[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP2219713A1 - Système d'injection à accouplement activé par actionnement - Google Patents

Système d'injection à accouplement activé par actionnement

Info

Publication number
EP2219713A1
EP2219713A1 EP08850618A EP08850618A EP2219713A1 EP 2219713 A1 EP2219713 A1 EP 2219713A1 EP 08850618 A EP08850618 A EP 08850618A EP 08850618 A EP08850618 A EP 08850618A EP 2219713 A1 EP2219713 A1 EP 2219713A1
Authority
EP
European Patent Office
Prior art keywords
engagement
injection device
housing
coupling
output
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08850618A
Other languages
German (de)
English (en)
Inventor
Eric Hattler
Jürg HIRSCHEL
Ulrich Moser
Markus Tschirren
Jan Baumert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecpharma Licensing AG
Original Assignee
Tecpharma Licensing AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007054019A external-priority patent/DE102007054019A1/de
Application filed by Tecpharma Licensing AG filed Critical Tecpharma Licensing AG
Publication of EP2219713A1 publication Critical patent/EP2219713A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means

Definitions

  • the invention relates to an injection device for administering a particular liquid product, such as. B. a drug.
  • a particular liquid product such as. B. a drug.
  • a drug for example, insulin preparations, growth hormones, or other similar medicaments to be administered to a human or animal patient can be administered with the injection device.
  • the injecting device may be sold together or separately with a separate drug which is used by the user of the injection device in this.
  • the injection device is distributed with a drug contained in the injection device, whereby the injection device can also be regarded as a disposable injection device, which is disposed of after complete release of the product.
  • the prior art discloses a disposable injection device containing medicaments, which are completely disposed of after the product has been distributed.
  • Such injection devices should be both inexpensive to manufacture and simple and safe to use.
  • the injection device comprises an actuating device which executes a rotational movement when actuated for the administration.
  • the actuator may be of a work performing means, such as. B. a motor or a spring can be actuated.
  • the actuator by muscle power such. B. operated by the pressure of a finger of the user on the actuator. It is thus preferred that in the injection device, the access from the outside to the actuator is possible.
  • the actuator may protrude proximally from a housing of the injection device and form, for example, the proximal end of the injection device.
  • the initiating a product release force can first on the actuator and then on a downstream of the actuator element or downstream elements such. B. an output device act.
  • the actuating device may be in one piece or preferably in several parts. It can also be axially movable in particular in addition to its rotational movement.
  • the thread preferably has a non-self-locking pitch. The actuator can then be screwed into or out of the housing.
  • the injection device further comprises an output device which rotates for the administration of the product.
  • the output device or at least a portion of the output device transmits its / its movement to the product, in particular a piston, which acts on the product to dispense product. It is therefore preferred that the output device or at least a part of the output device can perform an axial movement, preferably in the discharge direction.
  • the output device may be in one piece or preferably in several parts.
  • the actuator and the output device are coupled to each other in a product distribution, ie during actuation of the actuator for a product distribution, in particular rotationally fixed.
  • the injection device for this purpose comprises an engagement member which, upon actuation of the actuator for the administration of the product from a decoupled state in which the actuator is rotatable relative to the output device in a coupled state in which the actuator rotatably coupled to the output device is, is movable or moved.
  • the engagement member is preferably formed on or by the actuating device or at least of a part of the actuating device.
  • the engagement member is formed axially fixed to the actuator or to a part of the one or more part actuator.
  • the actuating device in particular the engagement member - if it is not in engagement with the output device - relative to the output device rotatably movable or lekssbewegbar or preferably both.
  • This is particularly advantageous for mounting the injection device or adjusting a product dose, since the actuating device is movable independently of the output device.
  • the actuator is rotatably coupled via the engaging member with the output device - such.
  • the actuator or at least the engaging member relative to the output device preferably only be moved axially.
  • the actuator or a part thereof can cooperate in the operation with the output device or with its part acting on the piston so that this or this is moved by a larger, same or more preferably smaller path in the longitudinal direction, as the actuator.
  • the movement of the actuating device is transmitted in a restricted manner to the output device or to the part of the output device which acts on the piston.
  • the output device or a part thereof may have a thread which engages in the housing or a housing-fixed part and has a smaller pitch than the thread with which the actuating device engages in the housing or a housing-fixed part, whereby the reduction is effected.
  • the ratio of the axial movements of the actuating device and the output device or a part thereof is 1 and that if the output device has a greater thread pitch than the actuating device, the output device or the part acting on the piston thereof performs a larger axial movement than the actuator.
  • the actuating device comprises a coupling member and a guide member.
  • the engagement member may be formed on the coupling member on the guide member or as a separate part between the coupling member and the guide member.
