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ES2054648T3 - Procedimiento para la determinacion de una sustancia capaz de fijarse. - Google Patents

Procedimiento para la determinacion de una sustancia capaz de fijarse.

Info

Publication number
ES2054648T3
ES2054648T3 ES87117411T ES87117411T ES2054648T3 ES 2054648 T3 ES2054648 T3 ES 2054648T3 ES 87117411 T ES87117411 T ES 87117411T ES 87117411 T ES87117411 T ES 87117411T ES 2054648 T3 ES2054648 T3 ES 2054648T3
Authority
ES
Spain
Prior art keywords
specifically binding
binding substance
substance
fix
determination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87117411T
Other languages
English (en)
Inventor
Wilhelm Dr Tischer
Josef Maier
Rolf Dr Deeg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2054648T3 publication Critical patent/ES2054648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Press Drives And Press Lines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PARA LA FABRICACION DE UNA SUSTANCIA ESPECIFICA CON FRAGUABILIDAD LA CUAL ES LATENTE EN UN MATERIAL PORTADOR INSOLUBLE, SE ACOPLA UNA PROTEINA SOLUBLE CON UN PESO MOLECULAR APROXIMADAMENTE SOBRE 500.000, LA CUAL ES MAS HIDROFOBA QUE LA SUSTANCIA ESPECIFICA FRAGUABLE, A LA SUSTANCIA ESPECIFICA FRAGUABLE ABSORBE ENTONCES EL CONJUGADO DEL SOCIO DE LA REACCION Y LA PROTEINA EN UNA FASE DE ACOPLAMIENTO HIDROFOBA, EL ASI FABRICADO MATERIAL PORTADOR SE ADECUA PARTICULARMENTE EN LA UTILIZACION JUNTO A LA FASE DE ACOPLAMIENTO-INMUNOGAS.
ES87117411T 1986-11-26 1987-11-25 Procedimiento para la determinacion de una sustancia capaz de fijarse. Expired - Lifetime ES2054648T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863640412 DE3640412A1 (de) 1986-11-26 1986-11-26 Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Publications (1)

Publication Number Publication Date
ES2054648T3 true ES2054648T3 (es) 1994-08-16

Family

ID=6314821

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87117411T Expired - Lifetime ES2054648T3 (es) 1986-11-26 1987-11-25 Procedimiento para la determinacion de una sustancia capaz de fijarse.

Country Status (13)

Country Link
US (1) US5061640A (es)
EP (1) EP0269092B1 (es)
JP (1) JPH0731205B2 (es)
KR (1) KR910002543B1 (es)
CN (1) CN1032164C (es)
AT (1) ATE86743T1 (es)
AU (1) AU592910B2 (es)
CA (1) CA1302245C (es)
DD (1) DD279741A5 (es)
DE (2) DE3640412A1 (es)
ES (1) ES2054648T3 (es)
GR (1) GR3007910T3 (es)
ZA (1) ZA878824B (es)

