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EP2277625A1 - Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus - Google Patents

Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus Download PDF

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Publication number
EP2277625A1
EP2277625A1 EP10189757A EP10189757A EP2277625A1 EP 2277625 A1 EP2277625 A1 EP 2277625A1 EP 10189757 A EP10189757 A EP 10189757A EP 10189757 A EP10189757 A EP 10189757A EP 2277625 A1 EP2277625 A1 EP 2277625A1
Authority
EP
European Patent Office
Prior art keywords
receptacle
cap
thread
sealing
longitudinal axis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10189757A
Other languages
German (de)
English (en)
Inventor
Franz Konrad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Greiner Bio One GmbH Austria
Original Assignee
Greiner Bio One GmbH Austria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greiner Bio One GmbH Austria filed Critical Greiner Bio One GmbH Austria
Publication of EP2277625A1 publication Critical patent/EP2277625A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/02—Caps or cap-like covers without lines of weakness, tearing strips, tags, or like opening or removal devices
    • B65D41/04—Threaded or like caps or cap-like covers secured by rotation
    • B65D41/08—Threaded or like caps or cap-like covers secured by rotation engaging a threaded ring clamped on the external periphery of the neck or wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs

Definitions

  • the invention relates to a receiving device comprising a closure device, a receptacle and a threaded arrangement arranged between them, as described in claim 1.
  • Various recording devices which describe from a receptacle and a coupling device can be coupled with it, are from the EP 867 678 B1 .
  • EP 1 174 085 B1 as well as the US 6,017,317 A1 known.
  • a coupling device in the form of a threaded arrangement is described between the closure device, in particular the cap, and the end of the receptacle to be closed, wherein the threaded arrangement in the region of the receptacle distributed over the circumference arranged thread segments, which are each arranged spaced apart in the circumferential direction.
  • the sealing device composed of a plurality of layers, which comprises a resealable layer, a connecting layer arranged between the latter and a gas barrier element, and a further connecting layer between the gas barrier element and the receiving container.
  • the resealable element is glued in the cap by means of a hot melt adhesive.
  • the connection or holding force of the further connection position between the gas barrier element and the receptacle is less than the connection force of the arranged between the resealable element and the cap hot melt adhesive.
  • closure devices of the same applicant are, for example, from EP 0 915 737 B1 have become known in which the conical sealing element used in the bottom region of the receptacle and held biased by means of engaging in the outer periphery of the receptacle cap so as to achieve sufficient tightness.
  • the coupling takes place via a pure snap action between the cap-like closure element and the receptacle.
  • the screwing-on movement takes place until the cap is applied far enough beyond the open front side of the receptacle, so that the guide extensions of the receptacle are moved in the free space between the end of the guide web or thread turn and the end wall of the cap.
  • a free rotation of the cap relative to the receptacle is possible without engagement of the coupling device is present.
  • the placement of the cap by a Aufschraubvorgang or a sliding over the cap with the guide web arranged thereon could be done on the or the guide extensions on the receptacle again. This is possible due to the elasticity of the cap.
  • a receiving device with a receptacle known has, which has two spaced apart in a longitudinal axis ends, at least one of which is formed with an opening.
  • the inner dimension of the receptacle in the region of the first open end in the plane aligned perpendicular to the longitudinal axis is greater than the inner dimension in the region of the further end in the plane aligned parallel thereto in the same spatial direction.
  • an annular component is used in the open end, which covers the open end side of the receptacle with a collar and a cylindrical wall portion projects into the interior of the receptacle at least partially.
  • the annular component has, following the cylindrical wall part, a shoulder and, connected thereto, a cross-sectional widening on which the elastic sealing element of the separating device is supported in the starting position.
  • the separator has a recess which is closed with a thin cover plate in the region of the upper end of the receptacle.
  • the filling of the interior is carried out by means of a puncture of the thin cover plate of the separator, the thin film and possibly the cap. Through this filling process, the vacuum is reduced in the interior, which also air is sucked into the interior. Subsequently, there is the centrifuging process, in which the separating device emerges from the annular member in the direction of the closed end and further comes with its sealing element on the inner surface of the receptacle to the plant. The rate of descent in the mixture or the already separated components is determined by the contact pressure of the elastic sealing element on the inner surface. By choosing the density of the entire separation device with respect to the components of the mixture to be separated, they float at the interface between the two different density media. A passage of the lighter medium during the centrifuging process is possible between the inner surface of the receptacle and the elastic sealing element.
  • Another receiving device with a separator is from the EP 1 005 910 A2 become known, which has a cylindrical receptacle with almost having a constant inner diameter. At the open end of the receptacle, a pierceable closure device is arranged, on which, even in the starting position, the separation device is arranged almost fitting.
  • This separator is formed of a flexible recoverable material, wherein on the outer periphery of the separator, a sealing device is provided for sealing with the inner surface of the receptacle.
  • a deformable element is still used in the interior, which is pressed during the application of the centrifugal force by the pressure exerted by the medium to the inner wall of the outer container and between the separator and the inserted deformed insert a flow channel is formed, which after removal of the Centrifugal force again assumes a sealing position with the arranged on the separator sealing elements, whereby the separated media remain separated from each other.
  • the other medium located between the closed end and the separating device can mix again with the medium separated therefrom, in one of the usual remaining amount of the other medium corresponding height is in the direction of the closed End cone-shaped widening end stop provided, with which the separator on the end stop, which penetrates through the aperture, runs up.
  • the separating device remains in this position and thereby the opening is closed with the stop and there can be no exchange or re-mixing of the two media.
  • EP 1 106 250 A2 Other recording devices with therein separation devices are from the EP 1 106 250 A2 .
  • EP 1 106 253 A2 and the EP 1 107 002 A2 have become known, the separation devices are formed in a variety of embodiments and based on the principle of deformability of a component of the separation device during the centrifugation and the density of votes between the media to be separated.
  • the present invention has for its object to provide a recording device formed from a closure device and a receptacle, in which the operator safety is increased for the person handling.
  • the object of the invention is achieved by a receiving device according to the features indicated in claim 1.
  • the resulting from the combination of features of the characterizing part of this claim advantages are that thereby still engaging threads the withdrawal movement of the cap can be supported together with the sealing device from the receptacle and at the same time already a pressure equalization between the interior of the receptacle and the outer atmospheric environment take place without aerosols being transferred to the person handling it.
  • These are derived between the outer surface of the receptacle and the inner surface of the cap skirt.
  • Another advantage is that only by applying a directed in the direction of the longitudinal axis of the receptacle or the cap pressure force (F) in cooperation of arranged between these components of the assembly thread assembly, this axially acting pressure force (F) a relative pivoting or rotational movement between generates these components and so the screwing up or screwing is performed.
  • This method according to the invention leads to a reduction in costs in the field of automatic assembly machines, since only a simple longitudinal movement with corresponding application of force is to be carried out here.
  • a cost reduction by the smaller footprint and by the possible with this method shorter cycle times can be achieved.
  • the cost of the resulting maintenance or repairs are reduced by the simplified joining process.
  • a procedure according to the features indicated in claims 2 to 4 is advantageous, because thereby the handling of the joining or mounting operation of the receiving device better and easier to perform.
  • the predetermined retention of the cap or the receptacle can optionally be brought to the receptacle and / or the cap in the relative pivoting or rotational movement by the application of the predeterminable compressive force (F).
  • the cap loosely placed on the receptacle then the one or more receptacles fixedly held and by subsequent application of the compressive force (F) the cap are moved in a rotational movement relative to the receptacle, whereby the joining process performed and at corresponding Selection until fully unscrewed.
  • a multiple arrangement of recording devices to be screwed is possible, whereby in addition a simple and quick installation can be carried out at low machine cost.
  • Threads the required compressive force for assembly can be reduced or reduced, whereby a safe and rapid joining process is possible. Likewise, however, this can additionally influence the sealing behavior between the sealing plug and the receptacle.
  • the pitch angle can be varied in other limits and so depending on the components to be joined, an exact fine tuning can be performed.
  • a further advantageous embodiment is that a simpler and better pre-centering of the cap relative to the receptacle is made possible at the beginning of the joining process.
  • the sealing device can be kept clearly positioned by the coupling device in the cap, whereby a common joining operation of the cap together with the sealing device is made possible with the end of the receptacle to be closed in one operation.
  • an embodiment of the cap according to the features specified in claim 38 is advantageous, since on the one hand improves the handling of the closure device for the removal of the receptacle and on the other hand, the support of the entire receiving device is improved in the storage position on a storage surface.
  • the pitch angle can be varied in other limits and so depending on the components to be joined an exact fine tuning can be performed.
  • a portion of the thread assembly is formed for the receptacle, at the same time achieved with a low material savings associated weight saving and the Aufschraub- or joining process can be facilitated.
  • a complete Aufschraub- or Aufsetzvorgang the cap can be achieved on the receptacle with a shorter pivoting angle.
  • the multi-start thread arrangement distributes the pressure force necessary for the joining or screwing operation over the entire circumference of the cap or receptacle, thus achieving uniform loading of the components to be joined.
  • a threaded arrangement is achieved in which seen over the circumference, the individual threads extend only over a portion of the circumference and a predeterminable gap remains between the threads. Due to this design, it is possible to arrange the mold parting plane of the tool to form the threads along the same and at the spaced apart locations in the region of the gap, the mold parting plane by the pitch-related displacement of the threaded ends or thread starts inclined to arrange between them. As a result, a simpler tool design and an associated easier opening movement is achieved. Due to the multiple arrangement of the cavities in a narrower space additional production and manufacturing costs for the tools can be saved.
