EP2989123A4 - Methods and compositions for treating bleeding disorders - Google Patents
Methods and compositions for treating bleeding disordersInfo
- Publication number
- EP2989123A4 EP2989123A4 EP14788399.5A EP14788399A EP2989123A4 EP 2989123 A4 EP2989123 A4 EP 2989123A4 EP 14788399 A EP14788399 A EP 14788399A EP 2989123 A4 EP2989123 A4 EP 2989123A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- methods
- bleeding disorders
- treating bleeding
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361814526P | 2013-04-22 | 2013-04-22 | |
PCT/US2014/034623 WO2014176125A1 (en) | 2013-04-22 | 2014-04-18 | Methods and compositions for treating bleeding disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2989123A1 EP2989123A1 (en) | 2016-03-02 |
EP2989123A4 true EP2989123A4 (en) | 2016-10-12 |
Family
ID=51792309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14788399.5A Withdrawn EP2989123A4 (en) | 2013-04-22 | 2014-04-18 | Methods and compositions for treating bleeding disorders |
Country Status (5)
Country | Link |
---|---|
US (1) | US20160060324A1 (en) |
EP (1) | EP2989123A4 (en) |
AU (1) | AU2014257369A1 (en) |
CA (1) | CA2910110A1 (en) |
WO (1) | WO2014176125A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
CN108117586A (en) | 2010-08-10 | 2018-06-05 | 洛桑聚合联合学院 | Erythrocyte binding therapeutic agent |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
WO2015140648A2 (en) | 2014-02-21 | 2015-09-24 | Ecole Polytecnique Federale De Lausanne (Epfl) Epfl-Tto | Glycotargeting therapeutics |
ES2938890T3 (en) | 2016-05-20 | 2023-04-17 | Octapharma Ag | Glycosylated VWF fusion proteins with improved pharmacokinetics |
WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
KR20190086269A (en) * | 2018-01-12 | 2019-07-22 | 재단법인 목암생명과학연구소 | Long-acting recombinant glycoproteins and menufacturing method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014179184A1 (en) * | 2013-04-28 | 2014-11-06 | Bayer Healthcarellc | Compositions for inducing immune tolerance to coagulation factor proteins |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE504074C2 (en) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Protein preparation for subcutaneous, intramuscular or intradermal administration |
US8691211B2 (en) * | 2009-03-10 | 2014-04-08 | Puget Sound Blood Center | Suppression of immune response to factor VIII in hemophilia A patients |
CA2756197A1 (en) * | 2009-03-24 | 2010-09-30 | Bayer Healthcare Llc | Factor viii variants and methods of use |
US9522183B2 (en) * | 2010-07-31 | 2016-12-20 | The Scripps Research Institute | Compositions and methods for inducing immune tolerance |
-
2014
- 2014-04-18 US US14/786,419 patent/US20160060324A1/en not_active Abandoned
- 2014-04-18 CA CA2910110A patent/CA2910110A1/en not_active Abandoned
- 2014-04-18 WO PCT/US2014/034623 patent/WO2014176125A1/en active Application Filing
- 2014-04-18 EP EP14788399.5A patent/EP2989123A4/en not_active Withdrawn
- 2014-04-18 AU AU2014257369A patent/AU2014257369A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014179184A1 (en) * | 2013-04-28 | 2014-11-06 | Bayer Healthcarellc | Compositions for inducing immune tolerance to coagulation factor proteins |
Non-Patent Citations (2)
Title |
---|
MATTHEW S. MACAULEY ET AL: "Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis", JOURNAL OF CLINICAL INVESTIGATION, vol. 123, no. 7, 1 July 2013 (2013-07-01), pages 3074 - 3083, XP055098288, ISSN: 0021-9738, DOI: 10.1172/JCI69187 * |
See also references of WO2014176125A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO2014176125A1 (en) | 2014-10-30 |
EP2989123A1 (en) | 2016-03-02 |
US20160060324A1 (en) | 2016-03-03 |
AU2014257369A1 (en) | 2015-11-12 |
CA2910110A1 (en) | 2014-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20151026 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20160908 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07K 14/755 20060101AFI20160902BHEP Ipc: A61K 38/37 20060101ALI20160902BHEP Ipc: A61K 47/48 20060101ALI20160902BHEP Ipc: A61K 38/00 20060101ALI20160902BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20170408 |