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EP3349901A1 - Sampling pipette comprising a control member with double function for ejecting a cone and unlocking the system for volume adjustment - Google Patents

Sampling pipette comprising a control member with double function for ejecting a cone and unlocking the system for volume adjustment

Info

Publication number
EP3349901A1
EP3349901A1 EP16770712.4A EP16770712A EP3349901A1 EP 3349901 A1 EP3349901 A1 EP 3349901A1 EP 16770712 A EP16770712 A EP 16770712A EP 3349901 A1 EP3349901 A1 EP 3349901A1
Authority
EP
European Patent Office
Prior art keywords
pipette
control member
control
locking member
cone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16770712.4A
Other languages
German (de)
French (fr)
Other versions
EP3349901B1 (en
Inventor
Bruno DUDEK
Stéphane Guichardon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilson SAS
Original Assignee
Gilson SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilson SAS filed Critical Gilson SAS
Priority to PL16770712T priority Critical patent/PL3349901T3/en
Publication of EP3349901A1 publication Critical patent/EP3349901A1/en
Application granted granted Critical
Publication of EP3349901B1 publication Critical patent/EP3349901B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0286—Ergonomic aspects, e.g. form or arrangement of controls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Definitions

  • the invention relates to the field of sampling pipettes, also called laboratory pipettes or liquid transfer pipettes, intended for sampling and dispensing liquid in containers or the like.
  • the pipettes concerned by the present invention are manually operated pipettes. These pipettes are intended to be held in the hand by an operator during liquid collection and dispensing operations, these operations being carried out by setting in motion a pipetting control button, obtained by the application of a pressure actuation on the same button. STATE OF THE PRIOR ART
  • a manually operated pipette remains relatively complex, especially because of the presence of multiple controls including the pipetting button, a locking member for blocking the sampling volume control system, or an eject button cones.
  • the subject of the invention is a manually operated sampling pipette comprising:
  • the pipette further comprises a dual-function control member for unlocking control of the brake ring and a cone ejection control, the control member being slidably mounted relative to the fixed pipette body.
  • the latter comprising a locking member of the brake ring
  • second elastic return means reminding the locking member in a locking position in which the locking member cooperates with the ring of braking for braking the rotation thereof
  • follower means of the axial movement of the dual-function control member
  • said follower means comprising a release member of the locking member
  • said pipette being configured so that the control member can occupy a nominal central position in which said second elastic return means bring the locking member of in its locking position, and can be moved axially, from its nominal central position, to each of the two following positions:
  • the invention improves the ergonomics of the pipette by providing a dual-function control member, replacing two separate members provided in the solutions of the prior art.
  • safety is also provided since the locking position of the locking member is obtained in the nominal central position of the dual function member, that is to say when there is no effort is applied on the latter by the operator. The risks of unwanted adjustment of the volume to be taken are thus reduced to nothing.
  • the blocking of the volume adjustment control screw is not produced by an effort of the operator, but results from the force developed by the second elastic return means. Consequently, the braking force of the screw is constant and independent of the operator's force, unlike pipettes of the prior art.
  • the design offered by the present invention requires the use of only one hand for the actuation of the dual function control member, whether to reach the low ejection position of cone, to reach the unlocked high position, or to reach the nominal central position from any of the last two positions. This provides a particularly satisfactory ergonomics.
  • the invention furthermore exhibits at least one of the following optional features, singly or in combination.
  • the pipette is configured so that the unlocking high position of the brake ring is an equilibrium position held by friction between said release member and the locking member. With this equilibrium position, the operator can adjust the volume to be taken without having to provide any effort to maintain the control member in the unlocked up position.
  • Said release member is a pivoting finger.
  • Said locking member comprises:
  • a ring arranged facing axially of a flange of the brake ring, a first end pivotally mounted on a fixed element of the pipette, and a second end opposite the first and intended to cooperate with said release element, so that the second end and the release member respectively form a cam and a cam follower.
  • the first end is pivotally mounted along an eccentric axis of rotation, arranged in a transverse plane of the pipette. Thanks to this eccentricity and the pivoting nature of the locking member, the latter acts as a lever arm when moving the control member to the unlocked top position.
  • the effort to be applied by the operator on the dual-function control member is therefore less than the force developed by the second elastic return means, which further improves ergonomics and reduces the risk of musculoskeletal disorders. skeletal.
  • a friction washer is interposed between said collar and the ring of the locking member.
  • Said follower means comprise at least one rotary angular sector rotating along an axis of rotation of the follower means, the toothed angular sector cooperating with a rack made on said dual-function control member, the toothed angular sector being rotationally integral with said release member .
  • the equilibrium position is held by friction between the second end of the locking member and the release element, the friction force being oriented with a component non-zero in the tangential direction relative to said axis of rotation of the follower means. Therefore, a simple downward pressure on the control member is sufficient to break the equilibrium position, and to bring it back to the nominal central position.
  • the pipette is configured so that in the unlocking position of the brake ring, said dual-function control member constitutes an axial stop for the pipetting control button in its stroke towards the bottom, and so that the axial displacement of the dual-function control member caused by the axial displacement of the pipetting control knob, generates, before the end of a purge stroke, a break of said position of equilibrium after which said locking member automatically moves towards its locking position, under the effect of the force developed by the second elastic return means.
  • This feature first allows the use of the pipetting control button rather than the dual function controller to return the controller to the nominal center position, in which the volume control system is blocked. Consequently, this feature also makes it possible to be certain that the volume control system is blocked after the first purge stroke, in the event that the operator has forgotten to proceed with such locking via the control member. dual function.
  • the pipette is configured so that the volume control screw is rotated by the control rod.
  • the cone ejector comprises an ejection rod biased upwards by the first elastic return means, and a lower ejection portion secured to a lower end of the ejection rod.
  • said double-acting control organ is equipped with stop means making it possible to limit its stroke towards the height relative to the fixed body of the pipette.
  • the pipette is a single-channel or multichannel pipette.
  • FIG. 1 shows a front view of a manually operated sampling pipette according to the present invention, with its double-acting control member arranged in nominal central position;
  • FIGS. 7a and 7b represent an enlarged portion of an upper part of the pipette shown in the preceding figures
  • FIGS. 8a and 8b show views similar to those of FIGS. 7a and 7b, with the dual-function control member being in the low position of cone ejection;
  • FIG. 8c represents a view similar to that of FIG. 1, with its dual-function control member being in the low position of cone ejection;
  • FIGS. 9a to 9c represent views similar to those of FIGS. 8a to 8c, with the dual-function control member being in the unlocked high position of the brake ring;
  • FIG. 10 shows a view similar to that of Figure 1, with its dual-function control member in the unlocked position of the brake ring, during a purge stroke of the control rod.
  • FIG. 1 there is shown a manually operated sampling pipette 1 intended to be held by the hand of an operator, who, with the aid of his thumb 4, is able to actuate the pipette for generate the dispensing of a liquid that has been previously sucked.
  • the pipette 1 comprises a handle 6 forming the upper body of the pipette, the handle of which opens a control rod 10 carrying at its upper end, in the pipetting position, a pipetting control button 12, the upper part of which is intended to undergo pressure from the operator's thumb.
  • a display screen (not shown) can be provided on the handle 6.
  • the pipette 1 comprises a removable lower part 14, which ends downwards by a cone holder 16 receiving a consumable 18, also called sampling cone.
  • a cone ejector 20 opens towards the bottom of the handle 6.
  • the ejector can be set in motion relative to the handle 6 and the lower part 14, both forming the fixed body 23 of the pipette.
  • FIGS. 2 and 3 there is shown the upper part of the pipette 1, of longitudinal axis 26.
  • the latter houses a portion of the cone ejector 20. It is an ejection rod 30 biased upwards by first elastic return means, preferably one or several compression springs 32.
  • the springs 32 act on a plate 33 fixed to the upper end of the rod 30.
  • the rod 30 is secured to a lower ejection portion 34 which travels outside the body fixed 23, along and around the lower part (as shown in Figure 1).
  • the pipette is equipped with a volume control system 36 to be sampled, housed inside the handle 6.
  • This system 36 comprises, upstream of the kinematic chain, a screw sample volume control.
  • This screw 38 is integral in rotation, along the axis 26, a braking ring 40 arranged around the screw 38, itself traversed by the control rod 10.
  • the adjustment of the volume to be taken is performed by the operator by turning the knob 12, which causes the rotation of the control rod 10, that of the screw 38, then that of the brake ring 40.
  • the rotation of the screw 38 drives a downstream part of the driveline of the adjustment system 36, whose actuation makes it possible to vary the volume which will then be taken.
  • the brake ring 40 is centered on the axis 26 and has a flange-shaped peripheral end 42 which extends in a transverse plane of the pipette.
  • the upper surface of the flange 42 supports a friction washer 44 of elastomer facing upwardly of a locking member 46 of the brake ring 40.
