EP3866747A1

EP3866747A1 - Device for temporarily connecting two containers

Info

Publication number: EP3866747A1
Application number: EP19813074.2A
Authority: EP
Inventors: David BOUTELOUP; Fabrice BOURDIER; Florence Bidamant
Original assignee: Coradin SAS
Current assignee: Coradin SAS
Priority date: 2018-10-19
Filing date: 2019-10-18
Publication date: 2021-08-25
Also published as: FR3087336A1; KR20210075034A; US11925601B2; MX2021000006A; CN112638347A; CO2021002485A2; CA3105225A1; FR3087336B1; RU2770286C1; JP2022503384A; CL2021000701A1; JP7368387B2; SG11202012853UA; ZA202101760B; BR112021001482A2; AU2019361309A1; US20210228445A1; IL280245A; CN112638347B; WO2020079383A1

Abstract

System for connecting containers, the system being intended to temporarily assemble a first and a second container, the connecting system comprising a closing sleeve provided with a first portion which is designed to be attached to the first container, and the closing sleeve also being provided with a second portion which is designed to enable the temporary attachment of the opening of the second container and a membrane separating the first and the second portion of the closing sleeve, the membrane being designed to be perforated by the second container when attaching the latter to the second portion of the closing sleeve, characterised in that the connecting system comprises a plug intended to close the second portion of the closing sleeve before the connecting system is used, the plug and the closing sleeve being obtained by means of a simultaneous method for injection moulding at least one plastic material, the plug being attached to the second portion of the closing sleeve once the plug and the closing sleeve are released from the respective moulds thereof.

Description

DESCRIPTION

TITLE: TEMPORARY CONNECTION DEVICE FOR TWO CONTAINERS

This patent application claims priority from the French patent application filed on October 19, 2018 under number FR1871237.

Field of the invention

The invention relates to a container connection device for the temporary assembly of said containers, generally a bottle for containing a substance and a bottle for containing a fluid, for the purpose of mixing said substance, such as a powder, a lyophilisate. or a liquid, and said fluid such as a solvent.

According to the present invention, the connection system comprises a closure sleeve, a first part of which is provided with a fixing system making it possible to ensure a tight connection with the opening of the bottle and a second part of which is adapted to allow fixing. temporary opening of the bottle. In order to prevent the contents of the bottle from inadvertently leaking from said bottle and being exposed to the influence of ambient air or water, the closure sleeve comprises a membrane separating the first and second parts of said closure sleeve. The connection system is adapted to allow the membrane separating the first and second part of the closure sleeve to be perforated as soon as the bottle is fixed to the second part of the closure sleeve. When the bottle and the bottle are fixed inside the closure sleeve, the fluid contained in said bottle can flow by repeated pressure on the bottle or any flexible element of the bottle, such as a flexible bottom, and penetrate inside said bottle, thus allowing the substance and said fluid to be mixed.

After mixing the substance and the fluid, the mixture can be transferred to the bottle and used at a location and time preferred by the user. State of the art

Systems for packaging a substance and a fluid in two separate containers for the purpose of mixing said substance and said fluid, at a time chosen by the user, are already known in the prior art. Such a system is, for example, disclosed in document EP 1009356 and is suitable for temporarily connecting a bottle made of rigid material, such as glass, to a bottle made of flexible material, such as plastic. According to the teaching of document EP 1009356, the bottle is particularly suitable for protecting the substance contained therein against the influence of various external elements such as water or oxygen and thus retaining the properties of said substance contained in said bottle. The device as shown in document EP 1009356 may contain a product such as a cosmetic product and / or a pharmaceutical product intended for the treatment of the skin. The substance used for such treatment typically has active ingredients having beneficial effects for the skin. Said assets, protected by the bottle, are not degraded during filling, any freeze-drying process or storage in the bottle. The user can, just before use, mix the substance and the fluid, using the system disclosed in document EP 1009356, in order to obtain a mixture which will be used for the treatment of the skin.

It should be noted that the connection system as disclosed in document EP 1009356 comprises a closure sleeve provided with a second part allowing the temporary fixing of the opening of a bottle which is essentially in the form of a cylinder. Inside said cylinder, the second part of the closure sleeve is provided with a thread allowing the temporary fixing of the bottle using said thread. Before use, said second part of said closure sleeve is open and includes an interior wall exposed to ambient air. Said non-sterile interior wall is therefore not protected against possible contamination.

