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ES2054502T3 - Esteres del acido 10-(1-hidroxietil)-11-oxo-1-azatriciclo(7.2.0.0(3.8))-undec-2-en-2-carboxilico y un procedimiento para su preparacion. - Google Patents

Esteres del acido 10-(1-hidroxietil)-11-oxo-1-azatriciclo(7.2.0.0(3.8))-undec-2-en-2-carboxilico y un procedimiento para su preparacion.

Info

Publication number
ES2054502T3
ES2054502T3 ES91914351T ES91914351T ES2054502T3 ES 2054502 T3 ES2054502 T3 ES 2054502T3 ES 91914351 T ES91914351 T ES 91914351T ES 91914351 T ES91914351 T ES 91914351T ES 2054502 T3 ES2054502 T3 ES 2054502T3
Authority
ES
Spain
Prior art keywords
sub
group
azatriciclo
carboxilico
undec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91914351T
Other languages
English (en)
Inventor
Alcide Perboni
Tino Rossi
Giovanni Gaviraghi
Antonella Ursini
Giorgio Tarzia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909018330A external-priority patent/GB9018330D0/en
Priority claimed from GB919104770A external-priority patent/GB9104770D0/en
Application filed by Glaxo SpA filed Critical Glaxo SpA
Application granted granted Critical
Publication of ES2054502T3 publication Critical patent/ES2054502T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LOS COMPUESTOS DE LA FORMULA GENERAL (I) EN QUE R SUB 1 REPRESENTA DE GRUPO (A), DONDE R SUB 4 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C SUB 1-4; P ES 0 O 1; R SUB 5 ES UN GRUPO SELECCIONADO DEL ALQUILO C SUB 1-6, CICLOALQUILO C SUB 5-8 OPCIONALMENTE SUSTITUIDO POR UN GRUPO ALQUILO C SUB 1-3, FENILO Y ALQUILO C SUB 1-4 SUSTITUIDO POR UN GRUPO ALCOXI C SUB 1-3; Y R SUB 2 ES UN GRUPO OR SUB 3 DONDE R SUB 3 ES UN GRUPO ALQUILO C SUB 1-5, SON ADMINISTRABLES ORALMENTE Y PRESENTAN UNA ACTIVIDAD ANTIBACTERIANA DE AMPLIO ESPECTRO.
ES91914351T 1990-08-21 1991-08-20 Esteres del acido 10-(1-hidroxietil)-11-oxo-1-azatriciclo(7.2.0.0(3.8))-undec-2-en-2-carboxilico y un procedimiento para su preparacion. Expired - Lifetime ES2054502T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909018330A GB9018330D0 (en) 1990-08-21 1990-08-21 Heterocyclic compounds
GB919104770A GB9104770D0 (en) 1991-03-07 1991-03-07 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2054502T3 true ES2054502T3 (es) 1994-08-01

Family

ID=26297540

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91914351T Expired - Lifetime ES2054502T3 (es) 1990-08-21 1991-08-20 Esteres del acido 10-(1-hidroxietil)-11-oxo-1-azatriciclo(7.2.0.0(3.8))-undec-2-en-2-carboxilico y un procedimiento para su preparacion.

Country Status (32)

Country Link
US (1) US5587374A (es)
EP (1) EP0495953B1 (es)
JP (2) JP3151215B2 (es)
KR (1) KR0169147B1 (es)
CN (1) CN1030917C (es)
AP (1) AP238A (es)
AT (1) ATE106887T1 (es)
AU (1) AU647178B2 (es)
CA (1) CA2067741C (es)
CY (1) CY2037A (es)
CZ (1) CZ280942B6 (es)
DE (1) DE69102415T2 (es)
DK (1) DK0495953T3 (es)
ES (1) ES2054502T3 (es)
FI (1) FI97136C (es)
HK (1) HK19495A (es)
HR (1) HRP940556B1 (es)
HU (2) HUT61024A (es)
IE (1) IE66122B1 (es)
IL (1) IL99248A (es)
MX (1) MX9100743A (es)
MY (1) MY106997A (es)
NO (1) NO300176B1 (es)
NZ (1) NZ239474A (es)
OA (1) OA09578A (es)
PL (1) PL169425B1 (es)
PT (1) PT98729B (es)
SG (1) SG169494G (es)
SI (1) SI9111427B (es)
SK (1) SK121392A3 (es)
WO (1) WO1992003437A1 (es)
YU (1) YU48079B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
AP294A (en) * 1992-08-31 1993-12-28 Glaxo Spa "10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo-(7.2.0.0.3.8) undec-2-ene-2-carboxylic acid derivatives".
GB9218781D0 (en) * 1992-09-04 1992-10-21 Glaxo Spa Heterocyclic derivatives
IN188720B (es) * 1997-11-06 2002-11-02 Panacea Biotec Ltd
EP1443047A4 (en) * 2001-11-05 2005-04-27 Sumitomo Pharma NEW CARBAPENE COMPOUNDS
EP1612211A4 (en) * 2003-04-08 2008-07-02 Dainippon Sumitomo Pharma Co NEW CARBAPENEM COMPOUNDS
JPWO2006025475A1 (ja) * 2004-09-03 2008-05-08 大日本住友製薬株式会社 新規なカルバペネム化合物
WO2006103999A1 (ja) * 2005-03-25 2006-10-05 Dainippon Sumitomo Pharma Co., Ltd. 新規なカルバペネム化合物
EP2085084A1 (en) 2008-01-29 2009-08-05 LEK Pharmaceuticals D.D. Use of inhibitor of beta-lactamases and its combination with beta-lactam antibiotics
EP2135871A1 (en) * 2008-06-18 2009-12-23 LEK Pharmaceuticals D.D. New trinem antibiotics and inhibitors of beta-lactamases
PL3621609T3 (pl) 2017-05-08 2022-11-14 Glaxosmithkline Intellectual Property Development Limited Sanfetrinem lub jego sól lub ester do stosowania w leczeniu zakażenia prątkami

