EP2918663A1 - Cleaning agent for inanimated surfaces with special efficacy against mucus, secretions, blood and biofilms - Google Patents
Cleaning agent for inanimated surfaces with special efficacy against mucus, secretions, blood and biofilms Download PDFInfo
- Publication number
- EP2918663A1 EP2918663A1 EP15156668.4A EP15156668A EP2918663A1 EP 2918663 A1 EP2918663 A1 EP 2918663A1 EP 15156668 A EP15156668 A EP 15156668A EP 2918663 A1 EP2918663 A1 EP 2918663A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cleaning
- acid
- weight
- concentrate
- cleaning agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/662—Carbohydrates or derivatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/36—Organic compounds containing phosphorus
- C11D3/361—Phosphonates, phosphinates or phosphonites
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3719—Polyamides or polyimides
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
Definitions
- the invention relates to an aqueous cleaning agent concentrate containing alkylpolyglucoside, complexing agent and enzyme and the use for cleaning medical devices and instruments, in particular endoscopes, and surfaces in medical facilities, with removal of body secretions, Schleimsanschmutzache, Blutanschmutzache and biofilms.
- detergents are often used which are equipped with a cleaning performance for proteins, fats or medical stains.
- the cleaners are used for cleaning medical instruments and medical devices, such as surgical instruments.
- the purpose of cleaning is to remove any adhering blood, body secretions and mucus stains on the surfaces before disinfecting.
- mucus contaminants are biopolymers consisting predominantly of polysaccharides.
- Polysaccharides consist of monosaccharide units linked by a glycosidic linkage.
- Muco-polysaccharides which contain not only simple sugars but also amino sugars and uronic acids, such as, for example, hyaluronic acid or heparin, can be found in the human body in mucilages. In cold water, they are difficult or partially insoluble ( Römpp Lexikon, Biotechnology, 1992, Georg Thieme Verlag, keyword Polysacchari de). When taking up water, therefore, slime-like colloids and gels are formed, which serve as protective substances (body slimes) in the body and protect against dehydration and abrasion. The removal of these Schleimanschmutzieux of the surfaces of medical devices and instruments is particularly difficult due to the low or lack of water solubility. Polysaccharides and mucilage are additionally crosslinked by calcium ions. This reduces the solubility in water.
- the body secretions are also based on polysaccharides bound with proteins, such as glycoproteins. These include e.g. Serum proteins, plasma proteins and mucoproteins.
- proteins such as glycoproteins. These include e.g. Serum proteins, plasma proteins and mucoproteins.
- the body secretions include saliva, gastric juice and mucus on the mucous membranes.
- the cleaning of medical instruments and devices is done manually, semi-automatically or fully automatically. Products suitable for manual cleaning can also be used in semi-automatic cleaning processes.
- EP 1 126 013 B2 is the use of liquid detergents which contain at least one nonionic surfactant and pyrrolidonecarboxylic acid, for the purification of, for example. Endoscopes by removal of X-ray contrast agents. It is described that enzyme-containing cleaners are problematic for occupational safety reasons, since these are classified as sensitizing substances and, accordingly, harmful to health.
- WO 01/76647 A1 describes a method for cleaning medical instruments, esp. Endoscopes, by immersion in an enzyme-containing solution.
- an enzyme-containing solution As a particularly suitable enzyme Subtilisin is used, which is stabilized with boron compounds.
- the surfactants used are nonionic surfactants, such as ethoxylates and propoxylates. These surfactants have the disadvantage that they are derived from petroleum and are therefore based on an expensive and limited available raw material.
- EP-1313832-B1 describes enzymatic cleaning systems for medical instruments.
- the aqueous compositions contain alkylpyrrolidone, C8 to C18 alkyl polysaccharides and enzymes. It is called a mixture of the enzymes amylase, protease and lipase.
- alkylpolysaccharides have the disadvantage that they are known as foaming surfactants and therefore can not be used in all cleaning processes.
- the object of the present invention is thus to provide a cleaning agent which is effective against stubborn Schleimanschmutzungen and Whysekrete based on polysaccharides and blood and biofilms and removes them in the cleaning process. As a result, a subsequent disinfection should be effective and sufficient treatment can be ensured.
- the cleaning agent is advantageously designed low foaming.
- the object is achieved by the use of the cleaning agent according to the invention for the removal of Schleimanschmutzache and Whysekreten based on polysaccharides, Blutanschmutzache and biofilms of inanimate surfaces.
- a cleaning agent is both the cleaning agent concentrate and the ready-to-use application solution.
- the application solution prepared from the concentrate is used for cleaning.
- the cleaning agent concentrate can also be used undiluted for cleaning, e.g. for stubborn dirt.
- a cleaning agent according to the invention is understood to mean both the cleaning agent concentrate according to the invention and the application solution according to the invention.
- Schleimanschmutz Institute biopolymers which consist predominantly of polysaccharides understood. These are predominantly mucilaginous substances such as muco-polysaccharides found in the human body.
- the Schleimanschmutzitch for example, come from the study or treatment of the gastric mucosa, the intestinal mucosa, the nasal mucosa or the bronchial mucosa. This body slime remains on the instruments and equipment back, which then has to be removed for treatment.
- Body secretions are polysaccharide-based molecules, especially those linked to proteins, such as glycoproteins.
- the body secretions include e.g. Saliva, bile, urine, pus or mucus on the mucous membranes.
- Biofilms also consist of a mucous layer. However, this mucus layer is formed by microorganisms. In it are microorganisms, e.g. Bacteria, algae, fungi, protozoa, embedded. Extracellular polymeric substances (EPS) excreted by the microorganisms form hydrogels in combination with water to form a mucilaginous matrix in which nutrients (for the bacteria) and other substances are dissolved. Often the matrix also traps inorganic particles or gas bubbles.
- the EPS consists of biopolymers, which are a wide range of polysaccharides, proteins, lipids and nucleic acids.
- alkyl polyglucosides are used as the nonionic surfactant.
- Alkyl polyglucosides (alkyl polyglycosides, APG) are also known as sugar surfactants designated. They are formed by reacting glucose with a fatty alcohol, whereby the glucose molecule is linked to the fatty alcohol via a glycosidic bond.
- Alkyl polyglucosides are nonionic surfactants made from up to 100% renewable raw materials. They offer special mildness and cleaning properties and are compatible with various surfactants. They have an excellent ecotoxicological profile and good biodegradability.
- Suitable fatty alcohols are fatty alcohols derived from natural fats and oils, such as coconut oil.
- alkylpolyglucosides which are used in the cleaning agent according to the invention are preferably selected from the group consisting of C4-alkylpolyglucoside, C6-alkylpolyglucoside, decylglucoside (C10-alkylpolyglucoside), cocoglucoside (C8-C18-alkylpolyglucoside), caprylyl / decylglucoside (C8-C10- Alkyl polyglucoside), lauryl glucoside (C 12 alkyl polyglucoside), C 8 -C 14 alkyl polyglucoside, C 12 -C 14 alkyl polyglucoside and C 8 -C 16 alkyl polyglucoside.
- Suitable products are for example Plantacare ® 2000 UP (decyl glucoside), Plantacare ® 810 UP (((Caprylyl / Decylglucoside, alkylpolyglucoside C8-C10), Plantacare ® 818 UP cocoglucoside, alkylpolyglucoside C8-C18), Plantacare ® 1200 UP (lauryl), Glucopon ® 215 UP (Caprylyl / Decylglucoside, alkylpolyglucoside C8-C10), Glucopon ® 225 DK (C8-10 alkyl polyglucoside), Glucopon ® 425 N / HH (C8-C14 polyglucoside) Glucopon ® 600 CS UP (C12-C14 alkyl polyglucoside), Glucopon ® 650 EC (alkyl polyglucoside C8-C14), Triton CG-4N ((alkyl polyglucoside
- the complexing agent is preferably biodegradable and is preferably selected from the group consisting of N- (1,2-dicarboxyethyl) aspartic acid (iminodisuccinic acid), polyaspartic acid, methylglycinediacetic acid, glutamic acid-N, N-diacetic acid, ethylenediamine di-succinate, ethylenediaminetetraacetic acid, nitrilotriacetic acid , Diethylenetriaminepentaacetic acid, Hydroxyethane-1,1-diphosphonic acid and disodium ethanoldiglycinate.
- the tri - or tetrasalts can be selected as complex images.
- the complex image is particularly preferably selected from the group consisting of iminodisuccinate tetrasodium salt, sodium salt of polyaspartic acid, trisodium methylglycine diacetic acid, tetra sodium salt of glutamic acid N, N-diacetic acid, tri-sodium-ethylenediamine di-succinate.
- Suitable products include Baypure ® DS 100/40, Baypure ® CX, Dissolvine ® GL-38, Natrlquest ® E 30 and Dissolvine ® GL-47.
- complexing agents are, for example, Trilon M (methylglycinediacetic acid or the metal salt), Trilon B, dissolvine NA (sodium salt of ethylenediaminetetraacetic acid), Trilon A, dissolvine A-40 (salt of nitrilotriacetic acid), Trilon C, dissolvine D-40 (salt of Diethylenetriaminepentaacetic acid), sequence 10H60 (salt of hydroxyethane-1,1-diphosphonic acid) and dissolvine EDG (disodium ethanoldiglycinate).
- the complexing agent is preferably present in the detergent concentrate according to the invention to 0.5 to 10 wt .-%, particularly preferably 1 to 5 wt .-%.
- the aqueous cleaning agent concentrate according to the invention contains at least one enzyme.
- the enzyme is selected from the group consisting of protease, amylase, lipase, cellulase and mixtures thereof.
- the cleaning agent according to the invention preferably contains only proteases and no further enzymes.