In the case where the container connection system according to document EP 1009356 is used to mix a substance and a fluid, as described above, it is possible that contamination potentially present on the inner wall of the closure sleeve propagates inside the bottle during the steps of transferring said fluid.

For the reason mentioned in the above paragraph, the container connection system as disclosed in document EP 1009356 is not suitable for mixing pharmaceutical products which must imperatively remain sterile before their use.

In view of the above observations, it appears that there is a need to improve the connection systems of existing containers intended to allow the mixing of a substance and a fluid.

One of the objectives of the present invention is to provide an improved container connection system compared to the system known in the prior art.

Another object of the present invention is to provide a container connection system comprising interior walls which remain sterile before the use of said container connection system.

Another object of the present invention is to provide a container connection system the presence of sterile interior walls of which generates the least additional cost possible during the production of such an improved container connection system.

Object of the invention

The object of the present invention is a container connection system intended for the temporary assembly of a first and a second container, said connection system comprising a closure sleeve, provided with a first part adapted to be fixed on the first container, and said closure sleeve also being provided with a second part, adapted to allow temporary fixing of the opening of the second container, and with a membrane separating said first and said second part from said closure sleeve , said membrane being adapted to be punctured by the second container when it is fixed on the second part of the closure sleeve, in which said system connection comprises a plug intended to close off the second part of the closure sleeve before using the connection system, said plug and said closure sleeve being obtained by means of a simultaneous injection molding process of a plastic material, the plug being fixed on the second part of the closing sleeve as soon as it leaves the plug and the closing sleeve of their respective molds.

According to one embodiment of the invention, the stopper is fixed to the second part of the closure sleeve before the stopper and said closure sleeve cool down to room temperature.

According to an embodiment of the invention, the membrane is an integral element of the closure sleeve and comprises a plastic material essentially similar, preferably similar, to the material used for the first part and the second part of said closure sleeve.

According to one embodiment of the invention, the stopper is provided with a frangible zone in the form of a tearable tongue adapted to be removed and thus facilitating the removal of said stopper from the second part of the closure sleeve.

A second aspect of the present invention relates to a method for obtaining a container connection system intended for the temporary assembly of a first and a second container, said connection system comprising a closure sleeve provided with a lower part, adapted to be fixed on the first container and provided with an upper part adapted to allow the fixing of the opening of the second container and provided with an integrated membrane, said membrane separating the upper part from the lower part of the sleeve closure, said membrane being adapted to be punctured by the second container when the latter is fixed to the upper part of said closure sleeve, in which said method comprises the following steps:

close the closure sleeve and the plug using a simultaneous injection molding process of at least one plastic,

fix the plug on the second part of the connection device so as to close said second part of the closure sleeve, as soon as they exit the plug and said closure sleeve from their respective molds.

According to one embodiment of the invention, the plug is fixed to the second part of the closure sleeve before said plug and said closure sleeve cool down to room temperature.

Brief description of the drawings

The object, object and characteristics of the present invention will appear more clearly on reading the present description which follows, made with reference to the figures in which: [Figure 1] shows a container connection system, according to a first embodiment , comprising a bottle, a sealing element, a closure sleeve and a stopper during their assembly,

- [Figure 2] shows a bottle, a dropper and a stopper during their assembly,

[FIG. 3] shows the bottle and the closure sleeve according to FIG. 1, and a bottle during the fixing of said bottle in said closure sleeve,

[FIG. 4] represents the bottle, the closure sleeve and the stopper according to FIG. 3, after their assembly,

- [Figure 5] shows the assembly according to Figure 4 with the plug removed,

- [Figure 6] shows a partial sectional view of a closure sleeve and a plug fixed to the second part of said closure sleeve,

- [Figure 7] shows a schematic view of a plurality of closure sleeves ready for exit from their mold and a plurality of plugs,

- [Figure 8] shows a schematic view of the positioning of a plurality of plugs aligned with, respectively, a plurality of closing sleeves before the exit of said closing sleeves from their respective molds, and

- [Figure 9] shows a second embodiment of a bottle and a closure sleeve according to the invention.

