[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP2066570B1 - Formbehälter mit erhobenem nippel und verwendung - Google Patents

Formbehälter mit erhobenem nippel und verwendung Download PDF

Info

Publication number
EP2066570B1
EP2066570B1 EP07843722A EP07843722A EP2066570B1 EP 2066570 B1 EP2066570 B1 EP 2066570B1 EP 07843722 A EP07843722 A EP 07843722A EP 07843722 A EP07843722 A EP 07843722A EP 2066570 B1 EP2066570 B1 EP 2066570B1
Authority
EP
European Patent Office
Prior art keywords
wall
container
stopper
longitudinal axis
body portion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP07843722A
Other languages
English (en)
French (fr)
Other versions
EP2066570A4 (de
EP2066570A2 (de
Inventor
Richard Q. Poynter
Peter J. Decoste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RP Scherer Technologies LLC
Original Assignee
RP Scherer Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RP Scherer Technologies LLC filed Critical RP Scherer Technologies LLC
Publication of EP2066570A2 publication Critical patent/EP2066570A2/de
Publication of EP2066570A4 publication Critical patent/EP2066570A4/de
Application granted granted Critical
Publication of EP2066570B1 publication Critical patent/EP2066570B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023—Neck construction
    • B65D1/0238—Integral frangible closures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents

Definitions

  • the invention relates to the field of molded containers, particularly to a blow-fill-seal (BFS) vial containing an internal elastomeric stopper, where the elastomeric stopper has a raised nipple that projects beyond the outer shell of the vial.
  • BFS blow-fill-seal
  • Small vials with elastomeric stoppers are traditionally used to contain small amounts of liquids, particularly liquid medications, or as storage and dispensing vessels for lyophilized medications that are reconstituted prior to use. Safe retention of the elastomeric stopper requires a foil over-cap, to prevent the expulsion of the stopper should pressure within the vial rise. Additionally, the elastomeric stoppers generally require siliconization as a lubricant to insert the stoppers in the vials during the manufacturing process, thus introducing a potentially additional chemical compound. Furthermore, glass vials are inherently liable to breakage. In the end, a stoppered glass vial requires at least three different structural compounds (glass, elastomers, and foil), and assembly requires numerous steps.
  • BFS low-fill-seal containers
  • resin is extruded and molded into a container, and the container is then filled and the resin container sealed, all is a series of automated steps, generally carried out in a continuous or near-continuous process in a sterile environment within the BFS molding machinery.
  • the evolution of this method of packaging is also well known in the art. Initially, various methods were described for blow molding a hollow thermoplastic article; for example, as seen in U.S. Pat. Nos. 3,137,748 and 3,288,898 . More complex process for manufacturing BFS containers are later seen in U.S. Pat. Nos.
  • the BFS manufacturing process traditionally includes sub-components such as a thermoplastic polymer storage and feeding system; an extruder with a parison head; a sterile air filling chamber; a specialized mandrel capable of filling the container, mold halves capable of opening and closing, and therein forming the container; and various downstream items of equipment, such as inspection and leak detection systems, labelers, and packaging machinery.
  • sub-components such as a thermoplastic polymer storage and feeding system; an extruder with a parison head; a sterile air filling chamber; a specialized mandrel capable of filling the container, mold halves capable of opening and closing, and therein forming the container; and various downstream items of equipment, such as inspection and leak detection systems, labelers, and packaging machinery.
  • Aseptic processing equipment such as tanks fitted with sterility filters, ensures that the BFS machinery is continuously provided with sterile product.
  • Thermoplastic polymer granules are typically fed via a vacuum tubing system into a hopper in the blow-fill-seal extruder, where they are heated to form a melt, typically at about 215° C.
  • the thermoplastic polymer melt is formed via a circular orifice into a plastic parison (hollow tube), which is held open by a stream of sterile filtered air.
  • the lower part of the divided mold halves then close to seal the bottom of the open parison and the parison wall is blown and/or compressed by vacuum to the cooled mold walls to form the lower part of the BFS container.
  • a filling mandrel fills a predetermined quantity of product into the container, and after withdrawal of the mandrel, the upper portion of the mold closes to form and seal the upper part of the BFS container.
  • an intermediate step includes placement of the insert in the correct position prior to encapsulation as part of the BFS process. Since multiple cavities may be built within a single mold, the rate of production is substantially related to the number of cavities in each BFS mold.
  • U.S. Patent NO. 5,878,900 discloses a contanier in accordance with the preamble of claim 1.
  • Vials with encapsulated stoppers generally resemble the type of prior art construction as illustrated in FIG. 1 .
  • There are a number of problems with such a construction Firstly, the relatively right angle shoulder where the encapsulated thermoplastic turns over the top of the stopper creates an area that is difficult to blow mold.
  • the need for a reproducible fracture area wherein the vial may be opened requires a weakened area for such a fracture area, which can be difficult to design into such packaging.
  • the designs owing to the fact that the stopper is encapsulated within the thermoplastic shell, result in a stopper surface that lies below the level of the shell.
  • the exposed surface of the stopper essentially lies in a hole, surround by a raised thermoplastic area, as seen in FIG. 2 . This can make access to the stopper, such as for cleaning and disinfection difficult.
  • the instant invention overcomes these and many other shortcomings of contemporary BFS vial design.
  • the present invention advances the state of the art with a variety of new capabilities and overcomes many of the shortcomings of prior devices in new and novel ways.
  • the present invention is a container according to claim 1, having a raised nipple .
  • the container comprises a cap portion, a body portion, and with an encapsulated stopper.
  • the present invention also concerns the use of such a container as stated in claim 16.
  • the body portion has a body portion wall having a wall shoulder portion with a distal aspect and a proximal aspect.
  • the body portion has an adjoining cap portion such that the body portion wall meets a cap portion wall at an engineered separation , site, designed to represent an area of weakness in the walls of the container.
  • the container has a stopper enclosed within the container shell that prevents the transfer of contents from the body portion to the cap portion.
  • a portion of the stopper is enclosed within the body portion and a portion of the stopper is enclosed within the cap portion.
  • the stopper has a stopper wall and a stopper shoulder with a central raised nipple having a nipple top surface with an injection site and a nipple sidewall.
  • the engineered separation site is adjacent to the nipple sidewall such that when the cap portion is removed from the body portion at the engineered separation site, a portion of the nipple extends out of the body portion.
  • the instant invention allows all of the top surface of the nipple to be easily cleaned, if desired, and allows substantially all of the top surface of the nipple to be accessed by a needle, or other removal means, to puncture the stopper and access the container contents.
  • the body wall shoulder portion, adjacent to the cap portion, may be configured at a non-orthogonal angle from the longitudinal axis of the container. This also has numerous advantages over the prior art, including but not limited to the following. It can be difficult, when the body wall should of a BFS vial comprises an orthogonal angle, to insure sufficient plastic at the bend to form a sufficiently strong container. Additionally, such a right-angle bend imposes a geometry that makes design of a suitable breakage line between the body and the cap of a BFS vial more difficult.
  • the wall shoulder portion further comprises at least one raised gusset, extending from the wall shoulder portion and having a lateral surface substantially parallel to the longitudinal axis of the container.
  • gusset(s) not only tend to strengthen the BFS vial, but cooperate with a variety of connectors.
  • Extending the length of the lateral surface increases the surface area of interaction between the container and the interior surface of a needle-free container, and a larger surface area for interaction results in a more stable cooperation between the elements and a more positive centering of a needle-free connector.