- suitable products are e.g. Savinase 16L or Savinase Ultra 16 L.
- the enzyme in the detergent concentrate is preferably from 0.05 to 10% by weight, more preferably from 0.1 to 5% by weight, more preferably from 0.1 to 1% by weight, most preferably 0.2 to 0.6 wt .-% included.
- the protease is able to split off the protein components contained in the stains, so that the stains can then be removed by the surfactant.
- the APGs, the complexing agent and the enzyme can be combined with each other in any number of quantitative ranges.
- the detergent concentrate according to the invention consists of 0.1 to 25 wt .-%, preferably 2 to 15 wt .-%, particularly preferably 5 to 10 wt .-% of the alkyl polyglucosides having a chain length of 4 to 18 carbon atoms, preferably 8 to 18 carbon atoms, From 0.1 to 15% by weight, preferably from 1 to 10% by weight, particularly preferably from 2 to 6% by weight, of the complexing agents, 0.1 to 5 wt .-%, preferably 0.1 to 1 wt .-%, particularly preferably 0.2 to 0.6 wt of the enzyme protease and From 0.5 to 15% by weight of auxiliaries and water, based on the detergent concentrate wherein the components to 100 wt .-% complement.
- each of the mentioned concentration ranges of the components can be combined with any other concentration range.
- the cleaning agent concentrate according to the invention can be converted into an application solution.
- the ready-to-use application solution preferably contains 0.1 to 20% by weight, more preferably 0.1 to 10% by weight, particularly preferably 1 to 5% by weight, of the detergent concentrate.
- the concentrate is diluted with water accordingly.
- the cleaning agent according to the invention is preferably used for the cleaning of surfaces of medical devices and medical instruments, in particular for the removal of body secretions and Schleimsanschmutzungen based on polysaccharides and blood, especially fibrin, and for the removal of such soiling of surfaces in medical facilities.
- the cleaning agent of the invention is more preferably used to remove biofilms from the surfaces of medical devices and medical instruments and to remove biofilms from the surfaces in medical facilities.
- the cleaning agent according to the invention can also be used for the simultaneous removal of on the one hand thoroughlysekreten and Schleimanschmutzache and blood and on the other hand biofilms.
- the cleaning agent according to the invention is particularly preferably used for the purification of thermolabile and thermostable medical instruments.
- the preferred use of the cleaning agent according to the invention is the removal of the body secretions, Schleimanschmutzache and Blutanschmutzungen and biofilms of endoscopes.
- Inanimate surfaces in medical facilities mean all surfaces on furniture and furnishings, as well as in the building itself.
- these include the surfaces of tables, cabinets, handles, but also floor coverings or walls.
- the detergents according to the invention can be used both for manual cleaning and in semi-automatic cleaning processes.
- semi-automatic cleaning they may e.g. in semiautomatic machines with basins with circulating cleaning fluid.
- the cleaning solutions foam little. They can therefore also be used in semi-automatic machines.
- cleaning agent of the invention can be used because of the low foaming. With a strong foaming this would not be possible due to the risk of injury.
- the cleaning of medical devices and medical instruments is usually carried out as dip cleaning or flushing, in which the objects to be cleaned are partially or completely immersed in the cleaning solution or rinsed with this.
- the cleaning of inanimate surfaces in medical facilities is usually done as a wipe cleaning.
- the cleaning agents according to the invention are particularly preferably used for cleaning endoscopes.
- Endoscopes can be prepared manually in a disinfection tank.
- endoscopes can also be processed in the circulation process (semi-automatic).
- Semiautomatic devices obtain their cleaning and disinfecting solution by dilution of the concentrate with dilution water and circulate this solution.
- the circulation can also be effected by appropriate connections via the individual endoscope channels. Then it is rinsed with water. But it can always be done only one step, either cleaning or disinfection. Older semiautomatic devices obtain their cleaning, disinfecting and rinsing solutions from tanks into which the liquids mentioned are recirculated.
- the cleaning agents according to the invention are particularly preferably used for manual or semi-automatic cleaning of endoscopes.
- the cleaning agent according to the invention triggers even at low temperatures and persistent contaminants, such as Wegsekrete and Schleimanschmutzieux, automatically from. Due to the low temperature and the composition of the cleaning agent, the cleaning is gentle and particularly well suited for thermolabile devices.
- the cleaning agent according to the invention thus has the advantage that it has a special cleaning performance in Schleimanschmutzungen (polysaccharides) and other difficult to remove secretions. Polysaccharides are hardened by calcium ions in the water and solidified and thus difficult to remove. It has been shown that binding of the lime contained in the water takes place in good time by the complexing agent contained in the cleaning agent according to the invention and the lime does not influence the cleaning action of the enzyme.
- composition preferably contains pyrrolidonecarboxylic acid or its sodium salt as auxiliaries, corrosion inhibitors, for example 1,2,3-benzotriazole, pH regulators, for example acetic acid, preservatives, for example hemiacetals and isothiazolinones.
- auxiliaries which are less preferred according to the invention are foam regulators, dispersants, solvents, dyes, perfume.
- the cleaning agent concentrate according to the invention contains the adjuvant pyrrolidonecarboxylic acid or its sodium salt, preferably at 0.1-5% by weight, more preferably at 0.5-2% by weight, based on the cleaning agent concentrate.
- the detergent concentrate according to the invention is composed as follows: Wt .-% connection ad 100 Water (INN) 5-10 Caprylyl / decyl glucoside 0.1-2 Sodium PCA (INCI) 0.1-0.5 1,2,3-benzotriazole 1-5 Polyaspartic acid, Na salt 0.2-0.6 Protease (subtilisin) 0.05-0.1 Hemiacetals and isothiazolinones 0.1-0.2 Acetic acid (DAB)
- the test of the cleaning agent according to the invention was carried out by vertical immersion of the soiled test specimens in 100 ml of the corresponding application solution for 15 minutes in order to test the self-cleaning performance of the product and thereby exclude the mechanical cleaning component.
- the experiments were carried out at room temperature in water of standardized hardness (17 ° dH). Since the enzymatic cleaning performance slows down at room temperature, the time to complete dissolution of the fibrin layer was extended in a dipping experiment. This test was used to detect an existing enzyme activity.
- the initial load of the control bodies was chosen as a reference (100%) and the biofilm residue loads as mean and standard deviations.
- a detergent concentrate was prepared from the ingredients listed in Table 1.
- Table 1 Composition of detergent concentrates according to the invention in% by weight example 1
- Example 2 Wt .-% Wt .-%
- composition according to Table 1 had a pH of 8-8.5.
- the detergent concentrate according to Table 1 was tested for its effectiveness against polysaccharides, proteins and biofilms in comparison to solutions of the comparison components according to Table 2 in polysaccharides and proteins.
- Table 2 Composition of the comparison concentrates in% by weight Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Wt .-% Wt .-% Wt .-% Wt .-% Decyl glucoside 1 6.3 6.3 - - Cocoglucoside 2 - - 6.3 6.3 Na salt of polyaspartic acid 3 2 2 4 protease - - - - pyrrolidone 1 1 1 1 benzotriazole 0.4 0.4 0.4 0.4 0.4 0.4 acetic acid 0.1 0.1 0.1 0.1 Hemiacetals and isothiazolinones 4 0.1 0.1 0.1 0.1 0.1 water Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 Ad 100 1 Plantacare
- the cleaning agent according to the invention has an excellent cleaning performance, both in the detachment of blood, as well as mucus, which is not achieved only by the surfactant or the combination of surfactant and complexing agent.
- Table 4 Purification behavior of aqueous comparative solutions with surfactant (APG) and complexing agent blood mucus 6.3% decylglucoside 1 + 1.7% tetrasodium iminodisuccinate 3 medium bad 6.3% decylglucoside 1 + 3.4% tetrasodium iminodisuccinate 3 medium bad 6.3% cocoglucoside 2 + 1.9% glutamic acid-N, N-diacetic acid, tetra-Na salt 4 bad medium 6.3% cocoglucoside 2 + 3.8% glutamic acid-N, N-diacetic acid, tetra-Na salt 4 bad medium 6.3% cocoglucoside 2 + 2% Na salt of polyaspartic acid 5
- the cleaning agent according to the invention also has an improved cleaning performance compared to other cleaning agents on the market.
- detergents were tested which contain alkyl ethoxylates, ie nonionic, low-foam surfactants, as surfactants.
- Comparative Example 5 is Sekusept ® multienzymes P Ecolab and in Comparative Example 6 to Bodedex ® forte of the company Paul Hartmann.
- the concentration data are the values from the safety data sheets.
- the application of the cleaning agent takes place in all examples at room temperature at about 25 ° C.
- the cleaning agent according to the invention has a good cleaning performance even at room temperature with respect to the non-water-soluble fibrin layer.
- the fibrin layer is completely dissolved by the combination of Example 1 according to the invention after a short time.
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Abstract
Die Erfindung betrifft ein wässriges Reinigungsmittel enthaltend Alkylpolyglucosid, Komplexbildner und Enzym und die Verwendung zur Reinigung von medizinischen Geräten und Instrumenten und an Oberflächen in medizinischen Einrichtungen, insbesondere Endoskopen, unter Entfernung Körpersekreten, Schleimanschmutzungen und Biofilmen. Es hat sich gezeigt, dass sich mit dem erfindungsgemäßen Reinigungsmittel Blut, Schleimanschmutzungen und Körpersekrete auf Basis von Polysacchariden besonders gut entfernen lassen. Gleichzeitig wird auch eine Entfernung von Biofilmen erzielt, so dass die medizinischen Instrumente und Geräte sehr gut für die anschließende Desinfektion aufbereitet sind.The invention relates to an aqueous cleaning agent comprising alkylpolyglucoside, complexing agent and enzyme and the use for cleaning medical devices and instruments and on surfaces in medical facilities, in particular endoscopes, removing body secretions, Schleimanschmutzungen and biofilms. It has been shown that blood, mucous soils and body secretions based on polysaccharides can be removed particularly well with the cleaning agent according to the invention. At the same time a removal of biofilms is achieved, so that the medical instruments and equipment are prepared very well for the subsequent disinfection.
