EP3166693A1

EP3166693A1 - Antiperspirant cosmetics comprising specific proteins from adnexa of mammals, birds, fish, insects or crustaceans and containing no aluminum and/or zirconium halides and/or hydroxy halides

Info

Publication number: EP3166693A1
Application number: EP15732236.3A
Authority: EP
Inventors: Bernhard Banowski; Stefan Evers
Original assignee: Henkel AG and Co KGaA
Current assignee: Henkel AG and Co KGaA
Priority date: 2014-07-08
Filing date: 2015-06-26
Publication date: 2017-05-17
Also published as: US20170112746A1; WO2016005207A1; DE102014213226A1

Abstract

The invention relates to an antiperspirant cosmetic containing at least one specific protein from adnexa of mammals, birds, fish, insects or crustaceans and containing no aluminum and/or zirconium halides and/or hydroxy halides. The invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in axillary hyperhidrosis even in the absence of antiperspirant aluminum salts.

Description

"Antiperspirant cosmetic products containing specific proteins derived from skin appendages of mammals, birds, fish, insects or crustaceans which do not contain halides and / or hydroxyhalides of aluminum and / or zirconium"

The present invention relates to an antiperspirant cosmetic agent without halides and / or hydroxides of aluminum and / or zirconium, which comprises at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1 .013 hPa, fragrances and waxes , optionally at least one propellant and special proteins from skin appendages of mammals, birds, fish, insects or crustaceans. The addition of the at least one specific protein results in an influence on the sweat gland (s).

Furthermore, the present invention relates to a packaging unit (kit-of-parts) containing a cosmetic agent according to the invention and a cosmetic agent with at least one antiperspirant active ingredient.

Moreover, the present invention relates to the use of specific proteins from skin appendages of mammals, birds, fish, insects or crustaceans for at least partially influencing the sweat gland (s).

In addition, the present invention relates to the use of a combination comprising at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes, optionally at least one propellant and special proteins from mammalian skin appendages, Birds, fish, insects or crustaceans containing, for the reduction and / or prevention of sweat, in particular underarm sweat or sweat other body regions. The combination according to the invention contains no halides and / or hydroxides of aluminum and / or zirconium.

Furthermore, the present invention relates to an antiperspirant cosmetic agent without halides and / or hydroxides of aluminum and / or zirconium, which at least one substance selected from the group of cosmetic oils, which are liquid at 20 ° C and 1 .013 hPa, fragrances and Waxing, optionally containing at least one propellant and at least one isolated from sheep's wool or goat's wool special keratin. The addition of the at least one special protein results in an influence on the sweat gland (s).

Finally, the present invention relates to a non-therapeutic cosmetic method for preventing and / or reducing the transpiration of the body, in which a Inventive antiperspirant cosmetic agent on the skin, especially on the skin of the armpits, is applied and for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, especially for at least 6 hours, remains on the skin of the armpits.

Washing, cleaning and caring for one's own body is a basic human need, and modern industry is constantly trying to meet these needs of man in a variety of ways. Especially important for daily hygiene is the permanent elimination or at least reduction of body odor and underarm wetness. Numerous specific deodorant or antiperspirant personal care products are known in the art which have been developed for use in body regions having a high density of sweat glands, especially in the underarm area. These are formulated in a wide variety of dosage forms, for example as powder, in stick form, as aerosol spray, pump spray, liquid and gel roll on application, cream, gel and as impregnated flexible substrates (towels).

Prior art cosmetic antiperspirants contain at least one antiperspirant compound, in particular in the form of halides and / or hydroxyhalides of aluminum and / or zirconium, in addition to at least one oil or a wax and a fragrance component or perfume. These antiperspirant compounds reduce sweat secretion of the body by temporarily narrowing and / or obstructing the excretory ducts of the sweat glands, so that the amount of sweat can be reduced by about 20 to 60 percent. On the other hand, they have an additional deodorizing effect due to their antimicrobial effect.

Halides and / or hydroxy halides of aluminum and / or zirconium, combined with the acidic pH of these antiperspirants, can cause unpleasant skin reactions in some users. In addition, the use of the aforementioned antiperspirant compounds can lead to staining on clothing.

There is therefore a need to exchange antiperspirant halides and / or hydroxy halides of aluminum and / or zirconium with other antiperspirant cosmetic agents. These antiperspirant active ingredients should have a good antiperspirant effect, good skin compatibility and easy formulatability. In addition, these antiperspirant active ingredients should have no negative impact on the storage stability of the antiperspirant cosmetic agents.

It is an object of the present invention to provide a perspiration-inhibiting cosmetic agent which avoids or at least mitigates the disadvantages of the prior art and which has good skin compatibility and at the same time reliable reduction has the underarm wetness. In addition, the antiperspirant cosmetic agent should have a high storage stability.

It has now surprisingly been found that the use of at least one protein from skin appendages of mammals, birds, fish, insects or crustaceans, which with a change in the pH of at least 0.5 in a pH range of pH 4.0 to pH 8.0 results in a change in the light absorption of 1 to 100%, resulting in antifreezing halides and / or hydroxy halides of aluminum and / or zirconium in antiperspirant effect in cosmetic products, which with the antiperspirant effect of formulations containing aluminum salts and / or aluminum Zirconium complexes is almost comparable.

The subject of the present invention is thus an antiperspirant cosmetic containing

a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1 .013 hPa, fragrances and waxes,

b) blowing agent in a total amount of 0 to 99 wt .-%, based on the total weight of the antiperspirant cosmetic agent, and

c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein in skin appendages of mammals, birds, fish, insects or crustaceans occurs and wherein the at least a protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt. %, based on the total weight of the sample mixture used for the determination of the change of the light absorption, causes a change in the light absorption of 1 to 100%,

wherein the antiperspirant cosmetic agent does not contain halides and / or hydroxy halides of aluminum and / or zirconium.

Through the use of the at least one protein from skin appendages of mammals, birds, fish, insects or crustaceans with the aforementioned special physical properties in the antiperspirant cosmetic agents according to the invention - without wishing to be limited to this theory - a targeted influencing of the sweat gland (n ). This targeted influencing of the sweat gland (s) may, for example, consist in a gelation of the at least one protein at pH values which are present exclusively within the excretory ducts of the sweat glands. In this way, an effective blockage of the excretory ducts of the sweat glands can be ensured without the antiperspirant effect of the cosmetic product according to the invention due to premature undesired gelation due to the addition of the at least one specific protein is reduced. Furthermore, the targeted influencing the sweat gland (s) but also in a disturbance of the charge balance within the sweat gland (s) exist, which leads to an influence on the sweat production, in particular to a reduction of welding production. Thus, even in the absence of antiperspirant halides and / or hydroxy halides of aluminum and / or zirconium, effective reduction of armpit sweat is ensured.

The term "antiperspirant" is understood according to the invention to reduce or reduce the perspiration of the sweat glands of the body.

In addition, the term "halides and / or hydroxy halides of aluminum and / or zirconium" in the present invention, in particular chlorides, bromides and iodides of aluminum and zirconium and compounds of the formulas AI (OH) _y X and Zr (OH) _z X understood, wherein X in the above formulas is a halide ion.

Furthermore, the term "cosmetic oil" in the context of the present invention is understood as meaning an oil which is suitable for cosmetic use and which is immiscible with water in all amounts.The cosmetic oil used according to the invention is neither fragrances nor essential oils ,

In addition, the term "fragrances" in the context of the present invention means substances having a molecular weight of 74 to 300 g / mol, which contain at least one osmophoric group in the molecule and have an odor and / or taste, ie they are able to Osmophore groups are groups covalently bound to the molecular skeleton in the form of hydroxy groups, formyl groups, oxo groups, alkoxycarbonyl groups, nitrile groups, nitro groups, azide groups, etc. In this context, the term "fragrances" in the sense of present invention even at 20 ° C and 1013 hPa liquid perfume oils, perfumes, or perfume oil ingredients.

