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ES2043610T3 - Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno. - Google Patents

Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno.

Info

Publication number
ES2043610T3
ES2043610T3 ES87101209T ES87101209T ES2043610T3 ES 2043610 T3 ES2043610 T3 ES 2043610T3 ES 87101209 T ES87101209 T ES 87101209T ES 87101209 T ES87101209 T ES 87101209T ES 2043610 T3 ES2043610 T3 ES 2043610T3
Authority
ES
Spain
Prior art keywords
polypeptide
production
hybrid polypeptide
hybrid
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87101209T
Other languages
English (en)
Inventor
Michito Tagawa
Masakatsu Wada
Masayuki Yamada
Midori Yokoyama
Naganori Numao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Central Glass Co Ltd
Hodogaya Chemical Co Ltd
Nippon Soda Co Ltd
Nissan Chemical Corp
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Central Glass Co Ltd
Hodogaya Chemical Co Ltd
Nippon Soda Co Ltd
Nissan Chemical Corp
Sagami Chemical Research Institute
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Glass Co Ltd, Hodogaya Chemical Co Ltd, Nippon Soda Co Ltd, Nissan Chemical Corp, Sagami Chemical Research Institute, Tosoh Corp filed Critical Central Glass Co Ltd
Application granted granted Critical
Publication of ES2043610T3 publication Critical patent/ES2043610T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN POLIPEPTIDO SIMILAR AL ACTIVADOR DEL PLASMINOGENO HIBRIDO QUE COMPRENDE UNA REGION DE POLIPEPTIDO RESPONSABLE DE UNA AFINIDAD A LA FIBRINA DERIVADA DE UN POLIPEPTIDO ACTIVADOR TISULAR DEL PLASMINOGENO Y UNA REGION DE POLIPEPTIDO RESPONSABLE DE UNA ACTIVIDAD ENZIMATICA DERIVADA DE UN POLIPEPTIDO DE PROUROQUINASA; UN SEGMENTO DE ADN DEL POLIPEPTIDO HIBRIDO; UN PLASMIDO QUE CONTIENE EL SEGMENTO DE ADN; UN MICROORGANISMO TRANSFORMADO CON EL ADN; Y UN PROCESO PARA LA PRODUCCION DEL POLIPEPTIDO HIBRIDO QUE COMPRENDE EL CULTIVO DEL MICROORGANISMO Y LA RECUPERACION DEL POLIPEPTIDO HIBRIDO DE LAS CELULAS CULTIVADAS.
ES87101209T 1986-01-31 1987-01-29 Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno. Expired - Lifetime ES2043610T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1773486 1986-01-31

Publications (1)

Publication Number Publication Date
ES2043610T3 true ES2043610T3 (es) 1994-01-01

Family

ID=11951975

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87101209T Expired - Lifetime ES2043610T3 (es) 1986-01-31 1987-01-29 Procedimiento para la produccion de un polipeptido hibrido del tipo activador de plasminogeno.

Country Status (7)

Country Link
EP (1) EP0231883B1 (es)
JP (1) JP2589687B2 (es)
DE (1) DE3781420T2 (es)
DK (1) DK175604B1 (es)
ES (1) ES2043610T3 (es)
SU (1) SU1732814A3 (es)
WO (1) WO1987004720A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
ZA879286B (en) * 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
NL8700013A (nl) * 1987-01-06 1988-08-01 Leuven Res & Dev Vzw Hybride plasminogeenactivatoren met verbeterde trombolytische eigenschappen en geneesmiddelen die deze plasminogeenactivatoren bevatten.
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
JP2561122B2 (ja) * 1988-04-13 1996-12-04 寳酒造株式会社 機能性ポリペプチド
JPH07143877A (ja) * 1993-10-01 1995-06-06 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ類似体
CN115552012A (zh) * 2020-03-31 2022-12-30 国立研究开发法人国立癌症研究中心 适于溶解纤维蛋白凝块的融合蛋白及包含该融合蛋白的药物组合物
WO2023195535A1 (ja) * 2022-04-08 2023-10-12 株式会社凜研究所 フィブリンに結合する抗体および当該抗体を含むフィブリン溶解性タンパク質および当該タンパク質を含む医薬製剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (es) * 1982-05-05 1984-10-22 Genentech Inc
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
JPS60136520A (ja) * 1983-12-23 1985-07-20 Otsuka Pharmaceut Co Ltd フイブリン吸着性ウロキナ−ゼ複合体
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
DK175604B1 (da) 2004-12-20
JPS62272975A (ja) 1987-11-27
WO1987004720A1 (en) 1987-08-13
SU1732814A3 (ru) 1992-05-07
DK50987A (da) 1987-08-01
JP2589687B2 (ja) 1997-03-12
EP0231883B1 (en) 1992-09-02
DE3781420T2 (de) 1993-02-25
DE3781420D1 (de) 1992-10-08
EP0231883A1 (en) 1987-08-12
DK50987D0 (da) 1987-01-30

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