  • the locking member 46 also shown in FIG. 6, is housed in a fixed hollow element 50, itself housed in the handle 6. It comprises a ring 52 arranged facing axially, downwards, of the washer of friction 44. In addition, it comprises a first end 54 pivotally mounted on the fixed element 50, along an axis of rotation 56 eccentric with respect to the axis 26, and arranged in a transverse plane of the pipette so as to be substantially orthogonal to the same axis 26. The axis of rotation 56 is preferably substantially tangent relative to the handle 6.
  • the locking member 46 also comprises a second end 58 opposite the first end 54, namely arranged diametrically opposite on the ring 52.
  • the pipette also comprises second elastic return means, made by one or more compression springs 60 whose upper end bears on an upper part of the fixed hollow element 50, and whose low end bears on the ring 52, and more precisely on a shoulder formed inside thereof.
  • the spring 60 thus forces the locking member 46 to press against the friction washer 44, and thus against the flange 42 of the brake ring which supports the same washer 44.
  • the pipette further comprises the dual-function control member 25, also shown in FIG.
  • the dual-function control member 25 also shown in FIG.
  • the pipette further comprises the dual-function control member 25, also shown in FIG.
  • the dual-function control member 25 also shown in FIG.
  • the actuating portion 62 is extended downwards by two axial support tongues 64, each equipped with an axial abutment tooth 66 designed to limit its upward stroke relative to the fixed body 23 in which the element 25 is slidably mounted axially.
  • the axial tabs 64 run inside the handle 6 and their low ends are opposite the plate 33 of the cone ejector, as is best seen in Figure 3.
  • one of the two tabs 64 is equipped with a rack 69 extending axially.
  • the pipette 1 is also equipped with means for tracking the axial movement of the dual-function control member 25, these follower means 68 being also shown in FIG. 5. They are housed in the handle 6, and comprise a release element 70 of the locking member 46, intended to cooperate with a lower surface of the second end 58.
  • the release member 70 is preferably a pivoting finger, while the lower surface of the second end 58 has a slope relative to a pipette transverse plane, so that these elements 70, 58 respectively form a cam and a follower cam.
  • the follower means 68 comprise a toothed angular sector 72, for example extending substantially 90 °.
  • This sector 72 like the finger 68 integral in rotation with the latter, are rotatably mounted on the handle 6 along an axis of rotation 74 arranged in a transverse plane of the pipette, and preferably parallel to the axis of rotation 56 of the locking member 46.
  • the toothed angular sector 72 meshes with the rack 69 of the dual-function control member 25.
  • control member 25 occupies a nominal central position with respect to the handle 6, this position being a position of equilibrium when no action is performed by the operator on this member 25.
  • this central nominal position also shown in Figures 7a and 7b, the spring 60 exerts a force that recalls the locking member 46 in a locking position, wherein the ring 52 is pressed against the flange 42 of the brake ring 40 More specifically, the effort developed by spring 60 leads the member 46 to pivot downwards from its first articulated end 54, to abut against the friction washer 44 supported by the flange 42.
  • the braking ring 40 remains locked in rotation, which causes the locking of the sampling volume adjustment system.
  • the operator can perform pipetting operations with the button 12 and the rod 10, without risking changing the setting of the volume to be taken.
  • the finger 70 remains at a distance from the second end 58 of the locking member, while the tabs 64 are spaced from the plate 33 of the ejector 20 by a small axial clearance 80, referenced on the figure 3.
  • control member 25 can be moved by the thumb of the operator either upwards in a high unlocking position of the braking ring 40, or downwards in a low position. cone ejection.
  • FIGS. 8a to 8c it is shown the low cone ejection position, in which the control member 25 presses on the plate of the cone ejector 20, via the lower end of its tabs 64.
  • the axial clearance 80 shown in Figure 3 is first quickly consumed, then the tabs 64 come into contact with the platen 33.
  • the further actuation of the control member 25 is made against the force developed by the springs 32, and thus pushing the entire ejector 20 downwards.
  • the ejector rod 30 then leaves part of the handle 6, as shown in Figure 8c. This movement thus causes the cone ejector 20 to move downwards by pressing on the cone, until ejection thereof.
  • the pivoting finger 70 raises the second end of the locking member 46, causing a rotation of this rotation along its axis of rotation 56.
  • This rotation of the member takes place against the force developed by the spring 60, but with an actuating force of the operator which is advantageously much lower than that of the spring 60, due to the leverage effect observed.
  • the pivoting of the locking member 46 upwardly causes the latter to reduce the axial pressure that it exerts on the flange 42 via the washer 44, until release of the braking ring 40.
  • This release is materialized by a absence of axial pressure between the two elements 52, 42, or by the conservation a very low pressure that does not prevent the braking ring 40 to rotate when adjusting the volume by the operator.
  • the friction force 90 between the cam 70 and the cam follower 58 which maintains the equilibrium position, is oriented with a non-zero component 92 in the tangential direction relative to the axis of rotation 74. Therefore, after adjusting the volume to be taken, the operator can exert a simple downward pressure on the control member 25 to oppose this friction force 90, and break this equilibrium position. The equilibrium is thus broken after a very short downward stroke of the control member 25. After this break, the operator can continue the descent of the control member 25 until it regains its position. nominal power plant. Simultaneously, the locking member 46 moves automatically and abruptly downwards towards its locking position, under the effect of the force developed by the spring 60 pressing on the ring 52 of this locking member 46.
  • control member 25 when the control member 25 is in the unlocked up position, it constitutes an axial stop for the control button 12 during its downward stroke. This is particularly interesting when the operator forgets to bring the member 25 in the central nominal position, after making a volume adjustment to take.
  • the locking member 46 automatically finds its locking position thanks to the force developed by the spring 60. Simultaneously, the purge stroke continuation with the control knob 12 continues to generate a sliding down of the dual-function control member 25, due to the retention of the axial stop between these two elements 12, 25. Moreover, it is preferentially made that when the button 12 when it reaches the end of the purge stroke, the dual-function control member 25 occupies its nominal central position. Therefore, in the event of forgetting the operator, this nominal central position is automatically found after the first downward stroke of the control rod 10 and its associated control knob 12.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

In order to improve the ergonomics of a sampling pipette, the invention provides a control member (25) intended to occupy a nominal central position in which a spring (60) brings a locking member (46) into the locking position thereof of the system for adjustment of the volume to be sampled, the member (25) being able to be axially displaced towards each of the two following positions: - a low position for ejecting a cone, in which the control member (25) presses on the cone ejector (20), the movement from the nominal central position to the low position being carried out against the springs (32); and - a high position for unlocking the braking ring (40), the movement of the control member (25) from the nominal central position to the high position driving a disengagement element (70) to move the locking member (46) against the spring (60), until release of the braking ring (40).

Description

PIPETTE DE PRELEVEMENT COMPRENANT UN ORGANE DE COMMANDE  SAMPLE PIPETTE COMPRISING A CONTROLLER
A DOUBLE FONCTION D'EJECTION DE CONE ET  A DOUBLE FUNCTION OF EJECTION OF CONE AND
DE DEVERROUILLAGE DU SYSTEME DE REGLAGE DE VOLUME DESCRIPTION  UNLOCKING VOLUME ADJUSTMENT SYSTEM DESCRIPTION
DOMAINE TECHNIQUE TECHNICAL AREA
L'invention se rapporte au domaine des pipettes de prélèvement, également dénommées pipettes de laboratoire ou encore pipettes de transfert de liquide, destinées au prélèvement et à la dispense de liquide dans des récipients ou similaires. The invention relates to the field of sampling pipettes, also called laboratory pipettes or liquid transfer pipettes, intended for sampling and dispensing liquid in containers or the like.
Les pipettes concernées par la présente invention sont les pipettes à actionnement manuel. Ces pipettes sont destinées à être tenues en main par un opérateur durant les opérations de prélèvement et de dispense de liquide, ces opérations étant réa lisées par mise en mouvement d'un bouton de commande de pipetage, obtenue par l'application d'une pression d'actionnement sur ce même bouton. ETAT DE LA TECHNIQUE ANTERIEURE  The pipettes concerned by the present invention are manually operated pipettes. These pipettes are intended to be held in the hand by an operator during liquid collection and dispensing operations, these operations being carried out by setting in motion a pipetting control button, obtained by the application of a pressure actuation on the same button. STATE OF THE PRIOR ART
Depuis de nombreuses années, la conception des pipettes à actionnement manuel fait l'objet de nombreuses améliorations. Ces améliorations visent en particulier à simplifier la conception des pipettes, ou encore à renforcer leur ergonomie. For many years, the design of manually operated pipettes has been the subject of many improvements. These improvements are intended in particular to simplify the design of the pipettes, or to improve their ergonomics.
Cependant, une pipette à actionnement manuel reste relativement complexe, notamment en raison de la présence de multiples commandes parmi lesquelles le bouton de pipetage, un organe de verrouillage servant à bloquer le système de réglage de volume de prélèvement, ou encore un bouton d'éjection du/des cônes.  However, a manually operated pipette remains relatively complex, especially because of the presence of multiple controls including the pipetting button, a locking member for blocking the sampling volume control system, or an eject button cones.
I l subsiste donc un besoin d'optimisation de la conception de telles pipettes, en particulier pour améliorer leur ergonomie.  There remains therefore a need to optimize the design of such pipettes, in particular to improve their ergonomics.