  • the coupling member is axially movable relative to the guide member by a clutch stroke.
  • the actuation is composed of a clutch stroke and a drive stroke, wherein in the coupling stroke, the engagement member is rotatably coupled to the output device and the drive stroke rotatably coupled to the actuator drive means a driven stroke or a Aus presenthub to move the piston for a product distribution is carried out.
  • the engaging member in the coupling member moving around the coupling stroke, the engaging member is in the coupled state.
  • the actuating means may comprise a spring member which acts between the coupling member and guide member to push apart in an unactuated state, so that the engagement member is in a decoupled state with the output device.
  • the spring member may be a separate spring member, such. B. be a coil spring made of metal or plastic.
  • the spring member may in particular be firmly connected to at least one coupling member and guide member.
  • the spring member may alternatively be formed in one piece to the coupling member or the guide member to a separate spring.
  • Coupling member and guide member are preferably only a limited way, in particular the clutch stroke, relative to each other movable.
  • coupling member and guide member may have interlocking stops which prevent the movement of the unactuated coupling member relative to the guide member against the direction of the clutch stroke.
  • the spring member can be arranged so that it achieves this effect.
  • coupling member and guide member are rotatably relative to each other, in particular permanently non-rotatably coupled.
  • Coupling member and guide member may have interlocking longitudinal guides for this purpose. It is likewise preferred that the engagement member rotationally fixed, in particular permanently rotationally fixed, relative to the coupling member or the guide member.
  • the engagement member may comprise a first transmission element and one of the coupling member and guide member may comprise a second transmission element, wherein upon movement of the coupling member about the coupling stroke, the first transmission element and the second transmission element engage, whereby the engagement member from the decoupled state in the coupled state is moved.
  • the transmission elements can, for example, on each other sliding surfaces, such. B. inclined planes, which convert an axial movement of the first transmission element in a radially directed to the longitudinal axis of the injection device movement of the second transmission element.
  • the first transmission element radially outward and the second transmission element radially inward.
  • the engagement member may have an engagement region which, in engagement with the output device, rotatably couples the actuation device with the output device, but preferably permits an axial movement of the actuation device relative to the output device.
  • the engagement region has radially inward.
  • the engagement member may be a separate part which is guided by the coupling member and / or the guide member for a radial movement.
  • the engagement member is formed on one of coupling member or guide member, in particular in one piece. It is further preferred that the engagement member is formed on a resilient arm, the z. B. can already be made during the injection molding of the coupling member or the guide member.
  • the arm may extend from the location where it is attached to the coupling member or the guide member at least partially in the circumferential direction, ie, about the longitudinal axis of the injection device. In a likewise preferred alternative, the arm may extend in the axial direction, ie approximately parallel to the longitudinal axis of the injection device. There may be several such arms, such. B. two arms, may be provided, each having an engaging member and are preferably distributed uniformly over the circumference of the coupling member or the guide member. It is generally preferred that the Arm is connected at one end to the coupling member or the guide member and having at its other end the engaging member.
  • the output device comprises circumferentially distributed and extending in the longitudinal direction of the injection device grooves.
  • the engaging member is movable into engagement, wherein in this engagement between the engaging member and the output device, an axial relative movement is possible and a rotational movement is locked.
  • d. H. Screwing which performs the actuator during its operation, in particular during the drive stroke, preferably takes place between the engaging member and the output device only an axial relative movement. It is generally preferred that in the coupled state of the engagement member, the actuator and the output device perform a rotational movement acting in the same direction.
  • the output device may be one or more parts.
  • the output device on actuation of the coupling member axial movement in the discharge direction on a piston which acts on a product run.
  • the output device in particular a piston rod, e.g. Apart from a flange acting on the piston, be formed integrally, wherein the piston rod at its outer periphery of the above-mentioned grooves for the engagement of the piston
  • Engaging member and a thread which is superimposed on the grooves has.
  • the regions arranged between two adjacent threads can have the grooves.
  • the thread of the piston rod may be in engagement with the housing of the injection device, wherein the piston rod during its rotation
  • Dumping movement d. H. one executes on the product to be dispensed or the piston acting on the product.
  • the output device is multi-part and comprises at least one output member and a piston rod.
  • the output device is multi-part and comprises at least one output member and a piston rod.
  • Output device having a driven member, which is sleeve-shaped, for example.
  • the output device may have a piston rod, which preferably of the Output member is surrounded.
  • Output member and piston rod may be connected to each other so that a rotational movement of the output member causes axial movement of the piston rod.
  • the output member is rotatable and axially fixed relative to the housing of the injection device.