In addition, the term "waxes" in the context of the present invention means substances which are kneadable at 20 ° C. or solid to brittle, have a coarse to fine-crystalline structure and are translucent to opaque, but not vitreous, in color Substances above 25 ° C without decomposition, slightly liquid above the melting point (slightly viscous), have a strong temperature-dependent consistency and solubility and are polishable under light pressure.

The term "protein" denotes according to the invention chemical compounds which form acid amide-like linked condensation products of amino acids through peptide bonds The number of amino acids in the proteins is preferably at least 2 and at most 1, 000 Amino acids. In the context of the present invention, the term "protein" also means hydrolyzates of a protein which contain protein fractions having different amino acid sequences and molecular weights, and in the context of the present invention also means mixtures of proteins occurring in skin appendages.

Furthermore, the term "skin appendages" in the context of the present invention are to be understood as meaning all structures which are formed from the dermis and epidermis, in particular hair, feathers, horn formations such as, for example, horns, fingernails, horn scales, claws and hooves, pearls, dandruff , Tanks and shells.

In addition, the term "change in the light absorption of the at least one protein" is understood to mean both the positive and negative changes in the light permeability of the sample mixture, in particular the protein solution, and the absorption of light by the at least one protein or the sample mixture.

Furthermore, the term "pH value change" is understood as meaning the continuous change in the pH The continuous change in the pH can be achieved, for example, by titration or uniform addition of a base or acid.

The term "sample mixture" refers according to the invention to a mixture of the at least one specific protein with a solvent, in particular water, buffer or saline aqueous solutions.

In addition, the term "fatty acids" as used in the present invention means aliphatic carboxylic acids having unbranched or branched carbon groups of 4 to 40 carbon atoms also be synthetically produced fatty acids.Furthermore, the fatty acids may be monounsaturated or polyunsaturated.

Finally, in the context of the present invention, the term "fatty alcohols" is to be understood as meaning aliphatic, monohydric, primary alcohols which have unbranched or branched hydrocarbon radicals having from 4 to 40 carbon atoms The fatty alcohols used in the context of the invention may also be monounsaturated or polyunsaturated ,

The statement wt .-% relates in the present case, unless stated otherwise, to the total weight of the antiperspirant cosmetic agents according to the invention. As a first constituent a), the cosmetic compositions according to the invention contain at least one substance which is selected from the group of cosmetic oils which are liquid at 20 ° C. and 1 .013 hPa, fragrances and waxes.

In the context of the present invention, the cosmetic oil which is liquid at 20 ° C. and 1 .013 hPa is selected from the group of (i) volatile cyclic silicone oils, in particular cyclic and linear silicone oils; (ii) volatile non-silicone oils, especially liquid paraffin oils and isoparaffin oils; (iii) nonvolatile silicone oils; (iv) non-volatile non-silicone oils; and (v) their mixtures.

According to the invention, the term "volatile oil" denotes oils which have a vapor pressure of 2.66 Pa to 40,000 Pa (0.02 to 300 mm Hg), preferably 10 to 12,000 Pa (20 ° C. and an ambient pressure of 1 .013 hPa). 0.1 to 90 mm Hg), more preferably from 13 to 3000 Pa (0.1 to 23 mm Hg), in particular from 15 to 500 Pa (0.1 to 4 mm Hg).

In addition, the term "nonvolatile oils" in the context of the present invention means oils which have a vapor pressure of less than 2.66 Pa (0.02 mm Hg) at 20 ° C. and an ambient pressure of 1.103 hPa.

It may be preferred according to the invention to use mixtures of volatile silicone oils and volatile non-silicone oils in the antiperspirant cosmetic agents according to the invention, since this results in a drier skin feel. Further, within the present invention, it may be preferred for the antiperspirant cosmetic agents to contain a non-volatile silicone oil and / or a non-volatile non-silicone oil to sequester insoluble ingredients such as talc or skin-dried ingredients.

Particularly preferred according to the invention is the use of mixtures of nonvolatile and volatile cosmetic oils, since in this way parameters such as skin feel, visibility of the residue and stability of the antiperspirant cosmetic agent according to the invention can be adjusted and the agent can thus be better adapted to the needs of the consumer.

The volatile and nonvolatile silicone oils which can be used in the context of the present invention, as well as volatile and nonvolatile non-silicone oils, are disclosed, for example, in the published patent applications DE 10 2010 063 250 A1 and DE 10 2012 222 692 A1.

According to a preferred embodiment of the present invention, the cosmetic oil which is liquid at 20 ° C and 1 .013 hPa in a total amount of 0.02 to 98 wt .-%, preferably from 2 to 85 wt .-%, preferably from 4 to 75 Wt .-%, more preferably from 6 to 70 wt .-%, even more preferably from 8 to 60 wt .-%, in particular from 8 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent. As component a) of the cosmetic compositions according to the invention, at least one fragrance may also be present. However, mixtures of different fragrances are preferably used, which together produce an appealing scent. Fragrances which can be used in the context of the present invention are disclosed, for example, in the published patent application DE 10 2010 063 250 A1.

Particularly pleasant-smelling antiperspirant cosmetic agents according to the invention are obtained if the at least one perfume in a total amount of 0.00001 to 15 wt .-%, preferably from 0.001 to 9 wt .-%, preferably from 0.01 to 8 wt .-% , more preferably from 0.1 to 7 wt .-%, even more preferably from 0.2 to 6 wt .-%, in particular from 0.2 to 2 wt .-%, based on the total weight of the antiperspirant cosmetic agent is.

Furthermore, the antiperspirant cosmetic agents according to the invention may contain as component a) a wax. Preferably, this wax is selected from the group of (i) fatty acid glycerol mono-, di- and triesters; (ii) Butyrospermum Parkii (Shea Butter); (iii) esters of saturated, monohydric Cs-is alcohols with saturated C12is monocarboxylic acids; (iv) linear, primary C 12-24 alkanols; (v) esters of a saturated monohydric C 16-6 o alkanol and a saturated C 8-36 monocarboxylic acid; (vi) glycerol triesters of saturated linear C 12-3o carboxylic acids which may be hydroxylated; (vii) natural vegetable waxes; (viii) animal waxes; (ix) synthetic waxes; and (x) their mixtures. In the context of the present invention preferably usable waxes are disclosed in the published patent application DE 10 2012 222 692 A1.

In the context of the present invention, it is preferred for the wax to be present in a total amount of from 0.01 to 50% by weight, preferably from 3 to 40% by weight, preferably from 5 to 30% by weight, in particular from 6 to 25 Wt .-%, based on the total weight of the antiperspirant cosmetic agent.

According to one embodiment of the present invention, it may be provided that the antiperspirant cosmetic agents according to the invention contain, as constituent b), a blowing agent in a total amount of 0 to 99% by weight, based on the total weight of the antiperspirant cosmetic agent. If the cosmetic compositions of the invention contain a propellant, this is preferably in a total amount of 1 to 98 wt .-%, preferably from 20 to 90 wt .-%, preferably from 30 to 85 wt%, in particular from 40 to 75 wt. %, based on the total weight of the antiperspirant cosmetic agent. In this case, the cosmetic compositions according to the invention are formulated as propellant-driven aerosols. Preferred propellants (propellants) are propane, propene, n-butane, isobutane, isobutene, n-pentane, pentene, isopentane, isopentene, methane, ethane, Dimethyl ether, nitrogen, air, oxygen, nitrous oxide, 1, 1, 1, 3-tetrafluoroethane, heptafluoro-n-propane, perfluoroethane, monochlorodifluoromethane, 1, 1 -difluoroethane, tetrafluoropropenes, both individually and in their mixtures. Also hydrophilic propellants, such. As carbon dioxide, can be used advantageously in the context of the present invention, when the proportion of hydrophilic gases is selected low and lipophilic propellant gas (eg., Propane / butane) is present in excess. Particularly preferred are propane, n-butane, isobutane and mixtures of these propellants. It has been found that the use of n-butane as the only propellant gas according to the invention can be particularly preferred.