EXPOSÉ DE L'INVENTION STATEMENT OF THE INVENTION
L'invention a donc pour but de répondre au moins partiellement au besoin identifié ci-dessus. Pour ce faire, l'invention a pour objet une pipette de prélèvement à actionnement manuel comprenant : The invention therefore aims to at least partially meet the need identified above. To this end, the subject of the invention is a manually operated sampling pipette comprising:
- un corps fixe de pipette ;  a fixed body of pipette;
- une tige de commande de pipetage à l'extrémité de laquelle est agencé un bouton de commande de pipetage ;  a pipetting control rod at the end of which is arranged a pipetting control button;
- un éjecteur de cône rappelé en position haute par rapport au corps fixe de pipette par des premiers moyens élastiques de rappel ;  - A conical ejector raised in the upper position relative to the fixed pipette body by first elastic return means;
- une vis de commande de réglage de volume de prélèvement ;  a control screw for adjusting the sampling volume;
- une bague de freinage de la vis de commande, solidaire en rotation avec celle-ci.  - A brake ring of the control screw, integral in rotation therewith.
Selon l'invention, la pipette comporte en outre un organe de commande à double fonction permettant une commande de déverrouillage de la bague de freinage et une commande d'éjection de cône, l'organe de commande étant monté coulissant relativement au corps fixe de pipette selon une direction axiale de la pipette, celle-ci comportant un organe de verrouillage de la bague de freinage, des seconds moyens élastiques de rappel rappelant l'organe de verrouillage dans une position de verrouillage dans laquelle cet organe de verrouillage coopère avec la bague de freinage afin de freiner la rotation de celle-ci, et des moyens suiveurs du mouvement axial de l'organe de commande à double fonction, ces moyens suiveurs comportant un élément de dégagement de l'organe de verrouillage, ladite pipette étant configurée de sorte que l'organe de commande puisse occuper une position centrale nominale dans laquelle lesdits seconds moyens élastiques de rappel amènent l'organe de verrouillage dans sa position de verrouillage, et puisse être déplacé axialement, à partir de sa position centrale nominale, vers chacune des deux positions suivantes :  According to the invention, the pipette further comprises a dual-function control member for unlocking control of the brake ring and a cone ejection control, the control member being slidably mounted relative to the fixed pipette body. in an axial direction of the pipette, the latter comprising a locking member of the brake ring, second elastic return means reminding the locking member in a locking position in which the locking member cooperates with the ring of braking for braking the rotation thereof, and follower means of the axial movement of the dual-function control member, said follower means comprising a release member of the locking member, said pipette being configured so that the control member can occupy a nominal central position in which said second elastic return means bring the locking member of in its locking position, and can be moved axially, from its nominal central position, to each of the two following positions:
- une position basse d'éjection de cône, dans laquelle l'organe de commande appuie sur l'éjecteur de cône, le déplacement de la position centrale nominale vers la position basse d'éjection de cône s'effectuant à rencontre de l'effort développé par lesdits premiers moyens élastiques de rappel ; et  a low position of cone ejection, in which the control member presses on the cone ejector, the displacement of the nominal central position towards the low position of cone ejection taking place against the effort developed by said first elastic return means; and
- une position haute de déverrouillage de la bague de freinage, le déplacement de l'organe de commande à double fonction de la position centrale nominale vers la position haute de déverrouillage conduisant ledit élément de dégagement à déplacer l'organe de verrouillage à rencontre de l'effort développé par lesdits seconds moyens élastiques de rappel, jusqu'à libération de la bague de freinage. - a high unlocking position of the brake ring, the displacement of the dual-function control member of the central position nominal to the unlocking high position leading said release member to move the locking member against the force developed by said second elastic return means until release of the brake ring.
L'invention améliore l'ergonomie de la pipette en prévoyant un organe de commande à double fonction, en remplacement de deux organes distincts prévus dans les solutions de l'art antérieur. A la simplicité procurée par l'invention, s'ajoute la sécurité puisque la position de verrouillage de l'organe de verrouillage est obtenue en position centrale nominale de l'organe à double fonction, c'est-à-dire lorsqu'aucun effort n'est appliqué sur ce dernier par l'opérateur. Les risques de déréglages non désirés du volume à prélever sont donc réduits à néants.  The invention improves the ergonomics of the pipette by providing a dual-function control member, replacing two separate members provided in the solutions of the prior art. In addition to the simplicity provided by the invention, safety is also provided since the locking position of the locking member is obtained in the nominal central position of the dual function member, that is to say when there is no effort is applied on the latter by the operator. The risks of unwanted adjustment of the volume to be taken are thus reduced to nothing.
Comme cela ressort de ce qui précède, le blocage de la vis de commande de réglage de volume n'est pas produit par un effort de l'opérateur, mais résulte de l'effort développé par les seconds moyens élastiques de rappel. Par conséquent, l'effort de freinage de la vis est constant et indépendant de la force de l'opérateur, contrairement aux pipettes de l'art antérieur.  As is apparent from the above, the blocking of the volume adjustment control screw is not produced by an effort of the operator, but results from the force developed by the second elastic return means. Consequently, the braking force of the screw is constant and independent of the operator's force, unlike pipettes of the prior art.
Enfin, il est noté que la conception offerte par la présente invention ne requiert l'emploi que d'une seule main pour l'actionnement de l'organe de commande à double fonction, que ce soit pour atteindre la position basse d'éjection de cône, pour atteindre la position haute de déverrouillage, ou encore rejoindre la position centrale nominale depuis l'une quelconque des deux dernières positions. Cela procure une ergonomie particulièrement satisfaisante.  Finally, it is noted that the design offered by the present invention requires the use of only one hand for the actuation of the dual function control member, whether to reach the low ejection position of cone, to reach the unlocked high position, or to reach the nominal central position from any of the last two positions. This provides a particularly satisfactory ergonomics.
L'invention présente par ailleurs au moins l'une quelconque des caractéristiques optionnelles suivantes, prises isolément ou en combinaison.  The invention furthermore exhibits at least one of the following optional features, singly or in combination.
La pipette est configurée de sorte que la position haute de déverrouillage de la bague de freinage est une position d'équilibre maintenue par friction entre ledit élément de dégagement et l'organe de verrouillage. Grâce à cette position d'équilibre, l'opérateur peut procéder au réglage du volume à prélever sans avoir à fournir un effort quelconque pour le maintien de l'organe de commande en position haute de déverrouillage.  The pipette is configured so that the unlocking high position of the brake ring is an equilibrium position held by friction between said release member and the locking member. With this equilibrium position, the operator can adjust the volume to be taken without having to provide any effort to maintain the control member in the unlocked up position.
Ledit élément de dégagement est un doigt pivotant. Ledit organe de verrouillage comporte : Said release member is a pivoting finger. Said locking member comprises:
- une bague agencée en regard axialement d'une collerette de la bague de freinage, une première extrémité montée pivotante sur un élément fixe de la pipette, ainsi qu'une seconde extrémité opposée à la première et destinée à coopérer avec ledit élément de dégagement, de sorte que la seconde extrémité et cet élément de dégagement forment respectivement une came et un suiveur de came.  a ring arranged facing axially of a flange of the brake ring, a first end pivotally mounted on a fixed element of the pipette, and a second end opposite the first and intended to cooperate with said release element, so that the second end and the release member respectively form a cam and a cam follower.
Dans ce cas de figure, la première extrémité est montée pivotante selon un axe de rotation excentré, agencé dans un plan transversal de la pipette. Grâce à cette excentricité et au caractère pivotant de l'organe de verrouillage, ce dernier agit tel un bras de levier lors du déplacement de l'organe de commande vers la position haute de déverrouillage. L'effort à appliquer par l'opérateur sur l'organe de commande à double fonction est donc inférieur à l'effort développé par les seconds moyens élastiques de rappel, ce qui améliore encore davantage l'ergonomie et réduit les risques de troubles musculo-squelettiques.  In this case, the first end is pivotally mounted along an eccentric axis of rotation, arranged in a transverse plane of the pipette. Thanks to this eccentricity and the pivoting nature of the locking member, the latter acts as a lever arm when moving the control member to the unlocked top position. The effort to be applied by the operator on the dual-function control member is therefore less than the force developed by the second elastic return means, which further improves ergonomics and reduces the risk of musculoskeletal disorders. skeletal.
De préférence, une rondelle de friction est interposée entre ladite collerette et la bague de l'organe de verrouillage.  Preferably, a friction washer is interposed between said collar and the ring of the locking member.
