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EP2757942B1 - Diagnostic measurement device - Google Patents

Diagnostic measurement device Download PDF

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Publication number
EP2757942B1
EP2757942B1 EP12778606.9A EP12778606A EP2757942B1 EP 2757942 B1 EP2757942 B1 EP 2757942B1 EP 12778606 A EP12778606 A EP 12778606A EP 2757942 B1 EP2757942 B1 EP 2757942B1
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EP
European Patent Office
Prior art keywords
measurement
unit
sensor
pressure sensor
pressure
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Application number
EP12778606.9A
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German (de)
French (fr)
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EP2757942A1 (en
Inventor
Yoon Ok Kim
Ok Kyung Cho
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/282—Holders for multiple electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4866—Evaluating metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesising signals from measured signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6843—Monitoring or controlling sensor contact pressure

Definitions

  • the invention relates to a measuring device for the non-invasive determination of at least one physiological parameter, with a diagnostic sensor unit for generating measurement signals, and with an evaluation unit for processing the measurement signals according to the preamble of claim 1.
  • the invention also relates to a method for non-invasive Determination of at least one physiological parameter.
  • Such a measuring device is from the WO 2011/022068 A1 known.
  • the known measuring device has a sensor unit which is integrated in the keyboard of a computer or in a mobile device for entertainment or communication technology.
  • the diagnostic sensor unit includes various measurement modalities, namely an optical measurement unit, an EKG unit, a temperature sensor and / or a bioelectric impedance unit.
  • the combination of the different measurement modalities enables a combined evaluation of the corresponding measurement signals by means of an evaluation unit programmed in a suitable manner.
  • the combination ensures high efficiency and reliability in the detection of pathological disorders.
  • the previously known measuring device enables a non-invasive indirect measurement of metabolic parameters. Ultimately, the non-invasive measurement of the glucose concentration or the blood glucose level is possible.
  • the object of the invention is to provide a measuring device with functionality that is expanded compared to the prior art.
  • Another object of the invention is to provide a measuring device with a diagnostic sensor unit that is as simple as possible, so that the measuring device can be manufactured overall inexpensively.
  • the invention proposes, starting from a measuring device of the type mentioned at the outset, that the measuring electrode is movably mounted on the diagnostic sensor unit.
  • the pressure sensor provided in the measuring device according to the invention detects a uniaxial pressure.
  • the pressure sensor detects a force exerted by the body tissue on the pressure sensor in a certain direction, usually in the direction perpendicular to the body surface on which the pressure sensor comes into contact.
  • a pressure sensor in the sense of the invention is therefore also to be understood as a force sensor.
  • the pressure exerted locally on the pressure sensor by the body tissue to be examined is detected. It is assumed that the pressure sensor uses a (comparatively small) contact surface that lies against the body surface and via which the pressure exerted by the body tissue is detected.
  • the size of the contact surface can range, for example, from 1 mm 2 to 10 cm 2 .
  • the pressure exerted locally on the pressure sensor in the sense of the invention is the pressure detected via this contact surface of the pressure sensor.
  • the essence of the invention is to use the pressure sensor as a diagnostic sensor.
  • the evaluation unit of the measuring device according to the invention can be set up to derive at least one of the following physiological parameters from the time profile of the measurement signal of the pressure sensor: pressure volume pulse, pulse amplitude, pulse width, pulse duration, Blood circulation, blood pressure, pulse pressure, heart rate, pulse wave speed, body temperature, metabolically generated heat.
  • the course of the measurement signal from the pressure sensor directly delivers the pressure volume pulse.
  • Various other physiological parameters can then be determined from this.
  • the pulse amplitude correlates with the body temperature, so that, preferably after appropriate calibration, the body temperature can be derived from the measurement signal of the pressure sensor, namely the body surface temperature and / or the body average temperature, the arterial blood temperature, the body core temperature or the metabolically produced amount of heat.
  • the body temperature can be derived from the measurement signal of the pressure sensor, namely the body surface temperature and / or the body average temperature, the arterial blood temperature, the body core temperature or the metabolically produced amount of heat.
  • Conclusions can also be drawn about the amount of heat flowing from the inside of the body to the end of the arterial capillaries and the temperature in the area of the arterial-venous capillaries or the surrounding body tissue.
  • the at least one pressure sensor must be brought into direct or indirect contact with the body surface of the user, for example by placing a finger on the device equipped with the pressure sensor. It is also conceivable that the pressure sensor is pressed onto the surface of the body tissue by means of suitable means. A retaining clip of a known type or an elastic cuff can be used for this. It is also conceivable that, for example by medically trained personnel, the measuring device with the pressure sensor is guided along the body of the user in order to measure the pressure at various points on the body. After applying the pressure sensor to the body of the user, the measurement signal is recorded for a predetermined period of time (several seconds to several minutes, or continuously). The time course of the measurement signal is then evaluated as described above.
  • the sensor unit of the measuring device has an optical measuring unit which comprises at least one radiation source for irradiating the body tissue and at least one radiation sensor for detecting the radiation scattered and / or transmitted by the body tissue, the evaluation unit for deriving the at least one physiological one Parameter is set up at least from the measurement signal of the pressure sensor and the optical measuring unit.
  • the optical measuring unit can be as in the above WO 2008/061788 A1 be described. For example, arterial oxygen saturation can be determined using the optical measuring unit.
  • the pressure volume pulse determined by means of the pressure sensor can supplement or partially replace the optical measurement, since the pressure volume pulse can be determined independently of the light absorption of individual body tissue or blood components.
  • the measurement signal of the pressure sensor can thus serve as a reference value and thereby increase the measurement accuracy.
  • the detection of the measurement signal from the pressure sensor enables the optical measurement to be simplified. For example, the measurement can be reduced to a smaller number of different wavelengths.
  • the sensor unit of the measuring device comprises a temperature sensor, the evaluation unit being set up to derive the at least one physiological parameter at least from the measurement signals of the pressure sensor and the temperature sensor.
  • the glucose concentration in the blood can be determined from a combined temperature and optical measurement. Accordingly, the temperature or heat measurement can usefully supplement the other measurement modalities.
  • the measurement signals from the temperature sensor allow conclusions to be drawn about the local heat exchange and thus the local metabolic activity.
  • the temperature sensor is also suitable for determining local blood flow.
  • the sensor unit of the measuring device according to the invention has an EKG unit for detecting an EKG signal via two or more EKG electrodes, the evaluation unit for deriving the at least one physiological parameter from at least the measurement signals of the pressure sensor and the EKG electrodes. Unit is set up.
  • the functional scope of the measuring device according to the invention is expanded by the EKG unit.
  • the evaluation unit of the measuring device can, for example, be set up to evaluate the time profile of the pressure volume pulse and the EKG signal. From this can in turn, the pulse wave speed can be determined, which among other things enables conclusions to be drawn about the blood pressure.
  • the combination of pressure sensor and EKG unit enables automated functional evaluation of the condition of the vascular system of the user of the measuring device.
  • the sensor unit of the measuring device has a bioelectrical impedance measuring unit, the evaluation unit being designed to derive the at least one physiological parameter from at least the measuring signal of the pressure sensor and the bioelectrical impedance measuring unit.
  • the bioelectric impedance measurement unit can be designed for local bioimpedance measurement.
  • the combination of pressure sensor and bioelectrical impedance measuring unit enables the amount of water contained in the body tissue, the percentage of fat-free mass in the body tissue and the percentage of body fat to be determined without having to determine or enter the total body mass.
  • the bioelectrical impedance measurement also enables, as in the cited WO 2008/061788 A1 described in detail, possibly in combination with other measurement modalities, a non-invasive determination of the glucose concentration.
  • the pressure sensor is mechanically coupled to a measuring electrode of the bioelectric impedance measuring unit and can thus detect the pressure exerted locally on the pressure sensor by the body tissue to be examined via the measuring electrode.
  • the measuring electrode and the pressure sensor use one and the same contact surface on the body for measuring signal acquisition.
  • the measuring electrode should be movably (e.g. resiliently) mounted on the diagnostic sensor unit.
  • the actual pressure sensor can then comprise a piezoresistive element, for example.
  • the piezoresistive element can advantageously be arranged under the measuring electrode of the bioelectric impedance unit. In this way, the force or pressure exerted on the electrode is converted directly into an electrical measurement signal.