  • an embodiment according to claim 50 or 51 proves to be advantageous because thereby jamming or jamming during the joining process in the region of the coupling device between the cap and the receptacle is avoided.
  • the embodiment according to claim 65 allows a further reduction of the friction coefficient even before the joining process, whereby a subsequent application of a coating can optionally be saved.
  • the object of the invention can also be achieved independently by the features of claim 76.
  • the surprising advantage resulting from the features of the characterizing part of claim 76 is that by providing at least one flow channel between the inside of the container wall of the receiving container and the insertable separating device, a flow connection between the portion of the interior on both sides of the separator to be used, namely between the separator and the closed end of the receptacle and between the separating device and the end closable by the closing device.
  • a minimum flow cross-section is defined which, with regard to the material to be filled, in the present case blood, has a sufficient size or a corresponding cross-section which causes the flow channel to be displaced due to the surface tension inherent in the blood or the density thereof during the process Filling process prevented.
  • At least one through-flow channel is created, which allows unimpeded insertion of the separating device into the interior in its initial position, without any inadvertent closing of the same being connected thereto.
  • the at least partially formed surface structure causes a beading of the material to be filled on the structured surface, wherein the surface structure embedded either in the nanometer or micrometer waveform or by additionally embedded in the material of the receptacle or embedded micro- or nanoparticles is created. In order for an adhesion and associated falsification of the subsequent analysis process is largely prevented.
  • the insertion of the sealing plug into the cap from this side can be substantially facilitated because the radially projecting approach of the sealing plug must be minimally compressed and then a secure mounting of the sealing plug in the cap can be achieved.
  • the Abschraubweg and the associated axial displacement of the sealing plug in the direction of the longitudinal axis is minimized so far that at least one channel is formed and still the threads of the thread assembly are engaged.
  • the embodiment according to claim 106 it is possible to achieve an even more effective coupling and associated firmer support between the sealing device and the cap.
  • a rolling backup for example, on a flat surface, for the entire recording device are created in their intended use.
  • a receiving device 1 eg for a mixture 2 of at least two to each other different components or media 3, 4, such as body fluids, tissue parts or tissue cultures shown.
  • the receiving device 1 consists of an approximately cylindrical receptacle 5 with two mutually distanced ends 6, 7, wherein in this embodiment, the end 6 is formed open and the end 7 is formed by an end wall 8 closed.
  • the open end 6 here is closed with a closure device 9 shown in a simplified manner, if necessary, and can, for example, according to the EP 0 445 707 B1 , of the EP 0 419 490 B1 , of the US 5,275,299 A , of the US 5,495,958 A as well as the US 5,522,518 A to avoid repetition, reference is made to the disclosure for the formation of the cap, the sealing device, the housing, the coupling device between the cap and the sealing device and the cap and the receptacle 5 and the arrangement of the retaining ring and is incorporated in the subject application.
  • a separator In a space enclosed by the receptacle 5 interior 10 may additionally be used a separator, which is not shown here.
  • the procedural procedure for the assembly or assembly between the closure device 9 and the receptacle 5 will be described in more detail below.
  • This receptacle 5 with the closure device 9 may for example be designed or used as an evacuated blood sampling tube in various embodiments.
  • the receptacle 5 for example, bottle, vial, piston-shaped or the like. Formed and made of a variety of materials, such as plastic or glass, be formed. Is selected for the receptacle 5 as the material plastic, this may be liquid-tight, in particular waterproof and optionally gas-tight and for example of polyethylene terephthalate (PET), polypropylene (PP), polyethylene (PE), polystyrene (PS), high-density polyethylene (PE -HD), acrylonitrile-butadiene-styrene copolymers (ABS) or the like or a combination thereof.
  • PET polyethylene terephthalate
  • PP polypropylene
  • PE polyethylene
  • PS polystyrene
  • PE -HD high-density polyethylene
  • ABS acrylonitrile-butadiene-styrene copolymers
  • the receptacle 5 has a container wall 11 with a wall thickness 12, wherein the container wall 11, starting from the one end 6 with an inner dimension 13 in a direction perpendicular to a running between the two ends 6, 7 longitudinal axis 14 level 15 out to a further, arranged in the region of the end 7 and extending parallel to the first plane 16 extending further level 16 with a smaller dimension 17 extends.
  • the container wall 11 of the receptacle 5 has an inner surface 18 facing the inner space 10 and an outer surface 18 facing away from it, which thus defines an outer circumference for the receptacle 5.
  • an internal cross section which may have a variety of cross-sectional shapes, such as circular, elliptical, oval, polygonal, etc., set.
  • the shape of the outer cross section may also be circular, elliptical, oval, polygonal, etc., but it is also possible to make the shape of the outer cross section different from the shape of the inner cross section.
  • the inner dimension 13 of the receptacle 5, starting from one end 6 to the distant from this further end 7 is continuously minimally reducing to the inner dimension 17 is formed, for example, the receptacle 5, if this plastic material in a Injection molding process is made to be able to easily remove from the injection molding tool.
  • this tapered taper between the two planes 15, 16 the extent of the decrease of the inner dimension from the larger dimension 13 to the smaller dimension 17 is predetermined.
  • the taper or taper angle is, based on the inner opposite surfaces of the receptacle 5, between 0.1 ° and 3.0 °, preferably between 0.6 ° and 1.0 °.
  • the dimensions described are based on the distance between the opposing inner or outer surfaces 18 of the components, the diameter, the circumference along an envelope or a Hüll line and the cross-section or the cross-sectional area respectively in one of the aligned perpendicular to the longitudinal axis 14 planes and always the same spatial direction for determining the dimensions 13, 17 can relate.
  • the end 6 has an open front side 19, which can be closed by the closure device 9, which can be opened as required.
  • the closure device 9 consists of a cap 20 enclosing the open end 19 and a sealing device 21 held therein, such as a sealing plug 22 made of a pierceable, highly elastic and self-sealing material, such as pharmaceutical rubber, silicone rubber or bromobutyl rubber.
  • This cap 20 is usually arranged concentrically to the longitudinal axis 14 and formed by a circular ring Cap jacket 23 formed.
  • a coupling device 28 Between the cap 20 and the sealing device 21 are means for coupling, such as coupling parts 24 to 27 of a coupling device 28, consisting in the cap 20 from at least over the inner circumference partially arranged projections 29, 30, optionally a retaining ring 31, and in the sealing device 21st from an at least partially projecting over its outer periphery approach 32nd
  • the sealing device 21 is formed in the present embodiment by the sealing plug 22 and has a circumferential and approximately concentric with the longitudinal axis 15 arranged cylindrical sealing surface 33, which comes in its sealing position in the section of the end 6 on the inner surface of the receptacle 5 to the plant.
  • the inner surface of the receptacle 5 should be formed in its surface quality as a sealing surface 34 in this section.
  • the sealing device 21 has an approximately perpendicular to the longitudinal axis 14 aligned, further sealing surface, which closes in cooperation with the voltage applied to the inner surface or sealing surface 34 sealing surface 33, the interior 10 of the receptacle 5 at the open end face 19 against the outside environment or seals.
  • the sealing device 21 may preferably have on the side facing the retaining ring 31, a recess 35 which has approximately the same cross-sectional area as an opening 36, wherein this opening 36 is formed in its dimension such that unimpeded passage of a not shown here Cannula and a subsequent piercing through the sealing device 21 is possible.
  • the coupling part 26 forming the projection 32 of the sealing plug 22, which protrudes over the sealing surface 33 at least in portions of the circumference flange is supported between the projections 29 and 30 and optionally the retaining ring 31, the distance from each other in two in the direction of the longitudinal axis 14 and perpendicular arranged to this aligned planes and, for example, as at least partially or annular circumferential projections or Arretierfort instruments are formed which a groove-shaped receiving area on the inside of the cap jacket 23 for the projection 32 of the sealing plug 22 form.
  • the retaining ring 31 has a larger outer diameter than an extending between the extensions 29 and 30 inner dimension in the direction perpendicular to the longitudinal axis 14.
  • the diameter of the opening 36 of the retaining ring 31 is smaller than a largest outer dimension of the projection 32 in a plane perpendicular to the longitudinal axis 14.
  • this outer dimension of the sealing device 21 is dimensioned so that it is greater than the inner dimension 13 of the inner cross-section and thus of the inner space 10 at least twice the wall thickness 12 of the receiving container 5
  • the Forming coupling part 25 having an inner opening width, which substantially corresponds to the inner dimension 13 of the receptacle 5 in its upper end 6, there is a very good support of the projection 32 in the cap 20 and a good seal between the interior 10 of the Receiving container 5 and the receiving device 1 surrounding atmosphere.
  • This inner opening width can also be chosen to be larger than the inner dimension 13 of the receptacle 5, whereby a lateral abutment of the extension 30 on the outer surface 18 of the receptacle 5 is possible.
  • the tightness of the closure device 9 for the open end face 19 of the receiving device 1 is further improved if an outer diameter of the sealing device 21 in the region of its sealing surface 33 in the relaxed state outside of the receptacle 5 is greater than the inner dimension 13 of the receptacle 5 in the sealing device 21 facing area.
  • a longitudinal or vertical extent of the projection 32 of the sealing device 21 in the direction of the longitudinal axis 14 is greater than a distance of a groove-shaped receiving area or a groove-shaped depression between the two extensions 29, 30 and optionally minus a thickness of the retaining ring 31.
  • cap casing 23 is designed as a cylinder stump sheath or as a truncated cone casing, whereby an overstretching of the cap casing 23 in the region of the upper end face 19 is ensured.
  • the cap 20 has two spaced apart in the direction of the longitudinal axis 14 of each other end portions 38, 39, wherein in the illustrated embodiment, the open end portion 39 is arranged across the open end 19 of the receptacle 5 cross and the end face 19 to close or even adjacent the extension 30 comes up. In the position shown here, the end face 19 fits snugly against the surface of the extension 30 facing this.
  • a threaded assembly 40 is further provided between the cap 20 and the receptacle 5, a threaded assembly 40.
  • a first part of the thread assembly 40 is disposed on an inner surface 41 of the cap skirt 23 and a second part of the thread assembly 40 on the outer surface 18 of the receptacle 5 extending. It should be noted at this point that the threaded arrangement 40 or the parts forming it have only been shown schematically in this figure in a simplified manner.
