EP2285442A4 - Methods and systems for assessing lung function and delivering therapeutic agents - Google Patents

Methods and systems for assessing lung function and delivering therapeutic agents

Info

Publication number: EP2285442A4
Authority: EP; European Patent Office
Prior art keywords: systems; methods; therapeutic agents; lung function; delivering therapeutic
Prior art date: 2008-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP09763304A

Other languages

German (de)

French (fr)

Other versions

EP2285442A1 (en

EP2285442B1 (en

Inventor

Nikolai Aljuri

Niyazi Beyhan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pulmonx Corp

Original Assignee

Pulmonx Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-12

Filing date

2009-06-03

Publication date

2012-08-15

2009-06-03 Application filed by Pulmonx Corp filed Critical Pulmonx Corp

2011-02-23 Publication of EP2285442A1 publication Critical patent/EP2285442A1/en

2012-08-15 Publication of EP2285442A4 publication Critical patent/EP2285442A4/en

2019-01-02 Application granted granted Critical

2019-01-02 Publication of EP2285442B1 publication Critical patent/EP2285442B1/en

Status Active legal-status Critical Current

2029-06-03 Anticipated expiration legal-status Critical

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0833—Measuring rate of oxygen consumption
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0402—Special features for tracheal tubes not otherwise provided for
- A61M16/0411—Special features for tracheal tubes not otherwise provided for with means for differentiating between oesophageal and tracheal intubation
- A61M2016/0413—Special features for tracheal tubes not otherwise provided for with means for differentiating between oesophageal and tracheal intubation with detectors of CO2 in exhaled gases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1025—Respiratory system
- A61M2210/1039—Lungs

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Physics & Mathematics (AREA)
Emergency Medicine (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Surgery (AREA)
Biophysics (AREA)
Pathology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Obesity (AREA)
Physiology (AREA)
Chemical & Material Sciences (AREA)
Anesthesiology (AREA)
Hematology (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP09763304.4A 2008-06-12 2009-06-03 Systems for assessing lung function and delivering therapeutic agents Active EP2285442B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6087408P	2008-06-12	2008-06-12
PCT/US2009/046138 WO2009152013A1 (en)	2008-06-12	2009-06-03	Methods and systems for assessing lung function and delivering therapeutic agents

Publications (3)

Publication Number	Publication Date
EP2285442A1 EP2285442A1 (en)	2011-02-23
EP2285442A4 true EP2285442A4 (en)	2012-08-15
EP2285442B1 EP2285442B1 (en)	2019-01-02

Family

ID=41417068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP09763304.4A Active EP2285442B1 (en)	2008-06-12	2009-06-03	Systems for assessing lung function and delivering therapeutic agents

Country Status (4)

Country	Link
US (1)	US20100158795A1 (en)
EP (1)	EP2285442B1 (en)
CN (1)	CN101970038B (en)
WO (1)	WO2009152013A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8808194B2 (en)	2010-07-01	2014-08-19	Pulmonx Corporation	Methods and systems for endobronchial diagnostics
EP2903514B1 (en)	2012-10-02	2022-11-23	Lutz Freitag	Systems for pulmonary diagnosis
CN104367325A (en) *	2014-12-01	2015-02-25	田庆	Lung collateral ventilation detection device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030051733A1 (en) *	2001-09-10	2003-03-20	Pulmonx	Method and apparatus for endobronchial diagnosis