  • the pressure sensor can be coupled to a measuring electrode of the EKG unit.
  • the measuring device offers a large number of advantages for determining one or more physiological parameters.
  • the measuring accuracy can be increased.
  • the pressure sensor can be used as a reference in order to uncover the errors in the measurement signals which are obtained by means of other measurement modalities.
  • the pressure sensor also has the advantage that it can be used with simple electronic circuits.
  • pressure sensors are energy-saving and easy to use in terms of both production and application.
  • Pressure sensors can be implemented in a small size and have a low fault tolerance.
  • the use of one or more pressure sensors in the measuring device according to the invention as the only measurement modality is just as possible as the use to supplement other measurement modalities.
  • the pressure volume pulse, the pulse frequency and other related parameters can be determined solely and exclusively from the measurement signal of the pressure sensor, which is sufficient for many practical applications. Accordingly, a (more complex) optical measurement or an EKG measurement can be dispensed with for a large number of application purposes.
  • the evaluation unit is designed to derive the at least one physiological parameter as a function of the depth in the body tissue.
  • Surface analytical and body-average analytical methods for determining physiological parameters are generally known and customary.
  • the depth analysis or the depth profile analysis or the depth cross-sectional profile analysis in which one or more physiological parameters are determined in a spatially resolved manner, in particular in a depth-resolved manner, is particularly advantageous.
  • a depth-resolved and time-dependent detection of physiological parameters is particularly preferred. The data obtained in this way make it possible to analyze in detail quantitative and spatially resolved physiological, in particular metabolic processes taking place in the body tissue.
  • a non-invasive depth analysis method for determining physiological parameters in which non-invasive physiological parameters and corresponding biochemical processes in the interior of the human body are determined as a function of depth.
  • a depth profile analysis by using the measurement modalities described above (pressure, temperature, optical measurement, bioelectric impedance, EKG), in each case individually or in combination, enables the determination of relevant physiological parameters for determining the composition of the body tissue, for example the tissue surrounding the capillaries.
  • the knowledge of the composition of the body tissue can in turn be used as a parameter in the calculation when deriving physiological parameters from the measurement signals.
  • a special variant of the depth profile analysis is the depth cross-sectional profile analysis.
  • the cross section of the body tissue in the direction of the depth, ie perpendicular to the body surface is analyzed from a starting point, whereby this starting point does not necessarily have to lie directly on the body surface.
  • a deep cross-sectional profile analysis can be carried out by bioelectrical impedance measurement, the distance or the relative position of the electrodes used from the examined body tissue, the strength of the current impressed for the impedance measurement and / or the measurement frequency being varied.
  • a measuring device according to the invention which comprises the above-mentioned measuring modalities individually or in combination, is therefore particularly well suited for the deep cross-sectional profile analysis.
  • blood circulation blood pressure, pulse amplitude, pulse pressure, pulse width, blood volume, body surface temperature, body average temperature, arterial blood temperature, body core temperature, the amount of heat transported from the inside of the body to the capillary ends Area of the arterial-venous capillaries or the surrounding tissue, pulse wave velocity, amount of heat produced by the metabolism, arterial oxygen saturation, oxygen saturation in the tissue, Oxygen consumption, body water mass, percentage of fat-free mass in body tissue, body fat percentage, glucose concentration, etc.
  • the hardware required for the measuring device can be made very compact, which is a significant advantage of the invention over the prior art.
  • the individual sensors require a space that can be, for example, smaller than 2 cm x 2 cm x 2 cm. Some sensors can even be realized with a construction volume of less than 1 cm x 1 cm x 1 cm or even smaller. Even a combination of several measurement modalities in the measurement device according to the invention can be implemented as a compact, portable device ("handheld") for depth analysis or for depth profile analysis. For example, the edge length of the device can be less than 10 to 20 cm. Even smaller dimensions are conceivable.
  • the hardware costs and thus the diagnostic costs are significantly lower when using the measuring device according to the invention than when using conventional spatially resolved diagnostic methods (e.g. computer tomography).
  • the above-mentioned underlying object is also achieved by a method for the non-invasive determination of at least one physiological parameter, in which the pressure exerted locally on a pressure sensor by a body tissue to be examined is detected, the at least one physiological parameter from the detected one Pressure is derived.
  • the Figure 1 illustrates the derivation of the pressure volume pulse from the measurement signal of a pressure or force sensor, which according to the invention is part of a diagnostic sensor unit.
  • the pressure sensor bears on the body surface of a patient in the area to be examined, so that the pressure sensor detects the pressure exerted locally by the body tissue on the pressure sensor, as in FIG Figure 1 can be seen as a function of time t.
  • the measurement signal is the pressure p.
  • the time course of the measurement signal p corresponds to the pressure volume pulse.
  • the diagram immediately shows that, for example, physiological parameters such as the pulse amplitude, the pulse width, the amount of blood, the pulse duration, the blood flow, the blood pressure, the pulse pressure and the heart rate can be derived from the measurement signal.
  • the pulse wave speed can also be determined.
  • the pulse amplitude correlates with the body temperature.
  • the pressure sensor of the measuring device according to the invention can be used to determine physiological parameters related to the temperature, such as the body surface temperature, the body average temperature, the arterial blood temperature, the body core temperature, the amount of heat generated by the metabolism, the amount of heat flowing from the inside of the body to the capillary ends, and that Temperature in the area of the arterial-venous capillaries or the surrounding tissue.
  • the sensor unit shown in cross section is designated as a whole by reference number 1.
  • the sensor unit comprises a bioelectric impedance measuring unit with a measuring electrode 2.
  • the measuring electrode 2 is an electrically conductive sheet trained whose in the Figure 2 above, horizontally running surface is brought into contact with the body surface of the user in order to detect electrical measurement signals (potentials) there.
  • the measuring electrode 2 is movable, namely resiliently mounted, which in the Figure 2 is indicated schematically.
  • the double arrow in the Figure 2 illustrates the mobility of the measuring electrode 2.
  • the pressure sensor 3 is supported on the back on a fixed part 4.
  • the measuring electrode 2 and the pressure sensor 3 are connected to an evaluation unit, not shown in the figures, of the measuring device according to the invention.
  • the measurement signals of the bioelectric impedance measuring unit and of the pressure sensor 3 are transmitted to the evaluation unit via this connection.
  • the evaluation unit derives at least one physiological parameter from the measurement signals.
  • the evaluation unit includes, for example, a suitably programmed microcontroller with interfaces for digitizing the measurement signals and with interfaces for outputting the results.
  • the Figure 3 shows schematically a plan view of the surface of the sensor unit 1 which is in contact with the body surface of the user of the measuring device during a measurement Figure 3 illustrated embodiment, the pressure sensor 3 is arranged centrally.
  • a plurality of measuring electrodes 2 are arranged in a matrix around the pressure sensor 3.
  • the electrodes 2 ' are feed electrodes of the bioelectric impedance measuring unit.
  • a measuring current is impressed on the body tissue via the feed electrodes 2 '.
  • the potentials thus created on the body surface are recorded via the measuring electrodes 2.
  • the matrix-like arrangement of the measuring and feed electrodes 2 and 2 ' allows a depth profile analysis of physiological parameters.
  • a depth-resolved derivation of physiological parameters can be made take place, as explained in more detail above.
  • a significantly larger number of measuring electrodes can be useful if, for example, a higher resolution is required for depth profile analysis.
  • the Figure 4 shows further embodiments, wherein the invention relates to the left side of this figure ..
  • at least one pressure sensor is arranged under at least one of the electrodes 2, 2 ', as in Figure 2 shown.
  • the electrodes 2 and 2 ' are arranged in a radial configuration around the central pressure sensor 3. All configurations are suitable for a deeply resolved determination of physiological parameters, as explained above.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Artificial Intelligence (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Description

Die Erfindung betrifft eine Messvorrichtung zur nicht-invasiven Bestimmung von wenigstens einem physiologischen Parameter, mit einer diagnostischen Sensoreinheit zur Erzeugung von Messsignalen, und mit einer Auswertungseinheit zur Verarbeitung der Messsignale gemäß dem Oberbegriff des Patentanspruchs 1. Außerdem betrifft die Erfindung ein Verfahren zur nicht-invasiven Bestimmung von wenigstens einem physiologischen Parameter.The invention relates to a measuring device for the non-invasive determination of at least one physiological parameter, with a diagnostic sensor unit for generating measurement signals, and with an evaluation unit for processing the measurement signals according to the preamble of claim 1. The invention also relates to a method for non-invasive Determination of at least one physiological parameter.