Lesdits moyens suiveurs comprennent au moins un secteur angulaire denté rotatif selon un axe de rotation des moyens suiveurs, le secteur angulaire denté coopérant avec une crémaillère pratiquée sur ledit organe de commande à double fonction, le secteur angulaire denté étant solidaire en rotation dudit élément de dégagement. De plus, en position haute de déverrouillage de la bague de freinage, la position d'équilibre est maintenue par friction entre la seconde extrémité de l'organe de verrouillage et l'élément de dégagement, l'effort de friction étant orienté avec une composante non nulle selon la direction tangentielle relativement audit axe de rotation des moyens suiveurs. Par conséquent, un simple appui vers le bas sur l'organe de commande suffit à rompre cette position d'équilibre, et à ramener ce dernier en position centrale nominale.  Said follower means comprise at least one rotary angular sector rotating along an axis of rotation of the follower means, the toothed angular sector cooperating with a rack made on said dual-function control member, the toothed angular sector being rotationally integral with said release member . In addition, in the unlocked high position of the brake ring, the equilibrium position is held by friction between the second end of the locking member and the release element, the friction force being oriented with a component non-zero in the tangential direction relative to said axis of rotation of the follower means. Therefore, a simple downward pressure on the control member is sufficient to break the equilibrium position, and to bring it back to the nominal central position.
En outre, la pipette est configurée de sorte qu'en position haute de déverrouillage de la bague de freinage, ledit organe de commande à double fonction constitue une butée axiale pour le bouton de commande de pipetage dans sa course vers le bas, et de sorte que le déplacement axial de l'organe de commande à double fonction provoqué par le déplacement axial du bouton de commande de pipetage, engendre, avant la fin d'une course de purge, une rupture de ladite position d'équilibre après laquelle ledit organe de verrouillage se déplace automatiquement en direction de sa position de verrouillage, sous l'effet de l'effort développé par les seconds moyens élastiques de rappel. In addition, the pipette is configured so that in the unlocking position of the brake ring, said dual-function control member constitutes an axial stop for the pipetting control button in its stroke towards the bottom, and so that the axial displacement of the dual-function control member caused by the axial displacement of the pipetting control knob, generates, before the end of a purge stroke, a break of said position of equilibrium after which said locking member automatically moves towards its locking position, under the effect of the force developed by the second elastic return means.
Cette fonctionnalité permet tout d'abord d'utiliser le bouton de commande de pipetage plutôt que l'organe de commande à double fonction pour faire revenir ce dernier en position centrale nominale, dans laquelle le système de réglage de volume est bloqué. En conséquence, cette fonctionnalité permet également d'avoir la certitude que le système de réglage de volume est bloqué après la première course de purge, dans l'hypothèse où l'opérateur aurait oublié de procéder à un tel verrouillage via l'organe de commande à double fonction.  This feature first allows the use of the pipetting control button rather than the dual function controller to return the controller to the nominal center position, in which the volume control system is blocked. Consequently, this feature also makes it possible to be certain that the volume control system is blocked after the first purge stroke, in the event that the operator has forgotten to proceed with such locking via the control member. dual function.
De préférence, la pipette est configurée de sorte que la vis de commande de réglage de volume soit entraînée en rotation par la tige de commande.  Preferably, the pipette is configured so that the volume control screw is rotated by the control rod.
De préférence, l'éjecteur de cône comporte une tige d'éjection rappelée en position haute pa r les premiers moyens élastiques de rappel, ainsi qu'une partie basse d'éjection solidaire d'une extrémité basse de la tige d'éjection.  Preferably, the cone ejector comprises an ejection rod biased upwards by the first elastic return means, and a lower ejection portion secured to a lower end of the ejection rod.
De préférence, ledit orga ne de comma nde à double fonction est équipé de moyens de butée permettant de limiter sa course vers le ha ut relativement au corps fixe de pipette.  Preferably, said double-acting control organ is equipped with stop means making it possible to limit its stroke towards the height relative to the fixed body of the pipette.
Enfin, la pipette est une pipette monocanal ou multicanaux.  Finally, the pipette is a single-channel or multichannel pipette.
D'autres avantages et caractéristiques de l'invention apparaîtront da ns la description détaillée non limitative ci-dessous. BRÈVE DESCRIPTION DES DESSINS  Other advantages and features of the invention will become apparent from the detailed non-limiting description below. BRIEF DESCRIPTION OF THE DRAWINGS
Cette description sera faite au regard des dessins annexés parmi lesquels ; - la figure 1 représente une vue de face d'une pipette de prélèvement à actionnement manuel selon la présente invention, avec son organe de commande à double fonction agencé en position centrale nominale ; This description will be made with reference to the appended drawings among which; - Figure 1 shows a front view of a manually operated sampling pipette according to the present invention, with its double-acting control member arranged in nominal central position;
- les figures 2 et 3 sont des vues agrandies en coupe axiale de la pipette montrée sur la figure précédente, selon deux plans de coupe axiaux distincts ;  - Figures 2 and 3 are enlarged views in axial section of the pipette shown in the previous figure, in two separate axial section planes;
- les figures 4 à 6 représentent en perspective différents éléments de la pipette montrée sur les figures précédentes ;  - Figures 4 to 6 show in perspective various elements of the pipette shown in the previous figures;
- les figures 7a et 7b représentent de manière agrandie une partie haute de la pipette montrée sur les figures précédentes ;  FIGS. 7a and 7b represent an enlarged portion of an upper part of the pipette shown in the preceding figures;
- les figures 8a et 8b représentent des vues analogues à celles des figures 7a et 7b, avec l'organe de commande à double fonction se trouvant en position basse d'éjection de cône ;  FIGS. 8a and 8b show views similar to those of FIGS. 7a and 7b, with the dual-function control member being in the low position of cone ejection;
- la figure 8c représente une vue similaire à celle de la figure 1, avec son organe de commande à double fonction se trouvant en position basse d'éjection de cône ;  FIG. 8c represents a view similar to that of FIG. 1, with its dual-function control member being in the low position of cone ejection;
- les figures 9a à 9c représentent des vues analogues à celles des figures 8a à 8c, avec l'organe de commande à double fonction se trouvant en position haute de déverrouillage de la bague de freinage ; et  FIGS. 9a to 9c represent views similar to those of FIGS. 8a to 8c, with the dual-function control member being in the unlocked high position of the brake ring; and
- la figure 10 représente une vue similaire à celle de la figure 1, avec son organe de commande à double fonction se trouvant en position haute de déverrouillage de la bague de freinage, lors d'une course de purge de la tige de commande.  - Figure 10 shows a view similar to that of Figure 1, with its dual-function control member in the unlocked position of the brake ring, during a purge stroke of the control rod.
EXPOSÉ DÉTAILLÉ DE MODES DE RÉALISATION PRÉFÉRÉS DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
En référence à la figure 1, il est représenté une pipette de prélèvement l à actionnement manuel, destinée à être tenue par la main d'un opérateur, qui, à l'aide de son pouce 4, est capable d'actionner la pipette pour engendrer la dispense d'un liquide qui a préalablement été aspiré. Referring to FIG. 1, there is shown a manually operated sampling pipette 1 intended to be held by the hand of an operator, who, with the aid of his thumb 4, is able to actuate the pipette for generate the dispensing of a liquid that has been previously sucked.
Plus précisément, la pipette 1 comprend une poignée 6 formant corps supérieur de la pipette, poignée de laquelle débouche une tige de commande 10 portant à son extrémité haute, en position de pipetage, un bouton de commande de pipetage 12 dont la partie supérieure est destinée à subir la pression du pouce de l'opérateur. A titre indicatif, il est noté qu'un écran d'affichage (non représenté) peut être prévu sur la poignée 6. More specifically, the pipette 1 comprises a handle 6 forming the upper body of the pipette, the handle of which opens a control rod 10 carrying at its upper end, in the pipetting position, a pipetting control button 12, the upper part of which is intended to undergo pressure from the operator's thumb. As a guide, it is noted that a display screen (not shown) can be provided on the handle 6.
Sous la poignée 6, la pipette 1 comporte une partie basse 14 amovible, qui se termine vers la bas par un embout porte-cône 16 recevant un consommable 18, également dénommé cône de prélèvement.  Under the handle 6, the pipette 1 comprises a removable lower part 14, which ends downwards by a cone holder 16 receiving a consumable 18, also called sampling cone.
Un éjecteur de cône 20 débouche vers le bas de la poignée 6. Comme cela sera mentionné ci-après, l'éjecteur peut être mis en mouvement relativement à la poignée 6 et la partie basse 14, formant tous les deux le corps fixe 23 de la pipette.  A cone ejector 20 opens towards the bottom of the handle 6. As will be mentioned below, the ejector can be set in motion relative to the handle 6 and the lower part 14, both forming the fixed body 23 of the pipette.
L'une des particularités de l'invention, qui sera détaillée ci-après, réside dans la mise en œuvre d'un organe de commande à double fonction 25, qui permet alternativement d'assurer la fonction de déverrouillage du système de réglage de volume de prélèvement, et la fonction d'éjection de cône. A cet égard, il est noté que dans le mode de réalisation décrit et représenté sur les figures, il s'agit d'une pipette monocanal portant un unique consommable 18. Cependant, il pourrait s'agir d'une pipette multicanaux portant plusieurs cônes, sans sortir du cadre de l'invention.  One of the peculiarities of the invention, which will be detailed below, resides in the implementation of a dual-function control device 25, which alternatively enables the unlocking function of the volume control system to be provided. sampling, and the function of cone ejection. In this regard, it is noted that in the embodiment described and shown in the figures, it is a single-channel pipette carrying a single consumable 18. However, it could be a multichannel pipette carrying several cones , without departing from the scope of the invention.