  • the piston rod for example, engage with a thread in the driven member, so that a rotational movement of the driven member relative to the piston rod causes an axial movement of the piston rod relative to the housing and the driven member.
  • the piston rod can in this case be accommodated relative to the housing in a rotationally fixed and axially displaceable manner in the housing or be supported therefrom. Suitable means for this are extending in the longitudinal direction of the piston rod groove or flattening.
  • the thread with which the piston rod engages in the driven member in this case can be opposite to the thread with which the actuating device engages in the housing.
  • the output member is non-rotatably connected to the piston rod, wherein the piston rod is axially movable relative to the output member. Suitable means for this are extending in the longitudinal direction of the piston rod groove or flattening.
  • the piston rod engages with its thread in the housing, so that a transmitted to the piston rod rotational movement of the output member screws the piston rod in the distal direction.
  • the thread of the piston rod has the same sense of rotation as the thread with which the actuating device engages in the housing.
  • the thread of the piston rod has a smaller pitch than the thread with which the actuating device engages in the housing.
  • the actuating device in particular the guide member of the actuating device in a threaded engagement with the housing, so that a rotational movement of the actuating device causes the axial movement thereof.
  • the actuating device in particular the guide member on at least one Abragung, which may be formed for example in the form of a threaded portion-shaped cam and which engages in a thread formed by the housing.
  • the thread has a sufficiently large pitch, so that no self-locking occurs, ie, that an axial force exerted on the actuator in a rotational or screwing movement of the actuator is implemented.
  • the guide member is preferably non-rotatably connected to the coupling member rotate during actuation, in particular during the drive stroke both guide member and coupling member.
  • the actuating device in particular the coupling member is guided straight, so that an unwanted rotational movement of the actuating device is prevented relative to the housing.
  • the housing of the injection device engages in the actuating device, in particular by means of a locking member.
  • the engagement of the detent member with the coupling member is preferably strong enough to lock the actuator against undesired rotation during or during the coupling stroke, but weak enough to permit a desired rotational movement of the actuator.
  • the coupling member may have at its outer periphery at least one profile section, in which engages the locking member of the housing and the actuator to
  • the at least one profile section can have juxtaposed in the circumferential direction of the coupling member and extending in the longitudinal direction grooves which the
  • the grooves may have flattened flanks corresponding to a desired, applied to the actuator
  • the locking member which in the grooves engages, have corresponding flanks, so that the locking member is pressed out of engagement with the grooves when a sufficiently large torque is applied.
  • the actuating direction can be rotated at least in one direction of rotation, preferably in both directions of rotation, when the actuating device has not yet been actuated.
  • the actuating device in particular the coupling member, at least one threaded portion into which engages the housing or formed on the housing, during the coupling stroke engaging in the at least one profile portion locking member when the coupling member is moved to the Kupplungshubs.
  • the at least one threaded portion may have a profilarmen reason. The reason may be formed by the outer circumference of the coupling member in the region of the at least one threaded portion.
  • the at least one threaded portion or its base may have a less pronounced profile than the at least one profile section.
  • the torque required for a rotation of the coupling member is reduced or / and simultaneously generates a weak audible or tactile click during rotation.
  • the profilarme threaded portion or its base is profile-free, whereby the torque required for the rotation of the coupling member can be reduced even more.
  • the at least one threaded portion of the coupling member may have the same pitch as the thread of the housing, in which engages the actuating device, in particular the guide member. During the drive stroke, the coupling member can perform a combined rotational and axial movement and slide with the at least one threaded portion on the locking member along.
  • the at least one profile section may be delimited by a threaded section in at least one, preferably in both axial directions.
  • the threaded portions may be groove-shaped.
  • the at least one threaded portion and / or the at least one profile section can partially or completely, in particular, wind around the circumference of the coupling member several times.
  • a plurality, in particular two profile sections and / or threaded sections can be arranged over the circumference.
  • the at least one threaded section is preferably delimited by a profile-free, in particular even profile-free, section extending in the longitudinal direction of the coupling element.
  • two profilme sections and two profile sections are evenly distributed over the circumference, which in particular may each have the same arc length, whereby each section extends approximately over a quarter of the circumference.
  • two locking members may be provided, which may be offset in the circumferential direction in 90 ° and in the axial direction by a quarter of the pitch of the at least one threaded portion. This ensures that always engages a locking member in a threaded portion or a profile section.
  • the adjustment of a product dose to be distributed is possible with the actuating device, which is why the actuating device can also be referred to as a dosing actuating device.
  • the dosage of the dispensed product dose can be made by means of a rotary movement of the actuator relative to the housing and the output device.
