EP2605761A1 - Device that is implantable in the temporal bone for delivering a material, and hearing aid provided with such a device - Google Patents
Device that is implantable in the temporal bone for delivering a material, and hearing aid provided with such a deviceInfo
- Publication number
- EP2605761A1 EP2605761A1 EP11758520.8A EP11758520A EP2605761A1 EP 2605761 A1 EP2605761 A1 EP 2605761A1 EP 11758520 A EP11758520 A EP 11758520A EP 2605761 A1 EP2605761 A1 EP 2605761A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- catheter
- component
- product
- particles
- magnetic field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0662—Ears
Definitions
- Device implantable in the temporal bone for administering a product and hearing aid provided with such a device
- the present invention relates to an implantable device in the temporal bone for the introduction of a product such as a drug product into the human body and more specifically into the inner ear.
- the invention also relates to a hearing aid provided with such a device.
- An implantable device in the cochlea includes a catheter having an end connected to a liquid product reservoir for placement beneath the skull skin and an opposed end pierced with an outlet port of the product.
- the placement of these catheters is however very delicate.
- hearing aids or cochlear implants comprising an outer unit, generally disposed behind the ear, and an internal unit.
- the external unit includes an extracranial speech processor picking up external sounds to convert them into a sequence of electrical signals that are sent to an emitter to be transmitted to an intracranial receiver of the internal unit.
- the internal unit has an electrode holder to which the intracranial receptor is connected so that the cochlear implant can excite the auditory receptors of the cochlea in response to electrical signals.
- the electrode holder of the cochlear implant has the shape of a thin tube which is threaded into the cochlea so that the tube extends substantially throughout the length of the curvilinear path thereof.
- implant cochlear can be used to administer medications.
- a hearing aid has been equipped with a catheter that extends along the electrode holder of the cochlear implant.
- the catheter has an end connected to a liquid product reservoir disposed under the skin of the skull and an opposite end pierced with one or more product outlets.
- the catheter is associated with means for moving the product in the catheter to the outlet of the catheter.
- An object of the invention is to improve the effectiveness of the injection of product into the body of a patient and more specifically into the inner ear thereof.
- an implantable device for administering at least one component contained in a liquid product, comprising a catheter and means for moving the component along the catheter.
- the product incorporates particles of transport of the component, these particles being movable under the effect of a magnetic field.
- the catheter has outlet portions of the component out of the catheter, the outlet portions being distributed along the catheter, and the moving means includes means for generating a magnetic field in the vicinity of each output portion to provide the portion component. output in output portion.
- the means for generating a magnetic field comprise coils surrounding the output portions and connected to a control module arranged to successively feed at least a portion of the coils.
- the plurality of output portions distributed along the catheter and the product moving means arranged to bring the component to each output portion allow the component to escape from the catheter at the most favorable locations for effective diffusion of the component. depending on the desired effect.
- This embodiment of the means for generating a magnetic field has a simple structure allowing effective movement of the component. In addition, this allows the component to be moved without moving the liquid product itself so that the pressure in the catheter and the inner ear fluid is not affected by the migration of the component.
- control module is arranged to be intracranial and, advantageously, the reservoir is connected to the catheter so as to allow subcutaneous implantation of the reservoir.
- the reservoir and the catheter are arranged in such a way that the catheter extends in the vicinity of the external auditory canal of the wearer of the device and, preferably, the device comprises an auxiliary element for displacing the component of the product.
- auxiliary element having an elongate outer casing which is arranged to be inserted into the external auditory canal and which contains magnetic means for creating at least one moving magnetic field along the catheter.
- the magnetic means of the auxiliary element comprise magnets distributed along a link surrounding two pulleys so as to extend in a longitudinal direction of the casing, one of the pulleys being connected to a drive motor in rotation .
- auxiliary element extends longitudinally a magnetic shielding screen for isolating the magnets of the strands of the link extending from on both sides of the pulleys.