En référence aux figures 2 et 3, il est représenté la partie haute de la pipette 1, d'axe longitudinal 26.  With reference to FIGS. 2 and 3, there is shown the upper part of the pipette 1, of longitudinal axis 26.
En partie basse de la poignée 6, celle-ci loge une partie de l'éjecteur de cône 20. Il s'agit d'une tige d'éjection 30 rappelée en position haute par des premiers moyens élastiques de rappel, de préférence un ou plusieurs ressorts de compression 32. Les ressorts 32 agissent sur une platine 33 fixée à l'extrémité haute de la tige 30. A son extrémité basse, la tige 30 est solidaire d'une partie basse d'éjection 34 qui chemine en dehors du corps fixe 23, le long et autour de la partie basse (comme cela est visible sur la figure 1).  In the lower part of the handle 6, the latter houses a portion of the cone ejector 20. It is an ejection rod 30 biased upwards by first elastic return means, preferably one or several compression springs 32. The springs 32 act on a plate 33 fixed to the upper end of the rod 30. At its lower end, the rod 30 is secured to a lower ejection portion 34 which travels outside the body fixed 23, along and around the lower part (as shown in Figure 1).
Autour de la tige de commande de pipetage 10, la pipette est équipée d'un système 36 de réglage de volume à prélever, logé à l'intérieur de la poignée 6. Ce système 36 comporte, en amont de la chaîne cinématique, une vis de commande de réglage de volume de prélèvement. Cette vis 38 est solidaire en rotation, selon l'axe 26, d'une bague de freinage 40 agencée autour de la vis 38, elle-même traversée par la tige de commande 10. Ainsi, de manière connue, le réglage du volume à prélever s'effectue par l'opérateur en tournant le bouton 12, qui entraîne la rotation de la tige de commande 10, celle de la vis 38, puis celle de la bague de freinage 40. Simultanément et de manière principale, la rotation de la vis 38 entraîne une partie aval de la chaîne cinématique du système de réglage 36, dont l'actionnement permet de faire varier le volume qui sera ensuite prélevé. Around the pipetting control rod 10, the pipette is equipped with a volume control system 36 to be sampled, housed inside the handle 6. This system 36 comprises, upstream of the kinematic chain, a screw sample volume control. This screw 38 is integral in rotation, along the axis 26, a braking ring 40 arranged around the screw 38, itself traversed by the control rod 10. Thus, in known manner, the adjustment of the volume to be taken is performed by the operator by turning the knob 12, which causes the rotation of the control rod 10, that of the screw 38, then that of the brake ring 40. Simultaneously and primarily, the rotation of the screw 38 drives a downstream part of the driveline of the adjustment system 36, whose actuation makes it possible to vary the volume which will then be taken.
La bague de freinage 40 est centrée sur l'axe 26 et comporte une extrémité périphérique en forme de collerette 42, qui s'étend dans un plan transversal de la pipette. La surface supérieure de la collerette 42 supporte une rondelle de friction 44 en élastomère, en regard vers le haut d'un organe 46 de verrouillage de la bague de freinage 40.  The brake ring 40 is centered on the axis 26 and has a flange-shaped peripheral end 42 which extends in a transverse plane of the pipette. The upper surface of the flange 42 supports a friction washer 44 of elastomer facing upwardly of a locking member 46 of the brake ring 40.
L'organe de verrouillage 46, également représenté sur la figure 6, est logé dans un élément creux fixe 50, lui-même logé dans la poignée 6. Il comporte une bague 52 agencée en regard axialement, vers le bas, de la rondelle de friction 44. De plus, il comporte une première extrémité 54 montée pivotante sur l'élément fixe 50, selon un axe de rotation 56 excentré par rapport à l'axe 26, et agencé dans un plan transversal de la pipette de manière à être sensiblement orthogonal à ce même axe 26. L'axe de rotation 56 est de préférence sensiblement tangent relativement à la poignée 6. L'organe de verrouillage 46 comprend également une seconde extrémité 58 opposée à la première extrémité 54, à savoir agencée diamétralement opposée sur la bague 52.  The locking member 46, also shown in FIG. 6, is housed in a fixed hollow element 50, itself housed in the handle 6. It comprises a ring 52 arranged facing axially, downwards, of the washer of friction 44. In addition, it comprises a first end 54 pivotally mounted on the fixed element 50, along an axis of rotation 56 eccentric with respect to the axis 26, and arranged in a transverse plane of the pipette so as to be substantially orthogonal to the same axis 26. The axis of rotation 56 is preferably substantially tangent relative to the handle 6. The locking member 46 also comprises a second end 58 opposite the first end 54, namely arranged diametrically opposite on the ring 52.
La pipette comporte également des seconds moyens élastiques de rappel, réalisés par un ou plusieurs ressorts de compression 60 dont l'extrémité haute appuie sur une partie haute de l'élément creux fixe 50, et dont l'extrémité basse appuie sur la bague 52, et plus précisément sur un épaulement pratiqué à l'intérieur de celle-ci.  The pipette also comprises second elastic return means, made by one or more compression springs 60 whose upper end bears on an upper part of the fixed hollow element 50, and whose low end bears on the ring 52, and more precisely on a shoulder formed inside thereof.
Le ressort 60 force ainsi l'organe de verrouillage 46 à se plaquer contre la rondelle de friction 44, et donc contre la collerette 42 de la bague de freinage qui supporte cette même rondelle 44.  The spring 60 thus forces the locking member 46 to press against the friction washer 44, and thus against the flange 42 of the brake ring which supports the same washer 44.
Comme indiqué précédemment, la pipette comprend en outre l'organe de commande à double fonction 25, également représenté sur la figure 4. Cet organe 25 spécifique à l'invention comporte une portion haute d'actionnement 62 faisant saillie en dehors de la poignée 6, et sur laquelle l'opérateur peut agir avec son pouce lorsqu'il agrippe la pipette. La portion d'actionnement 62 est prolongée vers le bas par deux languettes axiales d'appui 64, chacune équipée d'une dent de butée axiale 66 prévue pour limiter sa course vers le haut par rapport au corps fixe 23 dans lequel l'organe 25 est monté coulissant axialement. Les languettes axiales 64 cheminent à l'intérieur de la poignée 6 et leurs extrémités basses se trouvent en regard de la platine 33 de l'éjecteur de cône, comme cela est le mieux visible sur la figure 3. Enfin, l'une des deux languettes 64 est équipée d'une crémaillère 69 s'étendant axialement. As indicated above, the pipette further comprises the dual-function control member 25, also shown in FIG. Specific to the invention comprises an upper actuating portion 62 projecting outside the handle 6, and on which the operator can act with his thumb when gripping the pipette. The actuating portion 62 is extended downwards by two axial support tongues 64, each equipped with an axial abutment tooth 66 designed to limit its upward stroke relative to the fixed body 23 in which the element 25 is slidably mounted axially. The axial tabs 64 run inside the handle 6 and their low ends are opposite the plate 33 of the cone ejector, as is best seen in Figure 3. Finally, one of the two tabs 64 is equipped with a rack 69 extending axially.
La pipette 1 est également équipée de moyens suiveurs du mouvement axial de l'organe de commande à double fonction 25, ces moyens suiveurs 68 étant également représentés sur la figure 5. Ils sont logés dans la poignée 6, et comportent un élément 70 de dégagement de l'organe de verrouillage 46, destiné à coopérer avec une surface inférieure de la seconde extrémité 58. L'élément de dégagement 70 est préférentiellement un doigt pivotant, tandis que la surface inférieure de la seconde extrémité 58 présente une pente par rapport à un plan transversal de pipette, de façon à ce que ces éléments 70, 58 forment respectivement une came et un suiveur de came.  The pipette 1 is also equipped with means for tracking the axial movement of the dual-function control member 25, these follower means 68 being also shown in FIG. 5. They are housed in the handle 6, and comprise a release element 70 of the locking member 46, intended to cooperate with a lower surface of the second end 58. The release member 70 is preferably a pivoting finger, while the lower surface of the second end 58 has a slope relative to a pipette transverse plane, so that these elements 70, 58 respectively form a cam and a follower cam.
En outre, les moyens suiveurs 68 comprennent un secteur angulaire denté 72, par exemple s'étendant sur sensiblement 90°. Ce secteur 72, tout comme le doigt 68 solidaire en rotation de ce dernier, sont montés rotatifs sur la poignée 6 selon un axe de rotation 74 agencé dans un plan transversal de la pipette, et de préférence parallèle à l'axe de rotation 56 de l'organe de verrouillage 46. Le secteur angulaire denté 72 engrène avec la crémaillère 69 de l'organe de commande à double fonction 25.  In addition, the follower means 68 comprise a toothed angular sector 72, for example extending substantially 90 °. This sector 72, like the finger 68 integral in rotation with the latter, are rotatably mounted on the handle 6 along an axis of rotation 74 arranged in a transverse plane of the pipette, and preferably parallel to the axis of rotation 56 of the locking member 46. The toothed angular sector 72 meshes with the rack 69 of the dual-function control member 25.