Description
Gegenstand der Erfindung ist ein wässriges Reinigungsmittelkonzentrat, enthaltend Alkylpolyglucosid, Komplexbildner und Enzym und die Verwendung zur Reinigung von medizinischen Geräten und Instrumenten, insbesondere Endoskopen, und an Oberflächen in medizinischen Einrichtungen, unter Entfernung von Körpersekreten, Schleimanschmutzungen, Blutanschmutzungen und Biofilmen.The invention relates to an aqueous cleaning agent concentrate containing alkylpolyglucoside, complexing agent and enzyme and the use for cleaning medical devices and instruments, in particular endoscopes, and surfaces in medical facilities, with removal of body secretions, Schleimsanschmutzungen, Blutanschmutzungen and biofilms.
Zur Reinigung von unbelebten Oberflächen im medizinischen Bereich werden häufig Reinigungsmittel verwendet, die mit einer Reinigungsleistung bei Proteinen, Fetten oder medizinischen Anschmutzungen ausgestattet sind. Die Reiniger werden zur Reinigung von medizinischen Instrumenten und medizinischen Geräten, wie z.B. flexible Endoskope oder Metallinstrumente und allen anderen unbelebten Oberflächen in medizinischen Einrichtungen wie z.B. Kunststoffoberflächen, Tischoberflächen oder Griffen eingesetzt. Die Reinigung dient dazu, an den Oberflächen anhaftendes Blut, Körpersekrete und Schleimanschmutzungen zu beseitigen, bevor die Desinfektion erfolgt.For cleaning of inanimate surfaces in the medical field, detergents are often used which are equipped with a cleaning performance for proteins, fats or medical stains. The cleaners are used for cleaning medical instruments and medical devices, such as surgical instruments. flexible endoscopes or metal instruments and all other inanimate surfaces in medical facilities, e.g. Plastic surfaces, table surfaces or handles used. The purpose of cleaning is to remove any adhering blood, body secretions and mucus stains on the surfaces before disinfecting.
Bei diesen Schleimanschmutzungen handelt es sich um Biopolymere, die vorwiegend aus Polysacchariden bestehen. Polysaccharide bestehen aus Monosaccharideinheiten, die über eine glykosidische Bindung verbunden sind. Im menschlichen Körper sind in Schleimstoffen insbesondere Muco-Polysaccharide zu finden, die neben Einfachzuckern noch Aminozucker und Uronsäuren enthalten, wie z.B. Hyaluronsäure oder Heparin. In kaltem Wasser sind sie nur schwer oder teilweise gar nicht löslich (
Wasser mit Härtebildnern erschwert dadurch die Ablösung von Schleimstoffen von Oberflächen. Die Körpersekrete basieren ebenfalls auf Polysacchariden, die mit Proteinen gebunden sind, wie Glykoproteinen. Hierzu gehören z.B. Serumproteine, Plasmaproteine und Mucoproteine. Zu den Körpersekreten gehören Speichel, Magensaft und der Schleim auf den Schleimhäuten.Water with hardnesses makes it more difficult to detach mucus from surfaces. The body secretions are also based on polysaccharides bound with proteins, such as glycoproteins. These include e.g. Serum proteins, plasma proteins and mucoproteins. The body secretions include saliva, gastric juice and mucus on the mucous membranes.
Die Reinigung von medizinischen Instrumenten und Geräten erfolgt manuell, halbautomatisch oder vollautomatisch. Für die manuelle Reinigung geeignete Produkte können auch in halbautomatischen Reinigungsverfahren verwendet werden.The cleaning of medical instruments and devices is done manually, semi-automatically or fully automatically. Products suitable for manual cleaning can also be used in semi-automatic cleaning processes.
Aus
Auch
Es hat sich gezeigt, dass diese Reiniger häufig bei Schleimanschmutzungen (Polysacchariden), dickflüssigen Körpersekreten und Biofilmen eine nicht ausreichende Reinigungsleistung aufweisen. Nachteil der bekannten Reiniger ist somit, dass bei Anwendung auf Oberflächen, speziell im medizinischen Bereich, die Reinigung nicht ausreichend ist. In diesem Fall verbleiben nach der Reinigung organische Reste auf der Oberfläche, in die Mikroorganismen eingeschlossen sein können. Durch diese nicht entfernte Anschmutzung können Mikroorganismen den Desinfektionsvorgang überleben, so dass eine ausreichende Aufbereitung der Instrumente und Geräte auf Grund der unvollständigen Entfernung der Mikroorganismen nicht gewährleistet ist.It has been shown that these cleaners are not common in mucus soiling (polysaccharides), viscous body secretions and biofilms have sufficient cleaning performance. Disadvantage of the known cleaner is thus that when used on surfaces, especially in the medical field, the cleaning is not sufficient. In this case, after cleaning, organic residues remain on the surface in which microorganisms may be entrapped. By this not removed soiling microorganisms can survive the disinfection process, so that a sufficient treatment of the instruments and equipment due to the incomplete removal of the microorganisms is not guaranteed.
Aufgabe der vorliegenden Erfindung ist es somit, ein Reinigungsmittel bereitzustellen, das wirksam gegen hartnäckige Schleimanschmutzungen und Körpersekrete auf Basis von Polysacchariden und Blut und Biofilme ist und diese im Reinigungsprozess entfernt. Hierdurch soll eine anschließende Desinfektion umfassend wirksam sein und eine ausreichende Aufbereitung gewährleistet werden können. Für die halbautomatischen Reinigung und die manuelle Reinigung von spitzen oder scharfkantigen Instrumenten ist das Reinigungsmittel vorteilhafterweise schaumarm ausgeführt.The object of the present invention is thus to provide a cleaning agent which is effective against stubborn Schleimanschmutzungen and Körpersekrete based on polysaccharides and blood and biofilms and removes them in the cleaning process. As a result, a subsequent disinfection should be effective and sufficient treatment can be ensured. For semi-automatic cleaning and manual cleaning of pointed or sharp-edged instruments, the cleaning agent is advantageously designed low foaming.
Die Aufgabe wird erfindungsgemäß gelöst durch ein wässriges Reinigungsmittelkonzentrat für unbelebte Oberflächen, enthaltend:
- o mindestens ein Alkylpolyglucosid,
- o mindestens einen Komplexbildner,
- o mindestens ein Enzym und
- o Wasser.
- o at least one alkyl polyglucoside,
- o at least one complexing agent,
- o at least one enzyme and
- o water.
Weiterhin wird die Aufgabe gelöst durch die Verwendung des erfindungsgemäßen Reinigungsmittels zur Entfernung von Schleimanschmutzungen und Körpersekreten auf Basis von Polysacchariden, Blutanschmutzungen und Biofilmen von unbelebten Oberflächen.Furthermore, the object is achieved by the use of the cleaning agent according to the invention for the removal of Schleimanschmutzungen and Körpersekreten based on polysaccharides, Blutanschmutzungen and biofilms of inanimate surfaces.
Weitere Ausführungsformen sind Gegenstand der Unteransprüche oder nachfolgend beschrieben.Further embodiments are the subject matter of the subclaims or described below.
Im Sinne der Erfindung ist ein Reinigungsmittel sowohl das Reinigungsmittelkonzentrat als auch die gebrauchsfertige Anwendungslösung. Üblicherweise wird zur Reinigung die aus dem Konzentrat hergestellte Anwendungslösung eingesetzt. Das Reinigungsmittelkonzentrat kann aber auch unverdünnt zur Reinigung verwendet werden, z.B. bei hartnäckigen Verschmutzungen. Unter einem erfindungsgemäßen Reinigungsmittel wird sowohl das erfindungsgemäße Reinigungsmittelkonzentrat als auch die erfindungsgemäße Anwendungslösung verstanden.For the purposes of the invention, a cleaning agent is both the cleaning agent concentrate and the ready-to-use application solution. Usually, the application solution prepared from the concentrate is used for cleaning. The cleaning agent concentrate can also be used undiluted for cleaning, e.g. for stubborn dirt. A cleaning agent according to the invention is understood to mean both the cleaning agent concentrate according to the invention and the application solution according to the invention.
Unter Schleimanschmutzungen werden Biopolymere, die vorwiegend aus Polysacchariden bestehen, verstanden. Dabei handelt es sich hier vorwiegend um Schleimstoffe wie Muco-Polysaccharide, die im menschlichen Körper zu finden sind. Die Schleimanschmutzungen stammen beispielsweise von der Untersuchung oder Behandlung der Magenschleimhaut, der Darmschleimhaut, der Nasenschleimhaut oder der Bronchialschleimhaut. Hierbei bleibt Körperschleim auf den Instrumenten und Geräten zurück, der dann zur Aufbereitung entfernt werden muss.Under Schleimanschmutzungen biopolymers, which consist predominantly of polysaccharides understood. These are predominantly mucilaginous substances such as muco-polysaccharides found in the human body. The Schleimanschmutzungen, for example, come from the study or treatment of the gastric mucosa, the intestinal mucosa, the nasal mucosa or the bronchial mucosa. This body slime remains on the instruments and equipment back, which then has to be removed for treatment.
