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ES2041719T3 - Procedimiento para la obtencion de un agente antiulcerogeno. - Google Patents

Procedimiento para la obtencion de un agente antiulcerogeno.

Info

Publication number
ES2041719T3
ES2041719T3 ES88104306T ES88104306T ES2041719T3 ES 2041719 T3 ES2041719 T3 ES 2041719T3 ES 88104306 T ES88104306 T ES 88104306T ES 88104306 T ES88104306 T ES 88104306T ES 2041719 T3 ES2041719 T3 ES 2041719T3
Authority
ES
Spain
Prior art keywords
alcohyl
atom
antiulcerogenous
procedure
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88104306T
Other languages
English (en)
Inventor
Rainer Dr Schlecker
Klaus Dr Ruebsamen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2041719T3 publication Critical patent/ES2041719T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS BENZOFURANOS DE LA FORMULA GENERAL I CON LO CUAL R1 Y R2 PARA HIDROGENOS, ALCOHILO O FENILALCOHILO CON 1 HASTA 4 ATOMOS DE CARBONO EN EL RESTO ALQUILO RESPECTIVAMENTE, Y R4, QUE SON IGUAL O R3 DIFERENTE, PARA HIDROGENOS O C1 - C4 - ALCOHILO O JUNTOS PARA UNA CADENA DE 3 HASTA 5 ESLABONES, QUE PUEDE SER INTERRUMPIDO A TRAVES DE UN ATOMO DE OSIGENO O UN GRUPO - NR1, X PARA - CO - CH = CH -, - CO - CH2 - CH2 - O - CHOH - CH2 CH2, N PARA 2 O 3 Y HET PARA UN ANILLO AROMATICO DE 5 ESLABONES, EL CUAL QUE UN O - O S - ATOMO PARA UN ANILLO AROMATICO DE 5 O 6 ESLABONES, EL CUAL QUE CONTIENE UN HETEROATOMO DEL GRUPO N, O Y S Y DADO EL CASO EN ADICION UN N ATOMO (SUPLEMENTARIO), CON LO CUAL EL ANILLO PUEDE SER SUSTITUIDO A TRAVES C1 - C4 - ALCOHILO, FLUOR, CLORO, BROMO, NH2 O NR1R2, CON LO CUAL R1 Y R2 TIENEN LA SIGNIFICACION MENCIONADA POR ARRIBA. LA UTILIZACION DE ESTOS DERIVADOS BENZOFURANOS A LA FABRICACION DE AGENTES FARMACEUTICOS, PARTICULARMENTE ANTIULCEROGENOS Y ESTOS AGENTES PROPIOS.
ES88104306T 1987-03-30 1988-03-18 Procedimiento para la obtencion de un agente antiulcerogeno. Expired - Lifetime ES2041719T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873710469 DE3710469A1 (de) 1987-03-30 1987-03-30 Neue benzofuranderivate und diese enthaltende therapeutische mittel

Publications (1)

Publication Number Publication Date
ES2041719T3 true ES2041719T3 (es) 1995-04-01

Family

ID=6324338

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88104306T Expired - Lifetime ES2041719T3 (es) 1987-03-30 1988-03-18 Procedimiento para la obtencion de un agente antiulcerogeno.

Country Status (6)

Country Link
US (1) US4845096A (es)
EP (1) EP0284914B1 (es)
JP (1) JPS63258473A (es)
AT (1) ATE68494T1 (es)
DE (2) DE3710469A1 (es)
ES (1) ES2041719T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4225053A1 (de) * 1992-07-29 1994-02-03 Basf Ag Verfahren zur Herstellung von 4-Dialkoxymethylpyrazolen
DE69805596T2 (de) * 1997-12-16 2002-11-28 Ssp Co., Ltd. Imidazol-Derivat und dieses als aktiven Bestandteil enthaltendes Arzneimittel
AUPS110302A0 (en) * 2002-03-14 2002-04-18 Biomolecular Research Institute Limited Novel chalcone derivatives and uses thereof
US7223161B2 (en) * 2004-06-29 2007-05-29 Goei Co., Ltd. Cutting apparatus with dust discharging
AU2006225071B2 (en) * 2005-03-15 2012-01-12 The Regents Of The University Of California Novel potassium channel blockers and uses thereof
AU2007304880B9 (en) * 2006-10-04 2012-11-08 Bionomics Limited Novel benzofuran potassium channel blockers and uses thereof
AU2007304881B2 (en) 2006-10-04 2013-03-07 Bionomics Limited Novel chromenone potassium channel blockers and uses thereof
TW201008933A (en) * 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1209558A (en) * 1968-07-06 1970-10-21 Delalande Sa Derivatives of 5-cinnamoyl benzofuran and process for their preparation
GB1216381A (en) * 1968-07-06 1970-12-23 Delalande Sa Derivatives of benzimidazolyl-2-methyl piperazine and process for their preparation
BE786362A (fr) * 1971-07-26 1973-01-17 Delalande Sa Nouveaux derives de gamma-dialkylaminoalkoxy-6 dimethoxy-4,7 benzofurannes, leur procede de preparation et leur application en therapeutique
BE787838R (fr) * 1971-08-25 1973-02-22 Delalande Sa Nouveaux derives du cinnamoyl-5 benzofuranne, leur procede de preparation et leur utilisation en therapeutique
JPS5118947A (en) * 1974-08-08 1976-02-14 Mitsutoyo Seisakusho Keisokuki toni kokushokukuromutokinnyori memori moyotoohodokosuhoho
CH625234A5 (es) * 1976-07-12 1981-09-15 Delalande Sa
US4153620A (en) * 1976-07-12 1979-05-08 Delalande S.A. Certain N-5-[4,7-dimethoxy)-6-(monoalkylaminoethoxy, monocycloalkylaminoethoxy, or dialkylaminoethoxy) benzofuranyl], N'-methyl or ethyl ureas

Also Published As

Publication number Publication date
US4845096A (en) 1989-07-04
ATE68494T1 (de) 1991-11-15
EP0284914B1 (de) 1991-10-16
DE3865480D1 (de) 1991-11-21
JPS63258473A (ja) 1988-10-25
DE3710469A1 (de) 1988-10-20
EP0284914A1 (de) 1988-10-05

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