  • Fig. 2 are the according to the Fig. 1 shown components for assembly to form the receiving device 1, namely the closure device 9 with the open here end 6 of the receptacle 5 in a still separated position,
  • the closure device 9 with the open here end 6 of the receptacle 5 in a still separated position
  • the detailed description of each component on the previous Fig. 1 is referred to or referred to.
  • a first part of the thread assembly 40 such as a thread 42
  • a further part of the thread assembly 40 such as another simplified thread 43 shown also shown.
  • the receptacle 5 is held by means of a holding device 44 shown in a preferred vertical position shown here, wherein it is additionally possible to support the closed here end 7 of the receptacle 5 to a support surface 45 shown in simplified form.
  • the sealing plug 22 has been omitted for the sake of better clarity, in order to make the thread arrangement 40, in particular the thread 43 shown here, more readily apparent.
  • the cap 20 with the sealing plug 22 arranged therein can be applied to the end 6 of the receiving container 5 open here by means of devices or devices, not shown in detail. Assembly machines or similar from the known prior art manufacturing facilities are placed.
  • a part of a mounting device 46 is shown here in simplified manner above the cap 20, which in the direction of the longitudinal axis 14 according to the double arrow in the direction of the receptacle 5 or in the opposite direction by means of one or more adjustment means not shown here via adjusting means in its position relative to the stationary held receptacle 5 is designed to be adjustable or are.
  • This mounting device 46 may be formed for example by a corresponding pressure plate, which by means of known adjusting means, such as a cylinder-piston assembly, spindle drives, gear arrangement, magnetic or hydraulic drives, etc. in the predeterminable movement is offset. Both a simple but also multiple arrangement is possible.
  • a thrust bearing 47 is shown, with which it is possible, via the actuating means or the mounting device 46 impacted on the cap pressure force in cooperation with the threads 42, 43 of the threaded assembly 40 to bring the cap 20 in a relative to the receptacle 5 relative rotational or pivotal movement or to generate this and so to achieve the joining operation or assembly of the closure device 9 with the receptacle 5.
  • several of these thrust bearing 47 may be kept in a corresponding division of the pressure plate, which can be done in a corresponding multiple arrangement of units to be mounted of the receiving devices 1 space saving the joining or assembly process.
  • the threads 42 project beyond the outer surface 18 of the receptacle 5 in the direction away from the longitudinal axis 14 direction.
  • the plug 48 of the sealing plug 22 inserted into the interior 10 has a larger outer dimension in its untensioned state than the receptacle 5 in the area to be used, whereby in selecting the pressure force to be used for overcoming the resistance due to the between the plug 48 and the inner wall of the interior 10 caused friction is considered.
  • the pressure force to be used for generating the relative rotational or pivoting movement between the closure device 9 and the receptacle 5 should be between 10 N and 50 N in size.
  • At least one component forming the receiving device 1 is applied at least in regions in the region of the coupling device 37 to a coating (not illustrated here).
  • this coating can be applied to the part of the thread arrangement 40 formed on the receptacle 5 and / or to the part of the thread arrangement 40 arranged in the cap 20 and / or to at least one of the mutually facing sealing surfaces 33, 34 in the region of the plug 48 or Receiving container 5 may be applied.
  • This coating serves to reduce the friction between the components to be assembled. It is possible, e.g. to choose different coatings in the range of the thread assembly 40 and between the sealing plug 22 and the receptacle 5.
  • the coating can be applied to at least one component forming the receiving device 1 (closure device 9 with cap 20 and sealing device 21 or receiving container 5). This is preferably applied in the region of the coupling device 37 at least in regions, whereby this can be done on the part of the thread arrangement 40 formed on the receptacle 5 and / or in the cap 20. Not only the threads 42, 43 of the thread assembly 40 but also at least partially the inner surface 41 of the cap skirt 23 and / or at least partially the outer surface 18 of the receptacle 5 may be provided with the coating at least in the region of the thread assembly 40.
  • this coating can also be applied to the inner surface 18 of the receptacle 5 facing the sealing surface 33 of the plug 48 of the sealing device 21, which is facing the sealing surface 33 of the plug 48 of the sealing device 21. It is also advantageous if the coating in the respective coating area is continuous or continuous is formed with a predeterminable layer thickness.
  • the compressive force (F) is one of the components to be assembled (closure device 9, in particular cap 20, or receptacle 5) relative to the other of the components to be assembled (receptacle 5 and closure device 9, in particular cap 20) relative to this by free rotation to pre-position the common longitudinal axis 14. This is done by holding one of the two components, wherein in the interaction of the threads 42, 43, the mutual alignment takes place and so a perfect repeatable Aufschraubvorgang until reaching the end position can be achieved. During the relative rotational or pivotal movement about the common longitudinal axis 14, the threads 42, 43 of the thread assembly 40 are engaged over the entire length of the Einschraubweges until reaching the fully screwed position with each other.
  • the coating for facilitating the insertion movement of the sealing plug 22 of the sealing device 21, for example, silicone oils, waxes, waxy polymers, fatty alcohols, fatty acid esters, fatty acid amides can be used.
  • lubricants or lubricant additives can be mixed or introduced into the coating and applied to the cap 20 and / or the receptacle 5 and / or the sealing device 21 for reducing the frictional forces.
  • the coating comprises at least one lubricant or lubricant additive.
  • lubricant or lubricant additive already provided for the preparation of the cap 5 mixture or granules and the lubricant together melt or soften with the mixture or granules to form the plastic melt in a known form, whereby the lubricant or the lubricant is already part of the cap material or are.
  • the coating and / or the lubricant additives or the lubricant (s) mixed or incorporated therein and / or dissolved therein can be designed such that they not only greatly reduce the sliding friction between the components to be joined but also increase the static friction prevent accidental release of the components during normal use.
  • a specific opening movement of the closure device 9, in particular the cap 20 from the receptacle 5, can also be carried out simply for a later access to the interior 10, as is described, for example. is necessary for sampling from the collected medium.
  • a pitch angle 50 from a selected area with a lower limit of 2 °, preferably 3 °, in particular 5 ° , preferably of 8 °, 10 °, 13 °, 15 ° and having an upper limit of 30 °, preferably 25 °, in particular 20 °, preferably of 16 °, 13 ° or 12 °.
  • pitch angles 50 with a size of 9 °, 10 ° and 11 °, 12 ° have proven to be favorable.
  • the thread assembly 40 is designed to be more continuous in the region of the cap 20.
  • three threads 42 distributed over the inner surface 41 are preferably provided, wherein thread starts 51 to 53 of the individual threads 43 are arranged offset in the circumferential direction relative to each other by approximately 120 °.
  • a thread length of the individual threads or threads 43 forming the thread arrangement 40 is equal to or smaller than an inner circumference of the cap jacket 23 in the region of the thread arrangement 40 in the plane 49 aligned perpendicular to the longitudinal axis 14. This is due to the above-described three-start thread advantageous if a thread 43 extends approximately over half the inner circumference of the cap skirt 23. Furthermore, from the presentation, in particular the 3 and 4 to see that the one or more threads 43 are formed projecting beyond the inner surface 41 of the cap skirt 23 in the direction of the longitudinal axis 14. To reduce the friction between the threads 43 shown here in the region of the cap 20 and the previously briefly in the Fig.
  • the thread assembly 40 in particular the threads 42 and / or 43, at least partially provided with a coating not shown here. In this case, only the mutually interacting sections of the individual threads 42 and / or 43 may be provided with this coating, not shown.
  • the individual thread starts 51 to 53 are arranged close to the open and the receptacle 5 facing or cross-end portion 39 and extend due to their above-described slope or the pitch angle 50 to close to the extension 30 zoom.
  • the pitch angle 50 and the circumferential extent of the individual threads 43 is in the present embodiment for the cap 20 of the receptacle 5 for a nominal size of 13 mm, as this is currently a common standard size for the receiving device 1.
  • the holder of the sealing plug 22, in particular of the projection 32 between the two extensions 29 and 30 may optionally be made with the interposition of the retaining ring 31 but other mounting options are not excluded.
  • the description for the formation of the threads 42 relates to a receptacle 5, in particular blood sampling tube, with a nominal size in its diameter of 13 mm. In the event of deviations, in particular in diameter, the values described here must be correspondingly transferred to other nominal sizes.
  • the individual threads 42 are arranged to form the threaded assembly 40 on the outer surface 18 of the receptacle 5 evenly distributed.
  • thread starts 54 to 56 and threaded ends 57 to 59 limit the individual threads 42 in their longitudinal extent over the circumference. So is from a synopsis of Fig.
  • a pitch angle 60 of the threads 42 for forming the thread assembly 40 relative to a plane 49 oriented perpendicular to the longitudinal axis 14 is selected from a selected range having a lower limit of 2 °, preferably 3 °, especially 5 °, preferably 8 °, 10 °, 13 °, 15 ° and with an upper limit of 30 °, preferably 25 °, in particular 20 °, preferably of 16 °, 13 ° or 12 °.
  • pitch angle 60 with a size of 9 °, 10 ° and 11 °, 12 ° have proven to be favorable.
  • the threaded assembly 40 is formed more continuous, wherein the second part of the threaded assembly 40 also comprises three distributed over the outer surface 18 and the outer surface arranged threads 42.
  • the two selected pitch angles 50, 60 are in the same limits and, in order to achieve a perfect Aufschraubvorgang, each chosen the same size.
  • preferred pitch angles 50, 60 values with lower or upper limits of 3 ° and 20 °, 5 ° and 16 °, 8 ° and 13 °, and 10 ° and 12 ° have also been found, wherein the size of the selected pitch angle 50 , 60 is dependent on the combination of materials of the receptacle 5, the cap 20 and the sealing device 21 and the proposed coating.
  • the thread starts 54 to 56 of the individual threads 42 are arranged offset in the circumferential direction to each other approximately at 120 °.
  • the same also applies to the threaded ends 57 to 59.
  • directly adjacent to each other thread roots 54 to 56 and threaded ends 57 to 59 each spaced apart in the circumferential direction, whereby a sum of the thread lengths of the thread assembly 40 forming threads 42 in the direction perpendicular to the longitudinal axis 14 aligned Level 49 seen over the circumference equal to or smaller than an outer circumference of the receptacle 5 in the region of the thread assembly 40.
  • the respectively circumferentially immediately adjacent arranged threads 42 are spaced from each other in the circumferential direction.
  • the threads 42 extend between their thread beginning 54 to 56 and their threaded end 57 to 59 seen over the circumference over an angle 61, which may be for example between 50 ° and 80 °.
  • this angle 61 is selected to be in about 65 °.
  • the threads 42 have their full thread height 62, as shown in the enlarged view of Fig. 9 best seen.