  • the cap portion may have a cap portion wall formed with a grip enhancing feature such as a flattened tab (332), see FIGS 13(a) and 13(b) .
  • a flattened tab may have relatively short lateral expanse such that the easiest means of removing the cap portion from the body portion is to use two hands, one to grip the body portion and another to twist off the cap portion. While one-handed removal of the cap portion in such a design is not impossible, it may require a degree of hand strength not universally found among those desiring to use the container.
  • the hand strength required for one-handed opening may be decreased by increasing the moment arm of the tab, that is, the larger the tab relative to the container, the less force that must be applied at a distal point on the tab to effect a rupture at the engineered separation site. This allows easier removal of the cap portion from the body portion by torquing the cap portion. Such relative elongation of the tab simply increases the leverage available for opening the container at the engineered separation site.
  • the engineered separation site comprises a line of discontinuity in shell thickness between the body portion wall and the cap portion wall. The discontinuity creates a natural fracture zone between the adjoining body portion and cap portion.
  • the engineered separation site is formed by a progressive attenuation of the thickness of the wall shoulder portion tapering from a maximum thickness at the distal aspect of the wall shoulder portion to reach a minimum thickness at the proximal aspect of the wall shoulder portion (221), see FIG. 7 .
  • a container (10) with at least one diameter (12) and a longitudinal axis (14), comprising a container shell (50) comprising a body portion (200) with a body portion wall (220) having a wall shoulder portion (221) configured at a non-orthogonal angle from the longitudinal axis (14) of the container (10) having a distal aspect (222) and a proximal aspect (223) wherein the wall shoulder portion (221) further comprises at least one raised gusset (228) extending from the wall shoulder portion (221) and having a lateral surface (229) substantially parallel to the longitudinal axis (14) of the container (10) wherein the lateral surface (229) begins at the distal aspect (222) of the wall shoulder portion (221) and extends substantially parallel to the longitudinal axis (14) of the container at-least 25% of the longitudinal distance from the distal aspect (222) to the injection site (135) measured along the longitudinal axis (14) of the container (10), and an adjoining cap portion (300) having
  • a container (10) with at least one diameter (12) and a longitudinal axis (14), comprising a container shell (50) comprising a body portion (200) with a body portion wall (220) having a wall shoulder portion (221) configured at a non-orthogonal angle from the longitudinal axis (14) of the container (10) having a distal aspect (222) and a proximal aspect (223) wherein the wall shoulder portion (221) further comprises at least one raised gusset (228) extending from the wall shoulder portion (221) and having a lateral surface (229) substantially parallel to the longitudinal axis (14) of the container (10) wherein the lateral surface (229) begins at the distal aspect (222) of the wall shoulder portion (221) and extends substantially parallel to the longitudinal axis (14) of the container at least 25% of the longitudinal distance from the distal aspect (222) to the injection site (135) measured along the longitudinal axis (14) of the container (10), and an adjoining cap portion (300) having a cap
  • the molded container (10), see FIG. 4 of the instant invention enables a significant advance in the state of the art.
  • the detailed description set forth below in connection with the drawings is intended merely as a description of the presently preferred embodiments of the invention, and is not intended to represent the only form in which the present invention may be constructed or utilized.
  • the description sets forth the designs, functions, means, and methods of implementing the invention in connection with the illustrated embodiments. It is to be understood, however, that the same or equivalent functions and features may be accomplished by different embodiments that are also encompassed within the scope of the claims.
  • the instant invention comprises a molded container (10) with at least one diameter (12), see FIG. 7 , and a longitudinal axis (14), see FIG. 4 .
  • a container would be most commonly formed according to the traditional blow-fill-seal (BFS) methods described above.
  • BFS blow-fill-seal
  • the container (10) comprises a cap portion (300) and a body portion (200) with an encapsulated stopper (100).
  • the container has a container shell (50) comprising a body portion (200) with a body portion wall (220) having a wall shoulder portion (221) having a distal aspect (222) and a proximal aspect (223), best seen in FIG. 5 .
  • the terms "distal” and proximal” are intended to represent positions relatively farther and relatively nearer, respectively, from the longitudinal axis (14) of the container (10).
  • the body portion (200) has an adjoining cap portion (300), seen in FIG. 4 , having a cap portion wall (320), wherein the body portion wall (220) meets the cap portion wall (320) at an engineered separation site (400), seen in FIG. 4 .
  • the engineered separation site (400) is designed to represent an area of weakness in the walls (220, 320) of the container, such that a uniform and repeatable breakage area is created for the removal of the cap portion (300) from the body portion (200).
  • the container (10) has a stopper (100), well seen in FIG. 5 and shown in detail removed from the container in FIG. 6 , enclosed within the container shell (50), seen in FIG. 4 , that prevents the transfer of contents from the body portion (200) to the cap portion (300).
  • a portion of the stopper (100) is enclosed within the body portion (200) and a portion of the stopper (100) is enclosed within the cap portion (300), as seen in FIG. 4 .
  • the stopper (100) has a stopper wall (120) and a stopper shoulder (123), see FIG.
  • nipple (130) having a nipple top surface (134) with an injection site (135) and a nipple sidewall (132), as seen in FIG. 5 .
  • the engineered separation site (400), see FIG. 4 is adjacent to the nipple sidewall (132) such that when the cap portion (300) is removed from the body portion (200) at the engineered separation site (400) a portion of the nipple (130) extends out of the body portion (200), as seen in FIGS. 4 and 5 .
  • the instant invention allows all of the top surface (134) of the nipple (130) to be easily cleaned, if desired, and allows substantially all of the top surface (134) of the nipple (130) to be accessed by a needle, or other removal means, to puncture the stopper (100) and access the container (10) contents.
  • the injection site (135) on the top surface (134) of the nipple (130) is bounded by a raised injection guide (136) to assist in correct placement of the needle or other removal means into the stopper (100).
  • the body wall shoulder portion (221), adjacent to the cap portion (300), may be configured at a non-orthogonal angle, seen in FIG. 5 , from the longitudinal axis (14) of the container (10).
  • This also has numerous advantages over the prior art.
  • the traditional BFS vial such as the prior art examples seen in FIGS. 1 and 2 , have shoulders over the embedded stoppers that are configured approximately orthogonally to a longitudinal axis of the container, resulting in approximately a right-angle bend at the most lateral portion of the shoulder area. It can be difficult, given such an orthogonal angle, to insure sufficient plastic at the bend, to form a sufficiently strong container, using traditional BFS methods.