As a third component c), the antiperspirant cosmetic agent according to the invention comprises at least one specific protein from skin appendages of mammals, birds, fish, insects or crustaceans.

A particularly effective reduction of axillary sweat by the at least one specific protein is achieved in the context of the present invention, if the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1, 0 to 50 wt .-% , preferably from 1, 5 to 40 wt%, more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included. Without wishing to be limited to this theory, the use of the abovementioned amounts of the at least one specific protein results in a significant influence on the sweat gland (s) by protein formation in the excretory ducts of the sweat glands or by influencing the charge balance within the sweat gland (s). In this way, an excellent antiperspirant effect is ensured. Furthermore, the use of the abovementioned amounts of the at least one specific protein does not lead to unstable formulations, so that the stability of the antiperspirant cosmetic agents according to the invention is ensured even over long storage periods.

Particularly good results with regard to the reduction and / or reduction of underarm wetness and skin compatibility and storage stability are obtained when the at least one protein has an average molecular weight Mw of from 150 to 100,000 Da, preferably from 180 to 50,000 Da, preferably from 200 to 10,000 Da, more preferably from 250 to 8,000 Da, in particular from 300 to 5,000 Da. The average molecular weight Mw can be determined, for example, by gel permeation chromatography (GPC) (Andrews P., "Estimation of the Molecular Weight of Proteins by Sephadex Gel Filtration", Biochem J., 1964, 91, pages 222 to 233).

According to a preferred embodiment of the present invention, the at least one protein has an isoelectric point which is in the range of pH 4.0 to pH 10.0, preferably from pH 4.0 to pH 9.5, in particular from pH 4.0 to pH 8.0. In particular, proteins which have an isoelectric point in the abovementioned pH range have proven to be advantageous in terms of the antiperspirant effect and the stability of the cosmetic compositions according to the invention in the context of the present invention.

A particularly high antiperspirant effect, skin compatibility and storage stability is ensured in the context of the present invention, if the at least one protein a change in light absorption at a pH change of at least 0.5 in a pH range of pH 4.5 to pH 7 , 5, in particular from pH 5.0 to pH 7.0, at a concentration of 0.001 to 10 wt .-% protein, based on the total weight of the sample mixture used for pH measurement, and a temperature of 20 ° C causes. Without wishing to be limited to this theory, the use of the at least one specific protein, which causes a change in light absorption in a specific pH range, results in a significantly increased influence of the sweat gland (s) by pH-selective gel formation in the outflow ducts of the Sweat glands or by disrupting the charge balance of the sweat gland (s), so that an excellent antiperspirant effect of the cosmetic compositions of the invention is comparable, which is comparable to the antiperspirant effect of aluminum salt-containing or aluminum zirconium salt-containing cosmetic compositions of the prior art.

In the context of the present invention, it is preferred if the pH change is effected by addition of bicarbonates or carbonates, in particular of sodium bicarbonates.

According to a preferred embodiment of the present invention, the at least one protein is selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures.

According to the invention, the term "unmodified proteins" is to be understood as meaning proteins which have not been treated by means of chemical processes, for example hydrolysis or chemical modification, or by physical methods, such as, for example, purification, separation and irradiation. Furthermore, the term "hydrolyzed proteins" or "protein hydrolysates" according to the invention are to be understood as meaning proteins which are prepared by chemical, in particular alkaline or acid hydrolysis, by enzymatic hydrolysis and / or by a combination of both types of hydrolysis. For enzymatic degradation all hydrolytic enzymes are suitable, such as alkaline proteases. Overviews on the preparation of protein hydrolysates are, for example, G. Schuster and A. Domsch in soaps oils Fette wax 108, (1982) 177 and Cosm.Toil. 99, (1984) 63, by HW Steisslinger in Parf.Kosm. 72, (1991) 556 and F. Aurich et al. in Tens.Surf.Det. 29, (1992) 389 appeared. Mixtures of individual amino acids which are obtained merely by mixing the pure substances of the amino acids, as well as total hydrolysates which consist only of individual amino acids, do not fall within the scope of the present invention under the term "hydrolyzed proteins" or "protein hydrolysates".

In addition, the term "chemically modified proteins" in the context of the present invention are proteins which, by chemical reaction of the reactive groups of the proteins, in particular the hydroxyl, amine, imidazole, guanidino and / or thiol groups of the side chains of Amino acids of the protein, with hydrophobic and / or cationic and / or anionic compounds.

In addition, the term "physically modified proteins" in the context of the present invention are proteins which have been modified by physical action, in particular by heat and / or light and / or fractionation.

In the context of this embodiment, it is particularly preferred if the at least one protein is selected from the group of chemically modified, in particular hydrophobically modified, proteins. In this context, the hydrophobically modified protein has one or more C4-3o carbon chains, wherein the C4-3o hydrocarbon chains may be linear, cyclic, branched, unbranched, saturated, unsaturated and aromatic, and wherein the C4-30 hydrocarbon chains are via ether - And / or ester and / or amine and / or amide bonds are bound to the protein residue.

Moreover, it is preferred in the context of this embodiment if the at least one protein is selected from the group of chemically modified, in particular cationically modified, proteins. Preferably, the cationically modified protein therefore contains one or more radicals of the formula R -N ⁺ (CH ₃ ) 2 -CH ₂ -CH (OH) -CH ₂ -XR, in which R is an alkyl group having 1 to 30 carbon atoms, an alkenyl group having 1 to 30 carbon atoms, a hydroxyalkyl group having 1 to 30 carbon atoms, especially a methyl group, a C10-18 alkyl or a C10 -is alkenyl group, X is O, N or S and R is the protein residue. The cationization of the proteins with the above-described radicals can be achieved by reacting the Proteins, in particular the reactive groups of the amino acids of the proteins, with the corresponding halides of the above formula can be achieved, wherein the above-described radicals can be bound to the protein via ether and / or ester and / or amide and / or amine bonds. For the purposes of the present invention, the term "protein residue" is to be understood as meaning the backbone of the corresponding protein formed by the linking of amino acids, to which the cationic group is bonded via the abovementioned bonds.

According to a further preferred embodiment of the present invention, the at least one protein occurs in skin appendages of mammals, in particular in the wool of sheep or goats.

In this context, it is particularly preferred if the at least one protein is a keratin.

In the context of this embodiment, it is preferred if the at least one protein is a cationically functionalized and / or hydrolyzed keratin.

Moreover, in the context of this embodiment, it is particularly preferred if the at least one protein contains one or more radicals of the formula R -N ⁺ (CH 3) 2 -CH 2 -CH (OH) -CH 2 -X-R, in which R is a C10 -is-alkyl or a C10 -is-alkenyl group, X is O, N or S and R is the optionally hydrolyzed protein radical.

