EP4090754A4 - Tunable transposon systems - Google Patents

Tunable transposon systems Download PDF

Info

Publication number: EP4090754A4
Authority: EP; European Patent Office
Prior art keywords: tunable; transposon systems; transposon; systems; tunable transposon
Prior art date: 2020-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP21741482.0A

Other languages

German (de)

French (fr)

Other versions

EP4090754A2 (en

Inventor

Kathy NGO

Jenifer WOO

Binh Pham

Vu Truong-Le

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aridis Pharmaceuticals Inc

Original Assignee

Aridis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-01-18

Filing date

2021-01-17

Publication date

2024-04-24

2021-01-17 Application filed by Aridis Pharmaceuticals Inc filed Critical Aridis Pharmaceuticals Inc

2022-11-23 Publication of EP4090754A2 publication Critical patent/EP4090754A2/en

2024-04-24 Publication of EP4090754A4 publication Critical patent/EP4090754A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/90—Vectors containing a transposable element
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible

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Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Mycology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EP21741482.0A 2020-01-18 2021-01-17 Tunable transposon systems Withdrawn EP4090754A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US202062963022P	2020-01-18	2020-01-18
PCT/US2021/013788 WO2021146666A2 (en)	2020-01-18	2021-01-17	Tunable transposon systems

Publications (2)

Publication Number	Publication Date
EP4090754A2 EP4090754A2 (en)	2022-11-23
EP4090754A4 true EP4090754A4 (en)	2024-04-24

Family

ID=76864287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP21741482.0A Withdrawn EP4090754A4 (en)	2020-01-18	2021-01-17	Tunable transposon systems

Country Status (4)

Country	Link
EP (1)	EP4090754A4 (en)
CN (1)	CN115279910A (en)
CA (1)	CA3161872A1 (en)
WO (1)	WO2021146666A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2023060589A1 (en) *	2021-10-15	2023-04-20	深圳市深研生物科技有限公司	Multi-transposon system
CN114657153A (en) *	2022-05-24	2022-06-24	上海健士拜生物科技有限公司	rAAV recombinant packaging plasmid, plasmid system for rAAV packaging and preparation method of rAAV
BE1031211B1 (en) *	2022-12-28	2024-07-29	Quidditas Sa	Composition and its use for the treatment of hereditary diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015188191A1 (en) *	2014-06-06	2015-12-10	Wong Wilson W	Dna recombinase circuits for logical control of gene expression

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US20110023143A1 (en) *	2008-12-04	2011-01-27	Sigma-Aldrich Co.	Genomic editing of neurodevelopmental genes in animals
CN105154473B (en) *	2015-09-30	2019-03-01	上海细胞治疗研究院	A kind of transposon integration system of highly effective and safe and application thereof
KR20180091821A (en) *	2015-10-27	2018-08-16	리컴비네틱스 인코포레이티드	How to manipulate humanized CAR T-cells and platelets by genetic complementarity
WO2018160712A1 (en) *	2017-02-28	2018-09-07	The Penn State Research Foundation	Regenerating functional neurons for treatment of neural injury caused by disruption of blood flow

2021
- 2021-01-17 WO PCT/US2021/013788 patent/WO2021146666A2/en active Application Filing
- 2021-01-17 CA CA3161872A patent/CA3161872A1/en active Pending
- 2021-01-17 CN CN202180009675.0A patent/CN115279910A/en active Pending
- 2021-01-17 EP EP21741482.0A patent/EP4090754A4/en not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015188191A1 (en) *	2014-06-06	2015-12-10	Wong Wilson W	Dna recombinase circuits for logical control of gene expression