- the shielding screen makes it possible to isolate the magnets carried by the neighboring strand of the catheter of the magnets carried by the other strand so as to prevent the magnetic field generated by the latter from disturbing the displacement of the component of the product.
- the invention also relates to an auditory prosthesis such as a cochlear implant comprising an internal unit comprising an electrode holder along which a catheter connected to a liquid product reservoir and associated with particle displacement means which are sensitive to a magnetic field and which are associated with at least one component of the product.
- the catheter has exit portions of the component out of the catheter, the outlet portions being distributed along the catheter, and the moving means includes means for generating a magnetic field in the vicinity of each output portion to provide the portion component. output in output portion.
- the means for generating a magnetic field comprise coils surrounding the output portions and connected to a control module arranged to successively feed at least a portion of the coils.
- FIG. 1 is a partial schematic view of a hearing prosthesis according to the invention equipping a user's ear;
- FIG. 2 is an enlarged view in longitudinal section of the electrode holder of this prosthesis
- FIG. 3 is a schematic sectional view an auxiliary element for moving the product.
- the auditory prosthesis according to the invention of the cochlear implant type, comprises an external unit and an internal unit generally and respectively designated at 1 and 10.
- the external unit 1 comprises in a manner known in itself a housing 2, generally disposed behind the roof A of the user's ear, containing an extracranial processor capturing the external sounds to convert them into a series of electrical signals which are sent to a transmitter connected to the processor.
- the housing 2 also includes a power source supplying the processor and the transmitter.
- the internal unit 10, the cochlear implant itself, comprises a control module 11 and an electrode holder 12 separate from the control module 11 and connected thereto by electrical conductors.
- the control module 11 comprises a receiver for receiving signals wirelessly transmitted by the transmitter of the external unit 1 and for transmitting, to the electrode holder 12 of the cochlear implant, corresponding electrical signals so that the carrier Electrode 12 can excite the auditory receptors of cochlea B in response to electrical signals. This mode of operation is conventional and will not be described here.
- the electrode holder 12 is in the form of a thin tube which is threaded into the cochlea B so that the tube extends substantially throughout the length of the curvilinear course of the cochlea B.
- the hearing prosthesis is equipped with means for dispensing or administering, in the inner ear, at least one component of a liquid product such as a medicinal component.
- These means comprise a catheter 20 which extends along the electrode holder 12 of the cochlear implant, more precisely here within it, and comprises outlet portions 21 of the product which are distributed along the catheter 20.
- the outlet portions 21 may comprise at least one opening made directly in the wall of the catheter 20 or be made of a product permeable material and in particular a porous material forming a part of the wall of the catheter 20.
- the catheter 20 has an end portion 22 connected to a product reservoir 23 which is separated from the cochlear implant to extend behind the roof A under the skin of the skull of the user.
- the reservoir 23 and the end portion 22 are arranged and implanted in such a way that the end portion 22 of the catheter 20 extends in the vicinity of the external auditory canal C of the prosthesis wearer and parallel to the external auditory canal C.
- the catheter 20 is associated with means for moving the component of the product over its entire length.
- the displacement means are arranged to bring the component selectively to the outlet portions 21.
- the displacement means comprise means for generating a magnetic field in the vicinity of each output portion 21 and attract the product component to it as will be explained later.
- the means for generating a magnetic field comprise coils or solenoids 31 which surround the output portions 21 and are connected by electrical conductors to the control module 11 also arranged to successively supply at least a portion of the coils.
- the displacement means comprise an auxiliary element 40 for displacing the product, this auxiliary element comprises an elongated outer envelope 41 which is arranged to be introduced into the external auditory canal C and which contains magnetic means for creating at least one mobile magnetic field. along the outer casing 41.
- the magnetic means of the auxiliary element 40 comprise magnets 42 distributed along a link 43 surrounding two pulleys 44, 45 so as to extend in a longitudinal direction of the casing 41.
- the pulley 44 is connected to a mounted rotational drive motor 46 in the body of the element 41 and connected to a power supply module 47 contained in the envelope 41.