Eine derartige Messvorrichtung ist aus der WO 2011/022068 A1 bekannt.Such a measuring device is from the WO 2011/022068 A1 known.

Eine weitere ähnliche Messvorrichtung ist beispielsweise aus der WO 2008/061788 A1 bekannt. Die vorbekannte Messvorrichtung weist eine Sensoreinheit auf, die in die Tastatur eines Computers oder in ein mobiles Gerät der Unterhaltungs- oder Kommunikationstechnik integriert ist. Dabei umfasst die diagnostische Sensoreinheit verschiedene Messmodalitäten, nämlich eine optische Messeinheit, eine EKG-Einheit, einen Temperatursensor und/oder eine bioelektrische Impedanzeinheit. Die Kombination der verschiedenen Messmodalitäten ermöglicht eine kombinierte Auswertung der entsprechenden Messsignale mittels einer in geeigneter Weise programmierten Auswertungseinheit. Die Kombination gewährleistet dabei eine hohe Effizienz und Zuverlässigkeit bei der Erkennung von pathologischen Störungen. Insbesondere ermöglicht die vorbekannte Messvorrichtung eine nicht-invasive indirekte Messung von metabolischen Parametern. Letztlich ist damit die nicht-invasive Messung der Glukosekonzentration bzw. des Blutglukosespiegels möglich.Another similar measuring device is for example from the WO 2008/061788 A1 known. The known measuring device has a sensor unit which is integrated in the keyboard of a computer or in a mobile device for entertainment or communication technology. The diagnostic sensor unit includes various measurement modalities, namely an optical measurement unit, an EKG unit, a temperature sensor and / or a bioelectric impedance unit. The combination of the different measurement modalities enables a combined evaluation of the corresponding measurement signals by means of an evaluation unit programmed in a suitable manner. The combination ensures high efficiency and reliability in the detection of pathological disorders. In particular, the previously known measuring device enables a non-invasive indirect measurement of metabolic parameters. Ultimately, the non-invasive measurement of the glucose concentration or the blood glucose level is possible.

Aufgabe der Erfindung ist es, eine Messvorrichtung mit gegenüber dem Stand der Technik erweiterter Funktionalität bereit zu stellen. Aufgabe der Erfindung ist es weiterhin, eine Messvorrichtung mit möglichst einfach aufgebauter diagnostischer Sensoreinheit bereit zu stellen, so dass die Messvorrichtung insgesamt kostengünstig hergestellt werden kann.The object of the invention is to provide a measuring device with functionality that is expanded compared to the prior art. Another object of the invention is to provide a measuring device with a diagnostic sensor unit that is as simple as possible, so that the measuring device can be manufactured overall inexpensively.

Zur Lösung mindestens einer der genannten Aufgaben schlägt die Erfindung ausgehend von einer Messvorrichtung der eingangs genannten Art vor, dass die Messelektrode an der diagnostischen Sensoreinheit beweglich gelagert ist.To achieve at least one of the above-mentioned tasks, the invention proposes, starting from a measuring device of the type mentioned at the outset, that the measuring electrode is movably mounted on the diagnostic sensor unit.

Auf diese Weise ergibt sich eine besonders elegante Integration des Drucksensors.This results in a particularly elegant integration of the pressure sensor.

Der bei der erfindungsgemäßen Messvorrichtung vorgesehene Drucksensor detektiert einen uniaxialen Druck. Der Drucksensor detektiert, anders ausgedrückt, eine von dem Körpergewebe auf den Drucksensor ausgeübte Kraft in einer bestimmten Richtung, meist in der Richtung senkrecht zur Körperoberfläche, an der der Drucksensor zur Anlage kommt. Unter einem Drucksensor im Sinne der Erfindung ist somit auch ein Kraftsensor zu verstehen. Gemäß der Erfindung wird der von dem zu untersuchenden Körpergewebe lokal auf den Drucksensor ausgeübte Druck detektiert. Dabei wird davon ausgegangen, dass der Drucksensor eine (vergleichsweise kleine) Anlagefläche nutzt, die an der Körperoberfläche anliegt und über die der vom Körpergewebe ausgeübte Druck detektiert wird. Die Größe der Anlagefläche kann zum Beispiel im Bereich von 1 mm2 bis 10 cm2 liegen. Der lokal auf dem Drucksensor ausgeübte Druck im Sinne der Erfindung ist der über diese Anlagefläche des Drucksensors detektierte Druck.The pressure sensor provided in the measuring device according to the invention detects a uniaxial pressure. In other words, the pressure sensor detects a force exerted by the body tissue on the pressure sensor in a certain direction, usually in the direction perpendicular to the body surface on which the pressure sensor comes into contact. A pressure sensor in the sense of the invention is therefore also to be understood as a force sensor. According to the invention, the pressure exerted locally on the pressure sensor by the body tissue to be examined is detected. It is assumed that the pressure sensor uses a (comparatively small) contact surface that lies against the body surface and via which the pressure exerted by the body tissue is detected. The size of the contact surface can range, for example, from 1 mm 2 to 10 cm 2 . The pressure exerted locally on the pressure sensor in the sense of the invention is the pressure detected via this contact surface of the pressure sensor.

Kern der Erfindung ist es , den Drucksensor als diagnostischen Sensor zu verwenden. Beispielsweise kann die Auswertungseinheit der erfindungsgemäßen Messvorrichtung eingerichtet sein, aus dem zeitlichen Verlauf des Messsignals des Drucksensors wenigstens einen der folgenden physiologischen Parameter abzuleiten: Druckvolumenpuls, Pulsamplitude, Pulsbreite, Pulsdauer, Durchblutung, Blutdruck, Pulsdruck, Herzfrequenz, Pulswellengeschwindigkeit, Körpertemperatur, metabolisch erzeugte Wärme. Der Verlauf des Messsignals des Drucksensors liefert unmittelbar den Druckvolumenpuls. Daraus können dann diverse weitere physiologische Parameter bestimmt werden. Beispielsweise korreliert die Pulsamplitude mit der Körpertemperatur, so dass, vorzugsweise nach entsprechender Kalibrierung, aus dem Messsignal des Drucksensors die Körpertemperatur abgeleitet werden kann, nämlich die Körperoberflächentemperatur und/oder die Körperdurchschnittstemperatur, die arterielle Bluttemperatur, die Körperkerntemperatur oder die metabolisch produzierte Wärmemenge. Weiterhin können Rückschlüsse gezogen werden auf die vom Körperinneren zum Ende der arteriellen Kapillaren fließende Wärmemenge sowie auf die Temperatur im Bereich der arteriell-venösen Kapillaren bzw. des diese umgebenden Körpergewebes.The essence of the invention is to use the pressure sensor as a diagnostic sensor. For example, the evaluation unit of the measuring device according to the invention can be set up to derive at least one of the following physiological parameters from the time profile of the measurement signal of the pressure sensor: pressure volume pulse, pulse amplitude, pulse width, pulse duration, Blood circulation, blood pressure, pulse pressure, heart rate, pulse wave speed, body temperature, metabolically generated heat. The course of the measurement signal from the pressure sensor directly delivers the pressure volume pulse. Various other physiological parameters can then be determined from this. For example, the pulse amplitude correlates with the body temperature, so that, preferably after appropriate calibration, the body temperature can be derived from the measurement signal of the pressure sensor, namely the body surface temperature and / or the body average temperature, the arterial blood temperature, the body core temperature or the metabolically produced amount of heat. Conclusions can also be drawn about the amount of heat flowing from the inside of the body to the end of the arterial capillaries and the temperature in the area of the arterial-venous capillaries or the surrounding body tissue.