  • the actuating device is not actuated, ie the engaging element is decoupled from the output device.
  • a torque is applied, which is large enough to release the locking engagement of the housing in the coupling member in angular increments.
  • each rotation of the coupling member by a certain angle step is by clicking out and locking the housing from one groove to the next audible click and preferably also felt.
  • Each click can stand for a certain dose of product, which also allows visually impaired people to adjust the desired product dose.
  • the actuating device can be screwed proximally out of the housing.
  • the actuator is screwed in the distal direction, ie in the housing.
  • the actuator is actuated by an applied force in the distal direction, whereby locking member comes into engagement with the at least one threaded portion from engagement with the at least one profile section.
  • the engaging member is engaged with the Output device brought so that in a further actuation of the actuator of the drive stroke of the actuator is performed, whereby the actuator and the output device are rotated, which eventually leads to a movement of the output device or a part thereof in the discharge direction and thus for product distribution.
  • the injection device in particular the operation submission can also have a dose display with which the set product dose is visually readable.
  • a dose display drum may be provided which is rotationally and axially fixedly connected to the actuating device, in particular to the coupling member.
  • the dose indicating drum may at least partially surround the actuator.
  • the dose-indicating drum may have a helical dose scale at its circumference, in particular with a pitch corresponding to the pitch of the thread with which the actuating device and the housing are coupled.
  • the dose display drum may be surrounded by the housing or a portion of the housing, which preferably has a window for reading a particular scale value, the scale applied to the dose display drum.
  • the dose indicator drum is also threaded, causing the set product dose to reverse according to the drive stroke of the actuator. If the distribution is complete, the dose 0 appears in the window.
  • a stop member may be provided which serves, at the last dose setting, to allow only the setting of a product dose equal to the remainder of that contained in the injection device
  • the stop member is preferably in threaded engagement with the actuator.
  • the stop member is sleeve-shaped and between the
  • Actuator in particular the coupling member, e.g. the thread for that
  • Stop member may have, and the output device, in particular the output member arranged.
  • the thread in which the stop member engages preferably has a smaller pitch than the thread with which the actuator is in engagement with the housing and also preferably but not necessarily a smaller pitch than the thread with which the output means is in engagement with the housing.
  • the stop member is preferably in engagement with the output device in such an engagement that the stop member is rotatably and longitudinally movable relative to the output device. Preferably, this engagement, as well as the engagement in the thread of the actuator permanently.
  • the actuator is rotatable relative to the output device and also relative to the stop member.
  • the stop member Due to the threaded engagement of the actuator with the stop member and the longitudinal displaceability of the stop member relative to the output device, the stop member is axially displaced during dose setting. Since, in a product distribution, the actuating device and the output device are rotationally fixed relative to one another, the stop element is not displaced relative to the actuating device or to the output device during the product discharge.
  • the injection device preferably comprises a stop, which may be formed, for example, by the actuating device, to which the stop member is displaced a little further with each dosage. In the last presettable dosage with the injection device, the stop member is moved into engagement with the stop. A further metering is thus no longer possible since the stop member located in the stop with the actuating device blocks an increase in the product dose. This ensures that no higher product dose can be set than can actually be distributed, which can be used to avoid misuse.
  • FIGS. 2 A to 2D show different views of the injection device from FIGS. 1A to 1D in a state with a set product dose
  • FIGS. 3A to 3D show different views of the injection device from FIGS. 1A to 1D in a state after the coupling stroke has taken place
  • FIG. 4 shows a perspective view of one Housing and one
  • Figure 5 is a perspective view of a housing and a
  • FIG. 6 shows an actuating device with arms extending in the longitudinal direction of the injection device for an engaging member
  • Figure 7 shows different views of an injection device with in
  • FIG. 8 shows different views of the injection device from FIG. 7 after the coupling stroke has taken place
  • Figure 10 different views of an injection device with in
  • Circumferentially extending arms for an engaging member and before a coupling stroke
  • FIG. 11 shows different views of the injection device from FIG. 10 after a completed coupling stroke
  • FIG. 12 shows a coupling element, a guide element and a combination thereof with an arm extending in the longitudinal direction of the injection device for an engagement element
  • FIG. 12 shows a coupling element, a guide element and a combination thereof with an arm extending in the longitudinal direction of the injection device for an engagement element
  • Figure 13 is a coupling member, a guide member and a combination thereof and a circumferentially extending arm for a
  • the injection device comprises an actuating device 6, 7, 12, 13, which is arranged in a multi-part housing 1, 2, 3.
  • the housing 1, 2, 3 has an outer housing 1, an inner housing 2, which is rotatably and axially fixed to the outer housing 1 and a functional sleeve 3, which is also rotationally and axially fixed to the outer housing 1 and the inner Housing 2 is connected.