Als Körpersekrete werden Polysaccharid-basierte Moleküle bezeichnet, besonders solche die mit Proteinen gebunden sind, wie Glykoproteine. Zu den Körpersekreten gehören z.B. Speichel, Gallenflüssigkeit, Urin, Eiter oder der Schleim auf den Schleimhäuten.Body secretions are polysaccharide-based molecules, especially those linked to proteins, such as glycoproteins. The body secretions include e.g. Saliva, bile, urine, pus or mucus on the mucous membranes.
Biofilme bestehen ebenfalls aus einer Schleimschicht. Diese Schleimschicht wird aber von Mikroorganismen gebildet. In ihr sind Mikroorganismen, z.B. Bakterien, Algen, Pilze, Protozoen, eingebettet. Von den Mikroorganismen ausgeschiedene extrazelluläre polymere Substanzen (EPS) bilden in Verbindung mit Wasser Hydrogele, so dass eine schleimartige Matrix entsteht, in der Nährstoffe (für die Bakterien) und andere Substanzen gelöst sind. Oft werden von der Matrix auch anorganische Partikel oder Gasbläschen eingeschlossen. Die EPS bestehen aus Biopolymeren, dabei handelt es sich um ein weites Spektrum von Polysacchariden, Proteinen, Lipiden und Nukleinsäuren.Biofilms also consist of a mucous layer. However, this mucus layer is formed by microorganisms. In it are microorganisms, e.g. Bacteria, algae, fungi, protozoa, embedded. Extracellular polymeric substances (EPS) excreted by the microorganisms form hydrogels in combination with water to form a mucilaginous matrix in which nutrients (for the bacteria) and other substances are dissolved. Often the matrix also traps inorganic particles or gas bubbles. The EPS consists of biopolymers, which are a wide range of polysaccharides, proteins, lipids and nucleic acids.
Erfindungsgemäß werden als nichtionisches Tensid Alkylpolyglucoside eingesetzt. Alkylpolyglucoside (Alkylpolyglykoside, APG) werden auch als Zuckertenside bezeichnet. Sie entstehen durch Umsetzung von Glucose mit einem Fettalkohol, wobei das Glucosemolekül über eine glykosidische Bindung mit dem Fettalkohol verbunden wird. Alkylpolyglucoside sind nichtionische Tenside, die aus bis zu 100% nachwachsenden Rohstoffen hergestellt werden. Sie bieten besondere Milde und Reinigungseigenschaften und sind kompatibel mit verschiedenen Tensiden. Sie besitzen ein ausgezeichnetes ökotoxikologisches Profil und eine gute biologische Abbaubarkeit. Als geeignete Fettalkohole werden aus natürlichen Fetten und Ölen gewonnene Fettalkohole, wie Kokosöl, eingesetzt.According to the invention, alkyl polyglucosides are used as the nonionic surfactant. Alkyl polyglucosides (alkyl polyglycosides, APG) are also known as sugar surfactants designated. They are formed by reacting glucose with a fatty alcohol, whereby the glucose molecule is linked to the fatty alcohol via a glycosidic bond. Alkyl polyglucosides are nonionic surfactants made from up to 100% renewable raw materials. They offer special mildness and cleaning properties and are compatible with various surfactants. They have an excellent ecotoxicological profile and good biodegradability. Suitable fatty alcohols are fatty alcohols derived from natural fats and oils, such as coconut oil.
Die Alkylpolyglucoside, die im erfindungsgemäßen Reinigungsmittel eingesetzt werden, sind bevorzugt ausgewählt aus der Gruppe bestehend aus C4-Alkylpolyglucosid, C6-Alkylpolyglucosid, Decylglucosid (C10-Alkylpolyglucosid), Cocoglucosid (C8-C18-Alkylpolyglucosid), Caprylyl/ Decylglucoside (C8-C10-Alkylpolyglucosid), Laurylglucosid (C12-Alkylpolyglucosid), C8-C14-Alkylpolyglucosid, C12-C14-Alkylpolyglucosid und C8-C16-Alkylpolyglucosid. Geeignete Produkte sind beispielsweise Plantacare® 2000 UP (Decylglucosid), Plantacare® 810 UP ((Caprylyl/ Decylglucoside, Alkylpolyglucosid C8-C10), Plantacare® 818 UP (Cocoglucosid, Alkylpolyglucosid C8-C18), Plantacare® 1200 UP (Laurylglucosid), Glucopon® 215 UP (Caprylyl/ Decylglucoside, Alkylpolyglucosid C8-C10), Glucopon® 225 DK (Alkylpolyglucosid C8-10), Glucopon® 425 N/HH (Alkylpolyglucosid C8-C14) Glucopon® 600 CS UP (Alkylpolyglucosid C12-C14), Glucopon® 650 EC (Alkylpolyglucosid C8-C14), Triton CG-4N ((Alkylpolyglucosid C4), FC 4 (C4-Alkylpolyglucosid, Butylglucosid), FC 6 (C6-Alkylpolyglucosid, Hexylglucosid), Triton BG-10 (Alkylpolyglucosid C8-C10) und Triton CG 650 ((Alkylpolyglucosid C8-C16) . Das Alkylpolyglucosid ist im erfindungsgemäßen Reinigungsmittelkonzentrat bevorzugt zu 1 bis 25 Gew.-%, weiter bevorzugt 2 bis 15 Gew.-%, besonders bevorzugt 5 bis 10 Gew.-% und insbesondere bevorzugt zu 7 bis 8 Gew.-% enthalten.The alkylpolyglucosides which are used in the cleaning agent according to the invention are preferably selected from the group consisting of C4-alkylpolyglucoside, C6-alkylpolyglucoside, decylglucoside (C10-alkylpolyglucoside), cocoglucoside (C8-C18-alkylpolyglucoside), caprylyl / decylglucoside (C8-C10- Alkyl polyglucoside), lauryl glucoside (C 12 alkyl polyglucoside), C 8 -C 14 alkyl polyglucoside, C 12 -C 14 alkyl polyglucoside and C 8 -C 16 alkyl polyglucoside. Suitable products are for example Plantacare ® 2000 UP (decyl glucoside), Plantacare ® 810 UP (((Caprylyl / Decylglucoside, alkylpolyglucoside C8-C10), Plantacare ® 818 UP cocoglucoside, alkylpolyglucoside C8-C18), Plantacare ® 1200 UP (lauryl), Glucopon ® 215 UP (Caprylyl / Decylglucoside, alkylpolyglucoside C8-C10), Glucopon ® 225 DK (C8-10 alkyl polyglucoside), Glucopon ® 425 N / HH (C8-C14 polyglucoside) Glucopon ® 600 CS UP (C12-C14 alkyl polyglucoside), Glucopon ® 650 EC (alkyl polyglucoside C8-C14), Triton CG-4N ((alkyl polyglucoside C4), FC4 (C4 alkyl polyglucoside, butyl glucoside), FC6 (C6 alkyl polyglucoside, hexyl glucoside), Triton BG-10 (alkyl polyglucoside C8-C10) and Triton CG 650 ((alkyl polyglucoside C8-C16).) The alkyl polyglucoside is preferably in the detergent concentrate according to the invention to 1 to 25 wt .-%, more preferably 2 to 15 wt .-%, particularly preferably 5 to 10 wt .-% and particularly preferred to 7 to 8 wt .-% included.
Der Komplexbildner ist bevorzugt biologisch abbaubar und ist bevorzugt ausgewählt aus der Gruppe bestehend aus N-(1,2-Dicarboxyethyl)asparaginsäure (Iminodibernsteinsäure), Polyasparaginsäure, Methylglycindiessigsäure, Glutaminsäure-N,N-diessigsäure, Ethylendiamin-di-Succinat, Ethylendiamintetraessigsäure, Nitrilotriessigsäure, Diethylentriaminpentaessigsäure, Hydroxyethan-1,1-Diphosphonsäure und Dinatrium-Ethanoldiglycinat. Neben den genannten freien Säuren können auch deren Natrium- und Kaliumsalze, z.B. die Tri - oder Tetrasalze als Komplexbilder ausgewählt werden. Besonders bevorzugt ist der Komplexbilder ausgewählt aus der Gruppe bestehend aus Iminodisuccinat-Tetranatriumsalz, Natriumsalz der Polyasparaginsäure, tri-Natrium-Methyglycindiessigsäure, tetra-Natriumsalz der Glutaminsäure-N,N-diessigsäure, tri-Natrium-Ethylendiamin-di-Succinat. Geeignete Produkte sind beispielsweise Baypure® DS 100/40, Baypure® CX, Dissolvine® GL-38, Natrlquest® E 30 und Dissolvine® GL-47. Weitere geeignete Komplexbildner sind z.B. Trilon M (Methylglycindiessigsäure, bzw. das Metallsalz), Trilon B, Dissolvine NA (Natriumsalz der Ethylendiamintetraessigsäure), Trilon A, Dissolvine A-40 (Salz der Nitrilotriessigsäure), Trilon C, Dissolvine D-40 (Salz der Diethylentriaminpentaessigsäure), Sequion 10H60 (Salz der Hydroxyethan-1,1-Diphosphonsäure) und Dissolvine EDG (Dinatrium-Ethanoldiglycinat). Der Komplexbildner ist im erfindungsgemäßen Reinigungsmittelkonzentrat bevorzugt zu 0,5 bis 10 Gew.-%, besonders bevorzugt 1 bis 5 Gew.-% enthalten.The complexing agent is preferably biodegradable and is preferably selected from the group consisting of N- (1,2-dicarboxyethyl) aspartic acid (iminodisuccinic acid), polyaspartic acid, methylglycinediacetic acid, glutamic acid-N, N-diacetic acid, ethylenediamine di-succinate, ethylenediaminetetraacetic acid, nitrilotriacetic acid , Diethylenetriaminepentaacetic acid, Hydroxyethane-1,1-diphosphonic acid and disodium ethanoldiglycinate. In addition to the said free acids and their sodium and potassium salts, for example, the tri - or tetrasalts can be selected as complex images. The complex image is particularly preferably selected from the group consisting of iminodisuccinate tetrasodium salt, sodium salt of polyaspartic acid, trisodium methylglycine diacetic acid, tetra sodium salt of glutamic acid N, N-diacetic acid, tri-sodium-ethylenediamine di-succinate. Suitable products include Baypure ® DS 100/40, Baypure ® CX, Dissolvine ® GL-38, Natrlquest ® E 30 and Dissolvine ® GL-47. Further suitable complexing agents are, for example, Trilon M (methylglycinediacetic acid or the metal salt), Trilon B, dissolvine NA (sodium salt of ethylenediaminetetraacetic acid), Trilon A, dissolvine A-40 (salt of nitrilotriacetic acid), Trilon C, dissolvine D-40 (salt of Diethylenetriaminepentaacetic acid), sequence 10H60 (salt of hydroxyethane-1,1-diphosphonic acid) and dissolvine EDG (disodium ethanoldiglycinate). The complexing agent is preferably present in the detergent concentrate according to the invention to 0.5 to 10 wt .-%, particularly preferably 1 to 5 wt .-%.
