EP2412714A4 - Procédé de purification industrielle de phycotoxines biologiquement actives - Google Patents

Procédé de purification industrielle de phycotoxines biologiquement actives

Info

Publication number: EP2412714A4
Authority: EP; European Patent Office
Prior art keywords: phycotoxins; biologically active; industrial purification; purification; industrial
Prior art date: 2009-03-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP20100755518

Other languages

German (de)

English (en)

Other versions

EP2412714A1 (fr

EP2412714B1 (fr

EP2412714B9 (fr

Inventor

Gonzalez Marcelo Santiago Lagos

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Proteus SA

Original Assignee

Proteus SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-24

Filing date

2010-03-18

Publication date

2012-10-10

2010-03-18 Application filed by Proteus SA filed Critical Proteus SA

2012-02-01 Publication of EP2412714A1 publication Critical patent/EP2412714A1/fr

2012-10-10 Publication of EP2412714A4 publication Critical patent/EP2412714A4/fr

2015-11-11 Publication of EP2412714B1 publication Critical patent/EP2412714B1/fr

2016-01-25 Priority to HRP20160079TT priority Critical patent/HRP20160079T1/hr

2016-11-23 Application granted granted Critical

2016-11-23 Publication of EP2412714B9 publication Critical patent/EP2412714B9/fr

Status Active legal-status Critical Current

2030-03-18 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Cephalosporin Compounds (AREA)

EP10755518.7A 2009-03-24 2010-03-18 Procédé de purification industrielle de phycotoxines biologiquement actives Active EP2412714B9 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
HRP20160079TT HRP20160079T1 (hr)	2009-03-24	2016-01-25	Postupak industrijskog pročišćavanja biološki aktivnih fikotoksina

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CL2009000723A CL2009000723A1 (es)	2009-03-24	2009-03-24	Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.
PCT/IB2010/051187 WO2010109386A1 (fr)	2009-03-24	2010-03-18	Procédé de purification industrielle de phycotoxines biologiquement actives

Publications (4)

Publication Number	Publication Date
EP2412714A1 EP2412714A1 (fr)	2012-02-01
EP2412714A4 true EP2412714A4 (fr)	2012-10-10
EP2412714B1 EP2412714B1 (fr)	2015-11-11
EP2412714B9 EP2412714B9 (fr)	2016-11-23

Family

ID=42780210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP10755518.7A Active EP2412714B9 (fr)	2009-03-24	2010-03-18	Procédé de purification industrielle de phycotoxines biologiquement actives

Country Status (14)

Country	Link
EP (1)	EP2412714B9 (fr)
JP (1)	JP5728774B2 (fr)
KR (1)	KR20110130420A (fr)
AR (1)	AR075931A1 (fr)
BR (1)	BRPI1013548B8 (fr)
CA (1)	CA2754154C (fr)
CL (1)	CL2009000723A1 (fr)
DK (1)	DK2412714T5 (fr)
ES (1)	ES2562637T3 (fr)
HR (1)	HRP20160079T1 (fr)
HU (1)	HUE027480T2 (fr)
MX (1)	MX2011010005A (fr)
PE (1)	PE20110903A1 (fr)
WO (1)	WO2010109386A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8957207B2 (en)	2009-03-24	2015-02-17	Proteus S.A.	Methods for producing phycotoxins
EP2968225B1 (fr)	2013-03-15	2019-02-20	The Children's Medical Center Corporation	Formulations combinées de néosaxitoxine pour une anesthésie locale prolongée
US9902625B2 (en)	2014-09-03	2018-02-27	International Business Machines Corporation	Removal of HAB-produced toxins from bodies of water
GB201602576D0 (en)	2016-02-12	2016-03-30	Bergen Teknologioverforing As	Process
CN107602580B (zh) *	2017-09-08	2019-06-11	浙江理工大学	一种聚酮类化合物及其制备方法和应用
CN109142595A (zh) *	2018-08-23	2019-01-04	中国水产科学研究院黄海水产研究所	一种麻痹性贝类毒素标准溶液的制备方法
US12018034B2 (en)	2018-09-21	2024-06-25	The Cawthron Institute Trust Board	Semisynthetic methods of preparing GTX1,4 and neosaxitoxin
CN117964629A (zh) *	2018-09-21	2024-05-03	考思隆研究所托管委员会	将膝沟藻毒素制备性规模转化为新石房蛤毒素
WO2020058750A1 (fr) *	2018-09-21	2020-03-26	The Cawthron Institute Trust Board	Procédé semi-synthétique de préparation de néosaxitoxine
CN114657222A (zh) *	2022-04-08	2022-06-24	湖北省水利水电科学研究院	一种从水华束丝藻中提取类菌胞素氨基酸的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20080006579A1 (en) *	2006-06-21	2008-01-10	Degussa Gmbh	Processing of reaction solutions from whole-cell biotransformations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4001413A (en)	1973-06-12	1977-01-04	Astra Pharmaceutical Products, Inc.	Pharmaceutical local anesthetic composition employing saxitoxin
WO1998043619A2 (fr) *	1997-04-02	1998-10-08	The Regents Of The University Of California	Procede d'anesthesie
KR20040066816A (ko) *	2001-11-15	2004-07-27	마이크로 알제 코포레이션	3, 4-프로피온퍼하이드로퓨린을 포함하는 약학 조성물 및상기 조성물을 이용한 신경 전달의 블로킹 방법
EP1824488B1 (fr) *	2004-05-07	2017-08-09	Algenis SpA	Les phycotoxines et leur utilisation

