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EP2147092A4 - Souche de listeria exempte de résistance aux antibiotiques et procédé pour la construction et l'utilisation de celle-ci - Google Patents

Souche de listeria exempte de résistance aux antibiotiques et procédé pour la construction et l'utilisation de celle-ci

Info

Publication number
EP2147092A4
EP2147092A4 EP08742912A EP08742912A EP2147092A4 EP 2147092 A4 EP2147092 A4 EP 2147092A4 EP 08742912 A EP08742912 A EP 08742912A EP 08742912 A EP08742912 A EP 08742912A EP 2147092 A4 EP2147092 A4 EP 2147092A4
Authority
EP
European Patent Office
Prior art keywords
constructing
methods
same
antibiotic resistance
listeria strains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08742912A
Other languages
German (de)
English (en)
Other versions
EP2147092A2 (fr
Inventor
Yvonne Paterson
Thorsten Verch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/785,249 external-priority patent/US7855064B2/en
Priority claimed from US11/818,965 external-priority patent/US7858097B2/en
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of EP2147092A2 publication Critical patent/EP2147092A2/fr
Publication of EP2147092A4 publication Critical patent/EP2147092A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP08742912A 2007-04-16 2008-04-15 Souche de listeria exempte de résistance aux antibiotiques et procédé pour la construction et l'utilisation de celle-ci Withdrawn EP2147092A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/785,249 US7855064B2 (en) 2004-08-13 2007-04-16 Antibiotic resistance free vaccines and methods for constructing and using same
US11/818,965 US7858097B2 (en) 2004-08-13 2007-04-27 Antibiotic resistance free Listeria strains and methods for constructing and using same
PCT/US2008/004861 WO2008130551A2 (fr) 2007-04-16 2008-04-15 Souche de listeria exempte de résistance aux antibiotiques et procédé pour la construction et l'utilisation de celle-ci

Publications (2)

Publication Number Publication Date
EP2147092A2 EP2147092A2 (fr) 2010-01-27
EP2147092A4 true EP2147092A4 (fr) 2010-06-09

Family

ID=39876122

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08742912A Withdrawn EP2147092A4 (fr) 2007-04-16 2008-04-15 Souche de listeria exempte de résistance aux antibiotiques et procédé pour la construction et l'utilisation de celle-ci

Country Status (2)

Country Link
EP (1) EP2147092A4 (fr)
WO (1) WO2008130551A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
EP2288379A4 (fr) * 2008-05-19 2012-08-08 Advaxis Système de double distribution pour des antigènes hétérologues
US9650639B2 (en) 2008-05-19 2017-05-16 Advaxis, Inc. Dual delivery system for heterologous antigens
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
EP2498808A4 (fr) 2009-11-11 2014-01-08 Advaxis Compositions et méthodes de prévention de mutation d'échappement dans le traitement des tumeurs surexprimant her2/neu
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
WO2012138377A2 (fr) * 2010-10-01 2012-10-11 Trustees Of The University Of Pennsylvania Utilisation de vecteurs de vaccin de listeria pour renverser l'insensibilité au vaccin chez des individus infectés par des parasites
AU2012229218B2 (en) 2011-03-11 2017-03-02 Advaxis, Inc. Listeria-based adjuvants
EP2825195A4 (fr) 2012-03-12 2015-10-07 Advaxis Inc Inhibition de la fonction des cellules suppresseurs après traitement par un vaccin à base de listeria
RU2016136855A (ru) 2014-02-18 2018-03-22 Адваксис, Инк. Биомаркер-направленная многоцелевая иммунотерапия
JP7009061B2 (ja) 2014-04-24 2022-01-25 アドバクシス， インコーポレイテッド 組み換え型リステリアワクチン株およびこれを生産する方法
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
CA2998857A1 (fr) * 2015-09-15 2017-03-23 Anu Wallecha Procede de fabrication d'une formulation immunotherapeutique comprenant une souche de listeria de recombinaison
NZ753307A (en) 2016-11-30 2023-10-27 Advaxis Inc Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof
CN111356760A (zh) 2017-09-19 2020-06-30 阿德瓦希斯公司 细菌或李斯特菌菌株的冻干组合物和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017856A2 (fr) * 2004-08-13 2006-02-16 The Trustees Of The University Of Pennsylvania Procedes de production de vaccins non antibioresistants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6099848A (en) * 1997-11-18 2000-08-08 The Trustees Of The University Of Pennsylvania Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017856A2 (fr) * 2004-08-13 2006-02-16 The Trustees Of The University Of Pennsylvania Procedes de production de vaccins non antibioresistants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRUHN ET AL: "Listeria as a vaccine vector", MICROBES AND INFECTION, ELSEVIER, PARIS, FR LNKD- DOI:10.1016/J.MICINF.2007.05.010, vol. 9, no. 10, 7 May 2007 (2007-05-07), pages 1226 - 1235, XP022244468, ISSN: 1286-4579 *
VERCH THORSTEN ET AL: "Listeria monocytogenes-based antibiotic resistance gene-free antigen delivery system applicable to other bacterial vectors and DNA vaccines", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US LNKD- DOI:10.1128/IAI.72.11.6418-6425.2004, vol. 72, no. 11, 1 November 2004 (2004-11-01), pages 6418 - 6425, XP002508995, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
WO2008130551A2 (fr) 2008-10-30
EP2147092A2 (fr) 2010-01-27
WO2008130551A3 (fr) 2008-12-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20091106

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20100511

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 35/74 20060101ALI20100504BHEP

Ipc: C12N 1/21 20060101AFI20091119BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20101112