Das erfindungsgemäße wässrige Reinigungsmittelkonzentrat enthält mindestens ein Enzym. Bevorzugt ist das Enzym ausgewählt aus der Gruppe bestehend aus Protease, Amylase, Lipase, Cellulase und Mischungen hiervon. Bevorzugt enthält das erfindungsgemäße Reinigungsmittel nur Proteasen und keine weiteren Enzyme. Wenn Protease als einziges Enzym im Reinigungsmittel eingesetzt wird, sind geeignete Produkte z.B. Savinase 16L oder Savinase Ultra 16 L. Das Enzym ist im Reinigungsmittelkonzentrat bevorzugt zu 0,05 bis 10 Gew.-%, weiter bevorzugt 0,1 bis 5 Gew.-%, weiter bevorzugt 0,1 bis 1 Gew.%, besonders bevorzugt 0,2 bis 0,6 Gew.-% enthalten. Die Protease ist in der Lage, die in den Anschmutzungen enthaltenen Proteinanteile abzuspalten, so dass die Anschmutzungen dann durch das Tensid abgelöst werden können.The aqueous cleaning agent concentrate according to the invention contains at least one enzyme. Preferably, the enzyme is selected from the group consisting of protease, amylase, lipase, cellulase and mixtures thereof. The cleaning agent according to the invention preferably contains only proteases and no further enzymes. When protease is used as the only enzyme in the detergent, suitable products are e.g. Savinase 16L or Savinase Ultra 16 L. The enzyme in the detergent concentrate is preferably from 0.05 to 10% by weight, more preferably from 0.1 to 5% by weight, more preferably from 0.1 to 1% by weight, most preferably 0.2 to 0.6 wt .-% included. The protease is able to split off the protein components contained in the stains, so that the stains can then be removed by the surfactant.
Das erfindungsgemäße Reinigungsmittelkonzentrat enthält bevorzugt
- 0,1 bis 40 Gew.-%, besonders bevorzugt 1 bis 25 Gew.-% mindestens eines Alkylpolyglucosides mit einer Kettenlänge der Alkylkette mit 4 bis 18 Kohlenstoffatomen; bevorzugt 8 bis 18 Kohlenstoffatomen,
- 0,1 bis 15 Gew.-% mindestens eines Komplexbildners,
- 0,1 bis 10 Gew.-%, bevorzugt 0,1 bis 5 Gew.-% mindestens eines Enzyms, bevorzugt einer Protease, und
- Wasser
- 0.1 to 40 wt .-%, particularly preferably 1 to 25 wt .-% of at least one Alkylpolyglucosides having a chain length of the alkyl chain having 4 to 18 carbon atoms; preferably 8 to 18 carbon atoms,
- 0.1 to 15% by weight of at least one complexing agent,
- 0.1 to 10 wt .-%, preferably 0.1 to 5 wt .-% of at least one enzyme, preferably a protease, and
- water
Besonders bevorzugt enthält das erfindungsgemäße Reinigungsmittelkonzentrat
- 2 bis 15 Gew.-%, bevorzugt 5 bis 10 Gew.-% der Alkylpolyglucoside,
- 1 bis 10 Gew.-%, bevorzugt 2 bis 6 Gew.-% des Komplexbildners,
- 0,1 bis 1 Gew.%, bevorzugt 0,2 bis 0,6 Gew.-% des Enzyms Protease und
- Wasser
- From 2 to 15% by weight, preferably from 5 to 10% by weight, of the alkylpolyglucosides,
- 1 to 10 wt .-%, preferably 2 to 6 wt .-% of the complexing agent,
- 0.1 to 1 wt.%, Preferably 0.2 to 0.6 wt .-% of the enzyme protease and
- water
Die APGs, der Komplexbildner und das Enzym können in allen genannten Mengenbereichen beliebig miteinander kombiniert werden.The APGs, the complexing agent and the enzyme can be combined with each other in any number of quantitative ranges.
In einer bevorzugten Ausführungsform besteht das erfindungsgemäße Reinigungsmittelkonzentrat aus
0,1 bis 25 Gew.-%, bevorzugt 2 bis 15 Gew.-%, besonders bevorzugt 5 bis 10 Gew.-% der Alkylpolyglucoside mit einer Kettenlänge mit 4 bis 18 Kohlenstoffatomen, bevorzugt 8 bis 18 Kohlenstoffatomen,
0,1 bis 15 Gew.-%, bevorzugt 1 bis 10 Gew.-%, besonders bevorzugt 2 bis 6 Gew.-% der Komplexbildner,
0,1 bis 5 Gew.-%, bevorzugt 0,1 bis 1 Gew.-%, besonders bevorzugt 0,2 bis 0,6 Gew des Enzym Protease und
0,5 bis 15 Gew.-% Hilfsstoffe und Wasser,
bezogen auf das Reinigungsmittelkonzentrat wobei sich die Komponenten zu 100 Gew.-% ergänzen. Dabei kann jeder der genannten Konzentrationsbereiche der Komponenten mit jedem anderen Konzentrationsbereich kombiniert werden.In a preferred embodiment, the detergent concentrate according to the invention consists of
0.1 to 25 wt .-%, preferably 2 to 15 wt .-%, particularly preferably 5 to 10 wt .-% of the alkyl polyglucosides having a chain length of 4 to 18 carbon atoms, preferably 8 to 18 carbon atoms,
From 0.1 to 15% by weight, preferably from 1 to 10% by weight, particularly preferably from 2 to 6% by weight, of the complexing agents,
0.1 to 5 wt .-%, preferably 0.1 to 1 wt .-%, particularly preferably 0.2 to 0.6 wt of the enzyme protease and
From 0.5 to 15% by weight of auxiliaries and water,
based on the detergent concentrate wherein the components to 100 wt .-% complement. In this case, each of the mentioned concentration ranges of the components can be combined with any other concentration range.
Das erfindungsgemäße Reinigungsmittelkonzentrat kann in eine Anwendungslösung übergeführt werden. Die gebrauchsfertige Anwendungslösung enthält bevorzugt 0,1 bis 20 Gew-%, weiter bevorzugt 0,1 bis 10 Gew.-%, besonders bevorzugt 1 bis 5 Gew.-% des Reinigungsmittelkonzentrats. Zur Herstellung der erfindungsgemäßen Anwendungslösung aus dem erfindungsgemäßen Reinigungsmittelkonzentrat wird das Konzentrat entsprechend mit Wasser verdünnt.The cleaning agent concentrate according to the invention can be converted into an application solution. The ready-to-use application solution preferably contains 0.1 to 20% by weight, more preferably 0.1 to 10% by weight, particularly preferably 1 to 5% by weight, of the detergent concentrate. For the preparation of the invention Application solution from the detergent concentrate according to the invention, the concentrate is diluted with water accordingly.
Bevorzugt wird die Entfernung der Körpersekrete (Polysaccharide), Schleimanschmutzungen (Polysaccharide), Blutanschmutzungen einschließlich Fibrin, sowie Biofilme mit dem erfindungsmäßen Reinigungsmittel und die Verwendung des Reinigungsmittels bei Temperaturen zwischen 10 und 40°C, bevorzugt 15 und 30 °C, weiter bevorzugt 18 bis 26 °C, besonders bevorzugt Raumtemperatur (20 - 25 °C) durchgeführt.Preference is given to the removal of the body secretions (polysaccharides), Schleimanschmutzungen (polysaccharides), Blutanschmutzungen including fibrin, and biofilms with the erfindungsmäßen cleaning agent and the use of the cleaning agent at temperatures between 10 and 40 ° C, preferably 15 and 30 ° C, more preferably 18 to 26 ° C, more preferably room temperature (20 - 25 ° C) carried out.