  • the thread 42 in the section of its thread beginning 54 to 56 starting from the full thread height 62 toward the outer surface 18 of the receptacle 5 has a threaded outlet 63 which is formed in its height steadily decreasing. It is the same advantageous if the thread or the threads 42 in the section of their threaded ends 57 to 59, starting from their full thread height 62, towards the outer surface 18 of the receptacle 5 have a further threaded outlet 64, which is also formed in its height steadily decreasing. In most cases, the threaded outlet 63 and / or 64 is formed by a transition radius 65. But this thread outlet can also have any other form technical training to facilitate the joining process. This can also be selected differently depending on the material.
  • the manufacturing process in particular the Injection molding process to arrange the mold parting plane to form the receptacle 5 in the threads in each case at their highest point or the highest line thereof and between the immediately adjacent threaded starts 54 to 56 and threaded ends 57 to 59 this through a connecting line in the region of the outer surface 18 extending to connect with each other and continue to form the mold parting plane in this connection line.
  • the manufacturing process in particular the Injection molding process to arrange the mold parting plane to form the receptacle 5 in the threads in each case at their highest point or the highest line thereof and between the immediately adjacent threaded starts 54 to 56 and threaded ends 57 to 59 this through a connecting line in the region of the outer surface 18 extending to connect with each other and continue to form the mold parting plane in this connection line.
  • Such an arrangement of the mold parting plane for the formation of external threads is for example from the US 3,926,401 A as well as the US 2001/0055632 A1 known.
  • a similar training for internal thread is from the DE 30 47 856 C2 .
  • US 4,188,178 A such as US 5,667,870 A known.
  • the thread 42 has seen or seen in its cross section, ie in a parallel to and centrally through the longitudinal axis 14 extending plane, starting from its full thread height 62, toward the outer surface 18 of the receptacle 5 to a mutually different transition region , whereby a thread cross section of the thread 42 is formed asymmetrically in this plane.
  • the thread 42 has in the region of the outer surface 18 in a nearly parallel direction to the longitudinal axis 14 or in the reference plane described above, a base width 66, which may be 1.3 mm in the present embodiment. Starting from this base width 66, the thread 42 in the considered plane on the open end 19 of the receptacle 5 side facing an exclusive radius 67, which leads, starting from the outer surface 18 toward full thread height 62. In the section of the full thread height 62, the thread 42 has a likewise parallel to the longitudinal axis 14 extending vertex width 68, in the region of the mold parting plane can be arranged to extend. This vertex width 68 is approximately 0.6 mm in the above-described base width 66 of 1.3 mm.
  • the thread 42 On the side facing away from the open end face 19, the thread 42, starting from the outer surface 18, towards the full thread height 62 on a direction towards the open end face 19 inclined transition surface 69, said angle 70 in the present embodiment 5 ° the perpendicular to the longitudinal axis 14 aligned plane 49.
  • a further radius 71 is provided, which has a size of 0.3 mm in the present embodiment.
  • the first radius 67 in this embodiment 0.7 mm and passes from starting the outer surface 18 to the parallel vertex width 68 of the thread 42 via.
  • This vertex width 68 of the thread 42 may also be referred to as a vertex surface 72 become.
  • the apex surface 72 and the transition surface 69, in a view of the thread cross-section can also be referred to as a crest line or transition line or boundary line.
  • FIG. 10 is another and possibly independent solution for joining or mounting the receiving device 1 similar to the training as in the Fig. 2 shown.
  • illustrated components for assembly to form the receiving device 1, namely the closure device 9 are shown with the open end 6 of the receptacle 5 in a still separate position, in turn, to avoid unnecessary repetition, to the detailed description of the individual components on the previous one Fig. 1 to 9 is referred to or referred to.
  • the cap 20 is simplified in half section and shown without sealing device 21, wherein the cap 20 is still seen in a distant position from the receptacle 5 in the direction of the longitudinal axis 14.
  • the thread assembly 40 is shown simplified.
  • the reference numerals were analogous to those in Fig. 2 Registered training, wherein, in order to avoid unnecessary repetition, here omitted a detailed description and reference is made to the preceding embodiments and reference is made.
  • the receptacle 5 is rotatably supported in this embodiment via the thrust bearing 47 on the support surface 45 about the longitudinal axis 14, wherein the axial alignment or pre-positioning of the same with respect to the cap 20 and closure device 9 this is associated with a positioning device 75.
  • a positioning device 75 a guide hole 76 shown in simplified form is arranged, which ensures, for example, a vertical orientation of the receptacle 5 for the assembly or Fügelage.
  • This guide opening 76 has a sufficient clearance to the outer surface 18 of the receptacle 5 so as to be able to perform about the fixed cap 20 generated rotational or pivotal movement about the longitudinal axis 14 can.
  • different coatings may be provided on the outer surface 18 facing the inner surface of the guide opening 76, which are not shown here.
  • the thrust bearing 47 or on a movable mounting base being filled in a separate filling the mounting bracket with a corresponding number of receptacles 5, in a further station to be joined closure devices 9 also in a separate mounting support on which the support plate 74 is required to pivot or rotatably supported, also to load or insert them into the receptacles 73, then subsequently to move the so pre-filled mounting bracket to its own assembly station, in which the joining process according to the invention, namely Application of a pure compressive force to screw together.
  • the placement process takes place the closure device 9 on the receptacle 5 by a pure implementation of acting in the direction of the longitudinal axis 14 axial force in a relative rotational or pivotal movement between the components to be joined until the maximum Einschraubweg eg by a mechanical stop between the receptacle 5 and the cap 20th and / or the sealing device 21 is limited.
  • This unscrewing operation is controlled by the at least partially co-operating threads 42, 43, wherein in addition also held on the coupling device 28 in the cap 20 sealing device 21 also mitentfernt simultaneously removed from the receptacle 5 and is lifted.
  • a simultaneous secure decrease or separation of the closure device 9 from the receptacle 5 is possible.
  • a jerky opening or loosening of the sealing device 21 is avoided by the cooperating threads 42, 43 from the receptacle 5, wherein an inadvertent leakage of stored in the interior 10 of media 3, 4 and the mixture 2 is avoided.
  • the handling of the operating personnel is safer, which possible infection by leaking subsets and thus possible connected infections are ignored.
  • Fig. 11 are different training options of the receptacle 5 in a simplified representation of a single figure, but these can also be arbitrarily combined with each other as well as with each other as well as with the training options described above.
  • the illustration of the closure device 9 is omitted in this figure.
  • the detailed description in the preceding Fig. 1 to 10 referred or referred.
  • the same reference numerals or component designations are used for the same parts as in the preceding FIG.
  • a separating device 77 is provided, which is to be inserted into the receptacle 5 before closing the inner space 10 and is shown here in a position distant from the receptacle 5.
  • this separating device 77 according to the statements, as shown in the WO 02/078848 A2 the same applicant is described to be formed.
  • the receptacle and the closure device is on the aforementioned WO 02/078848 A2 Reference is made and incorporated this disclosure in the present application. The selected terms are analogously to the terms and representations chosen here.
  • the separating device 77 is inserted into the inner space 10 or a receiving space 78 in the region of the open end face 19 in the receptacle 5 and is there in the so-called starting position, in which after completion of the receptacle 5 with the closure device 9 also additionally simultaneously or even before the interior 10 is lowered to a lower pressure relative to the ambient pressure, in particular evacuated is.
  • the filling of the receiving device 1 is carried out in a conventional manner, for example in the form of a blood sample, with the associated piercing of the sealing device 21 with a cannula, not shown here, whereby the in the Fig. 1 shown mixture 2 from the media 3 and 4, in particular blood, flows through the flow channel or connection opening through the separator 77.
  • the receptacle 5 In the sealing position of the separator 77 within the The receptacle 5 is located in the so-called working position, which is dependent on the total filling volume of the receptacle and the volume proportion of the components of the mixture to be separated 2. Usually, the working position in about half of the longitudinal extent of the available receiving space 78 of the receptacle. 5 be elected.
  • the retaining device 79 In the region of the starting position adjacent to the end 6 of the receptacle 5 for the separating device 77 to be inserted into the inner space 10 or the receiving space 78, different embodiments of the retaining device 79 are shown for the latter. It is shown here in the right part of the figure that the retaining device 79 by at least one over the circumference of an inner surface 80 in the direction of the longitudinal axis 14 projecting projection 81 and / or by at least partially over the circumference of the inner surface 80 in the direction the longitudinal axis 14 projecting web 82 is formed. In this case, both the projection 81 and / or the web 82 can only be arranged in a continuous manner over the circumference and possibly also continuously over the entire circulation of the inner surface 80 over certain regions.
  • a further embodiment of the retaining device 79 is shown, which is formed by a reduction of the inner dimension 13 of the receiving space 78, starting from the open end face 19, the sealing surface 34 for the sealing device 21, not shown here, in particular the sealing surface 33 of the sealing plug 22, is trained.
  • This reduction can be effected by, for example, starting from the end 6 of the receptacle 5 to the retaining device 79, the normal wall thickness 12 of the receptacle 5 and from the retainer 79 in the direction of the other end 7 has a greater wall thickness, the magnification of the Wall thickness 12 by an offset of the inner surface 80 in the direction of the longitudinal axis 14 takes place.
  • the wall thickness 12 of the receptacle 5 between the starting position and the other end 7 in the range of the usual wall thickness 12 and only the wall thickness between the starting position and the open end 6 of the receptacle 5 form less.
  • the retaining device 79 is a positional positioning of the separating device 77 in the direction of the longitudinal axis 14 until reaching a predeterminable centrifugal force, in which the restraining forces are overcome and the displacement of the separating device 77 takes place relative to the receptacle 5 up to reaching the working position, predeterminable.
  • a positioning device 83 can be arranged between the receiving container 5 and the separating device 77, which is preferably formed by a mechanically acting stop.
  • This positioning device 83 can be formed, for example, by reducing an inner dimension 84 of the receiving space 78 or inner space 10, optionally forming a stop surface 85 oriented approximately perpendicular to the longitudinal axis 14. At this stop surface 85, both the sealing device arranged in the first end region of the separating device 77, in particular the sealing lips, as well as the further end region thereof or its components can be brought into abutment.