FIG. 1 shows a bottle 10 specifically adapted for packaging a substance such as a powder, a lyophilisate or a liquid. Said bottle 10 is made of a material suitable for protecting the substance contained therein against the influence of external elements, such as, inter alia, oxygen (0 ₂ ) and water (H ₂ 0). Glass is a very suitable material to fulfill this function. The bottle 10 comprises a bottom 1 1, at its lower end, and an opening 14 located at its upper end 12. Said opening is adapted to allow the output of the contents of said bottle 10. Near its upper end 12, the bottle 10 is provided with fixing means 13, in the form for example of circular protrusions, forming a surface on which the closure sleeve 30 can be fixed.

FIG. 1 represents a joining element 15 adapted to be inserted inside the bottle 10 to allow a tight connection between said bottle 10 and the closure sleeve 30. The joining element 15 can be produced, for example, in a flexible material such as rubber or thermoplastic elastomer. The closure sleeve 30, as shown in FIG. 1, is provided with a first part 31 adapted to be fixed on the bottle 10. It is not necessary to remove the closure sleeve 30 from the bottle 10 during the use of said bottle 10.

The closure sleeve 30 comprises a second part 32 specifically adapted for the temporary fixing of a bottle (as shown in FIG. 2). The inner wall 33 of the second part 32 is provided with fixing means (not shown in FIG. 1) allowing said temporary fixing of said bottle. The fixing means present on the inner wall 33 of the second part 32 of the closure sleeve 30 are, for example, in the form of a thread.

The second part 32 of the closure sleeve 30 can be closed, before the use of the bottle 10 and of said closure sleeve 30, using a plug 40. FIG. 2 represents a bottle 20 particularly suitable for use in combination with the bottle 10 and the closure sleeve 30, as shown in FIG. 1. The bottle 20 is suitable for packaging a fluid which can be mixed with the substance packaged in the bottle 10. Said fluid, packaged in the bottle 20 may be, for example, a solvent suitable for dissolving, at least partially, the substance contained in the bottle 10 and / or form with said substance an emulsion or suspension after mixing of said substance contained in bottle 10 and the fluid contained in bottle 20.

The bottle 20 has a lower end 21 forming the bottom of said bottle 20 and an upper end 22 provided with an opening adapted to allow the contents of said bottle 20 to flow outward. A dispenser 24 can be positioned on the opening located at the upper end 22 of the bottle 20. Said dispenser 24 can be used to expel outwards a precise dosage of the contents of the bottle 20. At its upper end 22, the bottle 20 is provided with fixing means 23, such as a thread, allowing the temporary fixing of said bottle 20 inside the second part 32 of the closure sleeve 30, as shown in FIG. 1. Said means of fixing 23 can also be used to fix a stopper 25, said stopper making it possible to protect the content of the bottle 20 before its use.

The bottle 20 is typically made of a flexible plastic material. The flexibility of the external wall of the bottle 20 allows the user to exert, with his finger, a certain pressure on the outside of said bottle 20 in order to deform it. The deformation of the bottle 20 allows the expulsion of its contents using the dispenser 24.

FIG. 3 shows the fixing of the bottle 20 inside the second part 32 of the closure sleeve 30. To allow said fixing, the cap 25 was first removed. When the bottle 20 is introduced inside the second part 32 of the closure sleeve 30, said bottle can be advanced towards a membrane 35. Said membrane 35 has the function of separating the interior of the first part 31 of the closure sleeve 30 and the interior of the second part 32 of said closure sleeve 30. The presence of said membrane 35 protects the substance 50 present inside the bottle 10, before using said bottle 10 and said closure sleeve 30. According to a preferred embodiment, the membrane 35 is an integral part of the closure sleeve 30, that -this being made of the same material as the first part 31 and the second part 32 of said closure sleeve 30. The membrane 35 forms a frangible zone adapted to be perforated by the distributor 24 of the bottle 20 during the introduction of said bottle 20 inside the second part 32 of the closure sleeve 30. When the membrane 35 is perforated, the distributor 24 can continue to advance until it is received inside an opening 16 present in the joining element 15. Said joining element 15 is present between the upper part of the bottle 10 and the inside of the first part 31 of the closure sleeve 30.

