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EP2129799A4 - Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same and kits using same - Google Patents

Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same and kits using same

Info

Publication number
EP2129799A4
EP2129799A4 EP08733628A EP08733628A EP2129799A4 EP 2129799 A4 EP2129799 A4 EP 2129799A4 EP 08733628 A EP08733628 A EP 08733628A EP 08733628 A EP08733628 A EP 08733628A EP 2129799 A4 EP2129799 A4 EP 2129799A4
Authority
EP
European Patent Office
Prior art keywords
same
stratifying
kits
nucleic acid
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP08733628A
Other languages
German (de)
French (fr)
Other versions
EP2129799B1 (en
EP2129799A1 (en
Inventor
Alain Moreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chu Sainte Justine
Original Assignee
Chu Sainte Justine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chu Sainte Justine filed Critical Chu Sainte Justine
Publication of EP2129799A1 publication Critical patent/EP2129799A1/en
Publication of EP2129799A4 publication Critical patent/EP2129799A4/en
Application granted granted Critical
Publication of EP2129799B1 publication Critical patent/EP2129799B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP08733628A 2007-03-19 2008-03-19 Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same Not-in-force EP2129799B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89549007P 2007-03-19 2007-03-19
US90841707P 2007-03-28 2007-03-28
PCT/CA2008/000524 WO2008113174A1 (en) 2007-03-19 2008-03-19 Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same and kits using same

Publications (3)

Publication Number Publication Date
EP2129799A1 EP2129799A1 (en) 2009-12-09
EP2129799A4 true EP2129799A4 (en) 2010-03-24
EP2129799B1 EP2129799B1 (en) 2012-06-20

Family

ID=39765327

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08733628A Not-in-force EP2129799B1 (en) 2007-03-19 2008-03-19 Methods of stratifying adolescent idiopathic scoliosis, isolated nucleic acid molecules for use in same

Country Status (11)

Country Link
US (2) US20100173296A1 (en)
EP (1) EP2129799B1 (en)
JP (1) JP5539739B2 (en)
KR (1) KR101320098B1 (en)
CN (1) CN101680031A (en)
AU (1) AU2008229601B2 (en)
CA (1) CA2682112C (en)
HK (1) HK1132014A1 (en)
IL (1) IL201016A (en)
MX (1) MX2009009974A (en)
WO (1) WO2008113174A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029094B2 (en) * 2010-10-04 2015-05-12 Chu Sainte-Justine Biomechanical-based methods of diagnosing scoliosis
EP3011332B1 (en) * 2013-06-17 2019-09-18 CHU Sainte-Justine New markers for severe progression of idiopathic scoliosis and uses thereof to stratify scoliotic patients and predict the risk of developing scoliosis
CN104789524A (en) * 2015-04-30 2015-07-22 四川大学 Osteoporotic rat primary osteoblasts isolated culture method and application thereof
EP3310926B1 (en) * 2015-06-16 2019-04-10 Centro de Investigación Biomédica en Red (CIBER) Method for the diagnosis/prognosis of adolescent idiopathic scoliosis
CN106841593B (en) * 2017-03-24 2018-08-17 北京致成生物医学科技有限公司 Application of the LACC1 and FHL2 genes in preparing scoliosis detection product
CN110184347B (en) * 2019-07-15 2021-01-26 中国医学科学院北京协和医院 Diagnostic marker for congenital spinal deformities

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5858709A (en) * 1996-10-15 1999-01-12 Smithkline Beecham P.L.C. Fibronectin binding protein B compounds
US20020160970A1 (en) * 1996-04-10 2002-10-31 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
CA2373854A1 (en) * 2002-02-28 2003-08-28 Alain Moreau Methods of diagnosing and counteracting adolescent idiopathic scoliosis
US6919181B2 (en) * 2002-03-25 2005-07-19 Agilent Technologies, Inc. Methods for generating ligand arrays
EP1639090A4 (en) * 2003-06-09 2008-04-16 Univ Michigan Compositions and methods for treating and diagnosing cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GIAMPIETRO P F ET AL: "An analysis of PAX1 in the development of vertebral malformations", CLINICAL GENETICS, vol. 68, no. 5, November 2005 (2005-11-01), pages 448 - 453, XP002567757, ISSN: 0009-9163 *
MARCIL A ET AL: "Pitx1 and Pitx2 are required for development of hindlimb buds", DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE, GB, vol. 130, no. 1, 1 January 2003 (2003-01-01), pages 45 - 55, XP008109650, ISSN: 0950-1991 *
See also references of WO2008113174A1 *

Also Published As

Publication number Publication date
KR20100015705A (en) 2010-02-12
AU2008229601B2 (en) 2013-05-02
CN101680031A (en) 2010-03-24
US20130029871A1 (en) 2013-01-31
US20100173296A1 (en) 2010-07-08
IL201016A0 (en) 2010-05-17
EP2129799B1 (en) 2012-06-20
CA2682112A1 (en) 2008-09-25
MX2009009974A (en) 2010-02-17
HK1132014A1 (en) 2010-02-12
WO2008113174A1 (en) 2008-09-25
JP5539739B2 (en) 2014-07-02
EP2129799A1 (en) 2009-12-09
AU2008229601A1 (en) 2008-09-25
KR101320098B1 (en) 2013-10-18
IL201016A (en) 2013-04-30
CA2682112C (en) 2015-08-25
JP2010521184A (en) 2010-06-24

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