  • the instant invention may also be configured so that the body portion wall (220) has an ingress preventer (224), seen in FIGS. 4 and 5 , wherein the ingress preventer (224) cooperates with a stopper ingress preventer (124) formed in the stopper wall (120).
  • the ingress preventer (224) cooperates with a stopper ingress preventer (124) formed in the stopper wall (120).
  • a wall retention surface (226) on the body portion wall (220) cooperates with a stopper retention surface (126) on the stopper wall (120).
  • such cooperation may provide sufficient frictional fit so that the stopper (100) is less likely to be forced into, or expelled from, the container (10).
  • the wall retention surface (226) further comprises at least one wall egress preventer (227), wherein the wall egress preventer (227) cooperates with a stopper egress preventer (127) on the stopper retention surface (126).
  • Such cooperation reduces the chances of the stopper (100) being inadvertently expelled from the container (10) such as, by way of example only, might be caused by an over pressurization of the interior of the container (10).
  • the wall shoulder portion (221) further comprises at least one raised gusset (228), seen in FIGS. 9b and 10 , extending from the wall shoulder portion (221) and having a lateral surface (229) substantially parallel to the longitudinal axis (14) of the container (10).
  • gusset(s) (228) not only tend to strengthen the BFS vial, but may cooperate with a variety of needle-free connectors, such as, by way of example only, the SMARTSITE® needle-free connector manufactured by Cardinal Health, Inc. of Dublin, Ohio, USA.
  • a larger surface area for interaction results in a more stable cooperation between the elements and a more positive centering of a needle-free connector, as will be discussed immediately below in relationship to FIGS. 8-11 .
  • FIGS. 8-11 The advantage of the at least one raised gusset design may be seen in FIGS. 8-11 .
  • a needle free connector (500) see FIG. 12a , of the type, by way of example only, of the SMARTSITE® needle-free connector poised at the moment of puncture of the injection site (135), see FIG. 8 , of the raised nipple (130).
  • FIG. 9a One skilled in the art can see, as would be confirmed by reference to FIG. 9a , that it is relatively easy for an operator to place the needle-free connector (500) eccentrically on the container (10), potentially leading to an unstable connection and an improper puncturing of the injection surface (135).
  • Typical features of a needle-free connector (500) may be seen in FIGS. 12a-12d , as well as in FIGS. 8 , 9a , and 10-11 .
  • some of the features of a typical needle-free connector include a connector male end fluid port ingress regulator (523), essentially shaped as a spike-like means for puncturing the stopper (100) at the injection site (135) and a connector male end fluid port interlock (524), essentially configured as resilient clips that allow the needle-free connector (500) to cooperate with various configurations of the body portion (200) of the container (10).
  • the raised gusset (228) design particularly embodiments employing a lateral surface (229) substantially parallel to the longitudinal axis of the container (10
  • the raised gusset(s) (228) As the needle-free connector approaches the top of the container (10), the raised gusset(s) (228), particularly the lateral edges (229), interacts with the clip-like sides of the needle-free connector. This tends to guide the needle-free connector to a proper central placement on the injection site (135).
  • the raised gusset(s) (228) tend to fill the interior volume of the needle-free connector and to insure a closer and more stable fit with the body portion (200) of the container (10).
  • FIGS. 12a-d The details of a typical needle-free container suitable for use with the instant invention are shown, by way of example only, in FIGS. 12a-d .
  • the cap portion (300) may have a cap portion wall (320) formed with a grip enhancing feature (330).
  • a grip enhancing feature (330) may be a flattened tab (332) having a lateral aspect (333).
  • the grip enhancing features may be a flattened tab (332) attached to the cap portion (300), seen in FIGS. 13a-b and 14a-b .
  • Such a flattened tab (332) may have relatively short lateral expanse such that the easiest means of removing the cap portion (300) from the body portion (200) is to use two hands, one to grip the body portion (200) and another to twist off the cap portion (300). Such a twisting motion is shown in FIG. 13b by the two-headed arrow indicating rotation that is shown on the cap portion (300). While one-handed removal of the cap portion (300) in such a design is not impossible, it may require a degree of hand strength not universally found among those desiring to use the container (10). It may be desirable to facilitate one-handed removal of the cap portion by altering the geometry of the tab (332).
  • the hand strength required for one-handed opening may be decreased by increasing the moment arm of the tab (332) that is, the larger the tab (332) relative to the container (10), the less force that must be applied at a distal point on the tab (332) to effect a rupture at the engineered separation site (400).
  • a tab (332) is shown in FIGS. 7 and 14b formed such that a distance from a most distant point on the tab (332), at the lateral aspect (333), from a center of the injection site (135) is at least 50% of the largest of the at least one diameter (12) of the container (10).
  • a similar construction may be seen in FIG. 14b .
  • the tab (332) is formed such that a distance from a most distant point on the tab (332), at the lateral aspect (333), from a center of the injection site (135) is at least 65% of the largest of the at least one diameter (12) of the container (10), as may be seen in FIG. 7 and FIG. 14b .
  • Such relative elongation of the tab (332) simply increases the leverage available for opening the container (10) at the engineered separation site (400).
  • Clean and accurate removal of the cap portion (300) from the body portion (200) may also be facilitated by refinements in the engineered separation site (400) where the body portion wall (220) meets the cap portion wall (320).
  • a site (400) could comprise, by way of example, a score line in the shell wall (52).
  • the engineered separation site (400) comprises a line of discontinuity in shell thickness between the body portion wall (220) and the cap portion wall (320). The discontinuity creates a natural fracture zone between the adjoining body portion (200) and cap portion (300). As seen in FIG.
  • the engineered separation site (400) is formed by a progressive attenuation of the thickness of the wall shoulder portion (221), see FIG. 5 , tapering from a maximum thickness at the distal aspect (222) of the wall shoulder portion (221) to reach a minimum thickness at the proximal aspect (223) of the wall shoulder portion (221).
  • the container with a raised nipple of the instant invention answers a long-felt need in the area of BFS containers having internally encapsulated stoppers.
  • the design of the invention allows a portion of the raised nipple to extend beyond the body portion of the container, after opening, such that it may be easily accessed and cleaned. Additional modifications, including the provision of an improved engineered separation site at the point of opening, and raised gussets that may provide a secure connection with various needle-free connectors improves the safety and efficiency found in this art.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ceramic Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Moulding By Coating Moulds (AREA)
  • Casting Or Compression Moulding Of Plastics Or The Like (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)

