EP2709991A4 - Utilisation d'antagonistes de cxcr4 - Google Patents
Utilisation d'antagonistes de cxcr4Info
- Publication number
- EP2709991A4 EP2709991A4 EP12786739.8A EP12786739A EP2709991A4 EP 2709991 A4 EP2709991 A4 EP 2709991A4 EP 12786739 A EP12786739 A EP 12786739A EP 2709991 A4 EP2709991 A4 EP 2709991A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cxcr4 antagonists
- cxcr4
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL12786739T PL2709991T3 (pl) | 2011-05-16 | 2012-05-15 | Zastosowanie antagonistów CXCR4 w leczeniu zespołu WHIM, mielokateksji, neutropenii i limfocytopenii |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486632P | 2011-05-16 | 2011-05-16 | |
| PCT/US2012/037970 WO2012158707A1 (fr) | 2011-05-16 | 2012-05-15 | Utilisation d'antagonistes de cxcr4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2709991A1 EP2709991A1 (fr) | 2014-03-26 |
| EP2709991A4 true EP2709991A4 (fr) | 2014-10-01 |
| EP2709991B1 EP2709991B1 (fr) | 2020-09-02 |
Family
ID=81755014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12786739.8A Active EP2709991B1 (fr) | 2011-05-16 | 2012-05-15 | Utilisation d'antagonistes du cxcr4 pour traiter: syndrome WHIM, myelokathexis, neutropénie et lymphocytopénie |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20150030561A1 (fr) |
| EP (1) | EP2709991B1 (fr) |
| JP (1) | JP2014513727A (fr) |
| KR (3) | KR20200016407A (fr) |
| CN (1) | CN103596935A (fr) |
| BR (1) | BR112013029482A2 (fr) |
| ES (1) | ES2831049T3 (fr) |
| MX (1) | MX365242B (fr) |
| PL (1) | PL2709991T3 (fr) |
| RU (1) | RU2638802C2 (fr) |
| WO (1) | WO2012158707A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3520823T3 (pl) | 2005-05-02 | 2021-11-22 | Genzyme Corporation | Terapia genowa zaburzeń neurometabolicznych |
| US9419667B2 (en) | 2013-04-16 | 2016-08-16 | Skyworks Solutions, Inc. | Apparatus and methods related to conformal coating implemented with surface mount devices |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| EP3389652B1 (fr) | 2015-12-14 | 2022-09-28 | X4 Pharmaceuticals, Inc. | Méthodes de traitement du cancer |
| WO2017106328A1 (fr) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Méthodes de traitement du cancer |
| EP3393468B1 (fr) | 2015-12-22 | 2022-09-14 | X4 Pharmaceuticals, Inc. | Méthodes pour le traitement d'une maladie immunodéficiente |
| GB201604213D0 (en) * | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
| CN109153722A (zh) | 2016-04-08 | 2019-01-04 | X4 制药有限公司 | 用于治疗癌症的方法 |
| WO2017223229A1 (fr) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Inhibiteurs de cxcr4 et leurs utilisations |
| CN109562106B (zh) | 2016-06-21 | 2023-03-21 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| AU2017322511B2 (en) * | 2016-09-08 | 2021-08-26 | Centro de Investigaciones Energeticas, Medioambientales Y Tecnologicas, O.A., M.P. | Gene therapy for patients with Fanconi anemia |
| CN109988153B (zh) * | 2017-12-29 | 2021-11-19 | 深圳夏浠湾医药科技有限公司 | 一种川芎嗪衍生物及其制备方法和应用 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| CN113662937B (zh) * | 2021-10-09 | 2022-08-23 | 江苏省人民医院（南京医科大学第一附属医院） | Plerixafor在上调EFTUD2表达和抑制HBV药物中的用途 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (fr) | 1962-12-19 | |||
| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| GB1524747A (en) | 1976-05-11 | 1978-09-13 | Ici Ltd | Polypeptide |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| EP0100172B1 (fr) | 1982-07-23 | 1987-08-12 | Imperial Chemical Industries Plc | Dérivés d'amides |
| US6001826A (en) | 1989-12-21 | 1999-12-14 | Anormed, Inc. | Chemical compounds |
| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9105489D0 (en) | 1991-03-15 | 1991-05-01 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5612478A (en) | 1995-03-30 | 1997-03-18 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US5606053A (en) | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| WO2000009152A1 (fr) | 1998-08-14 | 2000-02-24 | The University Of British Columbia | Antagonistes therapeutiques du recepteur de la chimiokine |
| JP2002506830A (ja) | 1998-03-13 | 2002-03-05 | ザ ユニバーシティ オブ ブリティッシュ コロンビア | 治療的ケモカイン受容体アンタゴニスト |
| NZ507161A (en) | 1998-03-30 | 2003-12-19 | Northwest Biotherapeutics Inc | Theraupeutic and diagonistic applications based on the role of the CXCR-4 gene in tumorigenesis |
| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| AU2334301A (en) | 1999-12-17 | 2001-06-25 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds |
| US20070160574A1 (en) | 2000-04-12 | 2007-07-12 | Ahmed Merzouk | Design of CXC chemokine analogs for the treatment of human diseases |
| CA2335109A1 (fr) | 2000-04-12 | 2001-10-12 | Chemokine Therapeutics Corporation | Traitement de cellules hematopoietiques avec des agonistes du cxcr4 |
| DE60103052T2 (de) | 2000-05-09 | 2005-03-03 | The University Of British Columbia, Vancouver | Verwendung von cxcr4 antagonisten zur behandlung von krebs und autoimmunkrankheiten |
| MXPA02012067A (es) | 2000-06-05 | 2004-08-19 | Univ Columbia | Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico. |
| CA2419631A1 (fr) | 2000-09-29 | 2002-04-04 | Anormed Inc. | Procede de preparation de polyamines cycliques a protection n-1 comportant n azotes sur leur noyau, et produits associes |
| CN1630517A (zh) | 2001-05-24 | 2005-06-22 | 吴羽化学工业株式会社 | 包含含氮化合物的具有cxcr4拮抗作用的药物 |
| PL364673A1 (en) | 2001-07-31 | 2004-12-13 | Anormed Inc. | Methods to mobilize progenitor/stem cells |
| US20030221931A1 (en) | 2002-02-28 | 2003-12-04 | Steve Marsh | Sliding device |
| US20030199464A1 (en) | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| ES2403932T3 (es) | 2002-08-27 | 2013-05-22 | Biokine Therapeutics Ltd. | Antagonista de CXCR4 y uso del mismo |
| US7504422B2 (en) | 2003-04-02 | 2009-03-17 | Taigen Biotechnology Co. Ltd. | Polyamine compounds |
| US7399776B2 (en) | 2003-04-02 | 2008-07-15 | Taigen Biotechnology | Polyamine compounds for treating chemokine receptor mediated diseases |
| BRPI0514343A (pt) | 2004-08-13 | 2008-06-10 | Anormed Inc | combinações de quimiocinas para mobilizar células progenitoras/tronco |
| US7501526B2 (en) | 2005-01-20 | 2009-03-10 | Taigen Biotechnology | Synthesis of polyamine compounds |
| WO2006095542A1 (fr) | 2005-03-04 | 2006-09-14 | Kureha Corporation | Composition pharmaceutique comprenant un compose amine |
| EP1924260A2 (fr) * | 2005-08-18 | 2008-05-28 | Novartis AG | Utilisation de ligands du cxcr4 pour le traitement du syndsome whim |
| US20070043012A1 (en) | 2005-08-19 | 2007-02-22 | Bridger Gary J | Methods to enhance chemotherapy |
| US20090221683A1 (en) * | 2005-10-18 | 2009-09-03 | Caritas St.Elizabeth Medical Center Of Boston, Inc | Combination of CXCR4 Antagonist and Morphogen to Increase Angiogenesis |
| WO2007106063A2 (fr) | 2006-02-24 | 2007-09-20 | Genzyme Corporation | Procédés servant à accroître le débit sanguin et/ou à favoriser la régénération d'un tissu |
| WO2008008854A2 (fr) | 2006-07-11 | 2008-01-17 | Emory University | Antagonistes de cxcr4 comprenant des structures de diazine et de triazine pour le traitement de troubles médicaux |
| BRPI0714799A2 (pt) | 2006-08-02 | 2013-05-21 | Genzyme Corp | terapia de combinaÇço |
