Michael Bech Sommer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2059396T3 publication Critical patent/ES2059396T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Automatic Cycles, And Cycles In General (AREA)
  • Catalysts (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE INDENO DE FORMULA GENERAL (I), EN LA QUE R1, R2, R3 Y N SON COMO SE DEFINE EN LA SOLICITUD 1, QUE SON INTERMEDIOS UTILES PARA LA OBTENCION DE DERIVADOS DE INDANO O INDENO FARMACOLOGICAMENTE ACTIVOS. TAMBIEN SE DESCRIBEN METODOS.
ES87309996T 1986-12-01 1987-11-12 Derivados de indeno y metodos. Expired - Lifetime ES2059396T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868628644A GB8628644D0 (en) 1986-12-01 1986-12-01 Intermediates

Publications (1)

Publication Number Publication Date
ES2059396T3 true ES2059396T3 (es) 1994-11-16

Family

ID=10608224

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87309996T Expired - Lifetime ES2059396T3 (es) 1986-12-01 1987-11-12 Derivados de indeno y metodos.

Country Status (17)

Country Link
US (1) US4873344A (es)
EP (1) EP0271225B1 (es)
JP (1) JP2622135B2 (es)
AT (1) ATE95810T1 (es)
AU (1) AU609751B2 (es)
CA (1) CA1302420C (es)
DE (1) DE3787790T2 (es)
DK (1) DK626587A (es)
ES (1) ES2059396T3 (es)
FI (1) FI90660C (es)
GB (1) GB8628644D0 (es)
IE (1) IE60380B1 (es)
IL (1) IL84429A (es)
NO (1) NO175527C (es)
NZ (1) NZ222614A (es)
PT (1) PT86242B (es)
ZA (1) ZA878993B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IS7282A (is) * 2001-12-21 2004-05-21 H. Lundbeck A/S Amínóindan afleiður sem serótónín og noradrenalínupptökuhindrar
CN1606552A (zh) * 2001-12-21 2005-04-13 H.隆德贝克有限公司 氨基茚满衍生物作为5－羟色胺和去甲肾上腺素摄取抑制剂
JP2009514915A (ja) * 2005-11-08 2009-04-09 ラボラトリオス・デル・ドクトル・エステベ・ソシエダッド・アノニマ インデン誘導体、それらの製造および薬剤としての使用
TW200819426A (en) 2006-08-31 2008-05-01 Lundbeck & Co As H Novel indane compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1124682A (en) * 1966-06-21 1968-08-21 Wyeth John & Brother Ltd Preparation of amines
DE1793488A1 (de) * 1968-09-25 1972-02-24 Knoll Ag Aminobenzocycloalkylnitrile
IE50867B1 (en) * 1980-02-29 1986-08-06 Kefalas As Indane derivatives
IL66831A0 (en) * 1981-10-05 1982-12-31 Kefalas As Indane derivatives
IE55972B1 (en) * 1982-10-07 1991-03-13 Kefalas As Phenylindene derivatives,acid addition salts thereof,and methods of preparation

Also Published As

Publication number Publication date
IL84429A0 (en) 1988-04-29
JPS63154652A (ja) 1988-06-27
CA1302420C (en) 1992-06-02
PT86242A (en) 1987-12-01
US4873344A (en) 1989-10-10
FI875050A0 (fi) 1987-11-16
PT86242B (pt) 1990-11-07
EP0271225A3 (en) 1989-12-06
NO874990L (no) 1988-06-02
IE60380B1 (en) 1994-07-13
EP0271225A2 (en) 1988-06-15
DK626587A (da) 1988-06-02
FI90660B (fi) 1993-11-30
FI90660C (fi) 1994-03-10
IL84429A (en) 1993-05-13
GB8628644D0 (en) 1987-01-07
JP2622135B2 (ja) 1997-06-18
DE3787790T2 (de) 1994-04-14
ZA878993B (en) 1988-10-26
NO175527C (no) 1994-10-26
EP0271225B1 (en) 1993-10-13
DK626587D0 (da) 1987-11-30
FI875050A (fi) 1988-06-02
AU8192887A (en) 1988-06-02
AU609751B2 (en) 1991-05-09
DE3787790D1 (de) 1993-11-18
IE873019L (en) 1988-06-01
NZ222614A (en) 1990-08-28
ATE95810T1 (de) 1993-10-15
NO175527B (no) 1994-07-18
NO874990D0 (no) 1987-11-30

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