- the power supply module 47 incorporates a rechargeable battery via a not shown block of connection to the electrical network.
- the power supply module 47 may be arranged to periodically control the driving of the motor 46 or on command of the control module 11 to which it is connected by a wireless link.
- a magnetic shielding screen 48 for isolating the magnets 42 of the strands of the link 43 extending on either side of the pulleys 44, 45.
- the product incorporates moveable particles under the effect of a magnetic field.
- the particles have a diameter of between about 10 nm and about 500 nm and comprise a paramagnetic core covered with a protective layer bearing clinging chemical terminations of the component, here an active ingredient.
- the core is in one of the following materials: magnetite, maghemite, iron-based metal oxide, steel alloy.
- the protective layer is made of one of the following materials: a natural polymer such as a carbohydrate; a synthetic organic polymer such as polyethylene glycol, a polyacetic acid; a silica; gold.
- the chemical termini comprise at least one of the following groups: an amino group, a carboxylic group, an aldehyde group, a thiol group.
- the particles are contained in a solution of identical composition or close to the liquids of the inner ear and the output portions are arranged to allow the passage of the component by passive or active diffusion by the magnetic field.
- the particles are attracted by the magnetic field produced by the magnets 43 and the magnetic fields produced selectively by the solenoids.
- the rotation of the pulley 44 thus causes the magnets 42 of the upper strand to move towards the catheter 20.
- said magnets 43 will attract the particles as they move along the upper run (the magnetic shielding screen 48 prevents the magnetic field of the magnets 42 from exerting an attractive force on the particles when the magnets 42 are on the lower strand of link 43).
- the solenoids 31 are controlled independently of each other so as to attract the particles to the outlet portion around which they extend.
- the auxiliary displacement element is intended to remain in the external auditory canal temporarily, a few minutes or tens of minutes, the time to bring particles in the vicinity of the portion of the catheter received in the electrode holder 12. This is particularly useful when it is necessary to quickly bring particles into the cochlea, for example after a refueling of the tank 23.
- the product may have a different composition.
- the particles can be used only to drive the fluid and no longer support for the active ingredients.
- the auxiliary element 40 for moving the product is optional. Although its use is particularly advantageous in the embodiment described since it makes it possible to accelerate the transport of the particles towards the outlet portions by compensating for the relative slowness of the displacement caused by the solenoids, the auxiliary element can be used alone or in combination. combination with other types of moving means such as electric field moving means.
- the auxiliary element is also operable to move a product to and into a catheter having a single terminal outlet.
- the displacement means can be arranged to move a whole product (for example by a pumping effect) or only a part of it as the only particles.
- Solenoids may extend around the outlet portions, or upstream or downstream thereof.
- the implantable device in the temporal bone of the invention can be implanted alone in the cochlea, without equipping a cochlear implant or, on the contrary, be included in a cochlear implant.
- the power supply module 47 can be housed in the external unit.