Claims (16)

  1. Ein Behälter (10) mit mindestens einem Durchmesser (12) und einer Längsachse (14), umfassend:
    a) eine Behälterhülle (50), umfassend einen Rumpfteil (200) mit einer Rumpfteilwand (220), welche einen Wandschulterteil (221) mit einem distalen Aspekt (222) und einem proximalen Aspekt (223) besitzt, wobei besagter distaler und proximaler Aspekt (222, 223) relativ zur Längsachse (14) des Behälters ist, und einen Kappenteil (300), welcher eine Kappenteilwand (320) besitzt; und
    b) einen von der Behälterhülle (50) umschlossenen Verschlussstöpsel (100), welcher den Transfer des Inhalts vom Rumpfteil (200) in den Kappenteil (300) verhindert, derart, dass ein Teil des Verschlussstöpsels (100) vom Rumpfteil (200) umschlossen ist, wobei die Rumpfteilwand (220) an die Kappenteilwand (320) angrenzt, und zwar an einer ausgeführten Trennstelle (400), bei welcher es sich um eine Diskontinuitätslinie in der Hüllendicke zwischen der Rumpfteilwand (220) und der Kappenteilwand (320) handelt, dadurch gekennzeichnet, dass:
    ein Teil des Verschlussstöpsels (100) vom Kappenteil (300) umschlossen ist, wobei der Verschlussstöpsel (100) eine Verschlussstöpselwand (120) und eine Verschlussstöpselschulter (123) mit einem mittleren erhabenen Nippel (130) besitzt, welcher über eine Nippeloberseite (134) mit einer Injektionsstelle (135) verfügt, die von einer erhabenen Injektionsführung (136) und einer Nippelseitenwand (132) begrenzt ist, und wobei die ausgeführte Trennstelle (400) derart an die Nippelseitenwand (132) angrenzt, dass wenn der Kappenteil (300) an der ausgeführten Trennstelle (400) vom Rumpfteil (200) entfernt wird, ein Teil des Nippels (130) aus dem Rumpfteil (200) herausragt.
  2. Der Behälter gemäß Anspruch 1, wobei der Wandschulterteil (221), welcher an den Kappenteil (300) angrenzt, in einem nicht-orthogonalen Winkel von der Längsachse (14) des Behälters (10) konfiguriert ist.
  3. Der Behälter gemäß Anspruch 2, wobei die Rumpfteilwand (220) einen Eintrittsverhinderer (224) besitzt, wobei besagter Eintrittsverhinderer (224) mit einem in der Verschlussstöpselwand (120) ausgebildeten Verschlussstöpsel-Eintrittsverhinderer (124) zusammenwirkt.
  4. Der Behälter gemäß Anspruch 3, wobei die Rumpfteilwand (220) über eine Wandhaltefläche (226) verfügt, wobei die Wandhaltefläche (226) mit einer Verschlussstöpsel-Haltefläche (126) an der Verschlussstöpselwand (120) zusammenwirkt.
  5. Der Behälter gemäß Anspruch 4, wobei die Wandhaltefläche (226) ferner mindestens einen Wandaustrittsverhinderer (227) umfasst, wobei der Wandaustrittsverhinderer (227) mit einem Verschlussstöpsel-Austrittsverhinderer (127) an der Verschlussstöpsel-Haltefläche (126) zusammenwirkt.
  6. Der Behälter gemäß Anspruch 5, wobei der Wandschulterteil (221) ferner mindestens ein erhabenes Winkelstück (228) umfasst, welches sich aus dem Wandschulterteil (221) erstreckt und eine Seitenfläche (229) im Wesentlichen parallel zur Längsachse (14) des Behälters (10) besitzt.
  7. Der Behälter gemäß Anspruch 6, wobei besagte Seitenfläche (229) am distalen Aspekt (222) des Wandschulterteils (221) beginnt und sich im Wesentlichen parallel zur Längsachse (14) des Behälters um mindestens 25 % des Längsabstands vom distalen Aspekt (222) zur Injektionsstelle (135) gemessen entlang der Längsachse (14) des Behälters (10) erstreckt.
  8. Der Behälter gemäß Anspruch 7, wobei die Seitenfläche (229) am distalen Aspekt (222) des Wandschulterteils (221) beginnt und sich im Wesentlichen parallel zur Längsachse (14) des Behälters um mindestens 50 % des Längsabstands vom distalen Aspekt (222) zur Injektionsstelle (135) gemessen entlang der Längsachse (14) des Behälters (10) erstreckt.
  9. Der Behälter gemäß Anspruch 8, wobei die Kappenteilwand (320) mit einem griffverbessernden Merkmal (330) ausgebildet ist.
  10. Der Behälter gemäß Anspruch 9, wobei das griffverbessernde Merkmal (330) eine abgeflachte Lasche (332) ist, welche einen seitlichen Aspekt (333) besitzt.