Sur les figures décrites précédemment, l'organe de commande 25 occupe une position centrale nominale par rapport à la poignée 6, cette position étant une position d'équilibre lorsqu'aucune action n'est effectuée par l'opérateur sur cet organe 25. Dans cette position centrale nominale également représentée sur les figures 7a et 7b, le ressort 60 exerce un effort qui rappelle l'organe de verrouillage 46 dans une position de verrouillage, dans laquelle la bague 52 est plaquée contre la collerette 42 de la bague de freinage 40. Plus précisément, l'effort développé par le ressort 60 conduit l'organe 46 à pivoter vers le bas depuis sa première extrémité articulée 54, pour venir en butée contre la rondelle de friction 44 supportée par la collerette 42. In the figures described above, the control member 25 occupies a nominal central position with respect to the handle 6, this position being a position of equilibrium when no action is performed by the operator on this member 25. this central nominal position also shown in Figures 7a and 7b, the spring 60 exerts a force that recalls the locking member 46 in a locking position, wherein the ring 52 is pressed against the flange 42 of the brake ring 40 More specifically, the effort developed by spring 60 leads the member 46 to pivot downwards from its first articulated end 54, to abut against the friction washer 44 supported by the flange 42.
Du fait de l'effort de friction s'exerçant entre les deux éléments 52, 42 par le biais de la rondelle 44, la bague de freinage 40 reste bloquée en rotation, ce qui entraîne le verrouillage du système de réglage de volume de prélèvement.  Due to the frictional force exerted between the two elements 52, 42 through the washer 44, the braking ring 40 remains locked in rotation, which causes the locking of the sampling volume adjustment system.
Par conséquent, dans cette position centrale nominale de l'organe de commande 25, l'opérateur peut réaliser des opérations de pipetage avec le bouton 12 et la tige 10, sans risquer de modifier le réglage du volume à prélever. Toujours dans cette même position, le doigt 70 reste à distance de la seconde extrémité 58 de l'organe de verrouillage, tandis que les languettes 64 sont espacées de la platine 33 de l'éjecteur 20 par un faible jeu axial 80, référencé sur la figure 3.  Therefore, in this nominal central position of the control member 25, the operator can perform pipetting operations with the button 12 and the rod 10, without risking changing the setting of the volume to be taken. Still in this same position, the finger 70 remains at a distance from the second end 58 of the locking member, while the tabs 64 are spaced from the plate 33 of the ejector 20 by a small axial clearance 80, referenced on the figure 3.
A partir de cette position centrale nominale, l'organe de commande 25 peut être déplacé par le pouce de l'opérateur soit vers le haut dans une position haute de déverrouillage de la bague de freinage 40, soit vers le bas dans une position basse d'éjection de cône.  From this nominal central position, the control member 25 can be moved by the thumb of the operator either upwards in a high unlocking position of the braking ring 40, or downwards in a low position. cone ejection.
En référence tout d'abord aux figures 8a à 8c, il est montré la position basse d'éjection de cône, dans laquelle l'organe de commande 25 appuie sur la platine de l'éjecteur de cône 20, via l'extrémité basse de ses languettes 64. Lors de la pression vers le bas du pouce de l'opérateur sur l'organe 25, le jeu axial 80 montré sur la figure 3 est tout d'abord rapidement consommé, puis les languettes 64 arrivent au contact de la platine 33. La poursuite de l'actionnement de l'organe de commande 25 s'effectue à rencontre de l'effort développé par les ressorts 32, et en repoussant donc l'ensemble de l'éjecteur 20 vers le bas. La tige d'éjection 30 sort alors en partie de la poignée 6, comme cela est montré sur la figure 8c. Ce mouvement conduit ainsi l'éjecteur de cône 20 à se déplacer vers le bas en appuyant sur le cône, jusqu'à éjection de celui-ci.  Referring firstly to FIGS. 8a to 8c, it is shown the low cone ejection position, in which the control member 25 presses on the plate of the cone ejector 20, via the lower end of its tabs 64. During the downward pressure of the thumb of the operator on the member 25, the axial clearance 80 shown in Figure 3 is first quickly consumed, then the tabs 64 come into contact with the platen 33. The further actuation of the control member 25 is made against the force developed by the springs 32, and thus pushing the entire ejector 20 downwards. The ejector rod 30 then leaves part of the handle 6, as shown in Figure 8c. This movement thus causes the cone ejector 20 to move downwards by pressing on the cone, until ejection thereof.
Le déplacement de l'organe 25 de la position centrale nominale à cette position basse n'entraîne aucun déplacement de l'organe de verrouillage 46, qui conserve sa position de verrouillage grâce à l'effort de plaquage développé par le ressort 60. En conséquence, durant cette opération d'éjection du cône, le réglage du volume à prélever n'est pas modifié. En outre, lors de ce même déplacement de l'organe de commande 25 vers le bas, la crémaillère 69 engrène avec le secteur denté 72, mais le doigt pivotant 70 n'entre pas en contact avec la seconde extrémité 58 de l'organe de verrouillage 46. En effet, ce doigt bascule vers le bas en même temps que descend l'organe de commande 25, de fait de son entraînement en rotation par le secteur denté 72. Durant le déplacement entre la position centrale nominale et la position basse d'éjection de cône, l'effort du ressort 60 sur l'organe de verrouillage 46 reste constant. The displacement of the member 25 from the nominal central position to this low position does not cause any displacement of the locking member 46, which retains its locking position thanks to the plating force developed by the spring 60. during this operation of ejection of the cone, the adjustment of the volume to be sampled is not modified. In addition, during the same movement of the control member 25 downwards, the rack 69 meshes with the toothed sector 72, but the pivoting finger 70 does not come into contact with the second end 58 of the control member. 46. Indeed, this finger tilts down at the same time that the control member 25 descends, due to its rotational drive by the toothed sector 72. During movement between the nominal central position and the low position d cone ejection, the force of the spring 60 on the locking member 46 remains constant.
Après éjection du cône et relâchement de la pression de l'opérateur sur l'organe de commande 25, ce dernier revient en position centrale nominale grâce à l'effort de rappel développé par les ressorts 32.  After ejection of the cone and release of the pressure of the operator on the control member 25, the latter returns to the nominal central position thanks to the return force developed by the springs 32.
En référence à présent aux figures 9a à 9c, il est montré la position haute de déverrouillage de la bague de freinage 40, position dans laquelle cette bague peut tourner librement, et donc accompagner la rotation de la tige de commande 10 appliquée via le bouton 12 par l'opérateur, pour régler le volume à prélever.  Referring now to Figures 9a to 9c, there is shown the unlocking top position of the brake ring 40, position in which this ring can rotate freely, and thus accompany the rotation of the control rod 10 applied via the button 12 by the operator, to adjust the volume to be taken.
Lors du déplacement vers le haut de l'organe 25 à partir de sa position centrale nominale, la rotation du secteur denté 72 entraîné par le mouvement axial des languettes 64 conduit le doigt 70 à pivoter vers le haut, jusqu'à entrer en contact avec la seconde extrémité 58 de l'organe de verrouillage 46. A partir de ce contact, les deux éléments 70, 58 remplissent leur fonction de came et de suiveur de came, respectivement.  During the upward movement of the member 25 from its nominal central position, the rotation of the toothed sector 72 driven by the axial movement of the tongues 64 causes the finger 70 to pivot upwards, until it comes into contact with the second end 58 of the locking member 46. From this contact, the two elements 70, 58 fulfill their cam and follower function, respectively.
Au fur et à mesure que la montée de l'organe 25 se poursuit sous l'effet de l'action exercée par l'opérateur, le doigt pivotant 70 fait remonter la seconde extrémité de l'organe de verrouillage 46, provoquant une rotation de celui-ci selon son axe de rotation 56. Cette rotation de l'organe s'effectue à rencontre de l'effort développé par le ressort 60, mais avec une force d'actionnement de l'opérateur qui est avantageusement largement inférieure à celle du ressort 60, en raison de l'effet de bras de levier observé. Le pivotement de l'organe de verrouillage 46 vers le haut conduit ce dernier à diminuer la pression axiale qu'il exerce sur la collerette 42 via la rondelle 44, jusqu'à libération de la bague de freinage 40. Cette libération se matérialise par une absence de pression axiale entre les deux éléments 52, 42, ou bien par la conservation d'une très faible pression qui n'empêche pas à la bague de freinage 40 de tourner lors du réglage du volume par l'opérateur. As the rise of the member 25 continues under the effect of the action exerted by the operator, the pivoting finger 70 raises the second end of the locking member 46, causing a rotation of this rotation along its axis of rotation 56. This rotation of the member takes place against the force developed by the spring 60, but with an actuating force of the operator which is advantageously much lower than that of the spring 60, due to the leverage effect observed. The pivoting of the locking member 46 upwardly causes the latter to reduce the axial pressure that it exerts on the flange 42 via the washer 44, until release of the braking ring 40. This release is materialized by a absence of axial pressure between the two elements 52, 42, or by the conservation a very low pressure that does not prevent the braking ring 40 to rotate when adjusting the volume by the operator.