| MX2009001445A (es) | 2006-08-07 | 2009-02-18 | Genzyme Corp | Terapia de combinacion. |
| NZ579875A (en) | 2007-02-28 | 2012-02-24 | Polyphor Ltd | Template-fixed peptidomimetics |
| CA2728124C (fr) | 2008-06-23 | 2014-12-02 | Research In Motion Limited | Procede pour fournir des capacites de dispositifs et de serveurs |
| US20110245265A1 (en) | 2008-08-29 | 2011-10-06 | Genzyme Corporation | Cxcr4 antagonists for kidney injury |
| JP2012516353A (ja) * | 2009-01-30 | 2012-07-19 | ジェンザイム・コーポレーション | 血液系悪性腫瘍を治療するための方法及び組成物 |
-
2012
- 2012-05-15 BR BR112013029482A patent/BR112013029482A2/pt not_active IP Right Cessation
- 2012-05-15 JP JP2014511460A patent/JP2014513727A/ja not_active Withdrawn
- 2012-05-15 KR KR1020207003632A patent/KR20200016407A/ko active Application Filing
- 2012-05-15 CN CN201280024014.6A patent/CN103596935A/zh active Pending
- 2012-05-15 ES ES12786739T patent/ES2831049T3/es active Active
- 2012-05-15 WO PCT/US2012/037970 patent/WO2012158707A1/fr active Application Filing
- 2012-05-15 KR KR1020137033309A patent/KR20140045411A/ko active Application Filing
- 2012-05-15 MX MX2013013308A patent/MX365242B/es active IP Right Grant
- 2012-05-15 EP EP12786739.8A patent/EP2709991B1/fr active Active
- 2012-05-15 PL PL12786739T patent/PL2709991T3/pl unknown
- 2012-05-15 RU RU2013155601A patent/RU2638802C2/ru active
- 2012-05-15 US US14/118,144 patent/US20150030561A1/en not_active Abandoned
- 2012-05-15 KR KR1020217023153A patent/KR20210094672A/ko not_active Application Discontinuation
-
2020
- 2020-07-13 US US16/927,856 patent/US20210161859A1/en not_active Abandoned
Non-Patent Citations (4)
| Title |
|---|
| BADOLATO ET AL: "Mechanisms of WHIM syndrome", DRUG DISCOVERY TODAY: DISEASE MECHANISMS, ELSEVIER, AMSTERDAM, NL, vol. 2, no. 4, 1 January 2005 (2005-01-01), pages 479 - 485, XP005213116, ISSN: 1740-6765, DOI: 10.1016/J.DDMEC.2005.11.010 * |
| LABROSSE B ET AL: "Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 8, 1 August 1998 (1998-08-01), pages 6381 - 6388, XP002224660, ISSN: 0022-538X * |
| MARCO A C NEVES ET AL: "Ligand-guided optimization of CXCR4 homology models for virtual screening using a multiple chemotype approach", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, KLUWER ACADEMIC PUBLISHERS, DO, vol. 24, no. 12, 20 October 2010 (2010-10-20), pages 1023 - 1033, XP019863448, ISSN: 1573-4951, DOI: 10.1007/S10822-010-9393-X * |
| See also references of WO2012158707A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013029482A2 (pt) | 2016-08-09 |
| RU2638802C2 (ru) | 2017-12-15 |
| JP2014513727A (ja) | 2014-06-05 |
| MX2013013308A (es) | 2014-02-27 |
| WO2012158707A1 (fr) | 2012-11-22 |
| KR20210094672A (ko) | 2021-07-29 |
| KR20200016407A (ko) | 2020-02-14 |
| PL2709991T3 (pl) | 2021-04-06 |
| EP2709991A1 (fr) | 2014-03-26 |
| ES2831049T3 (es) | 2021-06-07 |
| US20210161859A1 (en) | 2021-06-03 |
| EP2709991B1 (fr) | 2020-09-02 |
| RU2013155601A (ru) | 2015-06-27 |
| KR20140045411A (ko) | 2014-04-16 |
| CN103596935A (zh) | 2014-02-19 |
| MX365242B (es) | 2019-05-28 |
| US20150030561A1 (en) | 2015-01-29 |
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| A4 | Supplementary search report drawn up and despatched |
Effective date: 20140903 |
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| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 45/06 20060101ALI20140828BHEP Ipc: A61K 31/395 20060101ALI20140828BHEP Ipc: C07D 255/02 20060101AFI20140828BHEP Ipc: A61K 38/19 20060101ALI20140828BHEP |
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