Das erfindungsgemäße Reinigungsmittel wird bevorzugt zur Reinigung von Oberflächen medizinischer Geräte und medizinischen Instrumenten, insbesondere zur Entfernung von Körpersekreten und Schleimanschmutzungen auf Basis von Polysacchariden und Blut, insbesondere Fibrin, und zur Entfernung von derartigen Anschmutzungen von Oberflächen in medizinischen Einrichtungen verwendet. Das erfindungsgemäße Reinigungsmittel wird weiter bevorzugt zur Entfernung von Biofilmen von den Oberflächen medizinischer Geräte und medizinischer Instrumente und zur Entfernung von Biofilmen von den Oberflächen in medizinischen Einrichtungen verwendet. Das erfindungsgemäße Reinigungsmittel kann auch zur gleichzeitigen Entfernung von einerseits Körpersekreten und Schleimanschmutzungen und Blut und andererseits Biofilmen verwendet werden.The cleaning agent according to the invention is preferably used for the cleaning of surfaces of medical devices and medical instruments, in particular for the removal of body secretions and Schleimsanschmutzungen based on polysaccharides and blood, especially fibrin, and for the removal of such soiling of surfaces in medical facilities. The cleaning agent of the invention is more preferably used to remove biofilms from the surfaces of medical devices and medical instruments and to remove biofilms from the surfaces in medical facilities. The cleaning agent according to the invention can also be used for the simultaneous removal of on the one hand Körpersekreten and Schleimanschmutzungen and blood and on the other hand biofilms.
Besonders bevorzugt wird das erfindungsgemäße Reinigungsmittel zur Reinigung von thermolabilen und thermostabilen medizinischen Instrumenten verwendet. Die bevorzugte Verwendung des erfindungsgemäßen Reinigungsmittels ist die Entfernung der Körpersekrete, Schleimanschmutzungen und Blutanschmutzungen sowie der Biofilme von Endoskopen.The cleaning agent according to the invention is particularly preferably used for the purification of thermolabile and thermostable medical instruments. The preferred use of the cleaning agent according to the invention is the removal of the body secretions, Schleimanschmutzungen and Blutanschmutzungen and biofilms of endoscopes.
Unter unbelebte Oberflächen in medizinischen Einrichtungen sind dabei alle Oberflächen an Möbeln und Einrichtungsgegenständen, sowie im Gebäude selbst zu verstehen. Beispielweise gehören hierzu die Oberflächen von Tischen, Schränken, Griffen, aber auch Fußbodenbeläge oder Wände.Inanimate surfaces in medical facilities mean all surfaces on furniture and furnishings, as well as in the building itself. For example, these include the surfaces of tables, cabinets, handles, but also floor coverings or walls.
Die erfindungsgemäßen Reinigungsmittel können sowohl für die manuelle Reinigung als auch in halbautomatischen Reinigungsverfahren verwendet werden. Bei der halbautomatischen Reinigung können sie z.B. bei Halbautomaten mit Becken mit zirkulierender Reinigungsflüssigkeit eingesetzt werden. Unerwarteterweise schäumen die Reinigungslösungen trotz Verwendung der Alkylpolyglucoside als Tenside nur wenig. Sie können daher auch in den Halbautomaten eingesetzt werden. Auch für die manuelle Reinigung von spitzen oder scharfkantigen Geräten und Instrumenten kann das erfindungsgemäße Reinigungsmittel wegen der geringen Schaumentwicklung eingesetzt werden. Bei einer starken Schaumbildung wäre dieses aufgrund der Verletzungsgefahr nicht möglich.The detergents according to the invention can be used both for manual cleaning and in semi-automatic cleaning processes. In semi-automatic cleaning, they may e.g. in semiautomatic machines with basins with circulating cleaning fluid. Unexpectedly, despite the use of the alkyl polyglucosides as surfactants, the cleaning solutions foam little. They can therefore also be used in semi-automatic machines. Also for the manual cleaning of sharp or sharp-edged devices and instruments cleaning agent of the invention can be used because of the low foaming. With a strong foaming this would not be possible due to the risk of injury.
Die Reinigung von medizinischen Geräten und medizinischen Instrumenten erfolgt üblicherweise als Tauchreinigung oder Spülreinigung, bei der die zu reinigenden Gegenstände teilweise oder vollständig in die Reinigungslösung eingetaucht oder mit dieser gespült werden. Die Reinigung von unbelebten Oberflächen in medizinischen Einrichtungen erfolgt hingegen üblicherweise als Wischreinigung.The cleaning of medical devices and medical instruments is usually carried out as dip cleaning or flushing, in which the objects to be cleaned are partially or completely immersed in the cleaning solution or rinsed with this. The cleaning of inanimate surfaces in medical facilities, however, is usually done as a wipe cleaning.
Die erfindungsgemäßen Reinigungsmittel werden besonders bevorzugt zur Reinigung von Endoskopen verwendet. Endoskope können manuell in einer Desinfektionswanne aufbereitet werden. Neben der manuellen Aufbereitung können Endoskope auch im Zirkulationsverfahren (Halbautomat) aufbereitet werden. Halbautomaten beziehen ihre Reinigungs- und Desinfektionslösung durch Verdünnung des Konzentrates mit Verdünnungswasser und zirkulieren diese Lösung. Die Zirkulation kann auch durch entsprechende Anschlüsse über die einzelnen Endoskopkanäle erfolgen. Anschließend wird mit Wasser gespült. Es kann aber immer nur ein Schritt erfolgen, entweder die Reinigung oder die Desinfektion. Ältere Halbautomaten beziehen ihre Reinigungs-, Desinfektions- und Spül-Lösungen aus Tanks, in die die genannten Flüssigkeiten wieder rezirkuliert werden. Die erfindungsgemäßen Reinigungsmittel werden dabei besonders bevorzugt zur manuellen oder halbautomatischen Reinigung von Endoskopen verwendet.The cleaning agents according to the invention are particularly preferably used for cleaning endoscopes. Endoscopes can be prepared manually in a disinfection tank. In addition to manual reprocessing, endoscopes can also be processed in the circulation process (semi-automatic). Semiautomatic devices obtain their cleaning and disinfecting solution by dilution of the concentrate with dilution water and circulate this solution. The circulation can also be effected by appropriate connections via the individual endoscope channels. Then it is rinsed with water. But it can always be done only one step, either cleaning or disinfection. Older semiautomatic devices obtain their cleaning, disinfecting and rinsing solutions from tanks into which the liquids mentioned are recirculated. The cleaning agents according to the invention are particularly preferably used for manual or semi-automatic cleaning of endoscopes.
Es hat sich gezeigt, dass sich durch das erfindungsgemäße Reinigungsmittel nicht nur Blut sondern auch Polysaccharide, wie in Schleimanschmutzungen, besonders gut entfernen lassen. Es hat sich weiterhin gezeigt, dass sich durch das erfindungsgemäße Reinigungsmittel Proteinanschmutzungen (Körpersekrete) auch besonders gut entfernen lassen. Es hat sich weiterhin gezeigt, dass sich durch das erfindungsgemäße Reinigungsmittel Biofilme auch besonders gut entfernen lassen.It has been found that not only blood but also polysaccharides, as in mucus soils, can be removed particularly well by the cleaning agent according to the invention. It has further been shown that by the Detergents according to the invention also allow protein soiling (body secretions) to be removed particularly well. It has also been found that biofilms can also be removed particularly well by the cleaning agent according to the invention.
Überraschenderweise löst das erfindungsgemäße Reinigungsmittel bereits bei niedrigen Temperaturen auch hartnäckige Kontaminationen, wie Körpersekrete und Schleimanschmutzungen, selbsttätig ab. Durch die geringe Temperatur und die Zusammensetzung des Reinigungsmittels ist die Reinigung schonend und besonders gut auch für thermolabile Geräte geeignet.Surprisingly, the cleaning agent according to the invention triggers even at low temperatures and persistent contaminants, such as Körpersekrete and Schleimanschmutzungen, automatically from. Due to the low temperature and the composition of the cleaning agent, the cleaning is gentle and particularly well suited for thermolabile devices.
Überraschenderweise hat sich gezeigt, dass durch das erfindungsgemäße Reinigungsmittel nicht nur Blutanschmutzungen, sondern auch Fibrinreste bei niedriger Temperatur, wie Raumtemperatur, abgelöst werden.Surprisingly, it has been found that not only blood stains, but also fibrin residues at low temperature, such as room temperature, are removed by the cleaning agent according to the invention.
Durch die sehr gute Reinigung verbleiben keine organischen Reste und keine Biofilme auf der Oberfläche. Hierdurch kann bei der anschließenden Desinfektion eine vollständige Entfernung der Mikroorganismen auf der Oberfläche erfolgen. Die korrekte Aufbereitung der Instrumenten und Geräte wird hierdurch gewährleistet.The very good cleaning leaves no organic residues and no biofilms on the surface. This can be done on the surface in the subsequent disinfection complete removal of the microorganisms. The correct reprocessing of the instruments and equipment is thereby ensured.
Das erfindungsgemäße Reinigungsmittel hat somit den Vorteil, dass es eine besondere Reinigungsleistung bei Schleimanschmutzungen (Polysacchariden) und anderen schwer entfernbaren Sekreten aufweist. Polysaccharide werden durch Calciumionen im Wasser verhärtet und verfestigt und damit schlecht entfernbar. Es hat sich gezeigt, dass durch den im erfindungsgemäßen Reinigungsmittel enthaltenen Komplexbildner rechtzeitig eine Bindung des im Wasser enthalten Kalks erfolgt und der Kalk die Reinigungswirkung des Enzyms nicht beeinflusst.The cleaning agent according to the invention thus has the advantage that it has a special cleaning performance in Schleimanschmutzungen (polysaccharides) and other difficult to remove secretions. Polysaccharides are hardened by calcium ions in the water and solidified and thus difficult to remove. It has been shown that binding of the lime contained in the water takes place in good time by the complexing agent contained in the cleaning agent according to the invention and the lime does not influence the cleaning action of the enzyme.