  11. Der Behälter gemäß Anspruch 1, wobei die ausgeführte Trennstelle (400) durch eine progressive Verminderung der Dicke des Wandschulterteils (221) ausgebildet ist, welches sich von einer maximalen Dicke am distalen Aspekt (222) des Wandschulterteils (221) auf eine Mindestdicke am proximalen Aspekt (223) des Wandschulterteils (221) verjüngt.
  12. Der Behälter (10) gemäß Anspruch 1:
    wobei der Wandschulterteil (221) in einem nicht-orthogonalen Winkel von der Längsachse (14) des Behälters (10) konfiguriert ist und der Wandschulterteil (221) ferner mindestens ein erhabenes Winkelstück (228) umfasst, welches sich aus dem Wandschulterteil (221) erstreckt und eine Seitenfläche (229) im Wesentlichen parallel zur Längsachse (14) des Behälters (10) besitzt, wobei die Seitenfläche (229) am distalen Aspekt (222) des Wandschulterteils (221) beginnt und sich im Wesentlichen parallel zur Längsachse (14) des Behälters um mindestens 25 % des Längsabstands vom distalen Aspekt (222) zur Injektionsstelle (135) gemessen entlang der Längsachse (14) des Behälters (10) erstreckt, und
    wobei die ausgeführte Trennstelle (400) eine Diskontinuitätslinie in der Hüllendicke zwischen der Rumpfteilwand (220) und der Kappenteilwand (320) umfasst, welche durch eine progressive Verminderung der Dicke des Wandschulterteils (221) ausgebildet wird, welche sich von einer maximalen Dicke am distalen Aspekt (222) des Wandschulterteils (221) auf eine Mindestdicke am proximalen Aspekt (223) des Wandschulterteils (221) verjüngt.
  13. Der Behälter gemäß einem der Ansprüche 4 oder 5 und Anspruch 12, wobei die Wandhaltefläche (226) ferner mindestens einen Wandaustrittsverhinderer (227) umfasst, wobei der Wandaustrittsverhinderer (227) mit einem Verschlussstöpsel-Austrittsverhinderer (127) an der Verschlussstöpsel-Haltefläche (126) zusammenwirkt.
  14. Der Behälter (10) gemäß Anspruch 1:
    wobei der Wandschulterteil (221) ferner mindestens ein erhabenes Winkelstück (228) umfasst, welches sich aus dem Wandschulterteil (221) erstreckt und eine Seitenfläche (229) im Wesentlichen parallel zur Längsachse (14) des Behälters (10) besitzt, wobei die Seitenfläche (229) am distalen Aspekt (222) des Wandschulterteils (221) beginnt und sich im Wesentlichen parallel zur Längsachse (14) des Behälters um mindestens 25 % des Längsabstands vom distalen Aspekt (222) zur Injektionsstelle (135) gemessen entlang der Längsachse (14) des Behälters (10) erstreckt,
    die Kappenteilwand (320) mit einem griffverbessernden Merkmal (330) ausgebildet ist, wobei es sich bei dem griffverbessernden Merkmal (330) um eine abgeflachte Lasche (332) handelt, welche derart ausgebildet ist, dass ein Abstand von einem entferntesten Punkt der Lasche (332) von einer Mitte der Injektionsstelle (135) mindestens 65 % des größten von dem mindestens einen Durchmesser (12) des Behälters (10) beträgt, und
    wobei die ausgeführte Trennstelle (400) eine Diskontinuitätslinie in der Hüllendicke zwischen der Rumpfteilwand (220) und der Kappenteilwand (320) umfasst, welche durch eine progressive Verminderung der Dicke des Wandschulterteils (221) ausgebildet ist, welches sich von einer maximalen Dicke am distalen Aspekt (222) des Wandschulterteils (221) auf eine Mindestdicke am proximalen Aspekt (223) des Wandschulterteils (221) verjüngt.
  15. Der Behälter gemäß Anspruch 14, wobei die Seitenfläche (229) am distalen Aspekt (222) des Wandschulterteils (221) beginnt und sich im Wesentlichen parallel zur Längsachse (14) des Behälters um mindestens 50 % des Längsabstands vom distalen Aspekt (222) zur Injektionsstelle (135) gemessen entlang der Längsachse (14) des Behälters (10) erstreckt.
  16. Verwendung des Behälters (10) gemäß irgendeinem der Ansprüche 1-15 zur Aufbewahrung und Dispensierung einer fließfähigen Substanz.
EP07843722A 2006-10-04 2007-10-03 Formbehälter mit erhobenem nippel und verwendung Active EP2066570B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/542,869 US20080083691A1 (en) 2006-10-04 2006-10-04 Molded container with raised nipple and method for use
PCT/US2007/080267 WO2008042939A2 (en) 2006-10-04 2007-10-03 Molded container with raised nipple and method for use