With regard to the antiperspirant effect, the skin compatibility and the storage stability of the cosmetic compositions according to the invention, it is particularly preferred if the at least one protein is a keratin isolated from sheep's wool or goat's wool, wherein the keratin is hydrolyzed and / or wherein the keratin contains at least one Lauryldimoniumhydroxypropylgruppe , Without wishing to be limited to this theory, the use of these special proteins results in a significantly increased influence on the sweat gland (s) by pH-selective gel formation or disturbance of the charge balance within the excretory ducts of the sweat glands. In this way, an excellent antiperspirant effect of the cosmetic compositions of the invention is ensured, which is comparable to the antiperspirant effect of aluminum salt-containing or aluminum zirconium salt-containing cosmetic agents of the prior art. In addition, the use of these special proteins does not lead to a negative interaction with other ingredients in the antiperspirant cosmetic agent, so that a high storage stability of the antiperspirant cosmetic agents according to the invention is ensured. In addition, the cosmetic compositions of the invention have a high skin tolerance. It has been found to be advantageous in this context if the at least one protein lysine in 1, 0 to 2.5 mol .-%, histidine in 0.5 to 0.8 mol .-% and arginine in 7.0 to 8, 0 mol .-%, based on the total amount of all amino acids of the protein contains. The mole fraction of the aforementioned amino acids can be carried out, for example, by chromatographic determination using sulfonated polystyrene resins (Moore S. et al., "Chromatography of amino acids on sulfonated polystyrene resin"; J. of Biological Chem., 1951, 192, p. 663) to 681).

Furthermore, it has proved to be advantageous in this context if the at least one protein has a calcium content of 100 to 600 mg, a potassium content of 700 to 1400 mg, a phosphorus content of 40 to 150 mg and a sulfur content of 1 .100 to 5,700 mg, in each case based on 1 kg of the at least one protein. The contents given above can be determined, for example, by means of atomic emission spectrometry (ICP-OES) after microwave digestion with nitric acid (A. Oliveira et al., "Evaluation of Metal Ions in Rice Samples: Extraction and Direct Determination by ICP-OES", J. Braz. Chem. Soc., 2012, 23, pages 838-845).

According to a further particularly preferred embodiment of the present invention, the at least one protein brings about a change in the light absorption of from 1.5 to 90%, preferably from 2 to 80%, preferably from 2.5 to 70%, more preferably from 3 to 65%, in particular from 3.5 to 60%. In particular, proteins from certain skin appendages, which cause the aforementioned change in light absorption, in the context of the present invention to an excellent antiperspirant effect. The change in the light absorption can be done on a change in the light transmittance of the sample mixture, in particular by turbidity, as well as on the absorption of light by the sample mixture, in particular by the protein itself.

The changes of the light absorption underlying this invention with a pH change of at least 0.5 can be determined by measuring the light transmission of a light beam through the sample mixture. The measurements of the light transmission are performed using a Methrom Optrode 6.1 115,000 at a wavelength of 574 nm (green-yellow) in mV (resolution 0.1 mV) in an open sample vessel at 23 ° C and 1 .013 mbar. The pH change in the pH range of 4.0 to 8.0 is achieved by slowly and continuously adding a carbonate or bicarbonate solution, preferably a 1% by weight sodium bicarbonate solution, to the sample mixture to measure the pH achieved with a pH electrode and with stirring at a speed of 750 to 850 rpm. The change in the light absorption caused by the at least one protein is calculated according to the formula AL = [(| Li | / | Lo |] * 100. In this formula, Li stands for the light transmission after the pH has changed by at least 0.5 in the pH range of 4.0 to 8.0, preferably of pH 4.5 and 7.5, in particular of pH 5.0 and 7.0. Lo in this formula stands for the difference between the light transmission at pH 4.0 and at pH 8.0, preferably at pH 4.5 and at pH 7.5, in particular at pH 5.0 and at pH 7.0, ie for example light transmission at pH 8.0 minus light transmission at pH 4.0. The at least one specific protein in the antiperspirant cosmetic agents according to the invention effects a change in the light absorption of 1 to 100% determined by the above method. However, the present invention is not limited to antiperspirant cosmetic compositions containing at least one specific protein which effects a change in light absorption of 1 to 100% as determined by the above method. It also includes antiperspirant cosmetic compositions containing at least one specific protein which, by other methods, causes a change in light absorption of 1 to 100%.

In the context of the present invention, it is preferred if the concentration of the at least one protein in the sample mixture used to determine the change in the light absorption of 0.005 to 10 wt .-%, preferably from 0.05 to 5 wt .-%, preferably from 0 , 07 to 3 wt .-%, in particular from 0.09 to 2 wt .-%, based on the total weight of the sample mixture used for the determination of the change in the light absorption, is.

According to the invention, the at least one protein preferably effects a change in the light absorption with a pH change of at least 0.5 and at most 3.5, preferably at least 0.5 and at most 2.5, in particular at least 0.5 and at most 1, 5th The change in the pH can be achieved in particular by the addition of acids or bases, preferably bases in the form of carbonates or bicarbonates, in the appropriate amount.

According to another preferred embodiment of the present invention, the antiperspirant cosmetic agent has a pH of from pH 2 to pH 10. Within this range, a stable formulation of the cosmetic compositions of the invention is possible without undesirable interactions between the ingredients of the antiperspirant cosmetic agents according to the invention occur. The setting of the desired pH value can be carried out according to the invention by using acids and bases known to those skilled in the art and customary in antiperspirant cosmetic agents.

According to the invention, it is further preferred if the antiperspirant cosmetic agent additionally contains at least one preservative. Preservatives which are preferred according to the invention are formaldehyde releasers iodopropynyl butylcarbamates, parabens, phenoxyethanol, ethanol, benzoic acid and its salts, dibromodicyanobutane, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl urea, 5-chloro-2-methyl-4-isothiazoline. 3-one, 2-chloroacetamide, benzalkonium chloride, benzyl alcohol, salicylic acid and salicylates. Further in the context of the present Preservatives which can be used in the invention are the substances listed in Appendix 6 of the Cosmetics Regulation and cosmetic raw materials with preservative properties or raw materials which support or enhance the preservative action of the abovementioned preservatives. The preservatives are preferably in a total amount of 0.01 to 10 wt .-%, preferably from 0.1 to 7 wt .-%, preferably from 0.2 to 5 wt .-%, in particular from 0.3 to 2, 0 wt .-%, based on the total weight of the antiperspirant cosmetic agent included.

In the context of the present invention, it is preferred if the antiperspirant cosmetic agent is present as a water-in-oil emulsion. This may in particular be a sprayable water-in-oil emulsion, which can be sprayed by means of a propellant. In this context, it is preferred if the present invention in the form of a water-in-oil emulsion antiperspirant cosmetic agent containing at least one protein in a total amount of 0.1 to 70 wt .-%, preferably from 0.5 to 60 wt .-%, preferably from 1, 0 to 50 wt .-%, more preferably from 1, 5 to 40 wt%, even more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent contains.

However, it may equally be preferred according to the invention if the antiperspirant cosmetic agent is present as an oil-in-water emulsion. In this case, the cosmetic agent according to the invention is preferably sprayed as a propellant-free pump spray or Ouetschspray or applied as a roll-on. In this connection, it is preferred if the antiperspirant cosmetic agent present in the form of an oil-in-water emulsion comprises the at least one protein in a total amount of from 0.1 to 70% by weight, preferably from 0.5 to 60% by weight. , preferably from 1, 0 to 50 wt .-%, more preferably from 1, 5 to 40 wt%, even more preferably from 2.0 to 30 wt .-%, in particular from 2.0 to 20 wt .-% based on the total weight of the antiperspirant cosmetic agent.