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DE3725504A1 (de) * 1987-07-31 1989-02-09 Thraenhart Olaf Priv Doz Dr Verfahren und vorrichtung zum nachweis von antikoerpern und antigenen
DE3806431A1 (de) * 1988-02-29 1989-09-07 Boehringer Mannheim Gmbh Verfahren zur herstellung einer festphasenmatrix
US5268306A (en) * 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
IE64286B1 (en) * 1988-05-25 1995-07-26 Boehringer Mannheim Gmbh Process for the determination of an immunologically detectable substance and a suitable vessel therefor
DE3901638C2 (de) * 1988-05-25 1999-03-25 Roche Diagnostics Gmbh Verfahren zur Bestimmung einer immunologisch nachweisbaren Substanz und dazu geeignetes Reaktionsgefäß
US5362624A (en) * 1988-05-25 1994-11-08 Boehringer Mannheim Gmbh Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor
US5888728A (en) 1988-10-17 1999-03-30 Molecular Devices Corporation Hapten derivatized capture membrane and diagnostic assays using such membrane
DE3842700A1 (de) * 1988-12-19 1990-06-21 Boehringer Mannheim Gmbh Verfahren zur proteinimmobilisierung an einer festphase, so hergestellte protein tragende festphase sowie deren verwendung
DE3922873A1 (de) * 1989-04-25 1990-10-31 Boehringer Mannheim Gmbh Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen
US6333397B1 (en) 1989-04-25 2001-12-25 Roche Diagnostics Gmbh Monoclonal antibodies to troponin T and their production
DE3915135A1 (de) * 1989-05-09 1990-11-15 Boehringer Mannheim Gmbh Verfahren zum nachweis spezifisch bindefaehiger substanzen in koerperfluessigkeiten
US5270193A (en) * 1989-10-27 1993-12-14 E. I. Dupont De Nemours And Company Immobilization of biomolecules on perfluorocarbon surfaces
GB8927230D0 (en) * 1989-12-01 1990-01-31 Unilever Plc Reagents
DE3942999C2 (de) * 1989-12-27 1997-12-18 Progen Biotechnik Gmbh Verfahren zum Nachweis von malignen Erkrankungen
DE4024544A1 (de) * 1990-08-02 1992-02-06 Boehringer Mannheim Gmbh Analyseelement und verfahren zu seiner herstellung
DE4025726A1 (de) 1990-08-14 1992-02-20 Boehringer Mannheim Gmbh Bestimmung von biogenen aminen
WO1992003732A2 (en) * 1990-08-28 1992-03-05 Bioprobe International, Inc. Compositions and methods for enhanced binding in biological assays
JPH04363659A (ja) * 1991-06-10 1992-12-16 Smithkline Beckman Corp ビタミンｂ１２の分析
WO1992022816A1 (en) * 1991-06-11 1992-12-23 Csl Limited Solid phase immunoassay
DE4209215A1 (de) 1991-07-04 1993-01-07 Boehringer Mannheim Gmbh Hcv peptidantigene und verfahren zur bestimmung von hcv
DE4202850A1 (de) * 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh Analysenelement fuer immunoassays
DE4240980A1 (de) * 1992-08-07 1994-02-10 Boehringer Mannheim Gmbh HCV Peptidantigene und Verfahren zur Bestimmung von HCV
DE4312399A1 (de) * 1993-04-16 1994-10-20 Boehringer Mannheim Gmbh Verfahren zur Bestimmung der Bindung eines Transkriptionsfaktors an eine Nukleinsäure
DE4313975A1 (de) * 1993-04-28 1994-11-03 Cytech Biomedical Inc Immunisierungsmittel und Affinitätschromatographie-Trägermaterial
DE4343479A1 (de) * 1993-12-21 1995-06-22 Boehringer Mannheim Gmbh Acylierte Proteinaggregate und deren Verwendung zur Entstörung von Immunoassays
DE4343480A1 (de) * 1993-12-21 1995-07-06 Boehringer Mannheim Gmbh Acylierte Proteinaggregate und deren Verwendung zur Signalsteigerung in einem Immunoassay zum Nachweis von Antikörpern
DE19637718A1 (de) 1996-04-01 1997-10-02 Boehringer Mannheim Gmbh Rekombinante inaktive Core-Streptavidin Mutanten
DE19724787A1 (de) * 1997-06-06 1998-12-10 Biotez Berlin Buch Gmbh Bioche Streptavidin/Avidin beschichtete Oberflächen
US6033918A (en) * 1997-11-10 2000-03-07 Bayer Corporation Method and device for the detection of analyte in a fluid sample
DE19924643B4 (de) * 1999-05-28 2017-02-23 Roche Diagnostics Gmbh Verfahren zur Herstellung von Protein-beladenen Mikropartikeln
WO2003019182A1 (de) * 2001-08-10 2003-03-06 Roche Diagnostics Gmbh Verfahren zur herstellung von protein-beladenen mikropartikeln
CN102089662B (zh) * 2008-07-16 2015-05-27 雷迪奥米特医学公司 高容量固相
GB201105828D0 (en) 2011-04-06 2011-05-18 Vivacta Ltd A device for detecting an analyte
GB201121269D0 (en) 2011-12-12 2012-01-25 Vivacta Ltd A method forblood measurement
JP5717658B2 (ja) * 2012-01-13 2015-05-13 シスメックス株式会社 副腎皮質刺激ホルモンの検出方法および吸着剤
US20180074077A1 (en) 2015-03-25 2018-03-15 Alexion Pharmaceuticals, Inc. A method for measuring the protease activity of factor d of the alternative complement pathway
WO2016151557A1 (en) 2015-03-25 2016-09-29 Alexion Pharmaceuticals, Inc. A method for measuring the protease activity of c5 convertase of the alternative complement pathway
KR102165623B1 (ko) 2016-05-31 2020-10-15 에프. 호프만-라 로슈 아게 바이러스 항원의 혈청학적 탐지 방법
CN109154617B (zh) 2016-05-31 2022-08-26 豪夫迈·罗氏有限公司 用于hcv核心抗原的快速检测的预处理方法
CN110234995A (zh) 2017-02-02 2019-09-13 豪夫迈·罗氏有限公司 使用至少两种聚乙二醇化的分析物特异性结合试剂的免疫测定
BR112019027491A2 (pt) 2017-07-27 2020-07-07 F. Hoffmann-La Roche Ag proteína de fusão multiepítopo, método de produção de uma proteína, uso de uma proteína, método para detectar o antígeno e kit
CN113030456A (zh) * 2021-04-02 2021-06-25 山东康华生物医疗科技股份有限公司 一种抗环瓜氨酸肽抗体的检测试纸条、检测卡及试剂盒