Publications (3)

Publication Number Publication Date
EP2066570A2 EP2066570A2 (de) 2009-06-10
EP2066570A4 EP2066570A4 (de) 2009-11-11
EP2066570B1 true EP2066570B1 (de) 2011-01-05

Family

ID=39271606

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07843722A Active EP2066570B1 (de) 2006-10-04 2007-10-03 Formbehälter mit erhobenem nippel und verwendung

Country Status (8)

Country Link
US (2) US20080083691A1 (de)
EP (1) EP2066570B1 (de)
JP (1) JP5199265B2 (de)
CN (1) CN101600627A (de)
AT (1) ATE494235T1 (de)
BR (1) BRPI0720340B1 (de)
DE (1) DE602007011785D1 (de)
WO (1) WO2008042939A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9918900B2 (en) 2014-10-29 2018-03-20 R.P. Scherer Technologies, Llc Inverse blow-fill-seal packaging

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100254637A1 (en) * 2009-04-04 2010-10-07 Joseph John Lesko Handheld packet for one-handed operation
US10086984B2 (en) * 2009-06-30 2018-10-02 R.P. Scherer Technologies, Llc Molded container with opener and method for use
USD666289S1 (en) 2010-07-23 2012-08-28 BFS Pharma, Inc. Unit dose vial
WO2012026551A1 (ja) * 2010-08-27 2012-03-01 大塚製薬株式会社 薬液容器
US8672165B2 (en) 2011-11-22 2014-03-18 Spherical Precision, Inc. Containers with dispensing cap and methods of manufacturing the same
US9132238B2 (en) * 2012-06-26 2015-09-15 Becton, Dickinson And Company Blow fill seal luer syringe
US9364393B1 (en) 2012-08-17 2016-06-14 Healthstar, Inc. Packaging system for liquid medications
DE102012109194A1 (de) 2012-09-27 2014-04-17 B. Braun Avitum Ag Originalitätsverschluss zur Verwendung an einem Behälter, Behälter hiermit sowie Port zur Anordnung an dem Behälter
BR112018000067A2 (pt) 2015-07-02 2018-09-11 Andrew Koska Marc dispositivo de liberação de uso único previamente preenchido com um agente reconstituível
CA3021989A1 (en) * 2016-04-25 2017-11-02 Marc Andrew Koska Medical delivery system
CN109789953A (zh) 2016-09-28 2019-05-21 费森尤斯卡比德国有限公司 用于接收医疗液体的容器的封闭盖
CN111615409A (zh) 2017-11-17 2020-09-01 科斯卡家族有限公司 用于流体输送歧管的系统和方法
CN112906624B (zh) * 2021-03-12 2022-09-13 合肥工业大学 一种基于音视频多模态时序预测的视频数据特征提取方法
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4274543A (en) * 1978-01-23 1981-06-23 The Upjohn Company Vial and closure structure
US4226334A (en) * 1978-12-14 1980-10-07 Automatic Liquid Packaging, Inc. Stopper
DE3139084C2 (de) * 1981-10-01 1984-08-16 Gerhard 7166 Sulzbach-Laufen Hansen Verschluß für einen Behälter, insbesondere für eine Flasche
US4456200A (en) * 1982-07-06 1984-06-26 Storage Technology Corporation Pneumatic monitoring system for a magnetic tape drive
US4746017A (en) * 1987-08-18 1988-05-24 Bristol-Myers Company Safety container for glass vials
US5114030A (en) * 1990-08-30 1992-05-19 The West Company, Incorporated Tip off container cap with removable stem
DE4228090C2 (de) * 1992-08-24 1995-01-05 Pohl Gmbh & Co Kg Verschluß für eine Flasche
US5649637A (en) * 1994-06-02 1997-07-22 Automatic Liquid Packaging, Inc. Torque-resistant closure for a hermetically sealed container
DK0730858T3 (da) * 1995-03-09 1999-09-27 Hansen Bernd Flaske af plast og fremgangsmåde til dens fremstilling
US5924584A (en) * 1997-02-28 1999-07-20 Abbott Laboratories Container closure with a frangible seal and a connector for a fluid transfer device
US6571971B1 (en) * 2001-02-08 2003-06-03 Weller Engineering, Inc. Hermetically sealed container with pierceable entry port
AR040977A1 (es) * 2002-08-16 2005-04-27 Glaxosmithkline Biolog Sa Disposicion de cierre para un frasco para uso farmaceutico, el frasco, y procedimiento para su llenado y cerrado
EP1454609B1 (de) * 2003-03-05 2012-10-24 CSL Behring GmbH Transfervorrichtung
GB0318242D0 (en) * 2003-08-04 2003-09-03 Glaxosmithkline Biolog Sa Novel device
JP4579576B2 (ja) * 2004-05-18 2010-11-10 ファーマパック株式会社 樹脂製容器及びその製造方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9918900B2 (en) 2014-10-29 2018-03-20 R.P. Scherer Technologies, Llc Inverse blow-fill-seal packaging