Zur Gewinnung des Messsignals mittels der erfindungsgemäßen Messvorrichtung muss der wenigstens eine Drucksensor direkt oder indirekt mit der Körperoberfläche des Benutzers in Kontakt gebracht werden, beispielsweise in dem der Benutzer einen Finger auf die mit dem Drucksensor ausgestattete Vorrichtung auflegt. Ebenso ist es denkbar, dass der Drucksensor mittels geeigneter Mittel an die Oberfläche des Körpergewebes angepresst wird. Hierzu kann ein Halteclip an sich bekannter Art oder eine elastische Manschette dienen. Ebenso denkbar ist es, dass, zum Beispiel durch medizinisch geschultes Personal, die Messvorrichtung mit dem Drucksensor am Körper des Benutzers entlang geführt wird, um an verschiedenen Stellen am Körper den Druck zu messen. Nach Anlegen des Drucksensors am Körper des Benutzers wird das Messsignal während eines vorgegebenen Zeitraums (mehrere Sekunden bis mehrere Minuten, oder auch kontinuierlich) erfasst. Der Zeitverlauf des Messsignals wird dann, wie oben beschrieben, ausgewertet.To obtain the measurement signal by means of the measurement device according to the invention, the at least one pressure sensor must be brought into direct or indirect contact with the body surface of the user, for example by placing a finger on the device equipped with the pressure sensor. It is also conceivable that the pressure sensor is pressed onto the surface of the body tissue by means of suitable means. A retaining clip of a known type or an elastic cuff can be used for this. It is also conceivable that, for example by medically trained personnel, the measuring device with the pressure sensor is guided along the body of the user in order to measure the pressure at various points on the body. After applying the pressure sensor to the body of the user, the measurement signal is recorded for a predetermined period of time (several seconds to several minutes, or continuously). The time course of the measurement signal is then evaluated as described above.

Bei einer bevorzugten Ausgestaltung weist die Sensoreinheit der erfindungsgemäßen Messvorrichtung eine optische Messeinheit auf, die wenigstens eine Strahlungsquelle zur Bestrahlung des Körpergewebes und wenigstens einen Strahlungssensor zur Detektion der von dem Körpergewebe gestreuten und/oder transmittierten Strahlung umfasst, wobei die Auswertungseinheit zur Ableitung des wenigstens einen physiologischen Parameters zumindest aus dem Messsignal des Drucksensors und der optischen Messeinheit eingerichtet ist. Die optische Messeinheit kann wie in der oben zitierten WO 2008/061788 A1 beschrieben ausgestaltet sein. Mittels der optischen Messeinheit kann zum Beispiel die arterielle Sauerstoffsättigung bestimmt werden. Der mittels des Drucksensors bestimmte Druckvolumenpuls kann dabei die optische Messung ergänzen oder teilweise ersetzen, da der Druckvolumenpuls unabhängig von der Lichtabsorption einzelner Körpergewebe- oder Blutbestandteile bestimmt werden kann. Somit kann das Messsignal des Drucksensors als Referenzwert dienen und dadurch die Messgenauigkeit erhöhen. Außerdem ermöglicht die Erfassung des Messsignals des Drucksensors die Vereinfachung der optischen Messung. Beispielsweise kann die Messung auf eine geringere Anzahl unterschiedlicher Wellenlängen reduziert werden.In a preferred embodiment, the sensor unit of the measuring device according to the invention has an optical measuring unit which comprises at least one radiation source for irradiating the body tissue and at least one radiation sensor for detecting the radiation scattered and / or transmitted by the body tissue, the evaluation unit for deriving the at least one physiological one Parameter is set up at least from the measurement signal of the pressure sensor and the optical measuring unit. The optical measuring unit can be as in the above WO 2008/061788 A1 be described. For example, arterial oxygen saturation can be determined using the optical measuring unit. The pressure volume pulse determined by means of the pressure sensor can supplement or partially replace the optical measurement, since the pressure volume pulse can be determined independently of the light absorption of individual body tissue or blood components. The measurement signal of the pressure sensor can thus serve as a reference value and thereby increase the measurement accuracy. In addition, the detection of the measurement signal from the pressure sensor enables the optical measurement to be simplified. For example, the measurement can be reduced to a smaller number of different wavelengths.

Gemäß einer weiteren bevorzugten Ausgestaltung umfasst die Sensoreinheit der Messvorrichtung einen Temperatursensor, wobei die Auswertungseinheit zur Ableitung des wenigstens einen physiologischen Parameters zumindest aus den Messsignalen des Drucksensors und des Temperatursensors eingerichtet ist. Aus der zitierten WO 2008/061788 A1 ist es bekannt, dass aus kombinierter Temperatur- und optischer Messung die Glukosekonzentration im Blut ermittelt werden kann. Entsprechend kann die Temperatur- bzw. Wärmemessung die weiteren Messmodalitäten sinnvoll ergänzen. Die Messsignale des Temperatursensors ermöglichen Rückschlüsse auf den lokalen Wärmeaustausch und damit auf die lokale Stoffwechselaktivität. Außerdem ist der Temperatursensor zur Bestimmung der lokalen Durchblutung geeignet.According to a further preferred embodiment, the sensor unit of the measuring device comprises a temperature sensor, the evaluation unit being set up to derive the at least one physiological parameter at least from the measurement signals of the pressure sensor and the temperature sensor. From the quoted WO 2008/061788 A1 it is known that the glucose concentration in the blood can be determined from a combined temperature and optical measurement. Accordingly, the temperature or heat measurement can usefully supplement the other measurement modalities. The measurement signals from the temperature sensor allow conclusions to be drawn about the local heat exchange and thus the local metabolic activity. The temperature sensor is also suitable for determining local blood flow.

Bei einer weiteren bevorzugten Ausgestaltung weist die Sensoreinheit der erfindungsgemäßen Messvorrichtung eine EKG-Einheit zur Erfassung eines EKG-Signals über zwei oder mehr EKG-Elektroden auf, wobei die Auswertungseinheit zur Ableitung des wenigstens einen physiologischen Parameters zumindest aus den Messsignalen des Drucksensors und der EKG-Einheit eingerichtet ist. Durch die EKG-Einheit wird der Funktionsumfang der erfindungsgemäßen Messvorrichtung erweitert. Die Auswertungseinheit der Messvorrichtung kann zum Beispiel zur Auswertung des zeitlichen Verlaufs des Druckvolumenpulses und des EKG-Signals eingerichtet sein. Daraus kann wiederum die Pulswellengeschwindigkeit ermittelt werden, was unter anderem Rückschlüsse auf den Blutdruck ermöglicht. Die Kombination aus Drucksensor und EKG-Einheit ermöglicht, anders ausgedrückt, eine automatisierte funktionale Bewertung des Zustands des Gefäßsystems des Benutzers der Messvorrichtung.In a further preferred embodiment, the sensor unit of the measuring device according to the invention has an EKG unit for detecting an EKG signal via two or more EKG electrodes, the evaluation unit for deriving the at least one physiological parameter from at least the measurement signals of the pressure sensor and the EKG electrodes. Unit is set up. The functional scope of the measuring device according to the invention is expanded by the EKG unit. The evaluation unit of the measuring device can, for example, be set up to evaluate the time profile of the pressure volume pulse and the EKG signal. From this can in turn, the pulse wave speed can be determined, which among other things enables conclusions to be drawn about the blood pressure. In other words, the combination of pressure sensor and EKG unit enables automated functional evaluation of the condition of the vascular system of the user of the measuring device.

Die Sensoreinheit der erfindungsgemäßen Messvorrichtung weist eine bioelektrische Impedanzmesseinheit auf, wobei die Auswertungseinheit zur Ableitung des wenigstens einen physiologischen Parameters zumindest aus dem Messsignal des Drucksensors und der bioelektrischen Impedanzmesseinheit eingerichtet ist. Insbesondere kann die bioelektrische Impedanzmesseinheit zur lokalen Bioimpedanzmessung ausgebildet sein. Die Kombination aus Drucksensor und bioelektrischer Impedanzmesseinheit ermöglicht die Bestimmung der im Körpergewebe enthaltenen Wassermenge, des Anteils der fettfreien Masse am Körpergewebe sowie des Körperfettanteils, ohne dass notwendigerweise die Gesamtkörpermasse bestimmt bzw. eingegeben werden muss. Die bioelektrische Impedanzmessung ermöglicht weiterhin, wie in der zitierten WO 2008/061788 A1 im Detail beschrieben, ggfs. in Kombination mit weiteren Messmodalitäten, eine nicht-invasive Bestimmung der Glukosekonzentration.The sensor unit of the measuring device according to the invention has a bioelectrical impedance measuring unit, the evaluation unit being designed to derive the at least one physiological parameter from at least the measuring signal of the pressure sensor and the bioelectrical impedance measuring unit. In particular, the bioelectric impedance measurement unit can be designed for local bioimpedance measurement. The combination of pressure sensor and bioelectrical impedance measuring unit enables the amount of water contained in the body tissue, the percentage of fat-free mass in the body tissue and the percentage of body fat to be determined without having to determine or enter the total body mass. The bioelectrical impedance measurement also enables, as in the cited WO 2008/061788 A1 described in detail, possibly in combination with other measurement modalities, a non-invasive determination of the glucose concentration.

