EP2184984A4 - Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same - Google Patents

Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

Info

Publication number: EP2184984A4
Authority: EP; European Patent Office
Prior art keywords: methods; arylamino; mek; inhibitors; derivatives
Prior art date: 2007-07-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP08796733.7A

Other languages

German (de)

French (fr)

Other versions

EP2184984A1 (en

Inventor

Jean-Michel Vernier

Colin Edward Rowlings

Jean-Luc Girardet

Stuart Dimock

Barry Quart

Jeffrey N Miner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ardea Biociences Inc

Original Assignee

Ardea Biociences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-30

Filing date

2008-07-28

Publication date

2013-07-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40304796&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2184984(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-07-30 Priority claimed from US11/830,733 external-priority patent/US8101799B2/en

2008-07-28 Application filed by Ardea Biociences Inc filed Critical Ardea Biociences Inc

2010-05-19 Publication of EP2184984A1 publication Critical patent/EP2184984A1/en

2013-07-24 Publication of EP2184984A4 publication Critical patent/EP2184984A4/en

Status Ceased legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/06—Sulfonic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/28—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Agronomy & Crop Science (AREA)
Plant Pathology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Pest Control & Pesticides (AREA)
Urology & Nephrology (AREA)
Dentistry (AREA)

EP08796733.7A 2007-07-30 2008-07-28 Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same Ceased EP2184984A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US11/830,733 US8101799B2 (en)	2005-07-21	2007-07-30	Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
US3446408P	2008-03-06	2008-03-06
US3446608P	2008-03-06	2008-03-06
US4488608P	2008-04-14	2008-04-14
PCT/US2008/071392 WO2009018233A1 (en)	2007-07-30	2008-07-28	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

Publications (2)

Publication Number	Publication Date
EP2184984A1 EP2184984A1 (en)	2010-05-19
EP2184984A4 true EP2184984A4 (en)	2013-07-24

Family

ID=40304796

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08796733.7A Ceased EP2184984A4 (en)	2007-07-30	2008-07-28	Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same

Country Status (23)

Country	Link
EP (1)	EP2184984A4 (en)
JP (3)	JP2010535232A (en)
KR (3)	KR20100092424A (en)
CN (2)	CN103479604B (en)
AP (1)	AP2817A (en)
AU (2)	AU2008282338B2 (en)
BR (1)	BRPI0815659A2 (en)
CA (1)	CA2693390C (en)
CO (1)	CO6470808A2 (en)
CR (1)	CR11244A (en)
DO (1)	DOP2010000045A (en)
EA (2)	EA020624B1 (en)
EC (1)	ECSP109910A (en)
HK (1)	HK1147396A1 (en)
HN (1)	HN2010000203A (en)
IL (1)	IL203296A (en)
MA (1)	MA31881B1 (en)
MX (1)	MX2010001244A (en)
NZ (1)	NZ582929A (en)
PH (1)	PH12015501914A1 (en)
SV (1)	SV2010003469A (en)
TN (1)	TN2010000049A1 (en)
WO (1)	WO2009018233A1 (en)