According to a further preferred embodiment of the present invention, the cosmetic compositions according to the invention may contain only a low content of free water or no free water. For the purposes of the present invention, free water is understood to mean water which is different from water of crystallization, water of hydration or similar molecularly bound water of the constituents used. The antiperspirant cosmetic agent preferably contains free water in a total amount of less than 10% by weight, preferably less than 8% by weight, preferably less than 5% by weight, more preferably less than 3% by weight. even more preferably less than 1% by weight, in particular 0% by weight, based on the total weight of the antiperspirant cosmetic agent. Within the scope of a further embodiment, however, it is likewise preferred according to the invention if the antiperspirant cosmetic agent is present as an aqueous, aqueous-alcoholic or aqueous-glycolic solution. Since the cosmetic compositions according to the invention contain no antiperspirant halides and / or hydroxyhalides of aluminum and / or zirconium which have a reduced antiperspirant effect by the addition of protic solvents, protic solvents, such as aqueous solutions, can be used according to the invention for formulating the antiperspirant cosmetic agents according to the invention without a significant reduction in the antiperspirant effect. Therefore, the addition of the at least one specific protein, even with the use of protic solvents, ensures an effective influence on the sweat gland (s) and thus an excellent antiperspirant effect.

In connection with this embodiment of the present invention, it has surprisingly been found that the influence on the sweat gland (s) by the at least one specific protein can be significantly increased if the antiperspirant cosmetic agents according to the invention comprise free water in an amount of 5 to 99% by weight. based on the total weight of the antiperspirant cosmetic agent. In a particularly preferred embodiment of the present invention, the antiperspirant cosmetic agent therefore contains free water in a total amount of 5 to 96 wt .-%, preferably from 15 to 80 wt .-%, preferably from 30 to 70 wt .-%, in particular of 40 to 60 wt .-%, based on the total weight of the antiperspirant cosmetic agent.

Furthermore, it is preferred in connection with this embodiment if the antiperspirant cosmetic agent ethanol in a total amount of 1 to 99 wt .-%, preferably from 5 to 70 wt .-%, preferably from 7 to 50 wt .-%, in particular of 10 to 30 wt .-%, based on the total weight of the antiperspirant cosmetic agent contains. As stated above, even high levels of protic solvents, such as ethanol, can be used by the use of the at least one specific protein without adversely affecting the antiperspirant effect of the antiperspirant cosmetic agent of the present invention.

The application of the antiperspirant cosmetic agent according to the invention can be carried out by means of various methods. According to a preferred embodiment, the antiperspirant cosmetic agent is formulated as a spray application. The spray application is carried out with a spray device which contains a filling of the liquid, viscous-flowable, suspension-shaped or powdered antiperspirant cosmetic agent according to the invention in a container. The filling may be under the pressure of a propellant (compressed gas cans, aerosols, aerosols), or it may be a act mechanically operated pump sprayer without propellant (pump sprays / squeeze bottle). The atomization of the antiperspirant cosmetic agent may be effected physically, mechanically or electromechanically, for example by piezoelectric effects or electrical pumps. In the context of this embodiment, usable containers and removal devices are described for example in the published patent application DE 10 2012 222 692 A1.

The antiperspirant cosmetic may further preferably be formulated as a stick, soft solid, cream, gel, roll-on, loose or compact powder. The formulation of the antiperspirant cosmetic agents according to the invention in a particular dosage form, such as, for example, an antiperspirant roll-on, an antiperspirant stick or an antiperspirant gel, preferably conforms to the requirements of the intended use. Depending on the intended use, the antiperspirant cosmetic agents according to the invention can therefore be present in solid, semisolid, liquid, disperse, emulsified, suspended, gelatinous, multiphase or powdery form. For the purposes of the present invention, the term liquid also includes any types of solid dispersions in liquids. In the context of the present invention, multiphase antiperspirant cosmetic agents according to the invention are also understood to mean agents which have at least two different phases with a phase separation and in which the phases can be arranged horizontally, ie one above the other, or vertically, ie side by side. The application can be carried out, for example, with a roller ball applicator or by means of a fixed pin.

It may also be preferred within the scope of the present invention if the antiperspirant cosmetic agent is contained on and / or in a disposable substrate selected from the group of wipes, pads and bulbs. Particularly preferred are wet wipes, ie prefabricated for the user, preferably individually packaged, wet wipes, as they are for. B. from the field of glass cleaning or from the field of wet toilet paper are well known. Such wet wipes, which can advantageously also contain preservatives, are impregnated or applied with an antiperspirant cosmetic agent according to the invention and preferably individually packaged. Preferred substrate materials are selected from porous sheet-like cloths. These wipes include wipes of woven and nonwoven synthetic and natural fibers, felt, paper or foam, such as hydrophilic polyurethane foam. Deodorizing or antiperspirant substrates which are preferred according to the invention can be obtained by impregnation or impregnation or else by melting a perspiration-inhibiting cosmetic agent according to the invention onto a substrate. According to the invention, the antiperspirant cosmetic agent preferably contains at least one broad adjuvant selected from the group of (i) emulsifiers and / or surfactants; (ii) thickeners; (iii) chelating agents; (iv) deodorant agents; (v) monohydric and / or polyhydric alcohols and / or polyethylene glycols; (vi) skin-cooling agents; (vii) pH adjusters; (viii) skin care ingredients, such as moisturizers, skin soothing substances, skin lightening substances, skin smoothing substances; and (ix) their mixtures.

Emulsifiers and surfactants which are preferably suitable according to the invention are selected from anionic, cationic, nonionic, amphoteric, in particular ampholytic and zwitterionic emulsifiers and surfactants. Surfactants are amphiphilic (bifunctional) compounds which consist of at least one hydrophobic and at least one hydrophilic moiety. The hydrophobic moiety is preferably a hydrocarbon chain of 8 to 28 carbon atoms, which may be saturated or unsaturated, linear or branched. Most preferably, this C8-C28 alkyl chain is linear. Emulsifiers and surfactants which can preferably be used in the context of the present invention are disclosed, for example, in the published specifications DE 10 2012 222 692 A1, DE 10 2010 063 250 A1 and DE 10 2010 055 816 A1.

Substances which are selected from cellulose ethers, xanthan gum, sclerotium gum, succinoglucans, polygalactomannans, pectins, agar, carrageenan, tragacanth, gum arabic, karaya gum, tara gum, gellan, gelatin are preferably used to thicken the antiperspirant cosmetic agents according to the invention , Propylene glycol alginate, alginic acids and their salts, polyvinylpyrrolidones, polyvinyl alcohols, polyacrylamides, physical (eg by pre-gelatinization) and / or chemically modified starches, acrylic acid-acrylate copolymers, acrylic acid-acrylamide copolymers, acrylic acid-vinylpyrrolidone copolymers, Acrylic acid-vinylformamide copolymers and polyacrylates. Particularly preferred thickeners are furthermore selected from carbomers. Carbomers are thickening crosslinked polymers of acrylic acid, methacrylic acid and their salts. The crosslinking can be effected by means of polyfunctional compounds such as polyalkylene ethers of polysaccharides or polyalcohols, for example sucrose allyl ether, pentaerythritol allyl ether, propylene allyl ether. Preferred in the context of the present invention are homopolymers of acrylic acid or salts thereof which are crosslinked with a pentaerythritol allyl ether, a sucroseallyl ether or a propylene allyl ether. A thickening agent which can be used in the context of the present invention is a copolymer of Cio-30-alkyl acrylate, acrylic acid, methacrylic acid and esters thereof, which is crosslinked with a sucrose allyl ether or a pentaerythritol allyl ether. Thickener based on carbomers are products sold under the trade name Carbopol ^® (BF Goodrich, Ohio, USA) available such as Carbopol 934, Carbopol 940, Carbopol 941, Carbopol 971, Carbopol 974, Carbopol EZ2, Carbopol ETD 2001, Carbopol ETD 2020, Carbopol ETD 2050, Carbopol ultrez 10, Carbopol ultrez 20, or Carbopol ultrez 21. Furthermore, lipophilic thickening agents can be used to thicken the antiperspirant cosmetic agents according to the invention. Lipophilic thickeners which are preferred according to the invention are selected from hydrophobized clay minerals, bentonites, pyrogenic silicas and derivatives thereof.