Erfindungsgemäß ist der Drucksensor mechanisch an eine Messelektrode der bioelektrischen Impedanzmesseinheit gekoppelt und kann so den von dem zu untersuchenden Körpergewebe über die Messelektrode lokal auf den Drucksensor ausgeübten Druck detektieren. Auf diese Weise lässt sich der Drucksensor besonders elegant integrieren. Die Messelektrode und der Drucksensor benutzen für die Messsignalerfassung ein- und dieselbe Anlagefläche am Körper. Zur Ermöglichung der Druck- bzw. Kraftmessung sollte die Messelektrode dabei an der diagnostischen Sensoreinheit beweglich (z. B. federnd) gelagert sein. Der eigentliche Drucksensor kann dann zum Beispiel ein piezoresistives Element umfassen. Das piezoresistive Element kann vorteilhaft unter der Messelektrode der bioelektrischen Impedanzeinheit angeordnet sein. Auf diese Weise wird die auf die Elektrode ausgeübte Kraft bzw. der ausgeübte Druck direkt in ein elektrisches Messsignal umgewandelt.According to the invention, the pressure sensor is mechanically coupled to a measuring electrode of the bioelectric impedance measuring unit and can thus detect the pressure exerted locally on the pressure sensor by the body tissue to be examined via the measuring electrode. In this way, the pressure sensor can be integrated particularly elegantly. The measuring electrode and the pressure sensor use one and the same contact surface on the body for measuring signal acquisition. In order to enable pressure or force measurement, the measuring electrode should be movably (e.g. resiliently) mounted on the diagnostic sensor unit. The actual pressure sensor can then comprise a piezoresistive element, for example. The piezoresistive element can advantageously be arranged under the measuring electrode of the bioelectric impedance unit. In this way, the force or pressure exerted on the electrode is converted directly into an electrical measurement signal.

Alternativ oder zusätzlich kann der Drucksensor an eine Messelektrode der EKG-Einheit gekoppelt sein.Alternatively or additionally, the pressure sensor can be coupled to a measuring electrode of the EKG unit.

Die erfindungsgemäße Messvorrichtung bietet eine Vielzahl von Vorteilen für die Bestimmung eines oder mehrerer physiologischer Parameter. Die Messgenauigkeit kann erhöht werden. Der Drucksensor kann als Referenz verwendet werden, um die Fehler der Messsignale, die mittels anderer Messmodalitäten gewonnen werden, aufzudecken. Der Drucksensor hat weiterhin den Vorteil, dass dieser mit einfachen elektronischen Schaltungen nutzbar gemacht werden kann. Außerdem sind Drucksensoren energiesparend und sowohl produktions- als auch anwendungstechnisch einfach zu handhaben. Drucksensoren können in kleiner Größe realisiert werden und haben eine niedrige Fehlertoleranz. Der Einsatz eines oder mehrerer Drucksensoren bei der erfindungsgemäßen Messvorrichtung als einzige Messmodalität ist genauso möglich wie der Einsatz zur Ergänzung anderer Messmodalitäten. So können zum Beispiel der Druckvolumenpuls, die Pulsfrequenz und weitere damit zusammenhängende Parameter schon allein und ausschließlich aus dem Messsignal des Drucksensors bestimmt werden, was für viele praktische Anwendungen ausreicht. Entsprechend kann für eine Vielzahl von Anwendungszwecken auf eine (aufwendigere) optische Messung oder eine EKG-Messung verzichtet werden.The measuring device according to the invention offers a large number of advantages for determining one or more physiological parameters. The measuring accuracy can be increased. The pressure sensor can be used as a reference in order to uncover the errors in the measurement signals which are obtained by means of other measurement modalities. The pressure sensor also has the advantage that it can be used with simple electronic circuits. In addition, pressure sensors are energy-saving and easy to use in terms of both production and application. Pressure sensors can be implemented in a small size and have a low fault tolerance. The use of one or more pressure sensors in the measuring device according to the invention as the only measurement modality is just as possible as the use to supplement other measurement modalities. For example, the pressure volume pulse, the pulse frequency and other related parameters can be determined solely and exclusively from the measurement signal of the pressure sensor, which is sufficient for many practical applications. Accordingly, a (more complex) optical measurement or an EKG measurement can be dispensed with for a large number of application purposes.