  • This positioning device 83 thus forms a mechanical stop for the separating device 77 for terminating the relative adjustment movement relative to the receiving container 5 in the direction of the longitudinal axis 14 toward the further end 7.
  • the tapering of the receptacle 5 described above in its inner space 10 or receiving space 78 between the two mutually spaced planes 15, 16 may be between 0.1 ° and 3.0 °, preferably between 0.6 ° and 1.0 °.
  • For a receptacle of nominal size 13 mm (diameter) with the nominal length 100 mm may be the cone or cone angle relative to the longitudinal axis 14 and the outer surface 18, for example 0.34 °.
  • This conical or cone angle is chosen to be constant over the entire outer longitudinal extent between the two ends 6, 7.
  • the conical or cone angle of the inner surface 80, also with respect to the longitudinal axis 14, can also be 0.46 in the first partial area between the first end 6 and the positioning device 83, for example 0.46 ° and between the positioning device 83 and the plane 16 ° amount.
  • Fig. 12 to 16 is another possible and possibly independent training of the receptacle 5 for forming a closable with a closure device 9 receiving means 1 for body fluids, tissue parts or tissue cultures shown, again for like parts, the same reference numerals or component names, as in the preceding Fig. 1 to 11 be used. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 11 referred or referred. It need not be emphasized that this embodiment of the receptacle 5 described here but also with all other forms contained in this description can be combined with each other arbitrarily.
  • This receptacle 5 in turn serves as a receptacle 1 for body fluids, tissue parts or tissue cultures, in particular for the use of a mixture to be separated 2, consisting of at least the, a different density having media 3, 4, as already in the Fig. 1 has been shown simplified and described.
  • a mixture to be separated 2 consisting of at least the, a different density having media 3, 4, as already in the Fig. 1 has been shown simplified and described.
  • the thread arrangement 40 described above in the area of the open end 19 in the area of the first end 6 evenly distributed over the circumference are several, in the present case three, the outer surface 18 projecting beyond the direction away from the longitudinal axis 14 protruding extensions 86, such as this can already be deduced from the known state of the art.
  • At least one through-flow channel 87 in the region between the container wall 11 of the receptacle in the starting position of the inserted or deployable separation device 77 5 and the separator 77 is formed.
  • This flow-through channel 87 serves to spend the remaining in the interior 10 between the separator 77 and the other end 7 remaining amount of air to the separator 77 over into the interior 10 between the separator 77 and sealed by the sealing device 21 interior 10.
  • the flow-through channels 87 can also serve to allow residual quantities of the mixture 2, which have not flowed through the flow channel or the connection opening in the region of the separating device 77, also into the interior 10 of the receiving container 5 formed between the separating device 77 and the further end 7 spend.
  • the flow-through channel 87 is formed by at least one recessed 88 formed in the inner surface 80 of the container wall 11.
  • This recess 88 recessed in relation to the inner surface 80, has, starting from the inner surface 80 in the radial direction towards the outer surface 18, a depth 89 between 0.1 mm and 1.0 mm, preferably between 0.2 mm and 0.5 mm , on.
  • a plurality of distributed over the inner circumference arranged recesses 88 are provided, in which case a symmetrical division in relation to the longitudinal axis 14 over the inner circumference is advantageous.
  • the recess 88 has a coaxial with the sealing surface 34 arranged base surface 90, which thus limits the recess 88 in depth.
  • a first transition surface 93 is arranged in each case.
  • at least one further transition surface 94 can be arranged between one of the boundary surfaces 91, 92 of the recess 88, distanced from one another in the direction of the longitudinal axis 14, and the inner surface 80. These two transition surfaces 93, 94 may be selected such that they already form the mutually distanced boundary surfaces 91, 92.
  • boundary surfaces 91, 92 are in the direction of the longitudinal axis 14 as viewed across a longitudinal extent 95 distanced from each other.
  • the longitudinal extent 95 ends before the sealing surface 33 of the sealing plug 22 zuwendbaren sealing surface 34.
  • this is chosen to be shorter, only to form the flow passage 87 in the region of the inner surface 80 and the separator 77 during the filling process and only after a slight adjustment of the separator 77 towards its working position, only a passage of a component of the mixture through the To allow flow channel or the connection opening in the region of the separator 77. Otherwise, a sealing contact of the sealing lips of the separating device 77 on the inner surface 80 of the receptacle 5 to achieve a perfect separation result is preferable.
  • five recesses 88 are provided in the receptacle 5 over the inner periphery, which have a size or extent in the circumferential direction of 1.9 mm seen at a depth of 0.4 mm. These recesses have in the direction of the longitudinal axis 14, the longitudinal extent 95 of 3 mm. It is essential in the choice of the depth 89 of the recess 88, that in this area, the container wall 11 still has sufficient strength that is sufficient to ensure the shelf life of the receiving device 1 in its unused state (maintenance of the vacuum).
  • a period of e.g. Guaranteed 18 months within which the interior 10 preset vacuum is maintained. In this design, attention must be paid to the oxygen and water vapor permeability of the material, especially in this area.
  • a flow cross-section 98 is limited or fixed, which is dimensioned such that both subsets of the mixture 2 and residual amounts of air can flow simultaneously, but in the opposite direction, without a Clogging or laying of this flow-through channel 87 and the flow-through channels 87 associated therewith.
  • the minimum flow cross-section 98 of the at least one flow-through channel 87 in the plane 49 oriented perpendicular to the longitudinal axis 14 is at least 0.4 mm 2 .
  • This size represents the minimum extent of that cross-sectional area which is necessary when using the receiving device 1 as a blood sampling tube to allow a proper flow of a portion of the mixture or medium to be filled and a simultaneous displacement of residual amounts of air in the opposite direction of flow.
  • boundary surfaces 91, 92 and / or 96 or 97 it is advantageous if at least one of these boundary surfaces 91, 92 , 96, 97 and transition surfaces 93, 94 is concavely curved. But it would also be possible, one of these boundary surfaces 91, 92, 96, 97 and / or transition surfaces 93, 94 planar form.
  • the boundary surface 91 closer to the open end 19 or the transition surfaces 93, 94 form a relatively shallow transition towards the sealing surface 34 or inner surface 80 like this best of all Fig. 15 can be seen.
  • the boundary surface 91 is planar and the transition surface 94 arranged between the latter and the sealing surface 34 or inner surface 80 is convex, in particular by a radius, and the transition surface 93 formed between the base surface 90 and the boundary surface 91 is concave, preferably also by a radius. educated.
  • this surface has a surface structure which makes adhesion more difficult or prevented.
  • a surface structure according to the "lotus flower effect” can be used. This is just in this very sensitive area a deposition or adhesion of residues of the mixture 2 prevented.
  • this repellent surface structure can also be provided on the sealing device 21, the sealing surfaces 33, 34, the cap 20 and the separating device 77, wherein only a region-wise arrangement is possible.
  • FIGS. 17 and 18 In each case, a further and possibly independent training of the cap 20 and the receptacle 5 is shown in simplified form, again in order to avoid unnecessary repetition, to the detailed description in the preceding Fig. 1 to 16 is referred to or referred to. Likewise, the same reference numerals and component names for the same parts, as in the preceding Fig. 1 to 16 , used.
  • Fig. 17 the cap 20 with its cap skirt 23, wherein on the longitudinal axis 14 facing inner surface 41 in the region between the receiving container 5 facing end portion 39 and the extension 30 parts of the threaded assembly 40 are formed.
  • the one or more threads 43 are seen here over their longitudinal course, formed by a plurality of circumferentially successively arranged and spaced from each other, first thread segments 99.
  • the shape of the thread segments chosen here is chosen only as an example for a variety of possible embodiments and these can have a wide variety of spatial forms. Thus, these thread segments 99 also project beyond the inner surface 41 of the cap jacket 23 in the direction of the longitudinal axis 14.
  • Fig. 18 is the thread 42 on the receptacle 5 also seen over its longitudinal course formed by a plurality of circumferentially successively arranged and spaced from each other further thread segments 100. These thread segments 100 may in turn have a variety of spatial forms and the outer surface 18 of the receptacle 5 project beyond the direction of the longitudinal axis facing away.
  • the previously described in detail coating or a lubricant or a lubricant additive can be stored in at least one recess 101 in the region of the thread 43.
  • the recesses 101 are simplified only schematically and can be arranged, for example, between the individual thread segments 99 in the cap casing 23 and / or also directly in the region of the thread 43.
  • several recesses 101 distributed over the circumference in the cap casing 23 and the threads 43 may be arranged, which serve to receive the coating and / or the lubricant or a lubricant additive.
  • Fig. 19 is shown a further possible and possibly independent formation of the cap 20 in conjunction with the sealing device 21 inserted therein, again to avoid unnecessary repetition, to the previously detailed description in the Fig. 1 to 18 is referred to or referred to. Likewise, the same reference numerals and the same component designations are used for the same parts, as in the preceding Fig. 1 to 18 used.
  • at least one enforcement 102 is arranged, which forms an opening or an opening or even form a recess in the cap casing 23.
  • this enforcement 102 projects in the inserted or assembled state of the sealing device 21, a projection 32 superior projection 103 into it, which in addition to the holder or coupling of the sealing device 21 in the direction of the longitudinal axis 14 against rotation or further coupling of the sealing device 21 against the cap 20 forms about the longitudinal axis 14.
  • This enforcement 102 may have a variety of cross-sectional shapes and be formed, for example, round, polygonal, oval, etc., wherein the enforcement is preferably a window-like opening in the cap jacket 23. If, viewed over the circumference, a plurality of openings 102 are provided in the cap casing 23, it is advantageous if they are distributed uniformly over the circumference.
  • the individual projections 103 projecting through the passages 102 may also project beyond the outer surface of the cap jacket 23 and at the same time as preventing the entire receiving device from rolling or rotating be used on a flat or sloping surface. If the projections 103 protrude beyond the outer surface of the cap jacket 23 to a certain extent, they can also simultaneously serve as a handle or grip element for unscrewing the entire closure device 9 from the receptacle 5 and thus improve handling or even make it safer.
  • FIG. 19 Another additional and possibly independent training of the cap 20 is simplified in the Fig. 19 represented here, in which the receptacle 5 zuwendbaren and cross-end portion 39 of the cap 20 is a preferably all-round, and the end portion 39 superior apron-shaped protective element 104 is shown simplified.
  • This apron-shaped protective element 104 can only be arranged or formed on the cap jacket 23 in regions over the circumference, but preferably all around. It is possible to form the protective element 104 as a separate component on the cap casing 23 or to form the protective element 104 as an integral part of the cap casing 23. As shown in simplified form here, the protective element 104 has a continuously decreasing cross section with increasing distance from the end region 39.