The distributor 24 is preferably made using a relatively rigid material. The rigidity of the distributor 24 allows it to perforate the membrane 35 without the latter itself being deformed. Furthermore, the presence of the relatively rigid distributor 24 and a relatively flexible joining element 15 and provided with an opening 16 intended to receive said distributor 24, guarantees a seal between the exterior of the distributor 24 and the interior of the opening 16 after the complete introduction of the bottle 20 inside the second part 32 of the closure sleeve 30.

After complete insertion of the bottle 20 of the closure sleeve 30, the fluid contained inside said bottle 20 can flow, deforming the bottle 20 to increase the pressure inside said bottle 20, towards the inside the bottle 10. When the fluid is thus transferred from the bottle 20 towards the inside of the bottle 10, it is possible to shake the whole of the bottle 10, the closure sleeve 30 and the bottle 20 in order to obtain a mixture between the substance 50, present inside the bottle 10, and the fluid (not shown in FIG. 3). After the mixing of said fluid and the substance 50, the whole of the bottle 10, of the closure sleeve 30 and of the bottle 20 can be arranged vertically so that the bottle is located above the bottle 20 and, in aspirating through a deformation of the bottle 20, allow the transfer of the mixture of the substance 50 and the fluid from the bottle 10 to the bottle 20. As soon as the mixture is sucked inside the bottle 20, the latter can be used to dispense said mixture, so controlled, on the one hand by means of the deformation of the external wall of the bottle 20 and, on the other hand by using the dispenser 24. When the user no longer wishes to dispense the mixture, the bottle 20 can be closed using plug 25 (as shown in Figure 2).

The assembly of the bottle 10, the closure sleeve 30 and the bottle 20, according to the invention, is particularly suitable for mixing a fluid and a substance 50, thanks to a closure sleeve 30 provided a sterile interior. The sterile interior avoids potential contamination of the mixture of said fluid and said substance 50. To guarantee a sterile interior, the second part 32 of the closure sleeve 30 is, before its use, sealed with a plug.

40. The closure of the closure sleeve 30 with a plug 40 is shown in FIG. 4.

FIG. 4 shows the closure sleeve 30 fixed on the upper part of the bottle 10. The second part 32 of said closure sleeve 30 is wrapped and closed with a stopper 40. To remove the stopper 40, the latter is provided with a tearable tongue 41. A frangible zone, present between said tearable tongue 41 and the body of the stopper 40, facilitates the removal of the tearable tongue

41. When the tear-off tab 41 is removed, removal of the plug 40 from the closure sleeve 30 is facilitated.

FIG. 5 shows the assembly of the bottle 10 and the closure sleeve 30 after the cap 40 has been removed. According to the position as shown in FIG. 5, the assembly of the bottle 10 and said closure sleeve 30 is ready to receive the bottle 20, as shown in FIG. 3, inside the second part 32 of the closure sleeve 30.

6 shows a partial sectional view of the assembly of the closure sleeve 30 and the plug 40 after their assembly. In Figure 6, we can see the presence of the membrane 35, said membrane 35 being adapted to close the interior of the first part 31 relative to the interior of the second part 32 of the closure sleeve 30. The cap 40 is present to protect the interior wall 33 from any form of potential contamination before the use of the closure sleeve 30. In order to guarantee a sterile interior to the first part 31 of said closure sleeve 30, before use, the interior of said first part 31 is sterilized before and / or during the fixing of the closure sleeve 30 on the bottle 10. The permanent fixing of the first part 31 on the bottle 10 ( as shown in Figures 3 to 5) guarantees non-contamination of the interior of the first part 31 of the closure sleeve 30 before use.

According to the invention, the interior of the second part 32 of the closure sleeve 30 (as shown in FIG. 6) is kept sterile in a particular way.

Figure 7 schematically shows a plurality of closure sleeves 30 and a plurality of plugs 40. According to the present invention, said closure sleeves 30 and said plugs 40 are obtained by a simultaneous injection molding process. In other words, said closure sleeves 30 and said plugs 40 are directly assembled as soon as they are extracted from their respective molds, guaranteeing perfect sterility inside the second part 32 of the closure sleeves 30 as well as from inside the caps 40.