In order to further support the influence of the sweat gland (s) by the at least one specific protein, it may be advantageous for the antiperspirant cosmetic agents according to the invention to comprise at least one chelating agent, in a total amount of from 0.01 to 3.0% by weight, preferably from 0.02 to 1, 0 wt .-%, in particular from 0.05 to 0.1 wt .-%, based on the total weight of the antiperspirancy agent according to the invention, to add. In the context of the present invention, preferred chelating agents are selected from the group consisting of β-alaninediacetic acid, cyclodextrin, diethylenetriaminepentamethylenephosphonic acid, sodium, potassium, calcium disodium, ammonium and triethanolamine salts of ethylenediaminetetraacetic acid (EDTA), etidronic acid, hydroxyethylethylenediaminetetraacetic acid (HEDTA) and their sodium salts. Sodium salts of nitrilotriacetic acid (NTA), diethylenetriaminepentaacetic acid, phytic acid, hydroxypropylcyclodextrin, methylcyclodextrin, aminotrimethylenephosphonate-pentasodium, ethylenediamine tetramethylenephosphonate-pentasodium, diethylenetriamine-pentaacetate-pentasodium, pentasodium triphosphate, potassium EDTMP, sodium EDTMP, sodium dihydroxyethylglycinate, sodium phytate,

Sodium polydimethylglycinophenolsulfonate, tetrahydroxyethylethylenediamine, tetrahydroxypropylethylenediamine, tetrapotassium tetidronate, tetrasodium tetidronate,

Tetrasodiumiminodisuccinate, trisodium ethylenediamine disuccinate, tetrasodium N, N-bis (carboxymethyl) glutamate, tetrasodium DL-alanine-N, N-diacetate and desferrioxamine.

The deodorizing effect of the antiperspirant cosmetic agents according to the invention can be further increased if at least one deodorant active ingredient having antibacterial and / or bacteriostatic and / or enzyme-inhibiting and / or odor-neutralizing and / or odor-absorbing action in a total amount of 0.0001 to 40% by weight. %, preferably from 0.2 to 20 wt .-%, preferably from 1 to 15 wt .-%, in particular from 1, 5 to 5 wt .-%, based on the total weight of the antiperspirant cosmetic agent according to the invention, is contained. If ethanol is used in the compositions according to the invention, this does not apply in the context of the present invention as a deodorant active ingredient, but as a constituent of the carrier. Deodorant active substances which are preferred according to the invention are disclosed, for example, in the published patent application DE 10 2010 063 250 A1.

Preferred antiperspirant cosmetic agents according to the invention furthermore comprise at least one water-soluble polyvalent C 2-9 -alkanol having 2 to 6 hydroxyl groups and / or at least one water-soluble polyethylene glycol having 3 to 50 ethylene oxide units and Mixtures thereof. This does not include the abovementioned deodorant active ingredients in the form of 1, 2-alkanediols. Preferred alkanols and water-soluble polyethylene glycols are described, for example, in the published patent application DE 10 2010 063 250 A1.

According to another embodiment of the present invention, the antiperspirant cosmetic agents further contain at least one skin-cooling agent. Skin-cooling active ingredients suitable according to the invention are, for example, menthol, isopulegol and menthol derivatives, eg. Menthyl lactate, menthyl glycolate, menthyl ethyl oxamate, menthyl pyrrolidone carboxylic acid, menthyl methyl ether, menthoxy propane diol, menthone glycerol acetal (9-methyl-6- (1-methylethyl) -1, 4-dioxaspiro (4.5) decane-2-methanol), mono-menthyl succinate, 2-hydroxymethyl -3,5,5-trimethylcyclohexanol and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate. Preferred skin-cooling active ingredients are menthol, isopulegol, menthyl lactate, menthoxypropanediol, menthylpyrrolidonecarboxylic acid and 5-methyl-2- (1-methylethyl) cyclohexyl-N-ethyloxamate, and mixtures of these substances, in particular mixtures of menthol and menthyl lactate, menthol, menthol glycolate and menthyl lactate, menthol and menthoxypropanediol or menthol and isopulegol.

According to the invention, the pH adjusting agents used are preferably acids and / or alkalizing agents and / or buffers. As acids according to the invention preferably inorganic acids (such as hydrochloric acid, sulfuric acid or phosphoric acid) or organic acids (such as citric acid, tartaric acid or malic acid) are used. The alkalizing agents which can be used according to the invention are preferably selected from the group which is formed from ammonia, basic amino acids, alkali hydroxides, carbonates and bicarbonates, alkanolamines, for example amino-2-methyl-1-propanol, monoethanolamine, triethanolamine, diethanolamine and triisopropanolamine, alkali metal metasilicates, Urea, morpholine, N-methylglucamine, imidazole, alkali phosphates and alkali hydrogen phosphates. The alkali metal ions used are preferably lithium, sodium, potassium, in particular sodium or potassium. Suitable buffer systems in the context of the present invention are, in particular, carbonic bicarbonate buffers, carbonic acid silicate buffers, acetic acid acetate buffers, phosphate buffers, ammonia buffers, citric acid or citrate buffers, buffers based on tris (hydroxymethyl) aminomethane, buffers Base of 4- (2-hydroxyethyl) -1-piperazineethanesulfonic acid, buffer based on 4- (2-hydroxyethyl) -piperazine-1-propanesulfonic acid, buffer based on 2- (N-morpholino) ethanesulfonic acid and barbital acetate buffer , The choice of the corresponding buffer system depends on the desired pH of the antiperspirant cosmetic agents according to the invention.

In a preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention, - At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1, 0 to 50 wt .-%, preferably from 1, 5 to 40 wt%, more preferably from 2.0 to 30 wt %, in particular from 2.0 to 20% by weight,

From 12 to 98% by weight, preferably from 25 to 55% by weight, preferably from 30 to 50% by weight, in particular from 35 to 45% by weight, of water,

at least one emulsifier and / or a surfactant,

at least one pH adjusting agent,

- at least one preservative and

- at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C and 1 .013 hPa, fragrances and waxes

wherein the at least one protein is present in skin appendages of mammals, birds, fish, insects or crustaceans and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8 , 0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for determining the change in light absorption, a change in the light absorption of 1 to 100 %, causes.

In a further preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention,

- At least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1, 0 to 50 wt .-%, preferably from 1, 5 to 40 wt%, more preferably from 2.0 to 30 wt %, in particular from 2.0 to 20% by weight,

at least one emulsifier and / or a surfactant,

at least one pH adjusting agent,

- at least one preservative,

From 0.01 to 2% by weight, preferably from 0.1 to 1% by weight, preferably from 0.2 to 0.7% by weight, in particular from 0.3 to 0.5% by weight, of a thickener, and

wherein the at least one protein is present in skin appendages of mammals, birds, fish, insects or crustaceans and wherein the at least one protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8 , 0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the sample mixture used for determining the change in light absorption, a change in the light absorption of 1 to 100 %, causes. In a preferred embodiment, the antiperspirant cosmetic agents according to the invention are characterized in that they contain, based on the total weight of the antiperspirant cosmetic agent according to the invention,

at least one blowing agent in a total amount of from 1 to 98% by weight, preferably from 20 to 90% by weight, preferably from 30 to 85% by weight, in particular from 40 to 75% by weight,

at least one emulsifier and / or a surfactant,

at least one pH adjusting agent,

- at least one preservative and

at least one emulsifier and / or a surfactant,

at least one pH adjusting agent,

- at least one preservative,

- at least one substance selected from the group of cosmetic oils, which at 20 ° C and 1 .013 hPa are liquid, fragrances and waxes

In the context of the present invention, it may also be envisaged to prepare the cosmetic agent according to the invention as a two-component agent. For this purpose, the individual components are preferably stored in separate containers and applied in succession or simultaneously to the skin in any order. Separation into multicomponent systems is particularly preferred where incompatibilities of the ingredients are to be expected or feared.