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BRIAN E HEW ET AL: "RNA-guided piggyBac transposition in human cells", SYNTHETIC BIOLOGY, vol. 4, no. 1, 2 July 2019 (2019-07-02), pages ysz018, XP055737951, DOI: 10.1093/synbio/ysz018 *
DUPUY ADAM J. ET AL: "A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice", CANCER RESEARCH, vol. 69, no. 20, 14 October 2009 (2009-10-14), US, pages 8150 - 8156, XP093140527, ISSN: 0008-5472, Retrieved from the Internet <URL:https://aacrjournals.org/cancerres/article-pdf/69/20/8150/2615753/8150.pdf> DOI: 10.1158/0008-5472.CAN-09-1135 *
ERIC KOWARZ ET AL: "Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines", BIOTECHNOLOGY JOURNAL, vol. 10, no. 4, 2 March 2015 (2015-03-02), DE, pages 647 - 653, XP055684081, ISSN: 1860-6768, DOI: 10.1002/biot.201400821 *
FEDOROVA SVETLANA A ET AL: "Protein trap: a new Swiss army knife for geneticists?", MOLECULAR BIOLOGY REPORTS, SPRINGER NETHERLANDS, NL, vol. 47, no. 2, 14 November 2019 (2019-11-14), pages 1445 - 1458, XP036987601, ISSN: 0301-4851, [retrieved on 20191114], DOI: 10.1007/S11033-019-05181-Z *
MARTIN HOLZENBERGER ET AL: "Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)", GENESIS, WILEY-LISS, HOBOKEN, USA, vol. 26, no. 2, 23 February 2000 (2000-02-23), pages 157 - 159, XP072302733, ISSN: 1526-954X, DOI: 10.1002/(SICI)1526-968X(200002)26:2<157::AID-GENE19>3.0.CO;2-R *
MATTIA MATASCI ET AL: "The PiggyBac transposon enhances the frequency of CHO stable cell line generation and yields recombinant lines with superior productivity and stability", BIOTECHNOLOGY AND BIOENGINEERING, JOHN WILEY, HOBOKEN, USA, vol. 108, no. 9, 25 April 2011 (2011-04-25), pages 2141 - 2150, XP071108998, ISSN: 0006-3592, DOI: 10.1002/BIT.23167 *
NARAYANAVARI SUNEEL A. ET AL: "Sleeping Beauty transposition: from biology to applications", CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 52, no. 1, 4 October 2016 (2016-10-04), US, pages 18 - 44, XP055864384, ISSN: 1040-9238, Retrieved from the Internet <URL:https://tandfonline.com/doi/pdf/10.1080/10409238.2016.1237935> DOI: 10.1080/10409238.2016.1237935 *

Also Published As

Publication number	Publication date
CN115279910A (en)	2022-11-01
WO2021146666A2 (en)	2021-07-22
EP4090754A2 (en)	2022-11-23
CA3161872A1 (en)	2021-07-22
WO2021146666A3 (en)	2021-08-26
WO2021146666A8 (en)	2022-08-11

Publication	Publication Date	Title
EP4090754A4 (en)	2024-04-24	Tunable transposon systems
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EP4179320B8 (en)	2024-09-11	System
EP4131197A4 (en)	2023-07-19	Fall prevention system
EP4085145A4 (en)	2024-02-21	Guided excision-transposition systems
EP4225612A4 (en)	2024-04-17	Illuminated-marking system
EP4318260A4 (en)	2024-05-22	Data-saving system
AU2021902800A0 (en)	2021-09-16	Enviro-lid-catch
AU2021902772A0 (en)	2021-09-09	MyHerculead
AU2021902428A0 (en)	2021-08-19	Antenna2
AU2021902077A0 (en)	2021-07-22	Si-211
AU2021901795A0 (en)	2021-07-01	Build-A-bouquet
AU2021901682A0 (en)	2021-06-17	PoPLeveLPoP
AU2020902092A0 (en)	2020-07-09	Antimicrobial System
AU2021900733A0 (en)	2021-04-01	Mudgutz
AU2021900524A0 (en)	2021-03-18	Gyroball
AU2021900525A0 (en)	2021-03-18	BubbleSplint
AU2021900362A0 (en)	2021-02-25	Tab-Sleeve
AU2021900327A0 (en)	2021-02-25	Ridball
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Legal Events

Date	Code	Title	Description
2021-07-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2022-10-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2022-10-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2022-11-23	17P	Request for examination filed	Effective date: 20220707
2022-11-23	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-04-26	DAV	Request for validation of the european patent (deleted)
2023-04-26	DAX	Request for extension of the european patent (deleted)
2024-04-24	A4	Supplementary search report drawn up and despatched	Effective date: 20240321
2024-04-24	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 5/16 20060101ALI20240318BHEP Ipc: C12N 15/52 20060101ALI20240318BHEP Ipc: C12N 15/85 20060101ALI20240318BHEP Ipc: C12N 9/22 20060101ALI20240318BHEP Ipc: C12N 9/16 20060101ALI20240318BHEP Ipc: C12N 15/90 20060101AFI20240318BHEP
2024-07-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2024-08-14	18W	Application withdrawn	Effective date: 20240711