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CA2720671A1 (en) *	2008-04-14	2009-10-22	Ardea Biosciences, Inc.	Compositions and methods for preparing and using same
CN102143943B (en) *	2008-09-09	2014-03-12	弗·哈夫曼-拉罗切有限公司	Polymorphs of acyl sulfonamides
RU2579897C2 (en)	2008-09-26	2016-04-10	Онкомед Фармасьютикалс, Инк.	Agents linking frizzled receptor and their use
UY32486A (en) *	2009-03-11	2010-10-29	Ardea Biosciences Inc	TREATMENT OF CANCER CANCER
JP5767122B2 (en) *	2009-03-11	2015-08-19	アルデアバイオサイエンシズ，インコーポレイティド	Combination medicine comprising RDEA119 / BAY869766 for the treatment of certain cancers
KR20120094165A (en)	2009-10-13	2012-08-23	알로스팀 테라퓨틱스 엘엘씨	Novel mek inhibitors, useful in the treatment of diseases
WO2011047788A1 (en) *	2009-10-21	2011-04-28	Bayer Schering Pharma Aktiengesellschaft	Substituted benzosulphonamides
TWI535445B (en)	2010-01-12	2016-06-01	安可美德藥物股份有限公司	Wnt antagonists and methods of treatment and screening
CN102020651B (en)	2010-11-02	2012-07-18	北京赛林泰医药技术有限公司	6-aryl amino pyridone formamide MEK (methyl ethyl ketone) inhibitor
CN102649773A (en) *	2011-02-23	2012-08-29	苏州波锐生物医药科技有限公司	Amino aromatic hydrocarbon compound and application thereof to preparation of medicine for resisting malignant tumor
CA2833390A1 (en) *	2011-04-28	2012-11-01	Sloan-Kettering Institute For Cancer Research	Hsp90 combination therapy
EA026550B1 (en) *	2011-05-27	2017-04-28	Байер Интеллектчуал Проперти Гмбх	Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
EP2788378A4 (en) *	2011-12-09	2015-09-09	Oncomed Pharm Inc	Combination therapy for treatment of cancer
WO2013109142A1 (en)	2012-01-16	2013-07-25	Stichting Het Nederlands Kanker Instituut	Combined pdk and mapk/erk pathway inhibition in neoplasia
AU2013269809B2 (en) *	2012-05-31	2017-12-21	Bayer Pharma Aktiengesellschaft	Biomarkers for determining effective response of treatments of Hepatocellular carcinoma (HCC) patients
WO2013184572A1 (en)	2012-06-04	2013-12-12	Pharmacyclics, Inc.	Crystalline forms of a bruton's tyrosine kinase inhibitor
PL2909182T3 (en) *	2012-10-19	2020-06-01	Array Biopharma Inc.	Preparation of and formulation comprising a mek inhibitor
AU2013337702A1 (en)	2012-11-02	2015-05-21	Merck Patent Gmbh	Method of reducing adverse effects in a cancer patient undergoing treatment with a MEK inhibitor
CN105073195A (en)	2013-02-04	2015-11-18	昂科梅德制药有限公司	Methods and monitoring of treatment with a Wnt pathway inhibitor
EP2848246A1 (en)	2013-09-13	2015-03-18	Bayer Pharma Aktiengesellschaft	Pharmaceutical compositions containing refametinib
EP3046557A1 (en)	2013-09-20	2016-07-27	Stichting Het Nederlands Kanker Instituut	Rock in combination with mapk-pathway
WO2015041534A1 (en)	2013-09-20	2015-03-26	Stichting Het Nederlands Kanker Instituut	P90rsk in combination with raf/erk/mek
US20170027940A1 (en)	2014-04-10	2017-02-02	Stichting Het Nederlands Kanker Instituut	Method for treating cancer
WO2015178770A1 (en)	2014-05-19	2015-11-26	Stichting Het Nederlands Kanker Instituut	Compositions for cancer treatment
WO2015196072A2 (en)	2014-06-19	2015-12-23	Whitehead Institute For Biomedical Research	Uses of kinase inhibitors for inducing and maintaining pluripotency
EP3185900A4 (en)	2014-08-25	2018-05-02	Aimmune Therapeutics, Inc.	Egg protein formulations and methods of manufacture thereof
IL315294A (en)	2015-03-03	2024-10-01	Pharmacyclics Llc	Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
EA201992744A1 (en) *	2017-06-16	2020-05-27	Бета Фарма, Инк.	PHARMACEUTICAL COMPOSITIONS N- (2- (2- (DIMETHYLAMINO) ETOXY) -4-METOXY-5 - ((4- (1-METHYL-1H-INDOL-3-IL) PYRIMIDIN-2-IL) AMINO) Phenyl) Acrylamide AND HIS SALTS
BR112021018168B1 (en)	2019-03-21	2023-11-28	Onxeo	PHARMACEUTICAL COMPOSITION, COMBINATION AND KIT COMPRISING A DBAIT MOLECULE AND A KINASE INHIBITOR FOR THE TREATMENT OF CANCER
EP4054579A1 (en)	2019-11-08	2022-09-14	Institut National de la Santé et de la Recherche Médicale (INSERM)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use

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WO2007014011A2 (en) *	2005-07-21	2007-02-01	Ardea Biosciences, Inc.	N-(arylamino)-sulfonamide inhibitors of mek