  • the housing could be formed in one piece. Due to the multi-part of the housing, however, there are advantages during assembly.
  • a product container 4 is arranged, which has a distal, provided for a needle end and a proximal, with a displaceable piston 4a closed end.
  • the product container 4 is closed by a septum which can be perforated by the needle when attached to the housing.
  • the injection device shown is delivered with an inserted product container 4.
  • the product container 4 is not interchangeable, so that it is a so-called disposable injection device.
  • the product container 4 could also be formed directly by the outer housing 1.
  • the injection device further comprises an output device 9, 10, 11, which has a driven member 9, a received in the driven member 9, provided with an externally threaded piston rod 10 and a distal end of the piston rod 10 flange 11. Via the flange 11 a dispensing movement is transmitted to the piston 4a in the distal direction for product distribution.
  • the flange 11 is freely rotatable relative to the piston rod 10 and axially fixedly coupled to the piston rod 10.
  • the piston rod 10 has flats into which the sleeve-shaped output member 9 engages and thus permanently prevents rotation of the piston rod 10 relative to the output member 9, but an axial displacement of the piston rod 10 relative to the output member 9 allows.
  • the output member 9 is by means of a formed on the housing 1, 2, 3, in particular on the functional sleeve 3 pivot bearing 3a relative to the housing 1, 2, 3 rotatably and axially fixed.
  • the threaded rod 10 engages with its external thread in the internal thread 3 c of the functional sleeve 3 a.
  • the piston rod 10 engage with its thread in an inner thread formed on the tubular output member 9 and, e.g. with its flattening, rotationally fixed and axially displaceable can be received by the function sleeves 3.
  • the piston rod 10 then has a thread with a sense of rotation, which is opposite to the direction of rotation of the thread in the embodiment described first.
  • a rotation of the output device, ie the output member 9 and the piston rod 10 in one direction causes an axial displacement of the piston rod 10 in the distal direction due to the threaded engagement of the piston rod 10 with the thread of the functional sleeve 3 c or - alternatively - the output member 9.
  • the piston rod 10 screws in the distal direction.
  • each saw-toothed rib 9a has a flat and steep flank.
  • the flat flank makes it possible to rotate the output member 9 in a direction in which the piston rod 10 is displaced in the distal direction.
  • the steep flank prevents rotation of the output member 9 in the other direction of rotation, whereby the piston rod 10 would be screwed in the proximal direction. This ensures that the piston rod 10 can only be screwed in the distal direction, ie in the dispensing direction.
  • the sawtooth-shaped ribs 9a are distal to the region of the output member 9, which is arranged in the rotary bearing 3a. Proximal this area, the output member 9 evenly distributed over its circumference and extending in the longitudinal direction of the injection device grooves, as can be seen for example from Figure Ic.
  • These grooves are sawtooth-shaped in the embodiment shown, but may also have other shapes, in particular symmetrical tooth shapes.
  • the grooves serve on the one hand as anti-rotation and as a longitudinal guide for a sleeve-shaped stop member 8, which surrounds the output member 9 and engages with its inside in the grooves of the output member 9.
  • the stop member 8 is permanently rotatable relative to the output member 9 and axially displaceable.
  • the grooves arranged on the outer circumference of the output member 9 furthermore serve, in particular predominantly, for selectively providing an anti-rotation lock between the actuating device 6, 7, 12, 13 and the output device 9, 10, 11 in order to produce a rotational movement of the actuating device 6, 7 , 12, 13 to the output device 9, 10, 11 to transmit.
  • the actuator 6, 7, 12, 13 is used in the embodiment shown also for dose adjustment, which is why it can also be referred to as metering and actuating device 5, 6, 7, 12, 13.
  • the metering and actuating device 5, 6, 7, 12, 13 comprises a dose indicator drum 5, which is arranged in an annular gap between the sleeve-shaped inner housing 2 and the sleeve-shaped outer housing 1.
  • the dose indicating drum 5 has a dose scale extending helically around the dose indicating drum 5.
  • the currently set product dose can be read by the window Ia (FIG. 1A) formed in the outer housing 1.
  • a handle is formed ( Figure IA), in which the user of the injection device by gripping and turning a torque on the dose display drum 5 and thus on the metering and actuating device 5, 6, 7, 12, 13, in particular for dose adjustment, exercise.
  • the dose indicating drum 5 also has a radially inwardly formed shoulder at its proximal end portion, at which e.g. a stop 5a for the proximal end of the stop member 8 may be formed. The function of the stop member 8 will be described later in more detail.
  • a trained as a button actuator 12 is at the proximal end of the actuator 5, 6, 7, 12, 13, freely rotatably and axially fixed.
  • the actuator 12 can be mounted relative to the housing 1, 2, 3 as an adapter for e.g. a thumb of the user of the
  • Actuating 5, 6, 7, 12, 13 relative to the housing 1, 2, 3 performs a rotational movement.
  • the actuating device 5, 6, 7, 12, 13 further comprises a sleeve-shaped coupling member 6 axially and rotationally locked to the dose indicating drum 5.
  • the coupling member 6 has an internal thread on its inner circumference, which in particular is permanent in an external thread of the stop member 8 , engages.
  • the thread has a relatively small pitch, which is preferably only so large that the thread is self-locking.
  • profile sections 6b On the outer circumference of the coupling member 6 distributed over the circumference arranged profile sections 6b, which have a plurality of juxtaposed, extending in the longitudinal direction and a profile forming ribs or grooves 6a arranged.
  • the coupling member 6 in cross-section over the circumference of two profile sections 6b and two profilarme, here profile-free or smooth sections 6c.