  • An inner diameter 105 of the protective element 104 may correspond approximately to the outer diameter or the outer dimension of the receptacle 5, optionally in addition, the projection of the threads 42 on the outer surface 18 of the receptacle 5.
  • This protective element 104 serves to form an additional leakage protection or splash protection for a user of the receiving device 1 in order to avoid unwanted contact when taking off the closure device 9, which is possible by ejecting the contents from the receiving container 5. As a result, contagions or infection of the operating personnel can be reduced or avoided at all.
  • Fig. 20 is another possible and possibly independent training of the receptacle 5 is shown, again to avoid unnecessary repetition, to the detailed description in the preceding Fig. 1 to 19 is referred to or referred to. Likewise, the same reference numerals and component names are used for the same parts, as in the preceding Fig. 1 to 19 , used.
  • the receptacle 5 shown here is again preferably designed for insertion of a separation device 77, not shown here, and instead has the in the Fig. 12 to 16 shown and described recess 88 for forming the flow passage 87 in contrast to at least one, but preferably several, the inner surface 80 of the receptacle 5 in the direction of the longitudinal axis 14 projecting ribs 106 on.
  • the ribs 106 are web-shaped and preferably aligned parallel to the longitudinal axis 14. In most cases, a plurality of ribs 106 distributed over the circumference are arranged on the inner surface 80 of the container wall 11 and form between them - so seen in the circumferential direction - the flow-through channels 87 from.
  • the separation device 77 abuts the boundary surfaces of the ribs closer to the longitudinal axis 14 and thus faces, whereby between the separating device 77, the circumferentially spaced apart ribs 106 and the inner surface 80 of the container wall 11 or the flow channels 87th is limited or are.
  • a minimum cross-section of this flow-through channel 87 can again amount to at least 0.4 mm 2 , but can also be made larger.
  • Fig. 21 a possibility for applying the coating on the sealing surface 33 of the sealing device 21, in particular of the plug 48, which is the inner surface 18 of the receptacle 5 in the inserted state facing and thereby seals the inner space 10 from the outside atmospheric environment.
  • the projection 32 of the sealing device 21 may be held in a holder 107 shown here only in a simplified manner, wherein the sealing surface 33 to be coated is assigned a coating element 108 shown in a simplified manner. This is independently rotatable about a simple axis of rotation about its own axis and / or also additionally coupled with a drive.
  • the holder 107 with the sealing device 21 performs a rotational movement and it is by the system of the coating element 108 on the surface to be coated - here the sealing surface 33 - the coating material of the coating element 108 transmitted from.
  • On the presentation of the drive was omitted for better clarity. However, it would also be possible to drive the coating element 108 and to let the sealing device 21 held in the holder 107 rotate together with it through the system. It is also a superposition of the rotational movement with a movement gem. Registered double arrow in the direction of the longitudinal axis 14 of the sealing device 21 possible.
  • a supply device 109 is assigned to the coating element 108 for storing the coating agent.
  • a liquid coating agent e.g. Silicone oils, waxes, waxy polymers, fatty alcohols, fatty acid esters, fatty acid amides or the like used
  • this is stored in a container 110 and fed via a feed line 111, in which also a metering element 112 may be arranged.
  • the thereby supplied amount may be supplied dropwise in dependence on the number of pieces and the surface to be coated of the sealing plug 22 to be coated. In this case, cycle times can be selected in the supply line between 50 and 300 pieces, which means that after reaching the coated number of sealing plug 22 again a predeterminable unit of quantity of the coating composition, e.g. a drop or more is supplied.
  • the coating element 108 stores the coating agent supplied to it and delivers it to the surface or body to be coated in order to form the coating.
  • the sealing surface 33 - receiving openings 113 such. Pores, distributed over the sealing surface 33 are provided in order to bring in these additional coating agent for forming the coating can. This causes after the first insertion of the plug 48 into the receptacle 5 and a first removal, if the coating on the sealing surface 33 is already partially scraped, further coating agent is stored for a further easy insertion process.
  • the sealing device 21 in a preferably rectilinear guide rail such that the projection 32 rests on the guide rail, the plug 48 projects through the guide rail and the sealing surface 33 is brought into contact with the coating element 108 and thus transfers the coating agent becomes.
  • the coating element 108 may be formed as a strip-shaped component, which rests on the sealing surface 33 on one side and by a parallel movement of the coating member 108 to the guide rail, a combined rotational and longitudinal movement of the sealing device 21 is effected relative to the guide rail.
  • the sealing device 21 rotates on the one hand about its longitudinal axis 14 and on the other hand it is moved along the guide slot.
  • a plurality of sealing devices 21 may preferably be arranged at a distance from each other in succession in the guide slot, whereby then a plurality of sealing devices 21 can be coated simultaneously in a coating movement.
  • a possibility for applying the coating on the inner surface 18 of the receptacle 5 in the region of the open end face 19 is shown.
  • the surface to be coated, in particular the sealing surface 34, may correspond to that which faces the sealing surface 33 of the plug 48 in its inserted state.
  • the mandrel 114 radially protruding coating element 108 is arranged at approximately trained receptacle 5, wherein this is to be matched in its outer dimension to the inner dimension 13 of the receptacle 5.
  • the coating element 108 is held fixed in a groove-shaped recess 115 on the mandrel 114 and projects beyond the mandrel 114 in the radial direction.
  • the coating element 108 is tubular in this case.
  • the feed and the quantitative dosage can be as described in the Fig. 21 respectively.
  • the application of the coating to the outer surface 18 of the receptacle 5 in the region of the thread arrangement 40 can be carried out analogously to the coating on the inner surface 18, in which case the coating element has an opening adapted to the outer dimension of the receptacle 5.
  • a silicone amount between 0.1 mg and 0.001 mg, preferably between 0.07 mg and 0.04 mg, in particular of 0.055583 mg.
  • a silicon amount of between 0.6 mg and 0.1 mg, preferably between 0.4 mg and 0.2 mg, in particular of 0.27917 be applied mg.
  • Fig. 23 and 24 is a further possible and possibly independent training of the receiving device 1, in particular the closure device 9 for the receptacle 5, shown in an enlarged, schematically simplified representation, in turn, the same parts the same reference numerals or component names, as in the previous Fig. 1 to 22nd be used. Likewise, to avoid unnecessary repetition, the detailed description in the preceding Fig. 1 to 22nd referred or referred.
  • the extension 30 is arranged laterally next to the outer surface 18 of the receptacle 5 in the region of the open end face 19 and may also be formed adjacent thereto.
  • the plug 48 of the sealing plug 22 has in its central region - ie in the region of the longitudinal axis 14 - in the direction of the same thickness or thickness of about 3.0 to 4.0 mm, said thickness depends on the selected material of the sealing plug 22, in particular of the plug 48, is.
  • the plug 48 has the sealing surface 33 facing or facing the inner sealing surface 34 of the receptacle 5, which in this embodiment is shorter in the direction of the longitudinal axis 14 relative to the previously described embodiments.
  • the sealing surface 33 can be formed shorter in its longitudinal extent in the direction of the longitudinal axis 14, for example, by half. But it is also an extent in this direction between 1.0 mm and 2.5 mm, preferably 1.5 mm possible.
  • a further sealing surface 116 is provided in the region of the radially projecting shoulder 32 at the end face 19 facing the open end 19 of the receptacle 5 in the fully inserted position of the sealing plug 22 cooperates in the interior 10 of the receptacle 5. This makes it possible, at least partially, to compensate for the reduction of the sealing surface 33 in the region of the plug 48.
  • This has in the inserted state of the sealing plug 22 has the advantage that despite the reduction of the inner surface 18 and the sealing surface 34 of the receptacle 5 facing sealing surface 33 an additional sealing surface 116 in the region of the open end face 19 is created.
  • the extension 30, which is preferably arranged to run continuously over the entire inner circumference of the cap jacket 23, has in this embodiment shown here a clear inner width 118 which corresponds approximately to an outer dimension 119 of the receptacle 5 in the region of the open end 6.
  • the extension 30 may also be adjacent to the outer surface 18 of the receptacle 5 may be formed, in which case the inner clear width 118 of the extension 30 corresponds to the outer dimension 119 of the receptacle 5. If, however, the inner clear width 118 of the extension 30 is selected to be slightly smaller than the outer dimension 119 of the receptacle 5, there is a slight interference fit between the cap 20 and the receptacle 5. In these cases, then for the formation of the channel or channels 117 of the extension 30 viewed over the circumference formed at least partially interrupted or provide recesses on the receiving container 5 facing or adjacent surface.
  • a tapered in the direction of the longitudinal axis 14 bevel 120th is at the stopper 48 of the sealing device 21 between the receptacle 5 facing or zuwendbaren sealing surface 33 and the aligned approximately perpendicular to the longitudinal axis 14 and the interior 10 facing further sealing surface, a tapered in the direction of the longitudinal axis 14 bevel 120th arranged.
  • the bevel 120 may be formed, for example, as part of a conical surface. However, any other forms of space for forming the bevel 120 would also be possible.
  • the sealing surface 33 which is preferably formed cylindrical to the longitudinal axis 14, reduced in size or their size, in which case, for example, the sealing surface 33 on the plug 48 in the direction of the longitudinal axis 14, a longitudinal extent or an extent 121 between 1 , 0 mm and 2.5 mm, preferably 1.5 mm.
  • This length in the direction of the longitudinal axis 14 or the extent 121 is to be chosen such that when fully inserted sealing plug 22, the facing sealing surfaces 33, 34 and 116 and the open end 19 ensure sufficient gas tightness and liquid tightness over a predeterminable period of storage and a plant of the same is circumferentially continuous ,
  • Fig. 23 is indicated in dash-dotted lines in the region of the chamfer 120 that instead of this it is possible to form the channel or channels 117 by at least one groove-shaped recess 122 arranged in the region of the sealing surface 33 of the plug 48. It is also possible for a plurality of groove-shaped recesses 122 distributed over the circumference of the plug 48 or sealing surface 33 to be provided.
  • This depression 122 extends or extends from an edge region 123 facing the interior 10 of the receptacle 5 in the direction of the projection 32 and ends or ends at a distance 124 in front of the projection 32.
  • the distance 124 can also be between 1 , 0 mm and 2.5 mm, preferably 1.5 mm, while the extent of 121 correspond.
  • the sealing surface 33 passing over the circumference is formed on the stopper 48.
  • the interior 10 after closing with the closure device 9 has a relation to the local atmospheric pressure lower pressure, that is evacuated.
  • the interior 10 is filled only sterile, or in this one for the treatment of the material to be filled stocked active ingredient, and this is not evacuated. But it can also be filled in the evacuated interior 10 only or the active ingredients.

