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ES2058023B1 - DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO. - Google Patents

DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Info

Publication number
ES2058023B1
ES2058023B1 ES9202177A ES9202177A ES2058023B1 ES 2058023 B1 ES2058023 B1 ES 2058023B1 ES 9202177 A ES9202177 A ES 9202177A ES 9202177 A ES9202177 A ES 9202177A ES 2058023 B1 ES2058023 B1 ES 2058023B1
Authority
ES
Spain
Prior art keywords
chsi2
therapy
scoh
acid
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9202177A
Other languages
Spanish (es)
Other versions
ES2058023A1 (en
Inventor
Gernot Kohler
Anita Kohler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Franz Koehler Chemie GmbH
Original Assignee
Dr Franz Koehler Chemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Franz Koehler Chemie GmbH filed Critical Dr Franz Koehler Chemie GmbH
Priority to ES9202177A priority Critical patent/ES2058023B1/en
Publication of ES2058023A1 publication Critical patent/ES2058023A1/en
Application granted granted Critical
Publication of ES2058023B1 publication Critical patent/ES2058023B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

DERIVADOS DEL ACIDO 4-HIDROXIBUTIRICO, DE FORMULAS I Y II, EN DONDE RSI1 SC, RSI2 SC Y RSI3 SC SIGNIFICAN LOS RADICALES H-, CHSI3 SC-, CSI2 SCHSI5 SC-, CHSI2 SCOH-CHSI2 SC-, O CHSI2 SCOH-CHOH-CHSI2 SC-, O CON EL NITROGENO FORMAN UN HETEROCICLOALCANO CON 4 O 5 CARBONOS, SIENDO RSI4 SC UN ALCOHOL O POLIALCOHOL CON 1-5 CARBONOS Y 1-5 OXIGENOS, LINEAL O RAMIFICADO, O EN FORMA DE ANILLO, Y RSI1 SC Y RSI4 SC PUEDEN ESTAR CONDENSADOS ENTRE SI PARA FORMAR UN ETER CICLICO, Y RSI5 SC Y RSI6 SC INDEPENDIENTEMENTE SON H- O CHSI2 SCOH-. LAS SALES O AMIDAS DEL ACIDO GAMMAHIDROXIBUTIRICO SE OBTIENEN POR REACCION DE GAMMA-BUTIROLACTONA CON UN AMINOALCOHOL O UN DERIVADO DE LA MORFOLINA, AJUSTANDO EL PH A 7,5. ESTOS COMPUESTOS SE USAN EN PREPARACIONES PARENTERALES U ORALES PARA LA NARCOSIS EN LA ANESTESIA, PARA LA INDUCCION AL SUEÑO O SEDACION, PARA LA TERAPIA DE LA DESINTOXICACION ALCOHOLICA, PARA LA TERAPIA DE LA CATAPLEJIA O NARCOLEPSIA, Y PARA LA TERAPIA DE TRASTORNOS DEL SUEÑO.DERIVATIVES FROM 4-HYDROXIBUTYRIC ACID, OF FORMULAS I AND II, WHERE RSI1 SC, RSI2 SC AND RSI3 SC MEAN RADICALS H-, CHSI3 SC-, CSI2 SCHSI5 SC-, CHSI2 SCOH-CHSI2 SC-, OR CHSI2 SCOH-CHOH- CHSI2 SC-, OR WITH NITROGEN FORM A HETEROCICLOALCAN WITH 4 OR 5 CARBONS, RSI4 SC BEING AN ALCOHOL OR POLYALCOHOL WITH 1-5 CARBONS AND 1-5 OXYGEN, LINEAR OR BRANCHED, AND IN THE FORM OF A RING, AND RSI1 SC AND RSI4 SC MAY BE CONDENSED WITH EACH OTHER TO FORM A CYCLE ETHER, AND RSI5 SC AND RSI6 SC ARE INDEPENDENTLY H- OR CHSI2 SCOH-. THE SALTS OR AMIDES OF THE GAMMAHIDROXIBUTIRICO ACID ARE OBTAINED BY REACTION OF GAMMA-BUTIROLACTONE WITH AN AMINOALCOHOL OR A DERIVATIVE OF MORPHOLINE, ADJUSTING THE PH TO 7.5. THESE COMPOUNDS ARE USED IN PARENTERAL OR ORAL PREPARATIONS FOR NARCOSIS IN ANESTHESIA, FOR INDUCTION TO SLEEP OR SEDATION, FOR THERAPY OF ALCOHOLIC DETOXIFICATION, FOR THERAPY OF CATAPLEJIA OR NARCOLEPSIA, AND THERAPY OF THERAPY OF NARCOLEPSIA.

ES9202177A 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO. Expired - Fee Related ES2058023B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202177A ES2058023B1 (en) 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202177A ES2058023B1 (en) 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Publications (2)

Publication Number Publication Date
ES2058023A1 ES2058023A1 (en) 1994-10-16
ES2058023B1 true ES2058023B1 (en) 1995-10-01

Family

ID=8278609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202177A Expired - Fee Related ES2058023B1 (en) 1992-10-29 1992-10-29 DERIVATIVES OF THE ACID 4-HIDROXI-BUTIRICO.

Country Status (1)

Country Link
ES (1) ES2058023B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2631284A1 (en) * 1976-07-12 1978-01-26 Henkel Kgaa COSMETIC PRODUCTS CONTAINING SKIN MOISTURIZERS
EP0044801B1 (en) * 1980-07-17 1984-02-15 Josef Dr. Klosa Non hygroscopic salts of 4-hydroxy-butanoic acid, process for their preparation and their use for the manufacture of pharmaceutic agents
ES2058670T3 (en) * 1989-05-19 1994-11-01 Kao Corp AMIDIC DERIVATIVES AND DERMATOLOGICAL PREPARATIONS THAT CONTAIN THEM.
DE4113984C2 (en) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salts of 4-hydroxy butyric acid

Also Published As

Publication number Publication date
ES2058023A1 (en) 1994-10-16

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20180806