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ES2042507T3 - Procedimiento para la obtencion de carboxiamidas. - Google Patents

Procedimiento para la obtencion de carboxiamidas.

Info

Publication number
ES2042507T3
ES2042507T3 ES87101012T ES87101012T ES2042507T3 ES 2042507 T3 ES2042507 T3 ES 2042507T3 ES 87101012 T ES87101012 T ES 87101012T ES 87101012 T ES87101012 T ES 87101012T ES 2042507 T3 ES2042507 T3 ES 2042507T3
Authority
ES
Spain
Prior art keywords
procedure
obtaining
carboxiamides
cephalosporin
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87101012T
Other languages
English (en)
Inventor
Andre Dr Furlenmeier
Urs Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2042507T3 publication Critical patent/ES2042507T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA OBTENCION DE AMIDAS CON 2-BENZOTIAZOLILTIOESTERES DE ACIDOS CARBOXILICOS, CARACTERIZADOS PORQUE POR TRANSFORMACION SE OBTIENE LA AMINA EN FORMA DE UNA SAL DE ADICION DE ACIDO. ESTE PROCEDIMIENTO REPRESENTA UNA GRAN VENTAJA, CUANDO LA AMINA NO ES ESPECIALMENTE ESTABLE EN FORMA DE BASE LIBRE, COMO ES UN CASO FRECUENTE EN DERIVADOS DE LA 7-AMINO-CEFALOSPORINA. CON ESTE NUEVO PROCEDIMIENTO PUEDEN OBTENERSE CON UN BUEN RENDIMIENTO Y GRAN PUREZA DERIVADOS DE LA 7-ACILAMINO- CEFALOSPORINA.
ES87101012T 1986-02-07 1987-01-24 Procedimiento para la obtencion de carboxiamidas. Expired - Lifetime ES2042507T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH48786 1986-02-07

Publications (1)

Publication Number Publication Date
ES2042507T3 true ES2042507T3 (es) 1993-12-16

Family

ID=4188132

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87101012T Expired - Lifetime ES2042507T3 (es) 1986-02-07 1987-01-24 Procedimiento para la obtencion de carboxiamidas.

Country Status (20)

Country Link
EP (1) EP0231845B1 (es)
JP (1) JPH0745411B2 (es)
KR (1) KR940009793B1 (es)
CN (1) CN1019300B (es)
AR (1) AR243529A1 (es)
AT (1) ATE77378T1 (es)
AU (1) AU605754B2 (es)
CA (1) CA1339312C (es)
DE (1) DE3779768D1 (es)
DK (1) DK53787A (es)
ES (1) ES2042507T3 (es)
FI (1) FI88391C (es)
GR (1) GR3005744T3 (es)
HU (1) HU201767B (es)
IE (1) IE59862B1 (es)
IL (1) IL81457A (es)
NO (1) NO169231C (es)
PH (1) PH24285A (es)
PT (1) PT84254B (es)
ZA (1) ZA87745B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
AT406773B (de) * 1998-04-02 2000-08-25 Biochemie Gmbh Neues salz von 7-(2-(aminothiazol-4yl)-2-
KR100777450B1 (ko) 2005-05-28 2007-11-21 삼성전자주식회사 엔코더 속도 보정 방법 및 장치
WO2011042775A1 (en) * 2009-10-09 2011-04-14 Nectar Lifesciences Ltd. Process for preparation of cefotaxime acid
CN101792456A (zh) * 2010-03-11 2010-08-04 池州东升药业有限公司 一种头孢他美酯盐酸盐的制备方法
CN102093151B (zh) * 2011-01-13 2013-04-24 武汉大学 一种酰胺类化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
EP0075104A3 (de) * 1981-09-23 1984-11-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Cephalosporinderivate, Verfahren zu deren Herstellung und Zwischenprodukte dafür sowie entsprechende pharmazeutische Präparate
EP0115770B2 (en) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazole Derivatives
DE3583928D1 (de) * 1984-04-10 1991-10-02 Biochemie Gmbh Cephalosporinzwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung.
ATE71383T1 (de) * 1984-11-15 1992-01-15 Hoffmann La Roche Verfahren zur herstellung von cephalosporinestern.
AT383810B (de) * 1985-11-20 1987-08-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinderivaten

Also Published As

Publication number Publication date
PH24285A (en) 1990-05-29
JPH0745411B2 (ja) 1995-05-17
PT84254B (pt) 1989-09-14
EP0231845B1 (de) 1992-06-17
EP0231845A2 (de) 1987-08-12
AU6850787A (en) 1987-08-13
IE59862B1 (en) 1994-04-20
KR940009793B1 (ko) 1994-10-17
DE3779768D1 (de) 1992-07-23
EP0231845A3 (en) 1989-03-15
FI870446A0 (fi) 1987-02-02
HUT46328A (en) 1988-10-28
NO169231C (no) 1992-05-27
NO870482L (no) 1987-08-10
IE870317L (en) 1987-08-07
IL81457A0 (en) 1987-09-16
CN87100860A (zh) 1987-08-26
JPS6372692A (ja) 1988-04-02
DK53787D0 (da) 1987-02-02
GR3005744T3 (es) 1993-06-07
FI88391B (fi) 1993-01-29
KR870007939A (ko) 1987-09-23
FI870446A (fi) 1987-08-08
ZA87745B (en) 1987-09-30
IL81457A (en) 1992-03-29
CA1339312C (en) 1997-08-19
CN1019300B (zh) 1992-12-02
DK53787A (da) 1987-08-08
FI88391C (fi) 1993-05-10
NO169231B (no) 1992-02-17
HU201767B (en) 1990-12-28
PT84254A (en) 1987-03-01
AR243529A1 (es) 1993-08-31
NO870482D0 (no) 1987-02-06
AU605754B2 (en) 1991-01-24
ATE77378T1 (de) 1992-07-15

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