ES2058341T3 - Subunidades de proteina portadoras de somatomedina humana y proceso para producirlas. - Google Patents
Subunidades de proteina portadoras de somatomedina humana y proceso para producirlas.Info
- Publication number
- ES2058341T3 ES2058341T3 ES88904042T ES88904042T ES2058341T3 ES 2058341 T3 ES2058341 T3 ES 2058341T3 ES 88904042 T ES88904042 T ES 88904042T ES 88904042 T ES88904042 T ES 88904042T ES 2058341 T3 ES2058341 T3 ES 2058341T3
- Authority
- ES
- Spain
- Prior art keywords
- subunites
- somatomedine
- protein
- produce
- carrying human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un método que comprende la producción de un polipéptido que es un fragmento, una parte o un componente del complejo de glucoproteina humana que regula la actividad biológica de las somatomedinas mediante un proceso que implica el enlace de las somatomedinas, que depende de la hormona de crecimiento, y que presenta un peso molecular de aproximadamente 125000 a 160000 daltons, en condiciones de pH fisiológico, cuando forma complejo con las somatomedinas; en el que el polipéptido es capaz de unirse con las somatomedinas y con los polipéptidos similares a las somatomedinas y que tiene una secuencia de aminoácidos N-terminal de fórmula Gly-Ala-Ser-Ser-Ala-Gly-Leu-Gly-Pro-Val(1) (5) (10) Val-Arg-R-Glu-Pro-R-Asp-Ala-Arg-Ala(15) (20) Leu-Alaen la que R es cisteina o semicisteina; la 5-Ala puede ser Gly; y el 14-Glu puede ser Phe.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3488587A | 1987-04-06 | 1987-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2058341T3 true ES2058341T3 (es) | 1994-11-01 |
Family
ID=21879212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88904042T Expired - Lifetime ES2058341T3 (es) | 1987-04-06 | 1988-03-31 | Subunidades de proteina portadoras de somatomedina humana y proceso para producirlas. |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP0308500B1 (es) |
| JP (1) | JP2648951B2 (es) |
| AT (1) | ATE90690T1 (es) |
| AU (1) | AU627423B2 (es) |
| CA (1) | CA1340295C (es) |
| DE (1) | DE3881801T2 (es) |
| DK (1) | DK677688D0 (es) |
| ES (1) | ES2058341T3 (es) |
| IL (1) | IL85983A (es) |
| WO (1) | WO1988007863A1 (es) |
| ZA (1) | ZA882407B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5973115A (en) * | 1987-05-15 | 1999-10-26 | Amgen Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
| US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
| EP0418230B1 (en) * | 1988-04-12 | 1995-12-27 | Amgen Boulder Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
| ATE125268T1 (de) * | 1988-07-15 | 1995-08-15 | Cent Sydney Area Health Serv | Säureempfindliche subeinheit eines insulinähnlichen wachstumfaktors-bindeprotein- komplexes. |
| US5324820A (en) * | 1988-07-15 | 1994-06-28 | Central Sydney Area Health Service | Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex |
| US6465423B1 (en) | 1988-07-15 | 2002-10-15 | Central Sydney Area Health Service | Acid-labile subunit (ALS) of insulin-like growth factor binding protein complex |
| US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
| EP0800530A4 (en) * | 1994-07-20 | 1998-12-02 | Celtrix Pharma | IGF / IGFBP COMPLEX FOR PROMOTING BONE TRAINING AND REGULATING BONE REMODELING |
| US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
| US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
| AU762351B2 (en) | 1999-01-06 | 2003-06-26 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
| IL143834A0 (en) | 1999-01-06 | 2002-04-21 | Genentech Inc | Insulin-like growth factor (igf) i mutant variants |
| ES2301547T3 (es) | 2000-05-16 | 2008-07-01 | Genentech, Inc. | Tratamiento de trastornos del cartilago. |
| AU2002248609B2 (en) | 2001-03-14 | 2007-03-01 | Genentech, Inc. | IGF antagonist peptides |
| ES2527871T3 (es) | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
| NZ545940A (en) | 2003-09-12 | 2009-12-24 | Tercica Inc | Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency |
| EP1670822A2 (en) | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf binding proteins |
| DK2100614T3 (da) | 2005-06-17 | 2013-10-28 | Imclone Llc | Antistof mod PDGFR-alfa til anvendelse ved behandlingen af tumorer |
| WO2007092453A2 (en) | 2006-02-03 | 2007-08-16 | Imclone Systems Incorporated | Igf-ir antagonists as adjuvants for treatment of prostate cancer |
| PE20201166A1 (es) | 2017-09-11 | 2020-10-28 | Shire Human Genetic Therapies | Metodos y composiciones para tratar enfermedades pulmonares cronicas |
| KR20230113287A (ko) | 2020-10-19 | 2023-07-28 | 오크 힐 바이오 리미티드 | 신생아에 사용하기에 적합한 조성물 |
| MX2024008819A (es) | 2022-01-19 | 2024-09-17 | Oak Hill Bio Ltd | Composiciones y metodos para reducir la oxidacion de igf-1/igfbp. |
| WO2023242439A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Vascular stabilisation (preterm infants) |
| WO2023242440A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Treament of lungs in infants |
| WO2023242442A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Method of maturing/differentiating neurons and/or modulating the vagus nerve |
| WO2024170612A1 (en) | 2023-02-14 | 2024-08-22 | Oak Hill Bio Limited | Treatment of healing dysregulation in gi tissue |
-
1988
- 1988-03-31 DE DE88904042T patent/DE3881801T2/de not_active Expired - Fee Related
- 1988-03-31 AT AT88904042T patent/ATE90690T1/de active
- 1988-03-31 JP JP63503623A patent/JP2648951B2/ja not_active Expired - Lifetime
- 1988-03-31 WO PCT/US1988/001042 patent/WO1988007863A1/en active IP Right Grant
- 1988-03-31 ES ES88904042T patent/ES2058341T3/es not_active Expired - Lifetime
- 1988-03-31 AU AU17020/88A patent/AU627423B2/en not_active Ceased
- 1988-03-31 EP EP88904042A patent/EP0308500B1/en not_active Expired - Lifetime
- 1988-04-05 CA CA000563309A patent/CA1340295C/en not_active Expired - Fee Related
- 1988-04-05 IL IL8598388A patent/IL85983A/en unknown
- 1988-04-06 EP EP88303041A patent/EP0294021A1/en active Pending
- 1988-04-07 ZA ZA882407A patent/ZA882407B/xx unknown
- 1988-12-05 DK DK677688A patent/DK677688D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL85983A0 (en) | 1988-09-30 |
| ZA882407B (en) | 1988-09-28 |
| JP2648951B2 (ja) | 1997-09-03 |
| AU1702088A (en) | 1988-11-04 |
| CA1340295C (en) | 1998-12-29 |
| EP0308500A1 (en) | 1989-03-29 |
| IL85983A (en) | 1994-10-07 |
| ATE90690T1 (de) | 1993-07-15 |
| DE3881801T2 (de) | 1993-12-23 |
| AU627423B2 (en) | 1992-08-27 |
| EP0308500B1 (en) | 1993-06-16 |
| JPH01502986A (ja) | 1989-10-12 |
| DE3881801D1 (de) | 1993-07-22 |
| DK677688A (da) | 1988-12-05 |
| WO1988007863A1 (en) | 1988-10-20 |
| DK677688D0 (da) | 1988-12-05 |
| EP0294021A1 (en) | 1988-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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