Weiterhin enthält die Zusammensetzung bevorzugt als Hilfsstoffe Pyrrolidoncarbonsäure oder deren Natriumsalz, Korrosionsinhibitoren, z.B. 1,2,3-Benzotriazol, pH-Regulatoren, z.B. Essigsäure, Konservierungsmittel, z.B. Halbacetale und Isothiazolinone. Weitere Hilfsstoffe, die erfindungsgemäß weniger bevorzugt sind, sind Schaumregulatoren, Dispergiermittel, Lösungsmittel, Farbstoff, Parfüm.Furthermore, the composition preferably contains pyrrolidonecarboxylic acid or its sodium salt as auxiliaries, corrosion inhibitors, for example 1,2,3-benzotriazole, pH regulators, for example acetic acid, preservatives, for example hemiacetals and isothiazolinones. Other auxiliaries which are less preferred according to the invention are foam regulators, dispersants, solvents, dyes, perfume.
Das erfindungsgemäße Reinigungsmittelkonzentrat enthält den Hilfsstoff Pyrrolidoncarbonsäure oder deren Natriumsalz bevorzugt zu 0,1 - 5 Gew.-%, besonders bevorzugt zu 0,5 - 2 Gew.-% bezogen auf das Reinigungsmittelkonzentrat.The cleaning agent concentrate according to the invention contains the adjuvant pyrrolidonecarboxylic acid or its sodium salt, preferably at 0.1-5% by weight, more preferably at 0.5-2% by weight, based on the cleaning agent concentrate.
In einer bevorzugten Ausführungsform ist das erfindungsgemäße Reinigungsmittelkonzentrat wie folgt zusammengesetzt:
Die Polysaccharide stehen hier stellvertretend für Schleimanschmutzungen und Körpersekrete. Sie sind chemisch den Schleimanschmutzungen sehr ähnlich. Die Reinigungsleistung zur Entfernung von Polysacchariden wurde wie folgt getestet:
- a) Methode im manuellen Einlegeverfahren:
Aus den Reinigungsmittelkonzentraten gemäß Beispiel 1 und 2 und gemäß den Vergleichsbeispielen 1 bis 4 wurde jeweils mit Wasser eine 5%ige Anwendungslösung hergestellt. In eine mit 50 ml dieser 5%igen Anwendungslösung gefüllte 50 ml Glasflasche wurde ein Edelstahl- Prüfkörper mit standardisierten Blut-und Polysaccharid-Anschmutzungen (TOSI-FlexiCheck Prüfkörper der Firma PEREG GmbH) gestellt und mit einem Rüttler (Fa. Gerhardt, Typ LS 5, Programm 90) 10 Minuten lang geschüttelt. Danach wurden die Prüfkörper sofort aus der Lösung genommen und zum Trocknen auf Papier gelegt. Die Auswertung erfolgte optisch und wurde mittels Fotos dokumentiert. - b) Methode im halbautomatischen Reinigungsverfahren in der Maschine:
Die Reinigungsleistung im halbautomatischen Endoskopwaschautomaten ( Pauldrach Ecocleaner) wurde ebenfalls mit den TOSI-FlexiCheck Prüfkörpern durchgeführt. Es wurde aus dem Reinigungsmittelkonzentrat gemäß Beispiel 1 eine 1% Anwendungslösung hergestellt. Dabei wurde der Prüfkörper in eine Halterung geschraubt und lagen in der zirkulierenden 1%igen Anwendungslösung. Es wurde 5 Minuten gereinigt, 2 Minuten gespült und 2 Minuten getrocknet. Die Auswertung erfolgte optisch und wurde mittels Fotos dokumentiert.
- a) Method in manual loading procedure:
From the detergent concentrates according to Examples 1 and 2 and according to Comparative Examples 1 to 4, a 5% strength solution was prepared in each case with water. Into a 50 ml glass bottle filled with 50 ml of this 5% use solution, a stainless steel test specimen with standardized blood and polysaccharide stains (TOSI FlexiCheck test specimen from PEREG GmbH) was placed and with a shaker (Gerhardt, type LS 5 , Program 90) shaken for 10 minutes. Thereafter, the specimens were immediately out of solution taken and placed on paper to dry. The evaluation was done optically and was documented by means of photos. - b) Method in semi-automatic cleaning process in the machine:
The cleaning performance in the semi-automatic endoscope washing machine (Pauldrach Ecocleaner) was also carried out with the TOSI FlexiCheck test specimens. It was prepared from the detergent concentrate according to Example 1, a 1% application solution. The test specimen was screwed into a holder and placed in the circulating 1% application solution. It was cleaned for 5 minutes, rinsed for 2 minutes and dried for 2 minutes. The evaluation was done optically and was documented by means of photos.
Es hat sich gezeigt, dass sich durch das erfindungsgemäße Reinigungsmittel Polysaccharide besonders gut entfernen lassen.It has been found that polysaccharides can be removed particularly well by the cleaning agent according to the invention.
Die Reinigungsleistung bei der Entfernung von Blut/Eiweißanschmutzung (Standardblutanschmutzung) wurde wie folgt durchgeführt:
- a) Standardisierte Testanschmutzung:
Das Reinigungsverhalten einer Blutanschmutzung wird neben dem hohen Proteingehalt auch wesentlich durch den Prozess der Blutgerinnung bestimmt. Die dabei entstehenden Fibrinfasern sind gegenüber den sonst wasserlöslichen Blutproteinen für die Reinigung besonders relevant.
Deshalb findet eine standardisierte Testanschmutzung (M. Pfeifer: Standardisiere Testanschmutzung Blut 1, Zentr Steril 6. Jahrgang 1998, Heft 6, S 381-385 - b) Prüfkörper:
Neben der Standardisierung der Prüfanschmutzung ist auch die Reproduzierbarkeit der Prüfkörper und deren Kontamination von großer Bedeutung. Eine gleichbleibende Kontamination der Prüfkörper, bezüglich Menge und Schichtdicke, wird durch ein Robot-Dosiersystem erreicht. Erst diese Reproduzierbarkeit führt zu einer vergleichbaren Begutachtung unterschiedlicher Produkte. Als Prüfkörper dienen Edelstahlplättchen mit einer Abmessung von 20 X 70 mm. Verwendet wird Edelstahl Werkstoff 1.4301.
Nach Kontamination und Ablauf der Gerinnungsphase werden die Prüfkörper 24h bei Raumtemperatur getrocknet. - c) Simulation des Reinigungsverfahrens
Die Wirksamkeit eines Reinigungsverfahrens setzt sich zusammen aus der Reinigungsleistung des verwendeten Produkts und der eingesetzten Mechanik. Dadurch soll die Anschmutzung von der Oberfläche gelöst und abgetragen werden.
- a) Standardized test soiling:
The cleaning behavior of a blood stain is determined not only by the high protein content but also substantially by the process of blood clotting. The resulting fibrin fibers are particularly relevant to the otherwise water-soluble blood proteins for cleaning.
Therefore, a standardized test soiling (M. Pfeifer: Standardize test soiling Blood 1, Zentr Steril 6th year 1998, Issue 6, S 381-385 - b) test pieces:
In addition to the standardization of the test soiling, the reproducibility of the test specimens and their contamination is also of great importance. Consistent contamination of the specimens, in terms of quantity and layer thickness, is achieved by a robotic dosing system. Only this reproducibility leads to a comparable appraisal of different products. The test specimens are stainless steel plates with a dimension of 20 × 70 mm. Stainless steel material 1.4301 is used.
After contamination and the course of the coagulation phase, the test specimens are dried for 24 hours at room temperature. - c) Simulation of the cleaning process
The effectiveness of a cleaning process consists of the cleaning performance of the product used and the mechanism used. This is intended to loosen and remove the soiling from the surface.
Die Prüfung des erfindungsgemäßen Reinigungsmittels erfolgte durch 15 min senkrechtes Eintauchen der angeschmutzten Prüfkörper in 100 ml der entsprechenden Anwendungslösung um die Selbstreinigungsleistung des Produkts zu testen und dabei die mechanische Reinigungskomponente auszuschließen. Die Versuche wurden bei Raumtemperatur in Wasser standardisierter Härte (17°dH) durchgeführt. Da bei Raumtemperatur die enzymatische Reinigungsleistung verlangsamt abläuft, wurde bei einem Tauchversuch die Zeit bis zur vollständigen Auflösung der Fibrinschicht verlängert. Dieser Test diente zum Nachweis einer vorhandenen Enzymaktivität.The test of the cleaning agent according to the invention was carried out by vertical immersion of the soiled test specimens in 100 ml of the corresponding application solution for 15 minutes in order to test the self-cleaning performance of the product and thereby exclude the mechanical cleaning component. The experiments were carried out at room temperature in water of standardized hardness (17 ° dH). Since the enzymatic cleaning performance slows down at room temperature, the time to complete dissolution of the fibrin layer was extended in a dipping experiment. This test was used to detect an existing enzyme activity.
Es hat sich dabei gezeigt, dass sich durch das erfindungsgemäße Reinigungsmittel Proteinanschmutzungen auch besonders gut entfernen lassen.It has been found that protein contaminants can also be removed particularly well by the cleaning agent according to the invention.