Also Published As

Publication number Publication date
WO2008042939A2 (en) 2008-04-10
JP5199265B2 (ja) 2013-05-15
JP2010505710A (ja) 2010-02-25
CN101600627A (zh) 2009-12-09
WO2008042939A3 (en) 2008-12-04
US20090230077A1 (en) 2009-09-17
ATE494235T1 (de) 2011-01-15
BRPI0720340B1 (pt) 2019-02-26
EP2066570A4 (de) 2009-11-11
DE602007011785D1 (de) 2011-02-17
BRPI0720340A2 (pt) 2014-06-24
EP2066570A2 (de) 2009-06-10
US20080083691A1 (en) 2008-04-10

Similar Documents

Publication Publication Date Title
EP2066570B1 (de) Formbehälter mit erhobenem nippel und verwendung
US10456328B2 (en) Ampoule for medical liquid and method for producing an ampoule
US8277433B2 (en) Ampoules
FI120533B (fi) Muovipullo ja menetelmä sen valmistamiseksi
US9150336B2 (en) Closure cap for a container for receiving liquids and in particular an enteral nutrient solution, and container having such a closure cap
US6619516B2 (en) Hermetically sealed container with unitary drop-dispenser
US9108777B1 (en) Child resistant blow-fill seal container
KR102375726B1 (ko) 의료 액체용 앰플 및 앰플의 제조 방법
US4547900A (en) Flexible container with integral ports and diaphragm
US20100163577A1 (en) Container, particularly a hermetically sealed ampoule
CA1186284A (en) Flexible container with integral port and diaphragm
US8522994B2 (en) Hermetically sealed container
JP7301979B2 (ja) 薬物を収容して密封される容器
JPH0433824A (ja) 内容物を充填した容器の製造方法

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20090413

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

A4 Supplementary search report drawn up and despatched

Effective date: 20091013

RIC1 Information provided on ipc code assigned before grant

Ipc: B65D 51/00 20060101AFI20091007BHEP

Ipc: B65D 1/02 20060101ALI20091007BHEP

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: R.P. SCHERER TECHNOLOGIES, LLC

RTI1 Title (correction)

Free format text: MOLDED CONTAINER WITH RAISED NIPPLE AND USE

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REF Corresponds to:

Ref document number: 602007011785

Country of ref document: DE

Date of ref document: 20110217

Kind code of ref document: P

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602007011785

Country of ref document: DE

Effective date: 20110217

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20110105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

LTIE Lt: invalidation of european patent or patent extension

Effective date: 20110105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110416

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110505

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110406

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110505

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110405

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

RAP2 Party data changed (patent owner data changed or rights of a patent transferred)

Owner name: R.P. SCHERER TECHNOLOGIES, LLC

26N No opposition filed

Effective date: 20111006

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602007011785

Country of ref document: DE

Effective date: 20111006

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: R.P. SCHERER TECHNOLOGIES, LLC

Free format text: R.P. SCHERER TECHNOLOGIES, LLC#7690 CHEYENNE AVENUE, SUITE 100#LAS VEGAS, NV 89129 (US) -TRANSFER TO- R.P. SCHERER TECHNOLOGIES, LLC#C/O CSC SERVICES OF NEVADA, INC. 502 EAST JOHN STREET#CARSON CITY, NV 89706 (US)

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111031

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20111003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20110105

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 20220826

Year of fee payment: 16

Ref country code: GB

Payment date: 20220818

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20220822

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20220913

Year of fee payment: 16

Ref country code: DE

Payment date: 20220816

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20221101

Year of fee payment: 16

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602007011785

Country of ref document: DE

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20231003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231003

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231031

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240501

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20231004