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5139544A (en) *	1990-10-22	1992-08-18	Koch Engineering Company, Inc.	Gas-liquid contact column with improved mist eliminator and method
US5193544A (en) *	1991-01-31	1993-03-16	Board Of Trustees Of The Leland Stanford Junior University	System for conveying gases from and to a subject's trachea and for measuring physiological parameters in vivo
GB2324729B (en) *	1997-04-30	2002-01-02	Bradford Hospitals Nhs Trust	Lung treatment device
US5954766A (en) *	1997-09-16	1999-09-21	Zadno-Azizi; Gholam-Reza	Body fluid flow control device
JP3688994B2 (en) *	1998-06-03	2005-08-31	スコット・ラボラトリーズ・インコーポレイテッド	Sedation device, device for delivering medication to a patient, and integrated patient interface device
US6679264B1 (en) *	2000-03-04	2004-01-20	Emphasys Medical, Inc.	Methods and devices for use in performing pulmonary procedures
AU2001267097A1 (en) *	2000-06-16	2001-12-24	Rajiv Doshi	Methods and devices for improving breathing in patients with pulmonary disease
US6527761B1 (en) *	2000-10-27	2003-03-04	Pulmonx, Inc.	Methods and devices for obstructing and aspirating lung tissue segments
US20060135947A1 (en) *	2000-10-27	2006-06-22	Pulmonx	Occlusal stent and methods for its use
US7011094B2 (en) *	2001-03-02	2006-03-14	Emphasys Medical, Inc.	Bronchial flow control devices and methods of use
US7883471B2 (en) *	2001-09-10	2011-02-08	Pulmonx Corporation	Minimally invasive determination of collateral ventilation in lungs
JP4446739B2 (en) *	2001-10-11	2010-04-07	パルモンクス・コーポレイション	Bronchial flow control device and method of using the device
US6961600B2 (en) *	2002-02-13	2005-11-01	Trustees Of The University Of Pennsylvania	Transbronchial reflectance oximetric measurement of mixed venous oxygen saturation, and device therefor
CA2487413A1 (en) *	2002-06-05	2003-12-18	Yale University	Methods of treating angiogenesis, tumor growth, and metastasis
US7588033B2 (en) *	2003-06-18	2009-09-15	Breathe Technologies, Inc.	Methods, systems and devices for improving ventilation in a lung area
US8206684B2 (en) *	2004-02-27	2012-06-26	Pulmonx Corporation	Methods and devices for blocking flow through collateral pathways in the lung
US7451765B2 (en) *	2004-11-18	2008-11-18	Mark Adler	Intra-bronchial apparatus for aspiration and insufflation of lung regions distal to placement or cross communication and deployment and placement system therefor
US20070142742A1 (en) *	2005-07-13	2007-06-21	Pulmonx	Methods and systems for segmental lung diagnostics
US9265605B2 (en) *	2005-10-14	2016-02-23	Boston Scientific Scimed, Inc.	Bronchoscopic lung volume reduction valve
US8136526B2 (en) *	2006-03-08	2012-03-20	Pulmonx Corporation	Methods and devices to induce controlled atelectasis and hypoxic pulmonary vasoconstriction
US8342182B2 (en) *	2006-08-28	2013-01-01	Pulmonx Corporation	Functional assessment and treatment catheters and methods for their use in the lung

2009
- 2009-05-28 US US12/474,169 patent/US20100158795A1/en not_active Abandoned
- 2009-06-03 CN CN200980104533.1A patent/CN101970038B/en active Active
- 2009-06-03 WO PCT/US2009/046138 patent/WO2009152013A1/en active Application Filing
- 2009-06-03 EP EP09763304.4A patent/EP2285442B1/en active Active

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030051733A1 (en) *	2001-09-10	2003-03-20	Pulmonx	Method and apparatus for endobronchial diagnosis

Also Published As

Publication number	Publication date
WO2009152013A1 (en)	2009-12-17
US20100158795A1 (en)	2010-06-24
CN101970038B (en)	2015-11-25
EP2285442A1 (en)	2011-02-23
EP2285442B1 (en)	2019-01-02
CN101970038A (en)	2011-02-09

Publication	Publication Date	Title
IL290501A (en)	2022-04-01	Systems and methods for ex vivo lung care
HK1216726A1 (en)	2016-12-02	Permeant delivery system and methods for use thereof
EP2115651A4 (en)	2011-10-26	Systems and methods for online games
EP2318088A4 (en)	2012-02-08	Portable assemblies, systems, and methods for providing functional or therapeutic neurostimulation
EP2258395A4 (en)	2011-03-30	Therapeutic agent for fibroid lung
EP2265314A4 (en)	2013-09-04	Methods and devices for delivering injections
GB0722406D0 (en)	2007-12-27	Medico-surgical assemblies and methods
ZA201102269B (en)	2011-11-30	Systems for achieving and assisting an improved nutrution healthfulness data
ZA201101742B (en)	2011-11-30	Combination therapy for tuberculosis
IL201354A0 (en)	2010-05-31	Systems and methods for pulse delivery
EP2318901A4 (en)	2011-10-05	Systems and methods for speckle reduction
EP2370136A4 (en)	2015-12-30	Inhalation delivery methods and devices
EP2214557A4 (en)	2012-05-16	Breath delivery system and method
PL2144633T4 (en)	2015-02-27	A system for delivering therapeutic agents into living cells and cells nuclei
EP2224994A4 (en)	2012-05-02	Systems and methods for magnetic-assisted therapeutic agent delivery
GB2454412B (en)	2011-08-10	Hybrid riser systems and methods
EP2648697A4 (en)	2014-07-09	Methods for forming miniemulsions and use thereof for delivering bioactive agents
EP2360921A4 (en)	2015-05-20	Content delivering system
EP2285442A4 (en)	2012-08-15	Methods and systems for assessing lung function and delivering therapeutic agents
GB201102727D0 (en)	2011-03-30	Systems and methods for lottery-style games
HK1130555A1 (en)	2009-12-31	Methods and systems for determining efficacy of medicaments
GB2447547B (en)	2012-02-22	Method and system for patient evaluation
EP2234667A4 (en)	2011-06-01	Therapy calculation and therapy delivery modes
IL201711A0 (en)	2010-05-31	A system for delivering therapeutic agents into living cells and cells nuclei
GB201016383D0 (en)	2010-11-10	Bioelectromagnetic interface system