Le déplacement vers le haut de l'organe de commande à double fonction 25 est stoppé par ses dents de butée axiale 66, qui entrent en contact avec des éléments fixes correspondants (non représentés) du corps fixe 23. Une fois que la position haute de déverrouillage est atteinte, malgré l'effort important développé par le ressort 60 comprimé, cette position est auto-maintenue par la friction entre le doigt rotatif 70 et la seconde extrémité 58 de l'organe de verrouillage 46. Grâce à cet état d'équilibre, l'opérateur peut relâcher l'organe de commande 25 qui reste en position haute, pour ensuite tourner le bouton de commande 12 et procéder au réglage du volume à prélever.  The upward movement of the dual-function control member 25 is stopped by its axial stop teeth 66, which come into contact with corresponding fixed elements (not shown) of the fixed body 23. Once the upper position of unlocking is achieved, despite the significant force developed by the compressed spring 60, this position is self-maintained by the friction between the rotary finger 70 and the second end 58 of the locking member 46. Due to this equilibrium state , the operator can release the control member 25 which remains in the up position, then turn the control knob 12 and proceed to adjust the volume to be withdrawn.
L'effort de friction 90 entre la came 70 et le suiveur de came 58, qui maintient la position d'équilibre, est orienté avec une composante 92 non nulle selon la direction tangentielle relativement à l'axe de rotation 74. Par conséquent, après réglage du volume à prélever, l'opérateur peut exercer un simple appui vers le bas sur l'organe de commande 25 afin de s'opposer à cet effort de friction 90, et rompre cette position d'équilibre. L'équilibre est ainsi rompu après une très faible course vers le bas de l'organe de commande 25. Après cette rupture, l'opérateur peut poursuivre la descente de l'organe de commande 25 jusqu'à ce qu'il retrouve sa position centrale nominale. Simultanément, l'organe de verrouillage 46 se déplace automatiquement et brusquement vers le bas en direction de sa position de verrouillage, sous l'effet de l'effort développé par le ressort 60 appuyant sur la bague 52 de cet organe de verrouillage 46.  The friction force 90 between the cam 70 and the cam follower 58, which maintains the equilibrium position, is oriented with a non-zero component 92 in the tangential direction relative to the axis of rotation 74. Therefore, after adjusting the volume to be taken, the operator can exert a simple downward pressure on the control member 25 to oppose this friction force 90, and break this equilibrium position. The equilibrium is thus broken after a very short downward stroke of the control member 25. After this break, the operator can continue the descent of the control member 25 until it regains its position. nominal power plant. Simultaneously, the locking member 46 moves automatically and abruptly downwards towards its locking position, under the effect of the force developed by the spring 60 pressing on the ring 52 of this locking member 46.
En référence à présent à la figure 10, il est noté que lorsque l'organe de commande 25 est en position haute de déverrouillage, il constitue une butée axiale pour le bouton de commande 12 lors de sa course vers le bas. Cela s'avère particulièrement intéressant lorsque l'opérateur oublie de ramener l'organe 25 en position centrale nominale, après avoir effectué un réglage de volume à prélever.  Referring now to Figure 10, it is noted that when the control member 25 is in the unlocked up position, it constitutes an axial stop for the control button 12 during its downward stroke. This is particularly interesting when the operator forgets to bring the member 25 in the central nominal position, after making a volume adjustment to take.
En effet, lors d'une descente de la tige de commande 10 vers le bas et après la course de dispense, le bouton 12 entre en contact avec l'extrémité haute de l'organe 25 qui se retrouve entraîné à coulissement vers le bas avec ce même bouton 12. Après un faible déplacement axial de l'organe de commande 25, et avant la fin d'une course de purge du bouton 12, il se crée une rupture de la position d'équilibre de la came 70 et du suiveur de came 58, pour la même raison que celle exposée ci-dessus dans le cas d'un déplacement volontaire de l'organe 25 par l'opérateur. Indeed, during a descent of the control rod 10 downwards and after the dispensing stroke, the knob 12 comes into contact with the upper end of the member 25 which is found to be driven downwards with this same button 12. After a small axial displacement of the control member 25, and before the end of a purge stroke of the button 12, a break in the equilibrium position of the cam 70 and the cam follower 58 is created, for the same reason as that explained above in the case of a deliberate movement of the member 25 by the operator.
Par conséquent, après cette rupture de la position d'équilibre, l'organe de verrouillage 46 retrouve automatiquement sa position de verrouillage grâce à l'effort développé par le ressort 60. Simultanément, la poursuite de course de purge avec le bouton de commande 12 continue à générer un coulissement vers le bas de l'organe de commande à double fonction 25, du fait de la conservation de la butée axiale entre ces deux éléments 12, 25. De plus, il est préférentiellement fait en sorte que lorsque le bouton 12 arrive en fin de course de purge, l'organe de commande à double fonction 25 occupe sa position centrale nominale. De ce fait, en cas d'oubli de l'opérateur, cette position centrale nominale est automatiquement retrouvée après la première course vers le bas de la tige de commande 10 et de son bouton de commande associé 12.  Therefore, after this breaking of the equilibrium position, the locking member 46 automatically finds its locking position thanks to the force developed by the spring 60. Simultaneously, the purge stroke continuation with the control knob 12 continues to generate a sliding down of the dual-function control member 25, due to the retention of the axial stop between these two elements 12, 25. Moreover, it is preferentially made that when the button 12 when it reaches the end of the purge stroke, the dual-function control member 25 occupies its nominal central position. Therefore, in the event of forgetting the operator, this nominal central position is automatically found after the first downward stroke of the control rod 10 and its associated control knob 12.
Ensuite, le relâchement du bouton de commande 12 conduit à la remontée automatique de la tige de commande 10 d'une manière connue qui ne sera pas davantage décrite, tandis que l'organe de commande à double fonction 25 reste quant à lui placé dans sa position centrale nominale.  Then, the release of the control button 12 leads to the automatic raising of the control rod 10 in a known manner which will not be further described, while the dual-function control member 25 remains in its place in its nominal central position.
Bien entendu, diverses modifications peuvent être apportées par l'homme du métier à l'invention qui vient d'être décrite, uniquement à titre d'exemples non limitatifs.  Of course, various modifications may be made by those skilled in the art to the invention which has just been described, solely by way of non-limiting examples.

Claims

REVENDICATIONS
1. Pipette de prélèvement (1) à actionnement manuel comprenant :Hand-operated sampling pipette (1) comprising:
- un corps fixe de pipette (23) ; a fixed pipette body (23);
- une tige de commande de pipetage (10) à l'extrémité de laquelle est agencé un bouton de commande de pipetage (12) ;  - a pipetting control rod (10) at the end of which is arranged a pipetting control button (12);
- un éjecteur de cône (20) rappelé en position haute par rapport au corps fixe de pipette (23) par des premiers moyens élastiques de rappel (32) ;  - a cone ejector (20) biased in the upper position relative to the fixed pipette body (23) by first elastic return means (32);
- une vis (38) de commande de réglage de volume de prélèvement ; - une bague de freinage (40) de la vis de commande (38), solidaire en rotation avec celle-ci,  a screw (38) for controlling the sampling volume; - a braking ring (40) of the control screw (38), integral in rotation therewith,
caractérisée en ce qu'elle comporte en outre un organe de commande (25) à double fonction permettant une commande de déverrouillage de la bague de freinage (40) et une commande d'éjection de cône, l'organe de commande (25) étant monté coulissant relativement au corps fixe de pipette (23) selon une direction axiale de la pipette, celle-ci comportant un organe de verrouillage (46) de la bague de freinage (40), des seconds moyens élastiques de rappel (60) rappelant l'organe de verrouillage (46) dans une position de verrouillage dans laquelle cet organe de verrouillage coopère avec la bague de freinage (40) afin de freiner la rotation de celle-ci, et des moyens suiveurs (68) du mouvement axial de l'organe de commande à double fonction (25), ces moyens suiveurs (68) comportant un élément de dégagement (70) de l'organe de verrouillage (46), ladite pipette étant configurée de sorte que l'organe de commande (25) puisse occuper une position centrale nominale dans laquelle lesdits seconds moyens élastiques de rappel (60) amènent l'organe de verrouillage (46) dans sa position de verrouillage, et puisse être déplacé axialement, à partir de sa position centrale nominale, vers chacune des deux positions suivantes :  characterized in that it further comprises a dual function control member (25) for unlocking control of the brake ring (40) and cone ejection control, the control member (25) being slidably mounted relative to the fixed pipette body (23) in an axial direction of the pipette, the latter having a locking member (46) of the brake ring (40), second elastic return means (60) recalling the locking member (46) in a locking position in which said locking member cooperates with the brake ring (40) to slow the rotation thereof, and follower means (68) of the axial movement of the dual-function control member (25), said follower means (68) having a release member (70) of the locking member (46), said pipette being configured so that the control member (25) can occupy a central nominal position in which the s second elastic return means (60) bring the locking member (46) into its locking position, and can be moved axially from its nominal central position to each of the two following positions:
- une position basse d'éjection de cône, dans laquelle l'organe de commande (25) appuie sur l'éjecteur de cône (20), le déplacement de la position centrale nominale vers la position basse d'éjection de cône s'effectuant à rencontre de l'effort développé par lesdits premiers moyens élastiques de rappel (32) ; et - une position haute de déverrouillage de la bague de freinage (40), le déplacement de l'organe de commande à double fonction (25) de la position centrale nominale vers la position haute de déverrouillage conduisant ledit élément de dégagement (70) à déplacer l'organe de verrouillage (46) à rencontre de l'effort développé par lesdits seconds moyens élastiques de rappel (60), jusqu'à libération de la bague de freinage (40). a low cone ejection position, in which the control member (25) presses on the cone ejector (20), the displacement of the nominal central position towards the low cone ejection position taking place against the force developed by said first elastic return means (32); and - a high unlocking position of the brake ring (40), the displacement of the dual-function control member (25) from the nominal central position to the unlocking top position leading to said disengaging member (70) to be displaced the locking member (46) against the force developed by said second elastic return means (60), until release of the brake ring (40).