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  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Closures For Containers (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Closing Of Containers (AREA)
EP10189757A 2004-01-23 2005-01-14 Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus Withdrawn EP2277625A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0008004A AT500459B1 (de) 2004-01-23 2004-01-23 Verfahren zum zusammenbau einer kappe mit einem aufnahmebehälter
EP05700005A EP1711412B1 (fr) 2004-01-23 2005-01-14 Procede pour assembler un capuchon et un recipient

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP05700005.1 Division 2005-01-14

Publications (1)

Publication Number Publication Date
EP2277625A1 true EP2277625A1 (fr) 2011-01-26

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EP10189757A Withdrawn EP2277625A1 (fr) 2004-01-23 2005-01-14 Dispositif de retenue pour le sang, les liquides organiques, des échantillons de tissus ou de cultures de tissus
EP05700005A Active EP1711412B1 (fr) 2004-01-23 2005-01-14 Procede pour assembler un capuchon et un recipient

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EP05700005A Active EP1711412B1 (fr) 2004-01-23 2005-01-14 Procede pour assembler un capuchon et un recipient

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US (1) US8448800B2 (fr)
EP (2) EP2277625A1 (fr)
KR (1) KR101146711B1 (fr)
CN (1) CN1997455B (fr)
AT (2) AT500459B1 (fr)
AU (2) AU2005206216B2 (fr)
BE (1) BE1016618A5 (fr)
BR (1) BRPI0506975B8 (fr)
DE (1) DE502005010549D1 (fr)
FR (1) FR2865457A1 (fr)
RU (1) RU2336948C2 (fr)
WO (1) WO2005070781A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2649937A1 (fr) * 2012-04-11 2013-10-16 SARSTEDT AG & Co. Dispositif destiné au prélèvement et/ou à la réception de liquides corporels, notamment de sang
WO2023092168A1 (fr) 2021-11-29 2023-06-01 Greiner Bio-One Gmbh Dispositif de réception comportant une cloison et son procédé de production

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007006505B3 (de) * 2007-02-09 2008-08-07 Voll, Wolfgang, Dr. Behälter und medizinische Tupfer für biologische Materialien
EP1995182A1 (fr) * 2007-05-25 2008-11-26 F.Hoffmann-La Roche Ag Bouchon étanche pour récipient pour fluides et dispositif de prise de sang
JPWO2009020032A1 (ja) * 2007-08-03 2010-11-04 株式会社湯山製作所 バイアル瓶蓋締め装置及び薬剤収納取出装置
AT506652A1 (de) * 2008-04-01 2009-10-15 Greiner Bio One Gmbh Verschlussvorrichtung
RU2011143298A (ru) * 2009-03-27 2013-05-10 Клоужер Системз Интернэшнл, Инк. Формованная крышка с улучшенным распределением смазки
US7985188B2 (en) 2009-05-13 2011-07-26 Cv Holdings Llc Vessel, coating, inspection and processing apparatus
MX350703B (es) 2009-05-13 2017-09-14 Sio2 Medical Products Inc Metodo de gasificacion para inspeccionar una superficie revestida.
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
FR2949438B1 (fr) * 2009-08-25 2011-10-28 Valois Sas Ensemble et procede de conditionnement sous vide.
US11624115B2 (en) 2010-05-12 2023-04-11 Sio2 Medical Products, Inc. Syringe with PECVD lubrication
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
GB2487899A (en) 2011-02-01 2012-08-15 Olberon Ltd Needle holder with grip means
US8220225B1 (en) 2011-03-03 2012-07-17 Closure Systems International, Inc. Capping chuck assembly
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
US11116695B2 (en) 2011-11-11 2021-09-14 Sio2 Medical Products, Inc. Blood sample collection tube
JP6095678B2 (ja) 2011-11-11 2017-03-15 エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド 薬剤パッケージ用の不動態化、ｐＨ保護又は滑性皮膜、被覆プロセス及び装置
EP2846755A1 (fr) 2012-05-09 2015-03-18 SiO2 Medical Products, Inc. Enrobage protecteur en saccharide pour conditionnement pharmaceutique
ITMI20121793A1 (it) * 2012-10-23 2014-04-24 Copan Italia Spa Elemento di chiusura di un contenitore per fluidi biologici
US9664626B2 (en) 2012-11-01 2017-05-30 Sio2 Medical Products, Inc. Coating inspection method
EP2920567B1 (fr) 2012-11-16 2020-08-19 SiO2 Medical Products, Inc. Procédé et appareil pour détecter des caractéristiques d'intégrité de revêtement de barrière rapide
WO2014085346A1 (fr) 2012-11-30 2014-06-05 Sio2 Medical Products, Inc. Corps creux comportant un revêtement intérieur
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US20160015898A1 (en) 2013-03-01 2016-01-21 Sio2 Medical Products, Inc. Plasma or cvd pre-treatment for lubricated pharmaceutical package, coating process and apparatus
WO2014164928A1 (fr) 2013-03-11 2014-10-09 Sio2 Medical Products, Inc. Emballage muni d'un revêtement
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
WO2014144926A1 (fr) 2013-03-15 2014-09-18 Sio2 Medical Products, Inc. Procédé de revêtement
AT514833B1 (de) 2013-10-11 2015-07-15 Greiner Bio One Gmbh Abnahmebaugruppe, insbesondere für Blutproben
WO2015070273A1 (fr) * 2013-11-14 2015-05-21 Greiner Bio-One Gmbh Dispositif de réception, procédé de production de celui-ci et procédé de séparation d'un mélange
CN103663314B (zh) * 2013-12-05 2015-07-29 复旦大学 一种实验室用平头pcr管盖子压紧装置及其使用方法
CN103641049B (zh) * 2013-12-05 2015-07-29 复旦大学 一种实验室用圆头pcr管盖子压紧装置及其使用方法
EP3122917B1 (fr) 2014-03-28 2020-05-06 SiO2 Medical Products, Inc. Revêtements antistatiques pour des récipients en plastique
FR3025315B1 (fr) * 2014-08-29 2018-08-24 Biomerieux Dispositif d'obtention de matiere biologique et/ou d'information biologique a partir d'un echantillon a matrice heterogene
AT516972B1 (de) * 2015-04-02 2019-02-15 Red Bull Gmbh Flasche mit einer Verschlusskappe
AT517083B1 (de) 2015-05-04 2016-11-15 Greiner Bio-One Gmbh Abnahmebaugruppe, insbesondere für eine geringere Aufnahmemenge
CN108138316A (zh) 2015-08-18 2018-06-08 Sio2医药产品公司 具有低氧气传输速率的药物和其他包装
EP3618962B1 (fr) 2017-05-02 2021-05-26 Greiner Bio-One GmbH Module de prélèvement ou tube à essai pour une faible quantité de liquide corporel, comprenant un élément de prolongement
IT201700084310A1 (it) 2017-07-24 2019-01-24 Arol Spa Dispositivo di accoppiamento magnetico
USD876175S1 (en) 2017-10-13 2020-02-25 S. C. Johnson & Son, Inc. Combined container and lid
USD861480S1 (en) 2017-10-13 2019-10-01 S. C. Johnson & Son, Inc. Container and lid
USD859978S1 (en) 2017-10-13 2019-09-17 S. C. Johnson & Son, Inc. Container
USD861481S1 (en) 2017-10-13 2019-10-01 S. C. Johnson & Son, Inc. Container
DE102017220641A1 (de) * 2017-11-17 2019-05-23 Vetter Pharma-Fertigung GmbH & Co. KG Medikamentenbehälter
CN111655593B (zh) * 2017-12-22 2022-06-14 西氏医药服务公司 用于无菌填充小容量瓶的包装系统
WO2020012252A1 (fr) * 2018-07-11 2020-01-16 Agrawal Parth Rajeshkumar Appareil de collecte d'échantillons et procédé d'assemblage automatisé de celui-ci
DE102018219379A1 (de) * 2018-11-13 2020-05-14 Sarstedt Ag & Co. Kg Vorrichtung und Verfahren zur Gewinnung einer zellfreien Probenfraktion
CN109760935B (zh) * 2019-03-12 2023-09-01 汕头市柏达塑胶有限公司 一种灌装袋吸嘴
WO2020236503A1 (fr) * 2019-05-20 2020-11-26 Cummins Filtration Ip, Inc. Élément de filtration à interface d'étanchéité à gradient
CN110551615A (zh) * 2019-08-31 2019-12-10 会泽县恒易牧业有限公司 卧式沼气池
CN110562902B (zh) * 2019-10-12 2024-07-23 西安萃之健生物科技有限公司 添加有蓖麻油提取物的润滑油的生产装置及生产方法
CN110742033B (zh) * 2019-11-20 2024-10-01 安德倚 一种蚯蚓封装系统
AT525932A1 (de) 2022-02-17 2023-09-15 Greiner Bio One Gmbh Abnahmebaugruppe für organisches Material
USD1014780S1 (en) 2022-04-15 2024-02-13 Instrumentation Laboratory Co. Cuvette

