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ES2049656B1 - GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. - Google Patents

GROUPS OF DRUG CONJUGATES WITH ANTIBODIES.

Info

Publication number
ES2049656B1
ES2049656B1 ES09202001A ES9202001A ES2049656B1 ES 2049656 B1 ES2049656 B1 ES 2049656B1 ES 09202001 A ES09202001 A ES 09202001A ES 9202001 A ES9202001 A ES 9202001A ES 2049656 B1 ES2049656 B1 ES 2049656B1
Authority
ES
Spain
Prior art keywords
antibodies
groups
pharmacy
drug conjugates
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES09202001A
Other languages
Spanish (es)
Other versions
ES2049656A1 (en
Inventor
Gary Allen Koppel
Robin E Offord
Keith Rose
William Leonard Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to ES09202001A priority Critical patent/ES2049656B1/en
Publication of ES2049656A1 publication Critical patent/ES2049656A1/en
Application granted granted Critical
Publication of ES2049656B1 publication Critical patent/ES2049656B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION PROPORCIONA UN CONJUGADO FISIOLOGICAMENTE ACEPTABLE DE UN FARMACO DE FORMULA (I), EN LA QUE AC, R, RBS1 SC, X, Z, M, N, P, Q, R, S, Y, RBS2 SC, RBS3 SC Y RBS4 SC SE DEFINEN CON DETALLE EN LA MEMORIA DESCRIPTIVA. TAMBIEN PROPORCIONA COMPOSICIONES FARMACEUTICAS QUE CONTIENEN UN CONJUGADO DE LA INVENCION E INTERMEDIOS PARA PREPARAR LOS CONJUGADOS Y UN FARMACO MODIFICADO. REPRESENTA UN PROGRESO SIGNIFICATIVO EN EL CAMPO DE LOS FARMACOS DIRIGIDOS A UN OBJETIVO CONCRETO AL PERMITIR LA FIJACION DE MULTIPLES MOLECULAS DE FARMACO CITOTOXICO A UNA SOLA MOLECULA DE ANTICUERPO, TENIENDO APLICACION EN EL TRATAMIENTO DEL CANCER.THE INVENTION PROVIDES A PHYSIOLOGICALLY ACCEPTABLE CONJUGATE OF A PHARMACY OF FORMULA (I), IN WHICH AC, R, RBS1 SC, X, Z, M, N, P, Q, R, S, Y, RBS2 SC, RBS3 SC AND RBS4 SC ARE DEFINED IN DETAIL IN THE DESCRIPTIVE MEMORY. IT ALSO PROVIDES PHARMACEUTICAL COMPOSITIONS CONTAINING A CONJUGATE OF THE INVENTION AND INTERMEDIATES TO PREPARE THE CONJUGATES AND A MODIFIED PHARMACY. IT REPRESENTS SIGNIFICANT PROGRESS IN THE FIELD OF DRUGS AIMED AT A SPECIFIC OBJECTIVE BY ALLOWING THE ATTACHMENT OF MULTIPLE CYCLOTOXIC MOLECULES TO A SINGLE ANTIBODY MOLECULA, HAVING APPLICATION IN CANCER TREATMENT.

ES09202001A 1992-10-08 1992-10-08 GROUPS OF DRUG CONJUGATES WITH ANTIBODIES. Expired - Lifetime ES2049656B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES09202001A ES2049656B1 (en) 1992-10-08 1992-10-08 GROUPS OF DRUG CONJUGATES WITH ANTIBODIES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09202001A ES2049656B1 (en) 1992-10-08 1992-10-08 GROUPS OF DRUG CONJUGATES WITH ANTIBODIES.

Publications (2)

Publication Number Publication Date
ES2049656A1 ES2049656A1 (en) 1994-04-16
ES2049656B1 true ES2049656B1 (en) 1994-11-16

Family

ID=8278354

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09202001A Expired - Lifetime ES2049656B1 (en) 1992-10-08 1992-10-08 GROUPS OF DRUG CONJUGATES WITH ANTIBODIES.

Country Status (1)

Country Link
ES (1) ES2049656B1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1541435A (en) * 1975-02-04 1979-02-28 Searle & Co Immunological materials
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US4587046A (en) * 1982-05-18 1986-05-06 The Regents Of The University Of California Drug-carrier conjugates
JPS59116232A (en) * 1982-12-24 1984-07-05 Teijin Ltd Cell toxicity complex and its preparation
PT89504A (en) * 1988-01-27 1989-10-04 Lilly Co Eli PROCESS FOR THE PREPARATION OF CONJUGATES OF ANTIBODIES WITH VINCA HYDRAULICS
US5006652A (en) * 1988-08-08 1991-04-09 Eli Lilly And Company Intermediates for antibody-vinca drug conjugates
US5010176A (en) * 1988-11-10 1991-04-23 Eli Lilly And Company Antibody-drug conjugates

Also Published As

Publication number Publication date
ES2049656A1 (en) 1994-04-16

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