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1433131A (en) * 1972-03-13 1976-04-22 Astra Laekemedel Ab Penicillins
GB1425571A (en) * 1972-03-13 1976-02-18 Astra Laekemedel Ab Penicillins and cephaosporins
DE2811514A1 (de) * 1977-03-19 1978-09-21 Beecham Group Ltd Ester der 7-oxo-1-azabicyclo eckige klammer auf 3.2.0 eckige klammer zu hept- 2-en-2-carbonsaeure und deren derivate, verfahren zur herstellung dieser verbindungen und diese verbindungen enthaltende pharmazeutische zubereitungen
US4374848A (en) * 1981-09-14 1983-02-22 Merck & Co., Inc. 6-(1-Hydroxyethyl)cyclonocardicin
US4374849A (en) * 1981-09-14 1983-02-22 Merck & Co., Inc. 6-Amidocyclonocardicins
CZ285778B6 (cs) * 1989-09-08 1999-11-17 Glaxo S.P.A. Kyselina 10-(1-hydroxyethyl)-11-oxo-1-azatricyklo/7,2,0,03,8/-undec-2en-2-karboxylová a její deriváty, způsob jejich výroby, použití pro výrobu farmaceutických prostředků a farmaceutické prostředky s jejich obsahem
AU636913B2 (en) * 1989-10-11 1993-05-13 Takeda Chemical Industries Ltd. Tricyclic carbapenem compounds
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
GB9104832D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
CZ280942B6 (cs) 1996-05-15
DK0495953T3 (da) 1994-07-18
ATE106887T1 (de) 1994-06-15
CA2067741C (en) 2002-01-01
AU8421291A (en) 1992-03-17
CN1030917C (zh) 1996-02-07
DE69102415T2 (de) 1994-10-13
HU9201303D0 (en) 1992-07-28
SI9111427A (en) 1996-12-31
IL99248A (en) 1996-01-31
HUT61024A (en) 1992-11-30
DE69102415D1 (de) 1994-07-14
OA09578A (en) 1993-01-31
AU647178B2 (en) 1994-03-17
MY106997A (en) 1995-08-30
SI9111427B (sl) 2000-10-31
HU211584A9 (en) 1995-12-28
IE912944A1 (en) 1992-02-26
JP2000351730A (ja) 2000-12-19
SK278470B6 (en) 1997-06-04
CA2067741A1 (en) 1992-02-22
MX9100743A (es) 1992-04-01
PT98729B (pt) 1999-01-29
HRP940556B1 (en) 2000-06-30
KR920702361A (ko) 1992-09-03
CN1060094A (zh) 1992-04-08
YU142791A (sh) 1994-01-20
JPH05502044A (ja) 1993-04-15
WO1992003437A1 (en) 1992-03-05
NO300176B1 (no) 1997-04-21
FI97136B (fi) 1996-07-15
NO921521D0 (no) 1992-04-15
CY2037A (en) 1998-02-20
FI921717A0 (fi) 1992-04-16
YU48079B (sh) 1997-01-08
HRP940556A2 (en) 1996-06-30
IL99248A0 (en) 1992-07-15
KR0169147B1 (en) 1999-01-15
PT98729A (pt) 1992-07-31
EP0495953A1 (en) 1992-07-29
HK19495A (en) 1995-02-17
AP238A (en) 1993-02-04
SK121392A3 (en) 1997-06-04
JP3151215B2 (ja) 2001-04-03
AP9100320A0 (en) 1991-10-31
IE66122B1 (en) 1995-12-13
PL169425B1 (pl) 1996-07-31
CZ121392A3 (en) 1993-04-14
EP0495953B1 (en) 1994-06-08
NZ239474A (en) 1994-06-27
FI921717A (fi) 1992-04-16
NO921521L (no) 1992-06-22
FI97136C (fi) 1996-10-25
JP3461786B2 (ja) 2003-10-27
SG169494G (en) 1995-04-28
US5587374A (en) 1996-12-24

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