  • Each profile section 6b is peripherally bounded on each side by a profile-free section 6c.
  • Each profile section 6b has a plurality of grooves 6a arranged uniformly next to each other.
  • the profile sections 6b and the profile-free sections 6c extend in cross-section of the coupling member 6 over substantially the same circular arc section length. In the example shown, each of the sections 6b, 6c is about one quarter of the circumference of the coupling member 6 long.
  • the grooves 6a are formed by radially outwardly projecting ribs, which also extend in the longitudinal direction, wherein between two adjacent ribs, a groove is arranged.
  • the ribs or the grooves 6a have flattened edges, so that engaging in the groove locking member 2b, which is preferably designed as a locking cam 2b, in a sufficiently applied to the coupling member 6 torque out of engagement with a
  • Groove 6a is pressed and comes into engagement with the next groove 6a. This will create an audible or tactile click.
  • the locking cam 2b is formed on the inner housing 2 via a resilient arm which presses the locking cam 2b against the outer periphery of the coupling member 6.
  • the inner housing 2 has a total of two such locking cams, wherein the two locking cams are offset axially in the circumferential direction by 90 ° and in the axial direction by a quarter of the way that performs the coupling member 6 in a complete rotation. Since the profile sections 6b and the profile-free sections 6c are each about 90 ° above the Extending circumference, it is ensured that during the rotation of the coupling member 6 always one of the two locking cams 2b engages in a profile section 6b and the other of the two locking cams 2b in the profile-free section 6c. The fact that the profile sections 6a extend only partially over the circumference of the coupling member 6, a simple production of the coupling member 6 is made possible.
  • the coupling member 6 has at its periphery further threaded portions 6d, in particular threaded guides or thread grooves which extend through the profile sections 6b, i. extend in sections over the circumference of the coupling member 6.
  • the threaded portions 6d are at least as wide in the longitudinal direction of the injection device, as the locking cam 2b.
  • the metering and actuating device 5, 6, 7, 12, 13 further comprises a guide member 7, which is rotatably connected in this embodiment with the coupling member 6.
  • the coupling member 6 is axially, ie along the longitudinal axis of the injection device in particular by a Kupplungshub h displaced.
  • the guide member 7 has at least one, in this example, two radially projecting engagement cam 7a, which extend in sections over the circumference of the guide member 7.
  • the inner housing 2 has an internal thread 2a in the form of a helical circumferential groove into which the engagement cam 7a extends.
  • the engagement cam 7a therefore, although it extends only in sections over the circumference has a corresponding helical shape or pitch to fit into the thread 2a.
  • a rotational movement of the guide member 7 thus causes its axial movement and vice versa.
  • the path traveled by the actuating device 5, 6, 7, 12, 13 in one revolution corresponds to the pitch of the thread 2a.
  • the threaded sections 6d preferably also have the same pitch as the thread 2a.
  • the thread 2a is a double-threaded thread, wherein a first engagement cam 7a engage in the first thread and a second engagement cam 7a in the other thread.
  • the coupling member 6 is limited along the longitudinal axis relative to the guide member 7 in both directions and movable to the Kupplungshub h. To fall out of the
  • Actuator 5, 6, 7, 12, 13 to prevent from the proximal end of the housing 1, 2, 3, a movement of the coupling member 6 relative to the guide member 7 in the proximal direction by axially engaging, on the coupling member 6 and
  • Clasp trained spring member 15 which surrounds a cam b hook-shaped and is attached to the coupling member 6, take over.
  • the coupling member 6 can be displaced by a coupling stroke h relative to the guide member 7 in the distal direction, wherein the spring member 15 ( Figures 12 and 13) is tensioned.
  • the actuating device 5, 6, 7, 12, 13 has an engaging member 13.
  • the engagement member 13 may, as shown in Figures 6-8 and 12 or 9-11 and 13, be arranged in various ways. However, the arrangements shown have in common that the engagement member 13 is pressed in the distal direction of the movement of the coupling member 6 relative to the guide member 7 radially inwards, ie in the direction of the longitudinal axis of the injection device.
  • the inwardly pressed engagement member 13 engages with its engagement portion 13a ( Figures 12 and 13) in the grooves formed on the outer circumference of the output member 9. As a result, an anti-rotation between the output member 9 and engaging member 13 is formed.
  • the engaging member 13 is in turn rotatably connected to the metering actuator 5, 6, 7, 12, 13, that is connected to the coupling member 6 ( Figure 12) or the guide member 7 ( Figure 13).
  • the engagement members 13 shown in Figures 6-8 and 12 or 9-11 and 13 also have in common that they are arranged in particular at the end of a resilient arm.
  • the resilient arm is in particular integrally formed on the coupling member 6 ( Figure 12) or on the guide member 7 ( Figure 13). The arm makes it possible that the engagement member 13 is pressed in the distal direction during displacement of the coupling member 6 by the Kupplungshub h and moved when moving the coupling member 6 in the coupling stroke h opposite direction out of engagement with the output member 9.
  • the engagement member 13 has a first gear member 13b, which faces radially outward.
  • the first gear element 13b has a gear surface, which is formed according to the mechanism of action of an inclined plane.
  • the transmission element 13b is brought into engagement with a second transmission element 14 during the execution of the clutch stroke, which may be formed by the guide member 7 (FIG. 12) or the coupling member 6 (FIG. 13).