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2008
- 2008-07-28 EA EA201000268A patent/EA020624B1/en not_active IP Right Cessation
- 2008-07-28 WO PCT/US2008/071392 patent/WO2009018233A1/en active Application Filing
- 2008-07-28 CA CA2693390A patent/CA2693390C/en not_active Expired - Fee Related
- 2008-07-28 BR BRPI0815659-0A2A patent/BRPI0815659A2/en not_active Application Discontinuation
- 2008-07-28 AP AP2010005134A patent/AP2817A/en active
- 2008-07-28 JP JP2010520118A patent/JP2010535232A/en active Pending
- 2008-07-28 KR KR1020107004742A patent/KR20100092424A/en active Search and Examination
- 2008-07-28 AU AU2008282338A patent/AU2008282338B2/en not_active Ceased
- 2008-07-28 CN CN201310317815.8A patent/CN103479604B/en not_active Expired - Fee Related
- 2008-07-28 EA EA201400552A patent/EA032294B1/en not_active IP Right Cessation
- 2008-07-28 CN CN2008801088296A patent/CN101808516B/en not_active Expired - Fee Related
- 2008-07-28 NZ NZ582929A patent/NZ582929A/en not_active IP Right Cessation
- 2008-07-28 KR KR1020157020493A patent/KR20150091434A/en not_active Application Discontinuation
- 2008-07-28 MX MX2010001244A patent/MX2010001244A/en active IP Right Grant
- 2008-07-28 KR KR1020147017261A patent/KR20140098185A/en not_active Application Discontinuation
- 2008-07-28 EP EP08796733.7A patent/EP2184984A4/en not_active Ceased
2010
- 2010-01-13 IL IL203296A patent/IL203296A/en not_active IP Right Cessation
- 2010-01-29 EC EC2010009910A patent/ECSP109910A/en unknown
- 2010-01-29 CO CO10009526A patent/CO6470808A2/en not_active Application Discontinuation
- 2010-01-29 TN TNP2010000049A patent/TN2010000049A1/en unknown
- 2010-01-29 HN HN2010000203A patent/HN2010000203A/en unknown
- 2010-01-29 CR CR11244A patent/CR11244A/en not_active Application Discontinuation
- 2010-01-29 SV SV2010003469A patent/SV2010003469A/en unknown
- 2010-01-29 DO DO2010000045A patent/DOP2010000045A/en unknown
- 2010-02-19 MA MA32636A patent/MA31881B1/en unknown
2011
- 2011-02-18 HK HK11101625.8A patent/HK1147396A1/en not_active IP Right Cessation
2014
- 2014-11-14 JP JP2014231450A patent/JP6309880B2/en not_active Expired - Fee Related
2015
- 2015-01-28 AU AU2015200390A patent/AU2015200390B2/en not_active Ceased
- 2015-08-28 PH PH12015501914A patent/PH12015501914A1/en unknown
2017
- 2017-02-03 JP JP2017018477A patent/JP2017125021A/en active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007014011A2 (en) *	2005-07-21	2007-02-01	Ardea Biosciences, Inc.	N-(arylamino)-sulfonamide inhibitors of mek

Non-Patent Citations (2)

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Title
CAIRA M R: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1 January 1998 (1998-01-01), pages 163 - 208, XP001156954, ISSN: 0340-1022, ISBN: 978-3-540-36760-4, DOI: 10.1007/3-540-69178-2_5 *
See also references of WO2009018233A1 *

Also Published As

Publication number	Publication date
CN101808516B (en)	2013-08-28
AU2008282338A1 (en)	2009-02-05
KR20140098185A (en)	2014-08-07
HK1147396A1 (en)	2011-08-12
NZ582929A (en)	2012-03-30
CA2693390C (en)	2017-01-17
EA201400552A1 (en)	2014-09-30
EA032294B1 (en)	2019-05-31
EP2184984A1 (en)	2010-05-19
JP2015078199A (en)	2015-04-23
CO6470808A2 (en)	2012-06-29
MX2010001244A (en)	2010-08-31
KR20100092424A (en)	2010-08-20
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