Bei einer Messvorrichtung mit diagnostischer Sensoreinheit, die wie oben beschrieben ausgebildet ist, ist die Auswertungseinheit zur Ableitung des wenigstens einen physiologischen Parameters als Funktion der Tiefe im Körpergewebe eingerichtet Oberflächenanalytische und körperdurchschnittsanalytische Verfahren zur Bestimmung von physiologischen Parametern sind allgemein bekannt und üblich. Von besonderem Vorteil ist demgegenüber die Tiefenanlyse bzw. die Tiefenprofilanalyse oder die Tiefenquerschnittsprofilanlyse, bei denen ein oder mehrere physiologische Parameter ortsaufgelöst, insbesondere tiefenaufgelöst ermittelt werden. Besonders bevorzugt erfolgt eine tiefenaufgelöste und zeitabhängige Erfassung von physiologischen Parametern. Die so gewonnenen Daten ermöglichen es detailliert, im Körpergewebe ablaufende physiologische, insbesondere metabolische Prozesse quantitativ und ortsaufgelöst zu analysieren. Dies wiederum ermöglicht ein genaueres, für den Patienten bzw. für den Benutzer der Messvorrichtung bequemeres sowie kosten- und aufwandseffizienteres Vorgehen bei der Diagnose. Im Sinne der Erfindung wird ein nicht-invasives Tiefenanalyseverfahren zur Bestimmung von physiologischen Parametern bereitgestellt, bei dem nicht-invasiv physiologische Parameter und entsprechende biochemische Prozesse im Inneren des menschlichen Körpers tiefenabhängig bestimmt werden. Insbesondere ermöglicht eine Tiefenprofilanalyse durch Anwendung der oben beschriebenen Messmodalitäten (Druck, Temperatur, optische Messung, bioelektrische Impedanz, EKG), jeweils einzeln oder in Kombination, die Ermittlung relevanter physiologischer Parameter zur Bestimmung der Zusammensetzung des Körpergewebes, beispielsweise des die Kapillaren umgebenden Gewebes. Das Wissen um die Zusammensetzung des Körpergewebes kann wiederum als Parameter in die Berechnung bei der Ableitung von physiologischen Parametern aus den Messsignalen herangezogen werden. Eine spezielle Variante der Tiefenprofilanalyse ist die Tiefenquerschnittsprofilanalyse. Bei dieser wird der Querschnitt des Körpergewebes in Richtung der Tiefe, d. h. senkrecht zur Körperoberfläche, von einem Startpunkt aus analysiert, wobei dieser Startpunkt nicht notwendigerweise direkt an der Körperoberfläche liegen muss. Beispielsweise kann eine Tiefenquerschnittprofilanalyse durch bioelektrische Impedanzmessung erfolgen, wobei der Abstand bzw. die relative Position der verwendeten Elektroden zum untersuchten Körpergewebe, die Stärke des zur Impedanzmessung aufgeprägten Stroms und/oder die Messfrequenz variiert werden. Für die Tiefenquerschnittsprofilanalyse eignet sich somit eine erfindungsgemäße Messvorrichtung, die die oben aufgeführten Messmodalitäten einzeln oder in Kombination umfasst, besonders gut. Einzelne oder mehrere der folgenden physiologischen Parameter können gemäß der Erfindung tiefenanalytisch, tiefenprofilanalytisch oder tiefenquerschnittsprofilanalytisch erfasst werden: Durchblutung, Blutdruck, Pulsamplitude, Pulsdruck, Pulsbreite, Blutmenge, Körperoberflächentemperatur, Körperdurchschnittstempteratur, arterielle Bluttemperatur, Körperkerntemperatur, vom Körperinneren zu den Kapillarenden transportierte Wärmemenge, Temperatur im Bereich der arteriell-venösen Kapillaren bzw. des diese umgebenden Gewebes, Pulswellengeschwindigkeit, vom Metabolismus produzierte Wärmemenge, arterielle Sauerstoffsättigung, Sauerstoffsättigung im Gewebe, Sauerstoffverbrauch, Körperwassermasse, Anteil der fettfreien Masse am Körpergewebe, Körperfettanteil, Glukosekonzentration usw..In the case of a measuring device with a diagnostic sensor unit, which is designed as described above, the evaluation unit is designed to derive the at least one physiological parameter as a function of the depth in the body tissue. Surface analytical and body-average analytical methods for determining physiological parameters are generally known and customary. In contrast, the depth analysis or the depth profile analysis or the depth cross-sectional profile analysis, in which one or more physiological parameters are determined in a spatially resolved manner, in particular in a depth-resolved manner, is particularly advantageous. A depth-resolved and time-dependent detection of physiological parameters is particularly preferred. The data obtained in this way make it possible to analyze in detail quantitative and spatially resolved physiological, in particular metabolic processes taking place in the body tissue. This in turn enables a more precise, more cost-effective and more cost-effective procedure for the diagnosis for the patient or for the user of the measuring device. According to the invention, a non-invasive depth analysis method for determining physiological parameters is provided, in which non-invasive physiological parameters and corresponding biochemical processes in the interior of the human body are determined as a function of depth. In particular, a depth profile analysis by using the measurement modalities described above (pressure, temperature, optical measurement, bioelectric impedance, EKG), in each case individually or in combination, enables the determination of relevant physiological parameters for determining the composition of the body tissue, for example the tissue surrounding the capillaries. The knowledge of the composition of the body tissue can in turn be used as a parameter in the calculation when deriving physiological parameters from the measurement signals. A special variant of the depth profile analysis is the depth cross-sectional profile analysis. In this, the cross section of the body tissue in the direction of the depth, ie perpendicular to the body surface, is analyzed from a starting point, whereby this starting point does not necessarily have to lie directly on the body surface. For example, a deep cross-sectional profile analysis can be carried out by bioelectrical impedance measurement, the distance or the relative position of the electrodes used from the examined body tissue, the strength of the current impressed for the impedance measurement and / or the measurement frequency being varied. A measuring device according to the invention, which comprises the above-mentioned measuring modalities individually or in combination, is therefore particularly well suited for the deep cross-sectional profile analysis. Individual or more of the following physiological parameters can be recorded according to the invention in depth analysis, depth profile analysis or depth cross-section profile analysis: blood circulation, blood pressure, pulse amplitude, pulse pressure, pulse width, blood volume, body surface temperature, body average temperature, arterial blood temperature, body core temperature, the amount of heat transported from the inside of the body to the capillary ends Area of the arterial-venous capillaries or the surrounding tissue, pulse wave velocity, amount of heat produced by the metabolism, arterial oxygen saturation, oxygen saturation in the tissue, Oxygen consumption, body water mass, percentage of fat-free mass in body tissue, body fat percentage, glucose concentration, etc.

Dabei kann, was ein wesentlicher Vorteil der Erfindung gegenüber dem Stand der Technik ist, die für die Messvorrichtung benötigte Hardware sehr kompakt ausgeführt werden. Die einzelnen Sensoren benötigen einen Bauraum, der zum Beispiel kleiner als 2 cm x 2 cm x 2 cm sein kann. Einige Sensoren sind sogar mit einem Bauvolumen von weniger als 1 cm x 1 cm x 1 cm oder sogar noch kleiner zu realisieren. Selbst eine Kombination aus mehreren Messmodalitäten in der erfindungsgemäßen Messvorrichtung kann als kompaktes, portables Gerät ("handheld") zur Tiefenanalyse oder zur Tiefenprofilanalyse realisiert werden. Die Kantenlänge des Gerätes kann zum Beispiel weniger als 10 bis 20 cm betragen. Sogar kleinere Abmessungen sind denkbar. Die Hardwarekosten und damit die Diagnosekosten sind bei Verwendung der erfindungsgemäßen Messvorrichtung deutlich geringer als bei Anwendungen herkömmlicher ortsaufgelöster Diagnoseverfahren (z. B. Computertomographie).The hardware required for the measuring device can be made very compact, which is a significant advantage of the invention over the prior art. The individual sensors require a space that can be, for example, smaller than 2 cm x 2 cm x 2 cm. Some sensors can even be realized with a construction volume of less than 1 cm x 1 cm x 1 cm or even smaller. Even a combination of several measurement modalities in the measurement device according to the invention can be implemented as a compact, portable device ("handheld") for depth analysis or for depth profile analysis. For example, the edge length of the device can be less than 10 to 20 cm. Even smaller dimensions are conceivable. The hardware costs and thus the diagnostic costs are significantly lower when using the measuring device according to the invention than when using conventional spatially resolved diagnostic methods (e.g. computer tomography).

Die oben erwähnte zu Grunde liegende Aufgabe wird auch durch ein Verfahren zur nicht-invasiven Bestimmung von wenigstens einem physiologischen Parameter gelöst, bei dem der von einem zu untersuchenden Körpergewebe lokal auf einem Drucksensor ausgeübte Druck detektiert wird, wobei der wenigstens eine physiologische Parameter aus dem detektierten Druck abgeleitet wird.The above-mentioned underlying object is also achieved by a method for the non-invasive determination of at least one physiological parameter, in which the pressure exerted locally on a pressure sensor by a body tissue to be examined is detected, the at least one physiological parameter from the detected one Pressure is derived.

Ausführungsbeispiele der Erfindung werden im Folgenden anhand der Zeichnungen näher erläutert. Es zeigen:

Figur 1
Messsignal des Drucksensors der erfindungsgemäßen Messvorrichtung als Funktion der Zeit;
Figur 2
Ausführungsbeispiel einer Sensoreinheit der erfindungsgemäßen Messvorrichtung mit Messelektrode und Drucksensor;
Figur 3
weiteres Ausführungsbeispiel einer Sensoreinheit der erfindungsgemäßen Messvorrichtung mit matrixförmiger Anordnung von Messelektroden;
Figur 4
weitere Ausführungsbeispiele mit unterschiedlichen Konfigurationen der Messelektroden.
Exemplary embodiments of the invention are explained in more detail below with reference to the drawings. Show it:
Figure 1
Measuring signal of the pressure sensor of the measuring device according to the invention as a function of time;
Figure 2
Embodiment of a sensor unit of the measuring device according to the invention with measuring electrode and pressure sensor;
Figure 3
Another exemplary embodiment of a sensor unit of the measuring device according to the invention with a matrix-shaped arrangement of measuring electrodes;
Figure 4
further exemplary embodiments with different configurations of the measuring electrodes.