Legal Events

Date	Code	Title	Description
2011-01-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2011-02-23	17P	Request for examination filed	Effective date: 20100803
2011-02-23	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
2011-02-23	AX	Request for extension of the european patent	Extension state: AL BA RS
2011-09-21	DAX	Request for extension of the european patent (deleted)
2012-08-15	A4	Supplementary search report drawn up and despatched	Effective date: 20120718
2012-08-15	RIC1	Information provided on ipc code assigned before grant	Ipc: A61M 25/00 20060101AFI20120712BHEP Ipc: A61M 31/00 20060101ALI20120712BHEP Ipc: A61B 5/083 20060101ALI20120712BHEP
2015-07-08	17Q	First examination report despatched	Effective date: 20150609
2018-07-25	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2018-07-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: GRANT OF PATENT IS INTENDED
2018-08-22	INTG	Intention to grant announced	Effective date: 20180726
2018-11-27	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2018-11-30	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2018-11-30	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE PATENT HAS BEEN GRANTED
2019-01-02	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
2019-01-02	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D
2019-01-15	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP Ref country code: AT Ref legal event code: REF Ref document number: 1083598 Country of ref document: AT Kind code of ref document: T Effective date: 20190115
2019-01-17	REG	Reference to a national code	Ref country code: DE Ref legal event code: R096 Ref document number: 602009056525 Country of ref document: DE
2019-01-23	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2019-03-29	REG	Reference to a national code	Ref country code: CH Ref legal event code: NV Representative=s name: SERVOPATENT GMBH, CH
2019-04-10	REG	Reference to a national code	Ref country code: NL Ref legal event code: FP
2019-05-27	REG	Reference to a national code	Ref country code: LT Ref legal event code: MG4D
2019-06-15	REG	Reference to a national code	Ref country code: AT Ref legal event code: MK05 Ref document number: 1083598 Country of ref document: AT Kind code of ref document: T Effective date: 20190102
2019-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190402 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190502 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2019-08-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190403 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190402 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190502
2019-10-03	REG	Reference to a national code	Ref country code: DE Ref legal event code: R097 Ref document number: 602009056525 Country of ref document: DE
2019-10-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2019-11-08	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2019-11-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2019-12-11	26N	No opposition filed	Effective date: 20191003
2020-01-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2020-02-28	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2020-03-27	REG	Reference to a national code	Ref country code: BE Ref legal event code: MM Effective date: 20190630
2020-03-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2020-05-01	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190603
2020-05-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: BE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190630 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20190603
2020-06-15	REG	Reference to a national code	Ref country code: CH Ref legal event code: PCAR Free format text: NEW ADDRESS: WANNERSTRASSE 9/1, 8045 ZUERICH (CH)
2021-05-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2021-07-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102 Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20090603
2022-05-22	REG	Reference to a national code	Ref country code: DE Ref legal event code: R082 Ref document number: 602009056525 Country of ref document: DE Representative=s name: ZACCO LEGAL RECHTSANWALTSGESELLSCHAFT MBH, DE
2022-06-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20190102
2023-10-18	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230912
2023-10-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: CH Payment date: 20230702 Year of fee payment: 15
2024-07-08	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 20240627 Year of fee payment: 16
2024-07-10	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: DE Payment date: 20240618 Year of fee payment: 16
2024-07-18	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: NL Payment date: 20240618 Year of fee payment: 16
2024-07-31	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: FR Payment date: 20240627 Year of fee payment: 16
2024-10-21	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: CH Payment date: 20240701 Year of fee payment: 16