FIG. 8 represents a schematic view of an assembly as described in the paragraph above. A first mold, suitable for the production of a plurality of closure sleeves 30, is positioned near a second mold, suitable for the production of a plurality of plugs 40. According to the example shown in FIG. 8, the plugs 40 are extracted from their respective molds and each of them is positioned at the location from which the closure sleeves 30 are each extracted from their respective molds. When the plugs 40 are positioned at the ends of the closing sleeves 30, as shown in FIG. 8, said closing sleeves 30 are advanced, and extracted from their respective molds, so as to be automatically introduced, with their respective second part 32 , inside each of the plugs 40. When the assembly of the closing sleeves 30 and the respective plugs 40 is carried out, all of said closing sleeves 30 and said plugs 40 are removed from the outlet of the zone provided for the production of the closing sleeves 30, thus allowing the exit of the following products.

The closure sleeves 30 and the plugs 40 are typically produced using a plastic material such as HDPE or PP. A product obtained using above-mentioned materials present, on leaving the mold, a temperature of approximately 50 ° C. to 70 ^q C. With regard to the temperature of transformation of the materials greater than 200 ° C. and the high temperature on leaving the mold, it has been found that the wall 33 of each of the second parts 32 of each of the closure sleeves 30 remains sterile. This means that the positioning of the plug 40, on the second part 32 of the closure sleeve 30, guarantees the sealing of the interior wall 33 of each of said second portions 32 of each of the closure sleeves 30.

Figure 9 shows a second embodiment of a bottle 1 10 according to the invention, said bottle 1 10 being provided with a bottom 1 1 1 and an upper end 1 12. Said bottle 1 10, open in sound upper end 1 12, is provided with an opening 1 14 adapted to allow the flow of the contents of said bottle 1 10. Fixing means 1 13 are present outside the bottle 1 10, near the upper end 1 12. According to the embodiment shown in Figure 9, said fixing means 1 13 are in the form of a thread, said thread serving to fix the closure sleeve 130 on the bottle 1 10. The closure sleeve 130 is therefore screwed onto the thread 1 13 using its first part 131.

A joint element 1 15 is also shown in FIG. 9, said joint element 1 15 being adapted to be inserted between the bottle 1 10 and the first part 131 of the closure sleeve 130. The joint element 1 15 is produced in a relatively flexible material compared to the material used to make the bottle 1 10 and the closure sleeve 130. Therefore, as soon as it is assembled, the joining element 1 15 seals between the bottle 1 10 and the closure sleeve 130.

The bottle 1 10 is made of a suitable material for protecting a substance contained therein before its use. Said bottle 1 10 can, for example, be made of a material such as glass. The closure sleeve 130 is, in turn, made of a plastic material such as HDPE or PP. The closure sleeve 130 is provided, inside, with a membrane making it possible to separate its first part 131 from its second part 132. Said membrane is not shown in FIG. 9. However, its shape and its functionality are similar to those of the membrane 35 as shown in FIG. 3. Furthermore, in addition to the membrane integrated within the closure sleeve 130, it is possible to integrate a second membrane 136 between said closure sleeve 130 and the joining element 1 15. Said membrane 136 can be produced in a material such as aluminum and can be pre-fixed on the upper face (according to the orientation as shown in FIG. 9) of the joining element 1 15. Such a membrane 136 has not been shown in combination with the first embodiment as shown in Figures 1 to 6. It should be noted that such a membrane can be positioned on the joining element 15 as shown in Figures 1 and 3. The exterior of the second part 132 of the closure sleeve 130 is provided with a thread 138. Said thread 138 is used to fix a plug 140 to the outside. As soon as the plug 140 is fixed on the thread 138, outside the second part 132 of the closure sleeve 130, a tamper-evident ring 141 is automatically fixed, under the effect of its plastic deformation, behind the edge 139 at the end of said closure sleeve 130. A frangible zone 142 is present between the cap 140 and the tamper-evident ring 141, said frangible zone 142 being adapted to be breakable when the cap 140 is first opened using of thread 138.

According to the present invention, the closure sleeve 130 and the plug 140 are obtained by a simultaneous injection molding process. This means that said closure sleeve 130 and said plug 140 are directly assembled as soon as they are extracted from their respective mold, which guarantees perfect sterility from the inside of the second part 132 of said closure sleeve 130 and the inside the plug 140. The production and assembly of the closing sleeve 130 and the plug 140 are similar to those of the closing sleeve 30 and the plug 40, as described with reference to the above paragraphs concerning FIGS. 7 and 8.

Figure 9 shows the joining element 1 15 provided with an opening 1 17, said opening 1 17 being used in a lyophilization process.

