[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP2705023A4 - Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide - Google Patents

Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Info

Publication number
EP2705023A4
EP2705023A4 EP11854945.0A EP11854945A EP2705023A4 EP 2705023 A4 EP2705023 A4 EP 2705023A4 EP 11854945 A EP11854945 A EP 11854945A EP 2705023 A4 EP2705023 A4 EP 2705023A4
Authority
EP
European Patent Office
Prior art keywords
acetamide
naphthyl
methoxy
ethyl
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11854945.0A
Other languages
German (de)
French (fr)
Other versions
EP2705023A1 (en
Inventor
Rao Dodda Mohan
Reddy Pingili Krishna
Reddy Ambati Anna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symed Labs Ltd
Original Assignee
Symed Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symed Labs Ltd filed Critical Symed Labs Ltd
Publication of EP2705023A1 publication Critical patent/EP2705023A1/en
Publication of EP2705023A4 publication Critical patent/EP2705023A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP11854945.0A 2011-01-04 2011-01-04 Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide Withdrawn EP2705023A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2011/000003 WO2012093402A1 (en) 2011-01-04 2011-01-04 Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Publications (2)

Publication Number Publication Date
EP2705023A1 EP2705023A1 (en) 2014-03-12
EP2705023A4 true EP2705023A4 (en) 2014-11-19

Family

ID=46457287

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11854945.0A Withdrawn EP2705023A4 (en) 2011-01-04 2011-01-04 Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide

Country Status (3)

Country Link
EP (1) EP2705023A4 (en)
AR (1) AR083840A1 (en)
WO (1) WO2012093402A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102276492B (en) * 2010-06-08 2013-04-10 上海医药工业研究院 Agomelatine intermediate and its preparation method
FR2995896B1 (en) * 2012-09-26 2014-11-21 Servier Lab STABILIZED AMORPHOUS FORM OF AGOMELATIN, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
WO2014040228A1 (en) * 2012-09-11 2014-03-20 Les Laboratoires Servier Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
JO3339B1 (en) * 2012-09-11 2019-03-13 Shanghai Inst Pharmaceutical Ind Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
WO2014064706A1 (en) * 2012-10-22 2014-05-01 Symed Labs Limited Processes for the preparation of agomelatine using novel intermediates
CN102993040B (en) * 2012-11-30 2015-09-30 中国药科大学 A kind of novel method of synthesizing Agomelatine
CN103073441A (en) * 2012-12-27 2013-05-01 上海右手医药科技开发有限公司 Novel method for compositing (7- methoxy-1-naphthyl) and application of method in compositing of agomelatine
CN103113243A (en) * 2013-03-08 2013-05-22 山东方明药业集团股份有限公司 Synthetic method of 2-(7-methoxyl-1-naphthyl) ethylamine hydrochloride
CN104130154A (en) * 2013-05-03 2014-11-05 郭炳华 Method for preparing high-purity agomelatine
CZ2013621A3 (en) * 2013-08-13 2015-02-25 Zentiva, K.S. Agomelatine thermodynamically stable congealed solution for use in pharmaceutical formulation
WO2015124496A1 (en) 2014-02-19 2015-08-27 Synthon B.V. Pharmaceutical composition comprising amorphous agomelatine
WO2015189778A1 (en) * 2014-06-10 2015-12-17 Laboratorio Chimico Internazionale S.P.A. Agomelatine in solution adsorbates and compositions
CN104262197A (en) * 2014-08-28 2015-01-07 太仓运通生物化工有限公司 Synthesis method of 1-cyclohexenylacetonitrile
WO2016046833A2 (en) * 2014-09-24 2016-03-31 Symed Labs Limited Improved processes for the preparation of agomelatine using novel intermediates
EP3075724B1 (en) 2015-03-31 2023-07-12 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Solid form of agomelatine
CN105601537B (en) * 2016-01-25 2018-11-06 江西同和药业股份有限公司 A kind of preparation method of 2- (7- methoxy-1-naphthyls) acetonitrile
CN105669494A (en) * 2016-03-11 2016-06-15 上海韬鸿化工科技有限公司 Method for preparing 2-(7-methoxy-1-naphthyl) acetonitrile
CN107151221A (en) * 2017-06-19 2017-09-12 太仓卡斯特姆新材料有限公司 A kind of method for preparing the methoxynaphthalene acetonitrile of agomelatine important intermediate 7
CN109251151A (en) * 2017-07-12 2019-01-22 北京广为医药科技有限公司 N- (2- (substitution-naphthalene -1- base) ethyl) substituted amide class compound, its preparation and application thereof
CN107353229B (en) * 2017-08-08 2019-04-30 许昌恒生制药有限公司 A kind of preparation method of agomelatine intermediate body