  • the second transmission element 14 has a radially inwardly facing gear surface, which can also act according to the laws of an inclined plane.
  • the engagement member 13 may, as shown in Figure 12 along the longitudinal axis of the injection device have.
  • the curvature corresponds to the radius at which the arm is spaced from the longitudinal axis.
  • the arm on which the engaging member 13 is disposed is fixed to the coupling member 6.
  • the arm pointing along the longitudinal axis could be arranged on the guide member 7, in which case the second transmission element 14 could be arranged on the coupling member 6 instead of on the guide member 7.
  • the engagement member 13 may be formed on a circumferentially extending arcuate arm, as shown in FIG. As shown in Figure 13, the arm 13 is formed on the guide member 7, wherein the second transmission element 14 on the
  • Coupling member 6 is formed. Alternatively, it could extend circumferentially Arm be arranged on the coupling member 6, in which case the second transmission element 14 could be arranged on the guide member 7.
  • serpentine spring elements 15 or, as shown in FIG. 13, spring elements 15 designed as clasp have proven to be particularly advantageous.
  • the injection device is preferably delivered in the state shown in FIGS. 1A to 1D.
  • the coupling member 6 is pressed by the spring member 15 shown in Figure 12 or 13 relative to the guide member 7 in the proximal direction and held there.
  • the metering and actuating device 5, 6, 7, 12, 13 is in this case still unconfirmed.
  • One dose is not yet set.
  • At least one locking cam 2b engages in a profile section 6b of the coupling member 6.
  • the metering and actuating device 5, 6, 7, 12, 13 and the output device 9, 10 are not rotatably coupled in this state.
  • the handle formed by the user of the injection device applies torque to the handle formed at the proximal end of the dose indicating drum 5.
  • the metering and actuating device 5, 6, 7, 12, 13 is set in rotation, whereby they screwed out of the housing 1, 2, 3 in the proximal direction due to the threaded engagement 7a, 2a.
  • One of the two latching cams 2b engages in a profile section 6b, ie in a groove 6a, the other latching cam 2b engaging in a profile-free section 6c. This means that the torque applied to the metering and actuating device 5, 6, 7, 12, 13 must be large enough that the latching cam 2b is pressed out of engagement with the grooves 6a.
  • an audible or tactile signal is generated, which indicates the rotation of the metering and actuating device 5, 6, 7, 12, 13.
  • the output device 9, 10 performs during the dosage no rotational movement, since the engagement member 13 does not engage in the output member 9.
  • An unintentional rotation, z. B. caused by the clicking vibrations is prevented by the latching engagement of the locking element 3b in the output member 9.
  • the coupling member 6, which engages with an internal thread in the non-rotatably connected to the output member 9 stop member 8 performs at the dosage of a rotational movement relative to the stop member 8, whereby the stop member 8 is displaced in the direction of stop 5a due to the threaded engagement.
  • the stop member 8 is shown in Figures 2 and 3 differing from Figure 1 only in the representations C, but this is not to say that no stop member 8 is present.
  • FIG. 4 shows how the inner housing 2 and the coupling member 6 cooperate at the end of a dose setting and before actuation of the metering and actuating device 5, 6, 7, 12, 13.
  • a cam 2b engages in the grooves 6a of the profile section 6b.
  • FIGS. 2A to 2D show the injection device in an inflated state, in which the desired product dose can be read in the window 1a.
  • the metering and actuating device 5, 6, 7, 12, 13 is still not actuated in this state to initiate the product discharge, the metering actuator 5, 6, 7, 12, 13 is actuated and initially, as shown in Figures 3A to 3D in that the coupling member 6, together with the actuating member 12 and the dose indicating drum 5, is displaced in the distal direction by the coupling stroke h relative to the guide member 7.
  • FIGS. 3A to 3D show the injection device in a state shifted by the coupling stroke h.
  • the dose indicator drum 5, the coupling member 6 and the guide member 7 screw distally into the housing 1, 2, 3 due to the threaded engagement 7a, 2a and offset due to the engagement of the engaging member 13 in the driven member 9, the piston rod 10 in a direction of rotation in the same direction, alternatively - in a threaded engagement between the piston rod and driven member - in no rotation.
  • Stop member 8 is moved back towards the stop 5a. This can be repeated until the stop member 8 abuts the stop 5a, at which moment a
  • Dose indicator drum 5 still allow another dosage.
  • the distance of the stop member to the stop 5 is adjusted so that the stop member 8 then abuts against the stop 5a when the piston 4a occupies its most distal position in a distribution then carried out.
  • Figures 6, 7 and 8 show the injection device in the embodiment with an axially extending arm for the engagement member 13, wherein the arm is attached to the coupling member 6.
  • FIG. 7 shows the injection device with an unactivated metering and actuating device 5, 6, 7, 12, 13 d. H. that the engagement member 13 does not engage in the output member 9.
  • a displacement of the coupling member 6 by the coupling stroke h ( Figure 7) causes the engagement member 13 engages the output member 9, whereby the coupling member 6 is rotatably coupled relative to the output member 9 ( Figure 8).
  • Figs. 9, 10 and 11 the injection device in the embodiment with a circumferentially extending arm for the engaging member 13 is shown.
  • the arm is in This example is arranged on the guide member 7.
  • the injection device is shown in an unactuated state, ie, that the engagement member 13 does not engage in the output member 9.
  • the rotational and axial fixedly connected to the dose indicator drum 5 coupling member 6 is displaced by the Kupplungshub h ( Figure 10)
  • the engagement member 13 is pressed due to the interaction of the transmission elements 13b and 14 radially inwardly into a rotationally fixed engagement with the output member 9.