2009
- 2009-03-24 CL CL2009000723A patent/CL2009000723A1/es unknown
2010
- 2010-03-18 KR KR1020117021288A patent/KR20110130420A/ko active Search and Examination
- 2010-03-18 ES ES10755518.7T patent/ES2562637T3/es active Active
- 2010-03-18 MX MX2011010005A patent/MX2011010005A/es active IP Right Grant
- 2010-03-18 WO PCT/IB2010/051187 patent/WO2010109386A1/fr active Application Filing
- 2010-03-18 HU HUE10755518A patent/HUE027480T2/en unknown
- 2010-03-18 PE PE2011001285A patent/PE20110903A1/es active IP Right Grant
- 2010-03-18 BR BRPI1013548A patent/BRPI1013548B8/pt active IP Right Grant
- 2010-03-18 CA CA2754154A patent/CA2754154C/fr active Active
- 2010-03-18 EP EP10755518.7A patent/EP2412714B9/fr active Active
- 2010-03-18 DK DK10755518.7T patent/DK2412714T5/en active
- 2010-03-18 JP JP2012501444A patent/JP5728774B2/ja active Active
- 2010-03-23 AR ARP100100934A patent/AR075931A1/es active IP Right Grant
2016
- 2016-01-25 HR HRP20160079TT patent/HRP20160079T1/hr unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20080006579A1 (en) *	2006-06-21	2008-01-10	Degussa Gmbh	Processing of reaction solutions from whole-cell biotransformations

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EDWARD J. SCHANTZ ET AL: "The Purification and Characterization of the Poison Produced by Gonyaulax catenella in Axenic Culture", BIOCHEMISTRY, vol. 5, no. 4, 1 April 1966 (1966-04-01), pages 1191 - 1195, XP055036404, ISSN: 0006-2960, DOI: 10.1021/bi00868a011 *
GHAZAROSSIAN V E ET AL: "Identification of a poison in toxic scallops from a Gonyaulax tamarensis red tide", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 59, no. 4, 19 August 1974 (1974-08-19), pages 1219 - 1225, XP024777990, ISSN: 0006-291X, [retrieved on 19740819], DOI: 10.1016/0006-291X(74)90444-6 *
IL SHIK SHIN ET AL: "Reestablishment of Approval Toxin Amount in Paralytic Shellfish Poison-Infested Shellfish", J. FD HYG. SAFETY, 31 December 1998 (1998-12-31), pages 143 - 148, XP055036412, Retrieved from the Internet <URL:http://210.101.116.28/W_ftp41/14600812_pv.pdf> [retrieved on 20120827] *
LUBNA ZAMAN ET AL: "Occurrence of paralytic shellfish poison in Bangladeshi freshwater puffers", TOXICON, vol. 35, no. 3, 1 March 1997 (1997-03-01), pages 423 - 431, XP055036381, ISSN: 0041-0101, DOI: 10.1016/S0041-0101(96)00167-5 *
See also references of WO2010109386A1 *

Also Published As

Publication number	Publication date
BRPI1013548A2 (pt)	2016-09-20
ES2562637T9 (es)	2017-05-30
CA2754154C (fr)	2013-12-17
PE20110903A1 (es)	2012-01-19
EP2412714A1 (fr)	2012-02-01
AR075931A1 (es)	2011-05-04
CA2754154A1 (fr)	2010-09-30
BRPI1013548B8 (pt)	2021-05-25
HRP20160079T1 (hr)	2016-04-08
KR20110130420A (ko)	2011-12-05
HUE027480T2 (en)	2016-09-28
EP2412714B1 (fr)	2015-11-11
DK2412714T3 (en)	2016-02-01
CL2009000723A1 (es)	2009-06-19
DK2412714T5 (en)	2017-02-27
MX2011010005A (es)	2011-10-10
WO2010109386A1 (fr)	2010-09-30
BRPI1013548B1 (pt)	2020-06-09
JP5728774B2 (ja)	2015-06-03
ES2562637T3 (es)	2016-03-07
JP2012521408A (ja)	2012-09-13
EP2412714B9 (fr)	2016-11-23

Publication	Publication Date	Title
EP2412714A4 (fr)	2012-10-10	Procédé de purification industrielle de phycotoxines biologiquement actives
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PT3640218T (pt)	2022-01-26	Processo de tratamento de resíduos industriais
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EP2454202A4 (fr)	2015-06-10	Procédé de purification biologique
EP2412695A4 (fr)	2015-12-16	Procédé de purification du dihydroxybenzène
AU2009902254A0 (en)	2009-06-04	Salt purification process

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