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0447285A1 (en) * 1990-02-27 1991-09-18 Adir Et Compagnie Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them
WO2008137461A1 (en) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphthyl(ethyl) acetamides
WO2010102554A1 (en) * 2009-03-10 2010-09-16 上海医药工业研究院 New crystalline form vi of agomelatine, preparation method and application thereof
WO2012130837A1 (en) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Solid agomelatine in non-crystalline form
CN102716493A (en) * 2011-03-31 2012-10-10 天津药物研究院 Copolymer containing amorphous agomelatine, and preparation method, pharmaceutical composition and application thereof
WO2014040228A1 (en) * 2012-09-11 2014-03-20 Les Laboratoires Servier Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
WO2014041015A1 (en) * 2012-09-11 2014-03-20 Les Laboratoires Servier Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it.
WO2014095818A1 (en) * 2012-12-20 2014-06-26 Synthon B.V. Formulation comprising amorphous agomelatine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866335B1 (en) * 2004-02-13 2006-05-26 Servier Lab NEW PROCESS FOR THE SYNTHESIS OF AGOMELATIN
FR2934856B1 (en) * 2008-08-05 2010-08-13 Servier Lab NEW PROCESS FOR OBTAINING THE V-CRYSTALLINE FORM OF AGOMELATIN

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0447285A1 (en) * 1990-02-27 1991-09-18 Adir Et Compagnie Naphthalene derivatives, procedure for their preparation and pharmaceutical compositions containing them
WO2008137461A1 (en) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphthyl(ethyl) acetamides
WO2010102554A1 (en) * 2009-03-10 2010-09-16 上海医药工业研究院 New crystalline form vi of agomelatine, preparation method and application thereof
US20120004313A1 (en) * 2009-03-10 2012-01-05 Hanbin Shan Crystalline form vi of agomelatine, preparation method and application thereof
WO2012130837A1 (en) * 2011-03-28 2012-10-04 Ratiopharm Gmbh Solid agomelatine in non-crystalline form
CN102716493A (en) * 2011-03-31 2012-10-10 天津药物研究院 Copolymer containing amorphous agomelatine, and preparation method, pharmaceutical composition and application thereof
WO2014040228A1 (en) * 2012-09-11 2014-03-20 Les Laboratoires Servier Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it
WO2014041015A1 (en) * 2012-09-11 2014-03-20 Les Laboratoires Servier Stabilised amorphous form of agomelatine, a process for its preparation and pharmaceutical compositions containing it.
WO2014095818A1 (en) * 2012-12-20 2014-06-26 Synthon B.V. Formulation comprising amorphous agomelatine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2012093402A1 *

Also Published As

Publication number Publication date
AR083840A1 (en) 2013-03-27
WO2012093402A1 (en) 2012-07-12
EP2705023A1 (en) 2014-03-12

Similar Documents

Publication Publication Date Title
EP2705023A4 (en) Processes for the preparation of n-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
IL246265B (en) Process for preparing intermediates for the preparation of 5-fluoro-1h-pyrazolopyridines and some such compounds
HK1191354A1 (en) Process for the preparation of nitrile rubbers
PL2517700T3 (en) Pharmaceutically acceptable cocrystals of N-[2-(7-methoxy-1-naphthyl]acetamide and methods of their preparation
EP2526099A4 (en) Improved process for the preparation of amide intermediates and their use thereof
PL2723714T3 (en) Novel processes for the preparation of prostaglandin amides
EP2630143A4 (en) Processes for the preparation of rivaroxaban and intermediates thereof
HK1198584A1 (en) Process for the preparation of travoprost
HK1194733A1 (en) Process for the preparation of 1-acyl-4-phenylsulfonylprolinamide derivatives and intermediates 1--4-
ZA201306212B (en) An improved process for the preparation of voriconazole and intermediates thereof
HK1189571A1 (en) Process and intermediates for synthesizing agomelatine
IL232036A0 (en) Novel process for the preparation of acylguanidines and acylthioureas
EP2909166A4 (en) Processes for the preparation of agomelatine using novel intermediates
EP2882291A4 (en) An improved process for the preparation of memantine hydrochloride
PT2603319E (en) Process for the preparation of urethans
EP2680846A4 (en) Use of n-(4-methoxyphenyl)-1-phenyl-1h-pyrazol-3-amine and related compounds
EP2555616A4 (en) Process for the preparation of memantine hydrochloride
PT2702045T (en) Novel process for the preparation of etravirine
HRP20160767T1 (en) Process for the preparation of crystalline form i of agomelatine
HK1214585A1 (en) Process for the preparation of n-[5-(3-dimethylamino-acryloyl)-2- fluoro-phenyl]-n-methyl-ace tamide n-[5-(3--)-2--]-n--
PL390177A1 (en) Process for the preparation of α-(N-acylamino) alkilotriphenylphosphonium salts
AP3399A (en) New process for the synthesis of agomelatine
HUP1100291A2 (en) Process for the preparation of prostaglandin amides

Legal Events

Date Code Title Description
TPAC Observations filed by third parties

Free format text: ORIGINAL CODE: EPIDOSNTIPA

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20131120

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

A4 Supplementary search report drawn up and despatched

Effective date: 20141017

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 253/30 20060101ALI20141013BHEP

Ipc: C07C 213/02 20060101AFI20141013BHEP

Ipc: C07C 231/12 20060101ALI20141013BHEP

Ipc: C07C 233/18 20060101ALI20141013BHEP

Ipc: A61P 25/24 20060101ALI20141013BHEP

Ipc: C07C 231/02 20060101ALI20141013BHEP

Ipc: A61K 31/165 20060101ALI20141013BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20150514