Landscapes

  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système d'injection permettant l'administration d'un produit, lequel système comprend : a) un dispositif à actionnement (6, 7, 12, 13) qui, lorsqu'il est actionné, effectue un mouvement de rotation permettant l'administration, b) un dispositif de sortie (9, 10) qui effectue un mouvement de rotation permettant l'administration du produit et c) un élément à engagement (13) qui, lorsque le dispositif à actionnement (6, 7, 12, 13) est actionné, peut être amené d'un état désaccouplé, dans lequel le dispositif à actionnement (6, 7, 12, 13) peut pivoter par rapport au dispositif de sortie (9, 10), à un état accouplé, dans lequel le dispositif à actionnement (6, 7, 12, 13) est solidaire en rotation du dispositif de sortie (9, 10), en vue de l'administration du produit.
EP08850618A 2007-11-13 2008-11-12 Système d'injection à accouplement activé par actionnement Withdrawn EP2219713A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007054019A DE102007054019A1 (de) 2007-11-13 2007-11-13 Injektionsvorrichtung mit betätigungsaktivierter Kupplung
PCT/EP2008/009544 WO2009062686A1 (fr) 2007-11-13 2008-11-12 Système d'injection à accouplement activé par actionnement

Publications (1)

Publication Number Publication Date
EP2219713A1 true EP2219713A1 (fr) 2010-08-25

Family

ID=42352320

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08850618A Withdrawn EP2219713A1 (fr) 2007-11-13 2008-11-12 Système d'injection à accouplement activé par actionnement

Country Status (2)

Country Link
EP (1) EP2219713A1 (fr)
CN (1) CN101909677A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101870065B1 (ko) * 2011-10-17 2018-06-21 에스에이치엘 그룹 에이비 약물 투여 장치
CN112546352B (zh) * 2020-10-29 2022-05-10 宁波睿爱产品设计有限公司 一种药物注射装置
CN113384777B (zh) * 2021-05-22 2022-05-10 宁波睿爱产品设计有限公司 一种注射笔

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2009062686A1 *

Also Published As

Publication number Publication date
CN101909677A (zh) 2010-12-08

Similar Documents

Publication Publication Date Title
WO2009062686A1 (fr) Système d'injection à accouplement activé par actionnement
EP2829292B1 (fr) Dispositif d'entraînement et de dosage comprenant un élément de limitation pour empêcher le réglage d'une dose plus grande que disponible
EP1926514B1 (fr) Dispositif d'injection à accouplement à glissement à deux voies
EP0525525B1 (fr) Injecteur
EP1833535B1 (fr) Dispositif d'administration d'une dose de produit fluide pourvu d'un entrainement a barre de torsion
DE10237258B4 (de) Injektionsvorrichtung
EP3795194B1 (fr) Appareil d'injection destiné à l'administration ou à l'acheminement d'un fluide
WO2007071080A1 (fr) Dispositif d'injection doté d'un organe de dosage ou d'affichage a superposition axiale
EP2692377B1 (fr) Dispositif d'injection avec élément d'affichage de dose pour signaler fin d'injection
EP1890750B1 (fr) Compensation de longueur pour un dispositif de reglage d'un dispositif d'injection
CH706567A2 (de) Verbesserte Vorrichtung zum Einstellen einer Dosis mit einem Begrenzungsmechanismus für ein Gerät zur Verabreichung eines Produkts.
WO1995032749A2 (fr) Dispositif d'injection
WO2010072229A1 (fr) Dispositif de dosage pour un dispositif d'injection
EP3043840B1 (fr) Dispositif d'injection comportant un bouton d'actionnement dont l'actionnement provoque un mouvement de rotation
DE202013001350U1 (de) Injektionsgerät
EP2692376B1 (fr) Dispositif d'injection avec échelle de dosage en forme d'hélice ou de spirale
EP1838368B1 (fr) Dispositif d'injection avec un élément de dosage
EP2219713A1 (fr) Système d'injection à accouplement activé par actionnement
EP2692379B1 (fr) Dispositif d'injection avec un embrayage
EP2219714A1 (fr) Système d'injection muni d'un mécanisme à encliquetage pouvant être désaccouplé
CH709878A2 (de) Antriebs- und Dosiervorrichtung mit einem Begrenzungselement zur Verhinderung der Einstellung einer Dosis.
CH705427A2 (de) Injektionsvorrichtung mit übersetzter Dosisanzeige.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20100614

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Effective date: 20101103