Die Figur 1 illustriert die Ableitung des Druckvolumenpulses aus dem Messsignal eines Druck- bzw. Kraftsensors, der erfindungsgemäß Bestandteil einer diagnostischen Sensoreinheit ist. Der Drucksensor liegt an der Körperoberfläche eines Patienten in dem zu untersuchenden Bereich an, so dass der Drucksensor den von dem Körpergewebe lokal auf den Drucksensor ausgeübten Druck detektiert, und zwar, wie in Figur 1 zu sehen ist, als Funktion der Zeit t. Das Messsignal ist der Druck p. Der Zeitverlauf des Messsignals p entspricht dem Druckvolumenpuls. Anhand des Diagramms ist unmittelbar zu erkennen, dass aus dem Messsignal beispielsweise physiologische Parameter wie die Pulsamplitude, die Pulsbreite, die Blutmenge, die Pulsdauer, die Durchblutung, der Blutdruck, der Pulsdruck sowie die Herzfrequenz abgeleitet werden können. Zudem kann die Pulswellengeschwindigkeit ermittelt werden. Daraus können wiederum weitere verwandte physiologische Parameter abgeleitet werden. Beispielsweise ist bekannt, dass die Pulsamplitude mit der Körpertemperatur korreliert. Somit kann der Drucksensor der erfindungsgemäßen Messvorrichtung dazu genutzt werden, mit der Temperatur zusammenhängende physiologische Parameter zu bestimmen, wie die Körperoberflächentemperatur, die Körperdurchschnittstemperatur, die arterielle Bluttemperatur, die Körperkerntemperatur, die vom Metabolismus erzeugte Wärmemenge, die vom Körperinnerem zu den Kapillarenden fließende Wärmemenge sowie die Temperatur im Bereich der arteriell-venösen Kapillaren bzw. des diese umgebenden Gewebes.The Figure 1 illustrates the derivation of the pressure volume pulse from the measurement signal of a pressure or force sensor, which according to the invention is part of a diagnostic sensor unit. The pressure sensor bears on the body surface of a patient in the area to be examined, so that the pressure sensor detects the pressure exerted locally by the body tissue on the pressure sensor, as in FIG Figure 1 can be seen as a function of time t. The measurement signal is the pressure p. The time course of the measurement signal p corresponds to the pressure volume pulse. The diagram immediately shows that, for example, physiological parameters such as the pulse amplitude, the pulse width, the amount of blood, the pulse duration, the blood flow, the blood pressure, the pulse pressure and the heart rate can be derived from the measurement signal. The pulse wave speed can also be determined. Further related physiological parameters can in turn be derived from this. For example, it is known that the pulse amplitude correlates with the body temperature. Thus, the pressure sensor of the measuring device according to the invention can be used to determine physiological parameters related to the temperature, such as the body surface temperature, the body average temperature, the arterial blood temperature, the body core temperature, the amount of heat generated by the metabolism, the amount of heat flowing from the inside of the body to the capillary ends, and that Temperature in the area of the arterial-venous capillaries or the surrounding tissue.

Bei dem in Figur 2 dargestellten Ausführungsbeispiel ist die im Querschnitt dargestellte Sensoreinheit insgesamt mit der Bezugsziffer 1 bezeichnet. Die Sensoreinheit umfasst eine bioelektrische Impedanzmesseinheit mit einer Messelektrode 2. Die Messelektrode 2 ist als elektrisch leitendes Blech ausgebildet, deren in der Figur 2 oben dargestellte, horizontal verlaufende Oberfläche mit der Körperoberfläche des Benutzers in Kontakt gebracht wird, um dort elektrische Messsignale (Potentiale) zu erfassen. Die Messelektrode 2 ist beweglich, nämlich federnd gelagert, was in der Figur 2 schematisch angedeutet ist. Der Doppelpfeil in der Figur 2 illustriert die Beweglichkeit der Messelektrode 2. Unterhalb der Messelektrode 2 ist ein Drucksensor 3, zum Beispiel in Form eines piezoresistiven Elementes, angeordnet, der den von dem zu untersuchenden Körpergewebe über die Messeletrode 2 auf den Drucksensor 3 ausgeübten Druck detektiert. Dabei stützt sich der Drucksensor 3 an der Rückseite an einem fixen Teil 4 ab.At the in Figure 2 In the exemplary embodiment shown, the sensor unit shown in cross section is designated as a whole by reference number 1. The sensor unit comprises a bioelectric impedance measuring unit with a measuring electrode 2. The measuring electrode 2 is an electrically conductive sheet trained whose in the Figure 2 above, horizontally running surface is brought into contact with the body surface of the user in order to detect electrical measurement signals (potentials) there. The measuring electrode 2 is movable, namely resiliently mounted, which in the Figure 2 is indicated schematically. The double arrow in the Figure 2 illustrates the mobility of the measuring electrode 2. Below the measuring electrode 2 there is a pressure sensor 3, for example in the form of a piezoresistive element, which detects the pressure exerted on the pressure sensor 3 by the body tissue to be examined via the measuring electrode 2. The pressure sensor 3 is supported on the back on a fixed part 4.

Die Messelektrode 2 und der Drucksensor 3 sind mit einer in den Figuren nicht näher dargestellten Auswertungseinheit der erfindungsgemäßen Messvorrichtung verbunden. Über diese Verbindung werden die Messsignale der bioelektrischen Impedanzmesseinheit und des Drucksensors 3 an die Auswertungseinheit übertragen. Die Auswertungsseinheit leitet aus den Messsignalen wenigstens einen physiologischen Parameter ab. Hierzu umfasst die Auswertungseinheit zum Beispiel einen geeignet programmierten Mikrocontroller mit Schnittstellen zur Digitalisierung der Messsignale und mit Schnittstellen zur Ausgabe der Resultate.The measuring electrode 2 and the pressure sensor 3 are connected to an evaluation unit, not shown in the figures, of the measuring device according to the invention. The measurement signals of the bioelectric impedance measuring unit and of the pressure sensor 3 are transmitted to the evaluation unit via this connection. The evaluation unit derives at least one physiological parameter from the measurement signals. For this purpose, the evaluation unit includes, for example, a suitably programmed microcontroller with interfaces for digitizing the measurement signals and with interfaces for outputting the results.

Die Figur 3 zeigt schematisch eine Draufsicht auf die bei einer Messung an der Körperoberfläche des Benutzers der Messvorrichtung anliegende Oberfläche der Sensoreinheit 1. Bei dem in Figur 3 dargestellten Ausführungsbeispiel ist der Drucksensor 3 zentral angeordnet. Um den Drucksensor 3 herum sind mehrere Messelektroden 2 matrixförmig angeordnet. Bei den Elektroden 2' handelt es sich um Einspeiseelektroden der bioelektrischen Impedanzmesseinheit. Über die Einspeiseelektroden 2' wird dem Körpergewebe ein Messstrom aufgeprägt. Die dadurch an der Körperoberfläche entstehenden Potentiale werden über die Messeletroden 2 erfasst. Die matrixförmige Anordnung der Mess- und Einspeiseelektroden 2 bzw. 2' erlaubt erfindungsgemäß eine Tiefenprofilanalyse von physiologischen Parametern. Je nach relativer Position der einspeisenden und messenden Elektroden 2 bzw. 2' ergibt sich ein unterschiedlicher Weg des elektrischen Stroms durch das Körpergewebe. Durch Vergleich der erfassten Potentiale kann eine tiefenaufgelöste Ableitung von physiologischen Parametern erfolgen, wie oben näher erläutert. Bei dem dargestellten Ausführungsbeispiel sind insgesamt 16 Elektroden 2 bzw. 2' vorgesehen. Eine wesentlich größere Zahl von Messelektroden kann sinnvoll sein, wenn zum Beispiel eine höhere Auflösung bei der Tiefenprofilanalyse gewünscht wird.The Figure 3 shows schematically a plan view of the surface of the sensor unit 1 which is in contact with the body surface of the user of the measuring device during a measurement Figure 3 illustrated embodiment, the pressure sensor 3 is arranged centrally. A plurality of measuring electrodes 2 are arranged in a matrix around the pressure sensor 3. The electrodes 2 'are feed electrodes of the bioelectric impedance measuring unit. A measuring current is impressed on the body tissue via the feed electrodes 2 '. The potentials thus created on the body surface are recorded via the measuring electrodes 2. According to the invention, the matrix-like arrangement of the measuring and feed electrodes 2 and 2 'allows a depth profile analysis of physiological parameters. Depending on the relative position of the feeding and measuring electrodes 2 and 2 ', there is a different path of the electrical current through the body tissue. By comparing the recorded potentials, a depth-resolved derivation of physiological parameters can be made take place, as explained in more detail above. In the illustrated embodiment, a total of 16 electrodes 2 and 2 'are provided. A significantly larger number of measuring electrodes can be useful if, for example, a higher resolution is required for depth profile analysis.

