EP2035005A4 - Therapy using cytokine inhibitors - Google Patents
Therapy using cytokine inhibitorsInfo
- Publication number
- EP2035005A4 EP2035005A4 EP07798190A EP07798190A EP2035005A4 EP 2035005 A4 EP2035005 A4 EP 2035005A4 EP 07798190 A EP07798190 A EP 07798190A EP 07798190 A EP07798190 A EP 07798190A EP 2035005 A4 EP2035005 A4 EP 2035005A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- therapy
- cytokine inhibitors
- cytokine
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81226806P | 2006-06-09 | 2006-06-09 | |
US83307806P | 2006-07-24 | 2006-07-24 | |
US83527006P | 2006-08-03 | 2006-08-03 | |
PCT/US2007/070547 WO2007146712A2 (en) | 2006-06-09 | 2007-06-06 | Therapy using cytokine inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2035005A2 EP2035005A2 (en) | 2009-03-18 |
EP2035005A4 true EP2035005A4 (en) | 2011-07-06 |
Family
ID=38832677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07798190A Withdrawn EP2035005A4 (en) | 2006-06-09 | 2007-06-06 | Therapy using cytokine inhibitors |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2035005A4 (en) |
AR (1) | AR061273A1 (en) |
AU (1) | AU2007257959A1 (en) |
CA (1) | CA2691214A1 (en) |
CL (1) | CL2007001670A1 (en) |
PE (1) | PE20080935A1 (en) |
TW (1) | TW200814998A (en) |
WO (1) | WO2007146712A2 (en) |
Families Citing this family (76)
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KR101426093B1 (en) | 2006-02-10 | 2014-08-01 | 서미트 코포레이션 피엘씨 | Treatment of duchyen muscular dystrophy |
US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
WO2008043019A1 (en) | 2006-10-04 | 2008-04-10 | Pharmacopeia, Inc | 8-substituted 2-(benzimidazolyl) purine derivatives for immunosuppression |
AR063142A1 (en) | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | DERIVATIVES OF 2- (BENCIMIDAZOLIL) PURINE AND PURINONES 6-USEFUL SUBSTITUTES AS IMMUNOSUPPRESSORS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
WO2009012221A1 (en) * | 2007-07-13 | 2009-01-22 | Board Of Regents, The University Of Texas System | Heterocyclic modulators of cannabinoid receptors |
RS55735B1 (en) | 2007-08-03 | 2017-07-31 | Summit (Oxford) Ltd | Drug combinations for the treatment of duchenne muscular dystrophy |
US8304413B2 (en) | 2008-06-03 | 2012-11-06 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
JP2012508238A (en) * | 2008-11-07 | 2012-04-05 | ハー・ルンドベック・アクチエゼルスカベット | Amide with biological activity |
CN102548986A (en) | 2009-06-05 | 2012-07-04 | 链接医药公司 | Aminopyrrolidinone derivatives and uses thereof |
WO2011063076A1 (en) * | 2009-11-19 | 2011-05-26 | Itherx Pharmaceuticals, Inc. | Methods of treating hepatitis c virus with oxoacetamide compounds |
EP2633857B1 (en) * | 2009-12-23 | 2015-08-12 | ratiopharm GmbH | Solid pharmaceutical dosage form of ticagrelor and acetylsalicylic acid |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
MX355038B (en) * | 2010-03-30 | 2018-03-28 | Verseon Corp | Multisubstituted aromatic compounds as inhibitors of thrombin. |
US9035072B2 (en) | 2010-04-22 | 2015-05-19 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
AR081626A1 (en) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS |
EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081331A1 (en) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME |
US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
JP5677646B2 (en) | 2011-10-21 | 2015-02-25 | アッヴィ・インコーポレイテッド | DAA combination therapy (eg, with ABT-072 or ABT-333) for use in the treatment of HCV |
PH12014500832A1 (en) | 2011-10-21 | 2022-12-02 | Abbvie Inc | Methods for treating hcv |
AR092742A1 (en) | 2012-10-02 | 2015-04-29 | Intermune Inc | ANTIFIBROTIC PYRIDINONES |
CN110179795A (en) | 2013-03-15 | 2019-08-30 | 维颂公司 | The pharmaceutical applications of polysubstituted aromatic compounds as serpin |
CN106459042B (en) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | Anti-fibrosis pyridinone |
PT3925607T (en) | 2014-04-15 | 2023-09-26 | Vertex Pharma | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
JP2017528486A (en) | 2014-09-17 | 2017-09-28 | ヴァーセオン コーポレイション | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
WO2016094688A1 (en) | 2014-12-10 | 2016-06-16 | Massachusetts Institute Of Technology | Fused 1,3-azole derivatives useful for the treatment of proliferative diseases |
JP2018506563A (en) | 2015-02-27 | 2018-03-08 | ヴァーセオン コーポレイション | Substituted pyrazole compounds as serine protease inhibitors |
CN107921046B (en) * | 2015-06-12 | 2022-10-14 | 格林威治大学 | Triazine derivatives as interferon-gamma inhibitors |
TW201718581A (en) | 2015-10-19 | 2017-06-01 | 英塞特公司 | Heterocyclic compounds as immunomodulators |
DK3377488T3 (en) | 2015-11-19 | 2022-10-03 | Incyte Corp | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS |
AU2016374294B2 (en) | 2015-12-15 | 2019-06-27 | Astrazeneca Ab | Isoindole compounds |
ES2844374T3 (en) | 2015-12-22 | 2021-07-22 | Incyte Corp | Heterocyclic compounds as immunomodulators |
CN109071456A (en) | 2016-02-16 | 2018-12-21 | 麻省理工学院 | MAX bonding agent and application thereof as MYC regulator |