Citations (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2133019A (en) 1936-03-26 1938-10-11 Aetna Rubber Company Mold
US3897343A (en) 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator-hydrostatic pressure type
US3897337A (en) 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator assembly having interface-seeking piston with centrifugal valve
US3897340A (en) 1974-02-27 1975-07-29 Becton Dickinson Co Serum/plasma separator assembly with interface-seeking piston having coarse and fine band filters
US3926401A (en) 1975-02-28 1975-12-16 John D Northup Thread mold
US4079475A (en) 1977-03-09 1978-03-21 Coats & Clark, Inc. Process for manufacturing an internally cast or molded single threaded product
US4188178A (en) 1978-02-28 1980-02-12 Bernard Anscher Internally threaded plastic nut
US4202769A (en) 1977-06-16 1980-05-13 Greenspan Donald J Method for separating serum or plasma from the formed elements of blood
US4230231A (en) * 1979-04-16 1980-10-28 Coulter Electronics, Inc. Closure cap
DE3047856C2 (de) 1980-01-23 1985-05-02 Coats & Clark, Inc., Stamford, Conn. Schraubelement, insbesondere Schraubmutter
EP0311011A2 (fr) 1987-10-08 1989-04-12 Becton, Dickinson and Company Procédé pour séparer les composants d'un échantillon liquide possédant des poids spécifiques différents
WO1989009735A1 (fr) * 1988-04-15 1989-10-19 C.A. Greiner & Söhne Gesellschaft M.B.H. Dispositif de fermeture pour recipients cylindriques se pretant notamment au vide
EP0445707A2 (fr) * 1990-03-09 1991-09-11 C.A. Greiner & Söhne Gesellschaft M.B.H. Récipient cylindrique avec dispositif de fermeture
US5275299A (en) 1988-04-15 1994-01-04 C. A. Greiner & Sohne Gesellschaft Mbh Closure device for an in particular evacuable cylindrical housing
DE19513453A1 (de) 1994-04-22 1995-10-26 Becton Dickinson Co Blutsammelvorrichtung mit mechanischem Phasenabscheidungseinsatz
WO1996005770A1 (fr) 1994-08-19 1996-02-29 Karl Erik Sundstrom Dispositif de prelevement sanguin, de separation du plasma et de distribution haute precision du plasma
EP0753741A1 (fr) 1995-01-30 1997-01-15 Niigata Engineering Co., Ltd. Element de separation de composants et separateur de composants equipe dudit element
DE29618639U1 (de) 1996-10-25 1997-02-27 Moeller GmbH, 53115 Bonn Formteil mit Innengewinde
US5667870A (en) 1995-07-24 1997-09-16 Chip Coolers, Inc. Plastic article with interrupted interior threads for securing a threaded heat sink to a heat generating member
EP0867678A1 (fr) 1997-03-26 1998-09-30 Artur Zachajewicz Echangeur de chaleur à tube multicoaxial
US6017317A (en) 1997-03-26 2000-01-25 Becton Dickinson And Company Assembly for collecting blood or other body fluids
EP1005910A2 (fr) 1998-12-05 2000-06-07 Becton Dickinson and Company Tube centrifuge avec élément de séparation à symmétrie cylindrique, garniture et bouchon
EP1107002A2 (fr) 1999-12-03 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
EP1106252A2 (fr) 1999-12-06 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour la collecte, la préparation et la stabilisation d'un échantillon
EP1106250A2 (fr) 1999-12-03 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
EP1106251A2 (fr) 1999-12-06 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
EP1106253A2 (fr) 1999-12-06 2001-06-13 Becton Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
US20010055632A1 (en) 2000-05-30 2001-12-27 Semersky Frank E. Preform mold
EP1174085A1 (fr) 1997-03-26 2002-01-23 Becton, Dickinson and Company Dispositif pour collecter du sang ou d'autres fluides corporels
WO2002078848A2 (fr) 2001-03-30 2002-10-10 Greiner Bio-One Gmbh Dispositif de reception notamment pour liquides organiques, muni d'un dispositif de separation et dispositif de separation correspondant
EP0915737B1 (fr) 1996-08-02 2003-06-04 Greiner Bio-One GmbH Dispositif collecteur

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2048705A (en) * 1935-03-29 1936-07-28 Phoenix Glass Company Jar closure
US2187394A (en) * 1938-06-21 1940-01-16 Super Seal Vacuum Glass Contai Jar
US3428202A (en) * 1966-09-14 1969-02-18 Richard W Asmus Container closure and seal
US3998355A (en) * 1975-03-28 1976-12-21 United States Steel Corporation Plastic lids and pails
US4747498A (en) * 1986-06-27 1988-05-31 Sunbeam Plastics Corporation Safety dispensing closure-container package
US4948001A (en) * 1989-10-18 1990-08-14 Continental Can Company, Inc. Interrupted threads on a plastic bottle finish
US5858141A (en) * 1990-08-09 1999-01-12 Portola Packaging, Inc. Method and apparatus to attach foil seals to necks
AU707771B2 (en) 1996-01-30 1999-07-22 Obrist Closures Switzerland Gmbh Bottle finish and closure cap with double screw thread
US5687552A (en) * 1996-03-20 1997-11-18 Abbott Laboratories Adapter system for a capping machine for applying at least one predetermined axial load
US5967352A (en) 1997-03-28 1999-10-19 Portola Packaging, Inc. Interrupted thread cap structure
US6406671B1 (en) * 1998-12-05 2002-06-18 Becton, Dickinson And Company Device and method for separating components of a fluid sample

Patent Citations (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2133019A (en) 1936-03-26 1938-10-11 Aetna Rubber Company Mold
US3897343A (en) 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator-hydrostatic pressure type
US3897337A (en) 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator assembly having interface-seeking piston with centrifugal valve
US3897340A (en) 1974-02-27 1975-07-29 Becton Dickinson Co Serum/plasma separator assembly with interface-seeking piston having coarse and fine band filters
US3926401A (en) 1975-02-28 1975-12-16 John D Northup Thread mold
US4079475A (en) 1977-03-09 1978-03-21 Coats & Clark, Inc. Process for manufacturing an internally cast or molded single threaded product
US4202769A (en) 1977-06-16 1980-05-13 Greenspan Donald J Method for separating serum or plasma from the formed elements of blood
US4188178A (en) 1978-02-28 1980-02-12 Bernard Anscher Internally threaded plastic nut
US4230231A (en) * 1979-04-16 1980-10-28 Coulter Electronics, Inc. Closure cap
DE3047856C2 (de) 1980-01-23 1985-05-02 Coats & Clark, Inc., Stamford, Conn. Schraubelement, insbesondere Schraubmutter
EP0311011A2 (fr) 1987-10-08 1989-04-12 Becton, Dickinson and Company Procédé pour séparer les composants d'un échantillon liquide possédant des poids spécifiques différents
WO1989009735A1 (fr) * 1988-04-15 1989-10-19 C.A. Greiner & Söhne Gesellschaft M.B.H. Dispositif de fermeture pour recipients cylindriques se pretant notamment au vide
EP0419490B1 (fr) 1988-04-15 1993-11-10 C.A. Greiner & Söhne Gesellschaft M.B.H. Dispositif de fermeture pour recipients cylindriques se pretant notamment au vide
US5275299A (en) 1988-04-15 1994-01-04 C. A. Greiner & Sohne Gesellschaft Mbh Closure device for an in particular evacuable cylindrical housing
US5522518A (en) 1988-04-15 1996-06-04 C.A. Greiner & Sohne Gesellschaft M.B.H Closure device for a cylindrical housing
US5495958A (en) 1988-04-15 1996-03-05 C. A. Greiner & So/ hne Gesellschaft m.b.H Closure device for a cylindrical housing
EP0445707A2 (fr) * 1990-03-09 1991-09-11 C.A. Greiner & Söhne Gesellschaft M.B.H. Récipient cylindrique avec dispositif de fermeture
US5294011A (en) 1990-03-09 1994-03-15 C. A. Greiner & Sohne Gesellschaft M.B.H. Closure means for a cylindrical housing
EP0445707B1 (fr) 1990-03-09 1995-08-09 C.A. Greiner & Söhne Gesellschaft M.B.H. Récipient cylindrique avec dispositif de fermeture
DE19513453A1 (de) 1994-04-22 1995-10-26 Becton Dickinson Co Blutsammelvorrichtung mit mechanischem Phasenabscheidungseinsatz
WO1996005770A1 (fr) 1994-08-19 1996-02-29 Karl Erik Sundstrom Dispositif de prelevement sanguin, de separation du plasma et de distribution haute precision du plasma
EP0753741A1 (fr) 1995-01-30 1997-01-15 Niigata Engineering Co., Ltd. Element de separation de composants et separateur de composants equipe dudit element
US5667870A (en) 1995-07-24 1997-09-16 Chip Coolers, Inc. Plastic article with interrupted interior threads for securing a threaded heat sink to a heat generating member
EP0915737B1 (fr) 1996-08-02 2003-06-04 Greiner Bio-One GmbH Dispositif collecteur
DE29618639U1 (de) 1996-10-25 1997-02-27 Moeller GmbH, 53115 Bonn Formteil mit Innengewinde
EP1174085A1 (fr) 1997-03-26 2002-01-23 Becton, Dickinson and Company Dispositif pour collecter du sang ou d'autres fluides corporels
US6017317A (en) 1997-03-26 2000-01-25 Becton Dickinson And Company Assembly for collecting blood or other body fluids
EP0867678A1 (fr) 1997-03-26 1998-09-30 Artur Zachajewicz Echangeur de chaleur à tube multicoaxial
EP1174084B1 (fr) 1997-03-26 2003-06-18 Becton, Dickinson and Company Dispositif pour collecter du sang ou d'autres fluides corporels
EP1005910A2 (fr) 1998-12-05 2000-06-07 Becton Dickinson and Company Tube centrifuge avec élément de séparation à symmétrie cylindrique, garniture et bouchon
EP1107002A2 (fr) 1999-12-03 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
EP1106250A2 (fr) 1999-12-03 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
EP1106252A2 (fr) 1999-12-06 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour la collecte, la préparation et la stabilisation d'un échantillon
EP1106251A2 (fr) 1999-12-06 2001-06-13 Becton, Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
EP1106253A2 (fr) 1999-12-06 2001-06-13 Becton Dickinson and Company Appareil et procédé pour séparer des constituants d'un échantillon liquide
US20010055632A1 (en) 2000-05-30 2001-12-27 Semersky Frank E. Preform mold
WO2002078848A2 (fr) 2001-03-30 2002-10-10 Greiner Bio-One Gmbh Dispositif de reception notamment pour liquides organiques, muni d'un dispositif de separation et dispositif de separation correspondant

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2649937A1 (fr) * 2012-04-11 2013-10-16 SARSTEDT AG & Co. Dispositif destiné au prélèvement et/ou à la réception de liquides corporels, notamment de sang
WO2023092168A1 (fr) 2021-11-29 2023-06-01 Greiner Bio-One Gmbh Dispositif de réception comportant une cloison et son procédé de production

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AT500459B1 (de) 2010-08-15
KR20070004645A (ko) 2007-01-09
BE1016618A5 (fr) 2007-03-06
EP1711412A2 (fr) 2006-10-18
BRPI0506975B8 (pt) 2017-11-14
ATE488445T1 (de) 2010-12-15
CN1997455A (zh) 2007-07-11
RU2336948C2 (ru) 2008-10-27
WO2005070781A8 (fr) 2005-11-24
DE502005010549D1 (de) 2010-12-30
KR101146711B1 (ko) 2012-05-17
AU2005206216A1 (en) 2005-08-04
AU2010202765B2 (en) 2012-06-28
RU2006130370A (ru) 2008-02-27
WO2005070781A2 (fr) 2005-08-04
EP1711412B1 (fr) 2010-11-17
US8448800B2 (en) 2013-05-28
AU2010202765A1 (en) 2010-07-22
FR2865457A1 (fr) 2005-07-29
BRPI0506975B1 (pt) 2017-06-27
AU2005206216B2 (en) 2010-04-01
CN1997455B (zh) 2011-07-20
AT500459A1 (de) 2006-01-15
WO2005070781A3 (fr) 2006-10-12
US20080223815A1 (en) 2008-09-18
BRPI0506975A (pt) 2007-07-03

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