The method of filling the bottle 1 10 according to the present invention breaks down as follows. The bottle 1 10 is pre-sterilized during a suitable process, for example, the use of gamma rays or ethylene oxide. After said pre sterilization, said bottle 1 10 circulates on a sanitized production line and is filled with a sterile solution comprising at least one active ingredient and water then subjected to cryodessiccation conditions. At the end of this step, the joining element 1 15 provided, on its upper surface, with a membrane 136, penetrates inside the opening 1 14 of the bottle 1 10. First of all, the joining element 1 15 is introduced in order to keep at least part of the opening 1 17 outside of the bottle 1 10. After this step, the assembly consisting of the bottle 1 10 and the joining element 1 15 is introduced into a chamber provided for the lyophilization step. At the end of said lyophilization process, the joining element 1 15 is pushed completely inside the opening 1 14 of the bottle 1 10. Next, the assembly consisting of the closing sleeve 130 and the stopper 140 is fixed to the bottle 1 10 using, on the one hand, the thread 1 13 and, on the other hand, an additional thread located inside the first part 131 of the closure sleeve 130.

Thanks to the co-production of the closing sleeve 30, in combination with the plug 40, or even the closing sleeve 130 and the plug 140, the sterility of the respective inner wall 33, 133, of the respective closing sleeve 30, 130 and the interior of the respective cap 40, 140 is guaranteed.

Claims

1. container connection system intended for the temporary assembly of a first and a second container (10, 1 10), said connection system comprising a closure sleeve (30, 130), provided with a first part (31, 131) adapted to be fixed on the first container (10, 1 10), and said closure sleeve (30, 130) also being provided with a second part (32, 132), adapted to allow fixing temporary opening of the second container (20) and a membrane (35) separating said first (31, 131) and said second (32, 132) part of said closure sleeve (30, 130), said membrane (35) being adapted to be perforated by the second container (20) when it is fixed on the second part (32, 132) of the closure sleeve (30, 130), characterized in that said connection system comprises a plug ( 40, 140) intended to close off the second part (32, 132) of the closure sleeve (30, 130) before the use of the connection system, said plug (40, 140) and said closure sleeve (30, 130) being obtained by means of a simultaneous injection molding process of at least one plastic, the plug (40, 140) being fixed on the second part (32, 132) of the closure sleeve (30, 130) as soon as it leaves the plug (40, 140) and the closure sleeve (30, 130) from their respective molds .

2. container connection system for the temporary assembly of said containers according to claim 1, the plug (40, 140) being fixed on the second part (32, 132) of the closure sleeve (30, 130) before cooling. plug (40, 140) and closure sleeve (30, 130) to room temperature.

3. container connection system for the temporary assembly of said containers according to one of claims 1 or 2, wherein the membrane (35) is an integral element of the closure sleeve (30, 130) and comprises a plastic material essentially similar, preferably similar, to the material used for the first part (31, 131) and the second part (32, 132) of the closure sleeve (30, 130).

4. Container connection system intended for the temporary assembly of said containers according to one of claims 1, 2 or 3, in which the stopper (40) is provided with a frangible zone in the form of a tearable tongue (41), adapted to be removed and thus facilitating the removal of said plug (40) from the second part (32) of the closure sleeve (30).

5. container connection system for the temporary assembly of said containers according to one of claims 1, 2 or 3, wherein the cap (140) is provided with a tamper-evident ring (141), adapted to be separated from the body of said plug (140) during the initial opening of said plug (140).

6. Method for obtaining a container connection system intended for the temporary assembly of a first and a second container, said connection system comprising a closure sleeve provided with a lower part adapted to be fixed to the first container, provided with an upper part adapted to allow the fixing of the opening of the second container and provided with an integrated membrane, said membrane separating the upper part from the lower part of the closure sleeve, said membrane being adapted for be perforated by the second container when it is fixed on the upper part of the closure sleeve, characterized in that said method comprises the following stages: forming the closure sleeve and the stopper using a simultaneous injection molding process '' at least one plastic, fix the plug on the second part of the connection device ion thus closing said second part of the closure sleeve, as soon as it leaves the stopper and the closure sleeve of their respective molds.

7. Method according to claim 6, in which the plug is fixed to the second part of the closure sleeve before said plug and the closure sleeve cool down to room temperature.