EP3448392A4 (en) | 2016-04-28 | 2020-01-15 | Emory University | ALKYNOUS THERAPEUTIC NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND RELATED APPLICATIONS |
TW201808950A (en) | 2016-05-06 | 2018-03-16 | 英塞特公司 | Heterocyclic compounds as immunomodulators |
ES2905980T3 (en) | 2016-05-26 | 2022-04-12 | Incyte Corp | Heterocyclic compounds as immunomodulators |
EP3468604B1 (en) * | 2016-06-08 | 2021-01-20 | Support-Venture GmbH | Pharmaceutical combinations for treating cancer |
PE20190731A1 (en) | 2016-06-20 | 2019-05-23 | Incyte Corp | HETEROCICLICAL COMPOUNDS AS IMMUNOMODULATORS |
ES2930092T3 (en) | 2016-07-14 | 2022-12-07 | Incyte Corp | Heterocyclic compounds as immunomodulators |
US20180057486A1 (en) | 2016-08-29 | 2018-03-01 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
JP6883653B2 (en) | 2016-12-20 | 2021-06-09 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | Amino-triazolopyridine compounds and their use in the treatment of cancer |
ES2874756T3 (en) | 2016-12-22 | 2021-11-05 | Incyte Corp | Triazolo [1,5-A] pyridine derivatives as immunomodulators |
MD3558990T2 (en) | 2016-12-22 | 2023-02-28 | Incyte Corp | Tetrahydroimidazo[4,5-c]pyridine derivatives as PD-L1 internalization inducers |
US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
IL295660A (en) | 2016-12-22 | 2022-10-01 | Incyte Corp | Benzoxazole derivatives as immunomodulators |
BR112019024155A2 (en) * | 2017-05-15 | 2020-06-02 | Recurium Ip Holdings, Llc | ANALGESIC COMPOUNDS |
US11034654B2 (en) | 2017-06-14 | 2021-06-15 | Astrazeneca Ab | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators |
CN111646986B (en) * | 2017-09-13 | 2022-03-25 | 厦门稀土材料研究所 | Nicotinic acid derivative and preparation method and application thereof |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
AU2018346709A1 (en) | 2017-10-05 | 2020-04-16 | Fulcrum Therapeutics, Inc. | Use of p38 inhibitors to reduce expression of DUX4 |
RU2020124138A (en) | 2017-12-22 | 2022-01-24 | Хиберселл, Инк. | AMINOPYRIDINE DERIVATIVES AS PHOSPHATIDILINOSITOLPHOSPHATKINASE INHIBITORS |
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CN112752756B (en) | 2018-05-11 | 2024-06-25 | 因赛特公司 | Tetrahydro-imidazo[4,5-c]pyridine derivatives as PD-L1 immunomodulators |
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CN111825605B (en) * | 2019-04-19 | 2023-03-31 | 中国科学院上海药物研究所 | Aryl ketone amide compound and preparation method and application thereof |
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WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
AU2021373044A1 (en) | 2020-11-06 | 2023-06-08 | Incyte Corporation | Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof |
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CN113209112B (en) * | 2021-02-06 | 2021-12-24 | 广州市朝利良生物科技有限公司 | Novel coronavirus resistant medicine based on ACE2 and S protein binding target and application thereof |
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WO2024059220A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030008868A1 (en) * | 2001-05-16 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
-
2007
- 2007-06-06 EP EP07798190A patent/EP2035005A4/en not_active Withdrawn
- 2007-06-06 WO PCT/US2007/070547 patent/WO2007146712A2/en active Application Filing
- 2007-06-06 AU AU2007257959A patent/AU2007257959A1/en not_active Abandoned
- 2007-06-06 CA CA2691214A patent/CA2691214A1/en not_active Abandoned
- 2007-06-08 CL CL2007001670A patent/CL2007001670A1/en unknown
- 2007-06-08 PE PE2007000714A patent/PE20080935A1/en not_active Application Discontinuation
- 2007-06-08 TW TW096120764A patent/TW200814998A/en unknown
- 2007-06-08 AR ARP070102483A patent/AR061273A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030008868A1 (en) * | 2001-05-16 | 2003-01-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as anti-inflammatory agents |
WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
US20100273797A1 (en) * | 2003-09-11 | 2010-10-28 | Itherx Pharmaceuticals, Inc. | Alpha-ketoamides and derivatives thereof |
Also Published As
Publication number | Publication date |
---|---|
AU2007257959A1 (en) | 2007-12-21 |
WO2007146712A3 (en) | 2008-11-27 |
WO2007146712A2 (en) | 2007-12-21 |
EP2035005A2 (en) | 2009-03-18 |
CL2007001670A1 (en) | 2008-01-18 |
CA2691214A1 (en) | 2007-12-21 |
TW200814998A (en) | 2008-04-01 |
AR061273A1 (en) | 2008-08-13 |
PE20080935A1 (en) | 2008-08-02 |
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AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
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RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHUSTER, LEWIS, J. Inventor name: PRYOR, KENT Inventor name: MILLER, STEPHEN Inventor name: LARSON, CHRISTOPHER, J. Inventor name: KING, BERNARD Inventor name: HEPBURN, BONNIE Inventor name: GROVE, CARRIE, GAIL Inventor name: ERNST, JUSTIN Inventor name: DELAET, NANCY G., J. Inventor name: CROWLEY, CONSTANCE, A. |
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DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20110607 |
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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20120105 |