2. Pipette selon la revendication 1, caractérisée en ce qu'elle est configurée de sorte que la position haute de déverrouillage de la bague de freinage (40) est une position d'équilibre maintenue par friction entre ledit élément de dégagement (70) et l'organe de verrouillage (46). 2. Pipette according to claim 1, characterized in that it is configured so that the unlocking top position of the brake ring (40) is an equilibrium position held by friction between said release member (70) and the locking member (46).
3. Pipette selon la revendication 1 ou la revendication 2, caractérisée en ce que ledit élément de dégagement (70) est un doigt pivotant. 3. Pipette according to claim 1 or claim 2, characterized in that said release member (70) is a pivoting finger.
4. Pipette selon l'une quelconque des revendications précédentes, caractérisée en ce que ledit organe de verrouillage (40) comporte : 4. Pipette according to any one of the preceding claims, characterized in that said locking member (40) comprises:
- une bague (52) agencée en regard axialement d'une collerette (42) de la bague de freinage (40), une première extrémité (54) montée pivotante sur un élément fixe (50) de la pipette, ainsi qu'une seconde extrémité (58) opposée à la première et destinée à coopérer avec ledit élément de dégagement (70), de sorte que la seconde extrémité (58) et cet élément de dégagement (70) forment respectivement une came et un suiveur de came.  - A ring (52) arranged axially facing a flange (42) of the brake ring (40), a first end (54) pivotally mounted on a fixed element (50) of the pipette, and a second end (58) opposite to the first and intended to cooperate with said disengagement element (70), so that the second end (58) and the disengagement element (70) respectively form a cam and a cam follower.
5. Pipette selon la revendication précédente, caractérisée en ce que la première extrémité (54) est montée pivotante selon un axe de rotation excentré (56), agencé dans un plan transversal de la pipette. 5. Pipette according to the preceding claim, characterized in that the first end (54) is pivotally mounted along an eccentric axis of rotation (56), arranged in a transverse plane of the pipette.
6. Pipette selon la revendication 4 ou la revendication 5, caractérisée en ce qu'une rondelle de friction (44) est interposée entre ladite collerette (42) et la bague (52) de l'organe de verrouillage (46). 6. Pipette according to claim 4 or claim 5, characterized in that a friction washer (44) is interposed between said flange (42) and the ring (52) of the locking member (46).
7. Pipette selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens suiveurs (68) comprennent au moins un secteur angulaire denté (72) rotatif selon un axe de rotation (74) des moyens suiveurs, le secteur angulaire denté (72) coopérant avec une crémaillère (69) pratiquée sur ledit organe de commande à double fonction (25), le secteur angulaire denté étant solidaire en rotation dudit élément de dégagement (70). 7. Pipette according to any one of the preceding claims, characterized in that said follower means (68) comprise at least one toothed angular sector (72) rotatable about an axis of rotation (74) of the follower means, the angular sector toothed ( 72) cooperating with a rack (69) formed on said dual-function control member (25), the toothed angular sector being rotationally integral with said release member (70).
8. Pipette selon la revendication précédente combinée à la revendication 2, caractérisée en ce qu'en position haute de déverrouillage de la bague de freinage (40), la position d'équilibre est maintenue par friction entre la seconde extrémité (58) et l'élément de dégagement (70), l'effort de friction étant orienté avec une composante non nulle (92) selon la direction tangentielle relativement audit axe de rotation (74) des moyens suiveurs (68). 8. Pipette according to the preceding claim combined with claim 2, characterized in that in the unlocked high position of the brake ring (40), the equilibrium position is held by friction between the second end (58) and the release member (70), the frictional force being oriented with a non-zero component (92) in the tangential direction relative to said axis of rotation (74) of the follower means (68).
9. Pipette selon la revendication précédente, caractérisée en ce qu'elle est configurée de sorte qu'en position haute de déverrouillage de la bague de freinage9. Pipette according to the preceding claim, characterized in that it is configured so that in the unlocked high position of the brake ring
(40), ledit organe de commande à double fonction constitue une butée axiale pour le bouton de commande de pipetage (12) dans sa course vers le bas, et de sorte que le déplacement axial de l'organe de commande à double fonction (25) provoqué par le déplacement axial du bouton de commande de pipetage (12), engendre, avant la fin d'une course de purge, une rupture de ladite position d'équilibre après laquelle ledit organe de verrouillage (46) se déplace automatiquement en direction de sa position de verrouillage, sous l'effet de l'effort développé par les seconds moyens élastiques de rappel (60). (40), said dual-function control member provides an axial stop for the pipetting control knob (12) in its downward stroke, and so that the axial displacement of the dual-function control member (25) ) caused by the axial displacement of the pipetting control knob (12), causes, before the end of a purge stroke, a break in said equilibrium position after which said locking member (46) moves automatically in the direction of its locking position, under the effect of the force developed by the second elastic return means (60).
10. Pipette selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle est configurée de sorte que la vis (38) de commande de réglage de volume soit entraînée en rotation par la tige de commande (10). 10. Pipette according to any one of the preceding claims, characterized in that it is configured so that the screw (38) volume control volume is rotated by the control rod (10).
11. Pipette selon l'une quelconque des revendications précédentes, caractérisée en ce que l'éjecteur de cône (20) comporte une tige d'éjection (30) rappelée en position haute par les premiers moyens élastiques de rappel (32), ainsi qu'une partie basse d'éjection (34) solidaire d'une extrémité basse de la tige d'éjection (30). 11. Pipette according to any one of the preceding claims, characterized in that the cone ejector (20) comprises an ejection rod (30) biased upwards by the first elastic return means (32), as well as a lower ejection portion (34) integral with a lower end of the ejector rod (30).
12. Pipette selon l'une quelconque des revendications précédentes, caractérisée en ce que ledit organe de commande à double fonction (25) est équipé de moyens de butée (66) permettant de limiter sa course vers le haut relativement au corps fixe de pipette (23). 12. Pipette according to any one of the preceding claims, characterized in that said dual-function control member (25) is equipped with abutment means (66) for limiting its upward stroke relative to the fixed body of the pipette ( 23).
13. Pipette selon l'une quelconque des revendications précédentes, caractérisée en ce qu'elle est une pipette monocanal ou multicanaux. 13. Pipette according to any one of the preceding claims, characterized in that it is a single channel pipette or multichannel.
EP16770712.4A 2015-09-15 2016-09-14 Sampling pipette comprising a control member with double function for ejecting a cone and unlocking the system for volume adjustment Active EP3349901B1 (en)

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PL16770712T PL3349901T3 (en) 2015-09-15 2016-09-14 Sampling pipette comprising a control member with double function for ejecting a cone and unlocking the system for volume adjustment

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FR1558650A FR3040896B1 (en) 2015-09-15 2015-09-15 PRESSURE PIPETTE COMPRISING A DOUBLE-FUNCTION CONTROL MEMBER FOR CONE EJECTION AND UNLOCKING OF THE VOLUME ADJUSTMENT SYSTEM
PCT/EP2016/071625 WO2017046120A1 (en) 2015-09-15 2016-09-14 Sampling pipette comprising a control member with double function for ejecting a cone and unlocking the system for volume adjustment

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EP (1) EP3349901B1 (en)
JP (1) JP6800230B2 (en)
KR (1) KR20180052121A (en)
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BR (1) BR112018000944A2 (en)
CA (1) CA2997942A1 (en)
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US20180250667A1 (en) 2018-09-06
FR3040896A1 (en) 2017-03-17
EP3349901B1 (en) 2019-06-12
WO2017046120A1 (en) 2017-03-23
US10799860B2 (en) 2020-10-13
BR112018000944A2 (en) 2018-09-04
KR20180052121A (en) 2018-05-17
PL3349901T3 (en) 2019-12-31
CN108025305A (en) 2018-05-11
ES2744440T3 (en) 2020-02-25
JP2018532588A (en) 2018-11-08
CN108025305B (en) 2020-04-24
CA2997942A1 (en) 2017-03-23
FR3040896B1 (en) 2017-10-13
JP6800230B2 (en) 2020-12-16

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