A further subject of the present invention is therefore a packaging unit (kit-of-parts), comprising - made up separately - a) at least one first container (C1) containing a cosmetic agent (M1) comprising at least one antiperspirant active substance, and

b) at least one second container (C2) containing a cosmetic agent (M2) comprising at least one protein, wherein the at least one protein is present in skin appendages of mammals, birds, fish, insects or crustaceans, wherein the at least one protein is present at a pH Value Change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the Total weight of the sample mixture used for determining the change in light absorption, a change in light absorption of 1 to 100%, and wherein the cosmetic agent (M2) does not contain halides and / or hydroxy halides of aluminum and / or zirconium.

According to the invention, the term "antiperspirant active ingredient" is understood as meaning active ingredients which reduce or reduce the transpiration of the sweat glands of the body, but do not include the proteins contained in the cosmetic agent (M2) from skin appendages of mammals, birds, fish, insects or crustaceans which cause a change in light absorption of 1 to 100% under the conditions described above.

With respect to the cosmetic agent (M2) in the container (C2) mutatis mutandis applies to the cosmetic compositions of the invention. A further subject of the present invention is the use of a protein for at least partially influencing the sweat gland (s), wherein the at least one protein occurs in skin appendages of mammals, birds, fish, insects or crustaceans and wherein the at least one protein is at a pH Value Change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the Total weight of the sample mixture used for the determination of the change of the light absorption, a change of the light absorption of 1 to 100%, causes.

By influencing the sweat gland (s), the influencing of the sweat gland (s) according to the invention is to be understood as meaning that the secretion of sweat from the excretory duct is avoided or reduced. Without wishing to be limited to one theory, this can be done, for example, by forming a gel and / or precipitation of the at least one specific protein in the excretory duct of the sweat gland or the excretory ducts of the sweat glands. However, the use of the at least one specific protein can also lead to a disturbance of the charge balance within the excretory ducts of the sweat glands. Regarding the use according to the invention mutatis mutandis applies to the cosmetic antiperspirant agents of the invention.

In addition, another object of the present invention is the use of a combination containing

a) at least one substance selected from the group of cosmetic oils which are liquid at 20 ° C. and 1013 hPa, fragrances and waxes,

c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein occurs in skin appendages of mammals, birds, fish, insects or crustaceans, wherein the at least a protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt. %, based on the total weight of the sample mixture used to determine the change in light absorption, causes a change in light absorption of 1 to 100%, and wherein the combination does not contain halides and / or hydroxy halides of aluminum and / or zirconium,

for the reduction and / or prevention of sweat, in particular armpit sweat or perspiration of other body regions. For the purposes of the present invention, the term "combination" encompasses a mixture of the above-mentioned ingredients a), b) and c) With respect to the use of the abovementioned combination, what has been said with respect to the antiperspirant cosmetic agents according to the invention and to the use according to the invention applies mutatis mutandis ,

In addition, another object of the present invention is a antiperspirant cosmetic containing

c) at least one keratin isolated from sheep's wool or goat's wool in a total amount of from 0.1 to 70% by weight, based on the total weight of the antiperspirant cosmetic agent, wherein the keratin is hydrolyzed and / or wherein the keratin contains at least one lauryldimonium hydroxypropyl group,

In the context of this article, it is particularly preferred if the at least one protein lysine in 1, 0 to 2.5 mol .-%, histidine in 0.5 to 0.8 mol .-% and arginine in 7.0 to 8, 0 mol .-%, based on the total amount of all amino acids of the protein contains. The content of said amino acids can be determined as previously stated.

Furthermore, it is particularly preferred in the context of this article, if the at least one protein has a calcium content of 100 to 600 mg, a potassium content of 700 to 1 .400 mg, a phosphorus content of 40 to 150 mg and a sulfur content of 1 .100 to 5,700 mg , in each case based on 1 kg of the at least one protein. The stated contents can be determined, for example, by means of atomic emission spectrometry (ICP-OES), as stated above.

With regard to further preferred embodiments of this article, mutatis mutandis, the statements made regarding the antiperspirant cosmetic agents according to the invention, the use according to the invention and the method according to the invention apply.

Finally, another object of the present invention is a non-therapeutic cosmetic method for preventing and / or reducing transpiration of the body, in which an antiperspirant cosmetic according to the invention is applied to the skin, in particular to the skin of the armpits, and for at least 1 hour , preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, remains on the skin of the armpits. In the context of the method according to the invention, however, it may also be provided that first a cosmetic agent containing at least one antiperspirant halide and / or hydroxy halide of aluminum and / or zirconium, and then the cosmetic composition according to the invention is applied. However, it is also possible first to apply the cosmetic agent according to the invention and then to use a cosmetic agent comprising at least one antiperspirant halide and / or hydroxyhalide of aluminum and / or zirconium. In addition, the antiperspirant cosmetic agent according to the invention and the cosmetic agent containing at least one antiperspirant halide and / or hydroxyhalide of aluminum and / or zirconium can also be applied simultaneously to the skin. The time between application of the two remedies is from 0 seconds to 24 hours. Furthermore, it is preferred if the agents remain on the skin of the underarms after application for at least 1 hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours.

Regarding the method according to the invention mutatis mutandis applies to the antiperspirant cosmetic agents according to the invention as well as to the use according to the invention.

The following examples illustrate the present invention without, however, limiting it to:

Examples:

1. Change in light absorption

The determination of the change in light absorption caused by a hydrolyzed keratin having at least one lauryldimonium hydroxypropyl group and an average molecular weight M _w of about 1000 Da in a pH range of 4.5 to 7.5 at a pH change of 1, 0 is done, is done as follows:

Table 1: Sample solution (in% by weight)

* according to the invention

a> Croquat WKP PE-LQ (WD); (INCI: cocodimonium hydroxypropyl hydrolyzed keratin; 30% by weight solution in water; M _w about 1, 000 Da; Croda)

To determine the change in light absorption, a Methrom Titrando 905 from Methrom (USA) was used, which was equipped with a Methrom Optrode 6.11 15,000 and a pH Electrode is equipped by Methrom. The Methrom Titrando 905 is controlled via the Tiamo software from Methrom. First, 30 ml of a sample solution according to Table 1, which had a pH of 3.0, were placed in the open sample vessel of the Methrom Titrando 905. Subsequently, at 23 ° C. and 1 .013 mbar with stirring (stirring speed 8 of the Titrando 905, corresponding to 750 to 850 rpm), a 1% strength by weight sodium bicarbonate solution was continuously added until a pH of 7.5 was reached , During the addition of the 1% strength by weight sodium bicarbonate solution, the light transmission of a light beam through this sample solution was measured with a Methrom Optrode 6.1 1 15,000 at a wavelength of 574 nm (green-yellow) in mV (resolution 0.1 mV). Each measurement is carried out twice and from this the mean value is formed.