- the prosthesis may comprise a portion arranged to be placed in one of the following regions of the inner ear: saccule, vestibule, endolymphatic, semicircular canals, cochlea.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Prostheses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1056667 | 2010-08-19 | ||
PCT/FR2011/051930 WO2012022920A1 (en) | 2010-08-19 | 2011-08-18 | Device that is implantable in the temporal bone for delivering a material, and hearing aid provided with such a device |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2605761A1 true EP2605761A1 (en) | 2013-06-26 |
Family
ID=43798493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11758520.8A Withdrawn EP2605761A1 (en) | 2010-08-19 | 2011-08-18 | Device that is implantable in the temporal bone for delivering a material, and hearing aid provided with such a device |
Country Status (3)
Country | Link |
---|---|
US (1) | US20130225905A1 (en) |
EP (1) | EP2605761A1 (en) |
WO (1) | WO2012022920A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2013288825B2 (en) | 2012-07-13 | 2016-04-14 | Med-El Elektromedizinische Geraete Gmbh | Implantable fluid delivery system with floating mass transducer driven pump |
EP3799902A1 (en) * | 2016-02-02 | 2021-04-07 | Medtronic MiniMed, Inc. | Hybrid ambulatory infusion pump with contactless power transmission |
AU2017315679B2 (en) | 2016-08-23 | 2023-12-14 | Akouos, Inc. | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
KR20220157944A (en) | 2020-02-21 | 2022-11-29 | 아카우오스, 인크. | Compositions and methods for treating non-age-related hearing impairment in human subjects |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5921244A (en) * | 1997-06-11 | 1999-07-13 | Light Sciences Limited Partnership | Internal magnetic device to enhance drug therapy |
US6309410B1 (en) * | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
US20020022799A1 (en) * | 1999-12-28 | 2002-02-21 | Apple Marc G. | Enhanced energy balloon catheter |
CA2390591A1 (en) * | 2000-10-04 | 2002-04-11 | Peter Gibson | Cochlear implant electrode array |
US9089450B2 (en) * | 2000-11-14 | 2015-07-28 | Cochlear Limited | Implantatable component having an accessible lumen and a drug release capsule for introduction into same |
US20020147424A1 (en) * | 2000-12-26 | 2002-10-10 | Alvin Ostrow | Transdermal magnetic drug delivery system and method |
US20050260620A1 (en) * | 2001-05-18 | 2005-11-24 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of retinolblastoma (RBI) gene expression using short interfering nucleic acid (siNA) |
US20020188242A1 (en) * | 2001-06-12 | 2002-12-12 | Allan Wu | Method and invention for the treatment of diseases and disorders of the cervix |
EP2226043B1 (en) * | 2001-10-24 | 2014-12-31 | MED-EL Elektromedizinische Geräte GmbH | Implantable fluid delivery apparatus and implantable electrode |
US20100030130A1 (en) * | 2001-11-09 | 2010-02-04 | Cochlear Limited | Pharmaceutical intervention for modulation of neural plasticity |
US7218962B2 (en) * | 2002-03-29 | 2007-05-15 | Boston Scientific Scimed, Inc. | Magnetically enhanced injection catheter |
AU2003301077B2 (en) * | 2002-12-18 | 2009-12-24 | Hough Ear Institute | Otologic nanotechnology |
US20110077579A1 (en) * | 2005-03-24 | 2011-03-31 | Harrison William V | Cochlear implant with localized fluid transport |
WO2009010303A2 (en) * | 2007-07-18 | 2009-01-22 | Neue Magnetodyn Gmbh | System for administering active substances to an organism, devices for use in said type of system and method for producing said type of devices |
US20090149797A1 (en) * | 2007-12-05 | 2009-06-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System for reversible chemical modulation of neural activity |
US8447409B2 (en) * | 2008-10-15 | 2013-05-21 | Cochlear Limited | Electroneural interface for a medical implant |
WO2010054308A1 (en) * | 2008-11-10 | 2010-05-14 | Med-El Elektromedizinische Geraete Gmbh | Hydrogel-filled drug delivery reservoirs |
-
2011
- 2011-08-18 WO PCT/FR2011/051930 patent/WO2012022920A1/en active Application Filing
- 2011-08-18 US US13/817,465 patent/US20130225905A1/en not_active Abandoned
- 2011-08-18 EP EP11758520.8A patent/EP2605761A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of WO2012022920A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20130225905A1 (en) | 2013-08-29 |
WO2012022920A1 (en) | 2012-02-23 |
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Ipc: A61F 11/00 20060101ALI20140131BHEP Ipc: A61K 9/50 20060101ALI20140131BHEP Ipc: A61K 9/00 20060101AFI20140131BHEP Ipc: A61M 5/142 20060101ALI20140131BHEP |
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Inventor name: MIROIR, MATHIEU Inventor name: NGUYEN, YANN Inventor name: BOZORG GRAYELI, ALEXIS Inventor name: STERKERS, OLIVIER Inventor name: FERRARY, EVELYNE |
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18D | Application deemed to be withdrawn |
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