Die Figur 4 zeigt weitere Ausführungsbeispiele, wobei sich die Erfindung auf die linke Seite dieser Figur bezieht.. Bei den beiden linken Konfigurationen der Figur 4 ist wenigstens ein Drucksensor unter wenigstens einer der Elektroden 2, 2' angeordnet, wie in Figur 2 dargestellt. Bei der rechts in Figur 4 dargestellte Variante sind die Elektroden 2 und 2' in einer radialen Konfiguration um den zentralen Drucksensor 3 herum angeordnet. Sämtliche Konfigurationen eignen sich für eine tiefenaufgelöste Bestimmung von physiologischen Parametern, wie oben erläutert.The Figure 4 shows further embodiments, wherein the invention relates to the left side of this figure .. In the two left configurations of the Figure 4 at least one pressure sensor is arranged under at least one of the electrodes 2, 2 ', as in Figure 2 shown. At the right in Figure 4 In the variant shown, the electrodes 2 and 2 'are arranged in a radial configuration around the central pressure sensor 3. All configurations are suitable for a deeply resolved determination of physiological parameters, as explained above.

Claims (16)

  1. Measurement device for non-invasive determination of at least one physiological parameter, having a diagnostic sensor unit (1) for generating measurement signals, and having an evaluation unit for processing the measurement signals,
    wherein the diagnostic sensor unit (1) comprises at least one pressure sensor (3) that detects the pressure exerted locally on the pressure sensor (3) by a body tissue to be examined, wherein the evaluation unit is set up for derivation of at least one physiological parameter from the measurement signal of the pressure sensor (3),
    wherein the sensor unit (1) comprises a bioelectrical impedance measurement unit, wherein the evaluation unit is set up for derivation of the at least one physiological parameter at least from the measurement signals of the pressure sensor (3) and of the bioelectrical impedance measurement unit,
    wherein that the pressure sensor (3) is mechanically coupled with a measurement electrode (2) of the bioelectrical impedance measurement unit, and thereby detects the pressure locally exerted on the pressure sensor (3) by the body tissue to be examined, by way of the measurement electrode (2),
    wherein the evaluation unit is set up for derivation of the at least one physiological parameter as a function of the depth in the body tissue,
    characterized in that
    the measurement electrode (2) is movably mounted on the diagnostic sensor unit (1).
  2. Measurement device according to claim 1, characterized in that the at least one physiological parameter is detected as a function of time.
  3. Measurement device according to claim 1 or 2, characterized the evaluation unit is set up to produce a depth cross-sectional profile analysis of the at least one physiological parameter.
  4. Measurement device according to one of claims 1 to 3, characterized in that the strength of the impressed current for impedance measurement and / or the measurement frequency is varied.
  5. Measurement device according to one of claims 1 to 4, characterized in that in that the feed electrodes (2 ') and / or measurment electrodes (2) are arranged symmetrically.
  6. Measurement device according to one of claims 1 to 5, characterized in that the feed electrodes (2 ') and / or measurment electrodes (2) are arranged in a matrix.
  7. Measurement device according to one of claims 1 to 6, characterized in that the feed electrodes (2 ') and / or measurment electrodes (2) are arranged in a circular symmetry.
  8. Measurement device according to claim 7, characterized in that the evaluation unit is set up for deriving at least one of the following physiological parameters from the time progression of the measurement signal of the pressure sensor (3): pressure volume pulse, pulse amplitude, pulse width, pulse duration, perfusion, blood pressure, pulse pressure, heart rate, pulse wave velocity, body temperature, metabolically generated heat amount.
  9. Measurement device according 7 or 8, characterized by means for pressing the pressure sensor (3) against the surface of the body tissue
  10. Measurement device according to one of claims 1 to 9, characterized in that the sensor unit (1) comprises an optical measurement unit that comprises at least one radiation source for irradiation of the body tissue and at least one radiation sensor for detection of the radiation scattered and/or transmitted by the body tissue, wherein the evaluation unit is set up for derivation of the at least one physiological parameter at least from the measurement signals of the bioelectrical impedance measurement unit and of the optical measurement unit.
  11. Measurement device according to one of claims 1 to 10, characterized in that the sensor unit (1) comprises a temperature sensor, wherein the evaluation unit is set up for derivation of the at least one physiological parameter at least from the measurement signals of the pressure sensor and of the temperature sensor.
  12. Measurement device according to one of claims 1 to 11, characterized in that the sensor unit (1) comprises an EKG unit for detection of an EKG signal by way of two or more EKG electrodes, wherein the evaluation unit is set up for derivation of the at least one physiological parameter at least from the measurement signals of the pressure sensor and of the EKG unit.
  13. Measurement device according to one of claims 1 to 12, characterized in that, the pressure sensor (3) is mechanically coupled with a measurement electrode (2) of the EKG unit and/or of the bioelectrical impedance measurement unit, and thereby detects the pressure locally exerted on the pressure sensor (3) by the body tissue to be examined, by way of the measurement electrode (2).
  14. Measurement device according to one of claims 1 to 13, characterized in that the pressure sensor (3) comprises at least one piezoresistive element.
  15. Measurement device according to one of claims 1 to 14, characterized in that the evaluation unit is set up for derivation of the glucose concentration from the measurement signals.
  16. Method according to claim 15, characterized in that measurement signals are generated by means of a diagnostic sensor unit, from which signals the at least one physiological parameter is derived as a function of the depth in the body tissue, wherein the sensor unit comprises:
    at least one pressure sensor (3) that detects the pressure exerted locally on the pressure sensor (3) by a body tissue to be examined, and/or
    an optical measurement unit that comprises at least one radiation source for irradiation of the body tissue and at least one radiation sensor for detection of the radiation scattered and/or transmitted by the body tissue, and/or
    a temperature sensor, and/or
    an EKG unit for detection of an EKG signal by way of two or more EKG electrodes, and/or
    a bioelectrical impedance measurement unit.
EP12778606.9A 2011-09-21 2012-09-21 Diagnostic measurement device Active EP2757942B1 (en)

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CN105266807A (en) * 2015-06-25 2016-01-27 思澜科技（成都）有限公司 Array probe for measuring the impedance of biological tissue and measuring method
WO2017113377A1 (en) * 2015-12-31 2017-07-06 深圳市洛书和科技发展有限公司 Body surface-based noninvasive physical health comprehensive testing system
GB2583714B (en) * 2019-04-27 2023-03-01 Zedsen Ltd Non-Invasive Measurement
CN110547775B (en) * 2019-08-19 2022-11-18 贵州中医药大学 Cunkou pulse condition detection device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705048A (en) * 1983-08-11 1987-11-10 Vitacomm, Ltd. Vital signs monitoring system
US5467768A (en) * 1993-03-17 1995-11-21 Nihon Koden Corporation Multi-purpose sensor
DE19715421A1 (en) * 1996-04-17 1997-11-06 Mentop Elektronic Gmbh Electric skin resistance measurement device
EP1427332A1 (en) * 2001-08-24 2004-06-16 Glucosens, Inc. Biological signal sensor and device for recording biological signals incorporating the said sensor
IL163796A0 (en) * 2004-08-30 2005-12-18 Gribova Orna A Device for detecting changes in blood glucose level or dardiovacular condition
CN1739448A (en) * 2005-08-04 2006-03-01 浙江大学 Biological impedance, resistance or potential detecting electrode with dynamometer
KR101451448B1 (en) * 2006-11-23 2014-10-23 플로레, 잉고 Medical Measuring Device
DE102006055691A1 (en) * 2006-11-23 2008-05-29 Flore, Ingo, Dr. Measuring device for non-invasive determination of physiological parameter, has diagnostic measuring unit integrated in keyboard of computer, and evaluating unit for determining physiological parameter by processing measuring signals
WO2008106178A1 (en) 2007-02-27 2008-09-04 Hunter Manufacturing Co. Filtration heat transfer system
TWI543746B (en) * 2008-10-20 2016-08-01 王唯工 A tie and run type of physiological parameters detecting device
US20120059237A1 (en) * 2009-05-04 2012-03-08 Jack Amir System and method for monitoring blood glucose levels non-invasively
EP2467059B1 (en) * 2009-08-21 2019-11-06 Beth Israel Deaconess Medical Center, Inc. A hand-held device for electrical impedance myography
US20130324848A1 (en) * 2009-11-25 2013-12-05 Shigehiro Kuroki Biometric information measuring device and biometric information measuring system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
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CN103997959B (en) 2018-01-26

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