The change in light absorption caused by the above-mentioned peptides was determined according to the formula AL = [(| Li | / | Lo |] * 100. In this formula, Li stands for light transmittance after changing the pH by at least 0.5 in the pH range of 4.0 to 8.0, preferably of pH 4.5 and 7.5, in particular of pH 5.0 and 7.0 Lo in this formula represents the difference in light transmission at pH 4.0 and at pH 8.0, preferably at pH 4.5 and at pH 7.5, in particular at pH 5.0 and at pH 7.0.

At a pH change of 1.0, between pH 5.0 and pH 6.0 (light absorption at pH 6.0 forms value Li) in a pH range of 4.5 to 7.5 (difference in light absorption at pH 7 , 5 minus pH 4.5 forms Lo), this protein caused a change in light absorption AL of about 50%.

2. In vivo test for antiperspirant activity

To determine the antiperspirant effect, an antiperspirant study was carried out on the backs of 16 test persons. The following antiperspirants were used for this:

* Active ingredient

** according to the invention

On the back of 16 test persons 40 μί of the antiperspirant agent Vl and 75 μί of the cosmetic product EI l according to the invention were applied in each case on one side next to the backbone. After 5 minutes, the treated sites were covered with occlusive non-adsorbent film. After 2 hours, these non-absorbent pads were removed. The compositions were each applied to the back of the subjects for four consecutive days in the manner previously described. 24 h after the last application of the composition, absorbent pads were applied to the backs of the test persons applied to the places where previously the compositions were applied. Furthermore, on the other side of the spine at the same height also pads were applied, which served as a control. After sweating for about 15 minutes at 80 ° C in the sauna, the amount of perspiration absorbed by the pads was determined gravimetrically, comparing each composition with the corresponding untreated spot on the back. From the gravimetric determination of the amount of sweat, the sweat reduction was determined, with all the values determined were statistically significant.

The sweat reduction of the respective composition compared to an untreated skin site is shown in the following table:

The use of the particular protein results in a significant reduction in sweat reduction and in a satisfactory antiperspirant effect.

3. Formulations:

The protein used in the following examples is preferably a hydrolyzed keratin having at least one Lauryldimoniumhydroxypropylgruppe and an average molecular weight M _w of about 1, 000 Da:

Antiperspirant cosmetic agents according to the invention with a pH of 2.5 to 10.0 (amounts in% by weight)

Eumulgin B3 (INCI: Ceteareth-30, BASF)

Claims

claims:

1. antiperspirant cosmetic agent containing

c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein in skin appendages of mammals, birds, fish, insects or crustaceans occurs and wherein the at least a protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt. %, based on the total weight of the sample mixture used for determining the change in light absorption, causes a change in light absorption of 1 to 100%, wherein the antiperspirant cosmetic agent contains no halides and / or hydroxy halides of aluminum and / or zirconium.

2. antiperspirant cosmetic agent according to claim 1, characterized in that the at least one protein in a total amount of 0.5 to 60 wt .-%, preferably from 1, 5 to 50 wt .-%, preferably from 2 to 40 Gew. %, more preferably from 2.5 to 30 wt .-%, in particular from 3 to 20 wt .-%, based on the total weight of the antiperspirant cosmetic agent is included.

3. The antiperspirant cosmetic agent according to any one of claims 1 or 2, characterized in that the at least one protein has an average molecular weight M _w of 150 to 100,000 Da, preferably from 180 to 50,000 Da, preferably from 200 to 10,000 Da, more preferably from 250 to 8,000 Da, in particular from 300 to 5,000 Da.

An antiperspirant cosmetic composition according to any one of the preceding claims, characterized in that the at least one protein exhibits a change in light absorption at a pH change of at least 0.5 in a pH range of pH 4.5 to pH 7.5, in particular from pH 5.0 to pH 7.0, at a concentration of 0.001 to 10% by weight of protein, based on the total weight of the sample mixture used for pH measurement, and at a temperature of 20 ° C.

5. antiperspirant cosmetic agent according to any one of the preceding claims, characterized in that the pH change is effected by addition of bicarbonates or carbonates, in particular of sodium bicarbonates.

An antiperspirant cosmetic composition according to any one of the preceding claims, characterized in that the at least one protein is selected from the group of (i) unmodified proteins; (ii) hydrolyzed proteins; (iii) chemically modified proteins, in particular hydrophobically and / or cationically and / or anionically modified proteins; (iv) physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; (v) hydrolyzed unmodified proteins; (vi) hydrolyzed and chemically modified proteins, especially hydrolyzed and hydrophobically and / or cationically and / or anionically modified proteins; (vii) hydrolyzed and physically modified proteins, especially fractionated and / or purified and / or irradiated proteins; and (viii) their mixtures.

The antiperspirant cosmetic composition according to claim 6, characterized in that the cationically modified protein has one or more radicals of the formula R -N ⁺ (CH 3) 2 -CH 2 -CH (OH) -CH 2 -XR, in which R is for an alkyl group of 30 carbon atoms, an alkenyl group, 1 to 30 carbon atoms, a hydroxyalkyl group having 1 to 30 carbon atoms, especially a methyl group, a C 1-10 alkyl or a C 10-18 alkenyl group, X is O, N or S and R is the protein residue contains.

An antiperspirant cosmetic composition according to any one of the preceding claims, characterized in that the at least one protein is a keratin isolated from sheep's wool or goat's wool, wherein the keratin is hydrolyzed and / or wherein the keratin contains at least one lauryldimonium hydroxypropyl group.

9. antiperspirant cosmetic agent according to claim 8, characterized in that the at least one protein lysine in 1, 0 to 2.5 mol .-%, histidine in 0.5 to 0.8 mol .-% and arginine in 7.0 to 8.0 mol .-%, based on the total amount of all amino acids of the protein contains.

10. The antiperspirant cosmetic composition according to any one of claims 8 or 9, characterized in that the at least one protein has a calcium content of 100 to 600 mg, a potassium content of 700 to 1 .400 mg, a phosphorus content of 40 to 150 mg and a sulfur content of 1 .100 to 5,700 mg, in each case based on 1 kg of the at least one protein.

11. Packing unit (kit-of-parts), comprising - made up separately from one another - a) at least one first container (C1) containing a cosmetic agent (M1) comprising at least one antiperspirant active substance, and

12. use of at least one protein for at least partially influencing the sweat gland (s), wherein the at least one protein is present in skin appendages of mammals, birds, fish, insects or crustaceans and wherein the at least one protein at a pH change of at least 0, 5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt .-%, based on the total weight of the for determining the Change in light absorption used sample mixture, a change in light absorption of 1 to 100%, causes.

13. Use of a combination containing

c) at least one protein in a total amount of 0.1 to 70 wt .-%, based on the total weight of the antiperspirant cosmetic agent, wherein the at least one protein occurs in skin appendages of mammals, birds, fish, insects or crustaceans, wherein the at least a protein at a pH change of at least 0.5 in a pH range of pH 4.0 to pH 8.0, a temperature of 20 ° C to 40 ° C and a concentration of the protein of 0.001 to 10 wt. %, based on the total weight of the sample mixture used for the determination of the change of the light absorption, causes a change of the light absorption of 1 to 100%, and wherein the combination does not contain halides and / or hydroxy halides of aluminum and / or zirconium,

for the reduction and / or prevention of sweat, in particular armpit sweat or perspiration of other body regions.

14. Antiperspirant cosmetic containing

A non-therapeutic cosmetic method for preventing and / or reducing transpiration of the body, wherein a antiperspirant cosmetic according to any one of claims 1 to 10 or 14 is applied to the skin, in particular to the skin of the armpits, and for at least 1 Hour, preferably for at least 2 hours, preferably for at least 4 hours, in particular for at least 6 hours, remains on the skin of the armpits.