Die Reinigungsleistung zur Entfernung von Biofilmen wurde wie folgt getestet:
- a) Biofilmanzucht:
Ein gereinigter Silikonschlauch wurde über ca. 3 Monate mit der Keimsuspension von Pseudomonas aeruginosa (2.2.1) inkubiert. Nach der Anzuchtphase wurde der mit Biofilm beaufschlagte Silikonschlauch in Teillängen für Prüf- und Kontrollkörper (Testoberflächen von jeweils 17,6 cm2) ausgeschnitten und bis zur Verwendung bei 20°C tiefgekühlt gelagert. Von der mit Biofilm beaufschlagten Silikonoberfläche wurde die für den jeweiligen Test erforderliche Anzahl gleichgroßer Teilflächen (Standardgröße) entnommen und mit sterilfiltriertem Leitungswasser bei einer Strömungsgeschwindigkeit von 3 m/s über mindestens 3 x 5 Sekunden gespült, um die ggf. verbleibende Keimsuspension zu entfernen. - b) Ermittlung der Ausgangsbelastung mittels Kontrollkörpern:
Die Bestimmung der angezüchteten Biofilmbeladung erfolgte anhand von n = 10 Kontrollkörpern, entsprechend des nachfolgend beschriebenen Verfahrens zur Freisetzung und Untersuchung von Endotoxingehalten [EU/ml] (Bestimmung der Biofilmäquivalente). Aus dem Kollektiv der Kontrollkörper wurde der arithmetische Mittelwert (repräsentiert die Ausgangsbelastung) und die Standardabweichung der Endotoxingehalte errechnet. - c) Bestimmung der Biofilmäquivalente und Auswertung:
Alle Kontroll- und Biofilmprüfkörper wurden auf ihre jeweilige Biofilm- bzw. Biofilmrest- Beladung untersucht. Hierzu erfolgte zunächst ein Aufschluss mittels hypochlorithaltiger Lösung über eine Einwirkzeit von 30 Minuten bei 25°C zur Freisetzung der vorhandenen Endotoxine aus den gramnegativen Bakterienwänden des Biofilms. Danach wurde das Biofilmeluat in endotoxinfreie Reagenzröhrchen entleert und die Bestimmung des Endotoxingehaltes im kinetisch-turbidimetrischen Verfahren durchgeführt.
- a) biofilm breeding:
A cleaned silicone tube was incubated for about 3 months with the germinal suspension of Pseudomonas aeruginosa (2.2.1). After the growing phase, the biofilm-loaded silicone tubing was in partial lengths for test and control body (Test 17.6 cm2 each) cut out and stored frozen at 20 ° C until use. The number of equal-sized partial areas (standard size) required for the respective test was removed from the biofilm-loaded silicone surface and rinsed with sterile-filtered tap water at a flow speed of 3 m / s for at least 3 × 5 seconds in order to remove any remaining germinal suspension. - b) Determination of the initial load by means of control bodies:
The biofilm load was determined on n = 10 control bodies according to the method described below for the release and analysis of endotoxin levels [EU / ml] (determination of biofilm equivalents). From the collective of control bodies, the arithmetic mean (representing the initial load) and the standard deviation of endotoxin levels were calculated. - c) Determination of biofilm equivalents and evaluation:
All control and biofilm specimens were examined for their respective biofilm or biofilm residue loading. For this purpose, first a digestion using hypochlorite-containing solution over a contact time of 30 minutes at 25 ° C to release the existing endotoxins from the Gram-negative bacteria walls of the biofilm. Thereafter, the Biofilmeluat was emptied into endotoxin-free test tubes and carried out the determination of endotoxin content in the kinetic turbidimetric method.
Zur Bewertung der Wirksamkeit der Prüfprodukte (Reiniger) gegenüber Biofilm wurde die Ausgangsbelastung der Kontrollkörper als Bezugsgröße gewählt (100%) und die Biofilmrest- Belastungen als Mittelwerte und Standardabweichungen dargestellt.To evaluate the efficacy of the test products (cleaners) versus biofilm, the initial load of the control bodies was chosen as a reference (100%) and the biofilm residue loads as mean and standard deviations.
Es wurde ein Reinigungsmittelkonzentrat aus den in Tabelle 1 angegebenen Inhaltsstoffen hergestellt.
Die Zusammensetzung gemäß Tabelle 1 wies einen pH-Wert von 8 - 8,5 auf.The composition according to Table 1 had a pH of 8-8.5.
Das Reinigungsmittelkonzentrat gemäß Tabelle 1 wurde auf seine Wirksamkeit gegen Polysaccharide, Proteine und Biofilme im Vergleich zu Lösungen der Vergleichskomponenten gemäß Tabelle 2 bei Polysacchariden und Proteinen getestet. Hierzu wurden folgende Vergleichslösungen angesetzt:
Bei allen Beispielen wurde Verdünnungswasser mit einer Wasserhärte von 16 °dH (°deutscher Härte) eingesetzt.
Dabei gibt es folgende Bereiche für die Reinigungsergebnisse, die bei Schleim und Blut optisch bewertet wurden:
- gut: >70%
- mittel: 30-70%
- schlecht: bis 30%
- good:> 70%
- medium: 30-70%
- bad: up to 30%
Es zeigt sich, dass das erfindungsgemäße Reinigungsmittel eine hervorragende Reinigungsleistung, sowohl bei der Ablösung von Blut, als auch von Schleim hat, die nur durch das Tensid oder die Kombination aus Tensid und Komplexbildner nicht erreicht wird. Dieses ist auch unabhängig vom eingesetzten Komplexbildner, wie die nachfolgende Tabelle zeigt:
Aus dem Reinigungsmittelkonzentrat gemäß Beispiel 1, Tabelle 1 wurden zwei Anwendungslösungen durch Verdünnung mit Wasser hergestellt. Die Anwendungslösungen wurden auf ihre Wirksamkeit gegen Biofilme geprüft:
- 2%ige Anwendungskonzentration der Rezeptur Beispiel 1: 96,7 % Ablösung Biofilm
- 5%ige Anwendungskonzentration der Rezeptur Beispiel 1: 99,7 % Ablösung Biofilm
- 2% application concentration of the formulation Example 1: 96.7% detachment biofilm
- 5% application concentration of the formulation Example 1: 99.7% detachment biofilm
Die Ergebnisse belegen eine gute Wirksamkeit gegen Biofilm, die bei einer Ablösung von > 95 % gegeben ist.The results show a good activity against biofilm, which is given at a separation of> 95%.
Es hat sich zudem gezeigt, dass das erfindungsgemäße Reinigungsmittel auch eine verbesserte Reinigungsleistung gegenüber anderen auf dem Markt befindlichen Reinigungsmitteln besitzt. Es wurden zum Vergleich Reinigungsmittel getestet, die als Tenside Alkylethoxylate, also nichtionische, schaumarme Tenside, enthalten.
Bei Vergleichsbeispiel 5 handelt es sich um Sekusept® Multienzyme P der Firma Ecolab und bei Vergleichsbeispiel 6 um Bodedex® forte der Firma Paul Hartmann. Bei den Konzentrationsangaben handelt es sich um die Werte aus den Sicherheitsdatenblättern.In Comparative Example 5 is Sekusept ® multienzymes P Ecolab and in Comparative Example 6 to Bodedex ® forte of the company Paul Hartmann. The concentration data are the values from the safety data sheets.
Es wurden folgende Reinigungsleistungen erzielt:
Es zeigt sich, dass nur das erfindungsgemäße Reinigungsmittel gleichzeitig eine gute Reinigungsleistung gegenüber Blut und Schleim besitzt.It turns out that only the detergent of the invention has a good cleaning performance against blood and mucus at the same time.
Die Anwendung der Reinigungsmittel erfolgt in allen Beispielen bei Raumtemperatur bei ca. 25 °C.The application of the cleaning agent takes place in all examples at room temperature at about 25 ° C.
Es hat sich zudem gezeigt, dass das erfindungsgemäße Reinigungsmittel auch eine verbesserte Reinigungsleistung bei dem wasserunlöslichen Fibrin gegenüber anderen auf dem Markt befindlichen Reinigungsmitteln besitzt. Die Untersuchungen wurden bei Raumtemperatur durchgeführt.
Es wurden folgende Reinigungsleistungen erzielt:
Es zeigt sich, dass nur das erfindungsgemäße Reinigungsmittel auch schon bei Raumtemperatur eine gute Reinigungsleistung gegenüber der nichtwasserlöslichen Fibrinschicht besitzt. Die Fibrinschicht wird durch die erfindungsgemäße Kombination des Beispiels 1 nach kurzer Zeit komplett aufgelöst.It turns out that only the cleaning agent according to the invention has a good cleaning performance even at room temperature with respect to the non-water-soluble fibrin layer. The fibrin layer is completely dissolved by the combination of Example 1 according to the invention after a short time.
Claims (14)
2 bis 15 Gew.-%, bevorzugt 5 bis 10 Gew.-%, der Alkylpolyglucoside,
1 bis 10 Gew.-%, bevorzugt 2 bis 6 Gew.-% des Komplexbildners,
0,1 bis 1 Gew.-%, bevorzugt 0,2 bis 0,6 Gew.-% des Enzyms Protease und Wasser
enthält, bezogen auf das Reinigungsmittelkonzentrat.Cleaning concentrate according to one of the preceding claims, characterized in that the cleaning agent concentrate
From 2 to 15% by weight, preferably from 5 to 10% by weight, of the alkylpolyglucosides,
1 to 10 wt .-%, preferably 2 to 6 wt .-% of the complexing agent,
0.1 to 1 wt .-%, preferably 0.2 to 0.6 wt .-% of the enzyme protease and water
contains, based on the detergent concentrate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102014003484.4A DE102014003484A1 (en) | 2014-03-14 | 2014-03-14 | Cleaner for inanimate surfaces with special effectiveness against mucus, secretions, blood and biofilms |
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| Publication Number | Publication Date |
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| EP2918663A1 true EP2918663A1 (en) | 2015-09-16 |
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ID=52705944
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| Application Number | Title | Priority Date | Filing Date |
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| EP15156668.4A Withdrawn EP2918663A1 (en) | 2014-03-14 | 2015-02-26 | Cleaning agent for inanimated surfaces with special efficacy against mucus, secretions, blood and biofilms |
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| EP (1) | EP2918663A1 (en) |
| DE (1) | DE102014003484A1 (en) |
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| DE102014003484A1 (en) | 2015-09-17 |
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