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US4006059A (en) * 1974-07-29 1977-02-01 Purdue Research Foundation Hydrophobic noncovalent binding of proteins to support materials
US3966580A (en) * 1974-09-16 1976-06-29 The University Of Utah Novel protein-immobilizing hydrophobic polymeric membrane, process for producing same and apparatus employing same
US4069352A (en) * 1976-07-02 1978-01-17 Baxter Travenol Laboratories, Inc. Immunoadsorbent polymeric material and method of making same
US4210418A (en) * 1976-08-30 1980-07-01 Mallinckrodt, Inc. Container for immunochemical and enzymatical determinations or procedures
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SE8003732L (sv) * 1980-05-19 1981-11-20 Pharmacia Diagnostics Ab Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
DE3116491A1 (de) * 1981-04-25 1982-11-11 Basf Ag, 6700 Ludwigshafen "thermoplastische formmassen"
JPS5861466A (ja) * 1981-10-08 1983-04-12 Yatoron:Kk 血清学的凝集反応による測定方法
US4606855A (en) * 1982-07-26 1986-08-19 Mex Research Associates C/O Leon Reimer Monoclonal antibody to digoxin
US4572901A (en) * 1983-06-23 1986-02-25 Children's Hospital Medical Center Of Northern California Method and composition for protein immobilization
EP0142193A1 (en) * 1983-10-22 1985-05-22 Akzo N.V. Preparation of immunogens consisting of antigens and/or antigenic determinants bound to glycoside-containing carriers
JPS62132172A (ja) * 1985-12-04 1987-06-15 Shionogi & Co Ltd 固相化抗体およびその製造方法
US4808530A (en) * 1986-09-05 1989-02-28 The Ohio State University Protein immobilization by adsorption of a hydrophobic amidine protein derivative to a hydrophobic surface

Also Published As

Publication number Publication date
GR3007910T3 (es) 1993-08-31
AU8169587A (en) 1988-06-02
AU592910B2 (en) 1990-01-25
CN87107982A (zh) 1988-06-15
JPS63142268A (ja) 1988-06-14
KR910002543B1 (ko) 1991-04-23
DD279741A5 (de) 1990-06-13
CA1302245C (en) 1992-06-02
DE3640412A1 (de) 1988-06-09
CN1032164C (zh) 1996-06-26
ATE86743T1 (de) 1993-03-15
EP0269092A2 (de) 1988-06-01
EP0269092B1 (de) 1993-03-10
EP0269092A3 (en) 1990-01-24
US5061640A (en) 1991-10-29
ZA878824B (en) 1989-04-26
JPH0731205B2 (ja) 1995-04-10
KR890002227A (ko) 1989-04-10
DE3784638D1 (de) 1993-04-15

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