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ES2056207T3 - Alcoholes aromaticos tio-sustituidos, preparacion, intermedios y uso. - Google Patents

Alcoholes aromaticos tio-sustituidos, preparacion, intermedios y uso.

Info

Publication number
ES2056207T3
ES2056207T3 ES89302838T ES89302838T ES2056207T3 ES 2056207 T3 ES2056207 T3 ES 2056207T3 ES 89302838 T ES89302838 T ES 89302838T ES 89302838 T ES89302838 T ES 89302838T ES 2056207 T3 ES2056207 T3 ES 2056207T3
Authority
ES
Spain
Prior art keywords
alkyl
optionally protected
substituted
formula
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89302838T
Other languages
English (en)
Inventor
Stephen Richard Baker
Alec Todd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of ES2056207T3 publication Critical patent/ES2056207T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/20Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

COMPUESTOS FARMACEUTICOS DE LA FORMULA(I) EN LA QUE R1 ES ALQUILO HALO - SUSTITUIDO; X ES ALQUENILENO; Y R`- Y CONTIENE 6 S 34 C; R2 ES C1 - 5 ALQUIL SUSTITUIDO POR I) CARBOXILO OPCIONALMENTE PROTEGIDO, TETRAZOLILO O - CONR`R" OPCIONALMENTE PROTEGIDO CON NITRILO, EN DONDE R`Y R" SON H O C1 - 4 ALQUILO, II) FORMULA(II), EN DONDE R`Y R" SON H O C1 - C4 ALQUILO O III) FORMULA(III) DONDE E`,R" Y R``` SON H O C1 - 4 ALQUILO, O R2 ES UN GRUPO DE LA FORMULA(IV) EN DONDE R`ES H O UN RESIDUO DE AMINOACIDO PROTEGIDO OPCIONALMENTE; Y R3, R4 Y R5 SON H, CARBOXILO PROTEGIDO OPCIONALMENTE, C1 - 4 ALQUILO, C1 - 4 ALCOXI, HIDROXILO, TETRAZOLILO OPCIONALMENTE PROTEGIDO, HALO, TRIFLUOROMETILO, NITRILO, NITRO O - CONR`R" DONDE R`Y R" SON H O C1 - 4 ALQUILO.
ES89302838T 1988-03-24 1989-03-22 Alcoholes aromaticos tio-sustituidos, preparacion, intermedios y uso. Expired - Lifetime ES2056207T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888807016A GB8807016D0 (en) 1988-03-24 1988-03-24 Organic compounds & their pharmaceutical use

Publications (1)

Publication Number Publication Date
ES2056207T3 true ES2056207T3 (es) 1994-10-01

Family

ID=10634031

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89302838T Expired - Lifetime ES2056207T3 (es) 1988-03-24 1989-03-22 Alcoholes aromaticos tio-sustituidos, preparacion, intermedios y uso.

Country Status (20)

Country Link
US (1) US5021441A (es)
EP (1) EP0343777B1 (es)
JP (1) JPH024769A (es)
KR (1) KR890014568A (es)
CN (1) CN1036568A (es)
AR (1) AR246517A1 (es)
AT (1) ATE107292T1 (es)
AU (1) AU615994B2 (es)
DE (1) DE68916110T2 (es)
DK (1) DK146689A (es)
ES (1) ES2056207T3 (es)
GB (1) GB8807016D0 (es)
HU (1) HU203530B (es)
IE (1) IE63218B1 (es)
IL (1) IL89665A0 (es)
MX (1) MX15390A (es)
NZ (1) NZ228460A (es)
PH (1) PH27529A (es)
PT (1) PT90059B (es)
ZA (1) ZA892224B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8709546D0 (en) * 1987-04-22 1987-05-28 Lilly Industries Ltd Pharmaceutical use of organic compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513005A (en) * 1981-06-18 1985-04-23 Lilly Industries Limited SRS-A antagonists
DE3469169D1 (en) * 1983-04-21 1988-03-10 Merck Frosst Canada Inc Leukotriene antagonists, their production and use and compositions containing them
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
GB8432144D0 (en) * 1984-12-20 1985-01-30 Lilly Industries Ltd Organic compounds
GB8502258D0 (en) * 1985-01-30 1985-02-27 Lilly Industries Ltd Organic compounds
GB8530222D0 (en) * 1985-12-07 1986-01-15 Lilly Industries Ltd Organic compounds
US4785004A (en) * 1985-12-23 1988-11-15 Ciba-Geigy Corporation Aromatic thioethers
GB8709547D0 (en) * 1987-04-22 1987-05-28 Lilly Industries Ltd Organic compounds
GB8709546D0 (en) * 1987-04-22 1987-05-28 Lilly Industries Ltd Pharmaceutical use of organic compounds

Also Published As

Publication number Publication date
PT90059B (pt) 1994-05-31
AU3159889A (en) 1989-09-28
DK146689D0 (da) 1989-03-22
EP0343777A1 (en) 1989-11-29
ZA892224B (en) 1990-11-28
MX15390A (es) 1993-10-01
GB8807016D0 (en) 1988-04-27
KR890014568A (ko) 1989-10-24
DE68916110D1 (de) 1994-07-21
PT90059A (pt) 1989-11-10
IE63218B1 (en) 1995-04-05
NZ228460A (en) 1991-03-26
CN1036568A (zh) 1989-10-25
AU615994B2 (en) 1991-10-17
DE68916110T2 (de) 1994-09-22
PH27529A (en) 1993-08-18
US5021441A (en) 1991-06-04
JPH024769A (ja) 1990-01-09
EP0343777B1 (en) 1994-06-15
DK146689A (da) 1989-09-25
AR246517A1 (es) 1994-08-31
IE890939L (en) 1989-09-24
HU203530B (en) 1991-08-28
ATE107292T1 (de) 1994-07-15
IL89665A0 (en) 1989-09-28
HUT50458A (en) 1990-02-28

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