[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

EP1951042A4 - SPIROLACTAM CGRP RECEPTOR ANTAGONISTS - Google Patents

SPIROLACTAM CGRP RECEPTOR ANTAGONISTS

Info

Publication number
EP1951042A4
EP1951042A4 EP06837559A EP06837559A EP1951042A4 EP 1951042 A4 EP1951042 A4 EP 1951042A4 EP 06837559 A EP06837559 A EP 06837559A EP 06837559 A EP06837559 A EP 06837559A EP 1951042 A4 EP1951042 A4 EP 1951042A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
cgrp receptor
spirolactam
spirolactam cgrp
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP06837559A
Other languages
German (de)
French (fr)
Other versions
EP1951042A2 (en
EP1951042B1 (en
Inventor
Ian M Bell
Craig A Stump
Cory R Theberge
Steven N Gallicchio
C Blair Zartman
Harold G Selnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of EP1951042A2 publication Critical patent/EP1951042A2/en
Publication of EP1951042A4 publication Critical patent/EP1951042A4/en
Application granted granted Critical
Publication of EP1951042B1 publication Critical patent/EP1951042B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP06837559A 2005-11-18 2006-11-14 Spirolactam tricyclic cgrp receptor antagonists Active EP1951042B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73797705P 2005-11-18 2005-11-18
PCT/US2006/044181 WO2007061692A2 (en) 2005-11-18 2006-11-14 Spirolactam tricyclic cgrp receptor antagonists

Publications (3)

Publication Number Publication Date
EP1951042A2 EP1951042A2 (en) 2008-08-06
EP1951042A4 true EP1951042A4 (en) 2010-11-03
EP1951042B1 EP1951042B1 (en) 2012-10-10

Family

ID=38067728

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06837559A Active EP1951042B1 (en) 2005-11-18 2006-11-14 Spirolactam tricyclic cgrp receptor antagonists

Country Status (6)

Country Link
US (1) US7947677B2 (en)
EP (1) EP1951042B1 (en)
JP (1) JP2009515973A (en)
AU (1) AU2006316642A1 (en)
CA (1) CA2629415A1 (en)
WO (1) WO2007061692A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006316646A1 (en) 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam bicyclic CGRP receptor antagonists
JP2009515971A (en) 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド Spirohydantoin aryl CGRP receptor antagonist
EP1951228B1 (en) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Bicyclic spirohydantoin cgrp receptor antagonists
US7851464B2 (en) 2005-11-18 2010-12-14 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
CA2629415A1 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam tricyclic cgrp receptor antagonists
CA2629421A1 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists
EP2029575B1 (en) * 2006-05-09 2014-10-22 Merck Sharp & Dohme Corp. Substituted spirocyclic cgrp receptor antagonists
JP5437070B2 (en) * 2006-08-26 2014-03-12 アボット ゲーエムベーハー ウント カンパニー カーゲー Substituted benzimidazolone derivatives, drugs containing the same and uses thereof
EP2152674B1 (en) 2007-05-22 2011-08-03 Boehringer Ingelheim International GmbH Benzimidazolone chymase inhibitors
WO2010107605A1 (en) 2009-03-18 2010-09-23 Merck Sharp & Dohme Corp. Cgrp receptor antagonists
JOP20200116A1 (en) 2015-04-24 2017-06-16 Amgen Inc Methods for treating or preventing migraine headache
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
JP7339262B2 (en) 2018-01-12 2023-09-05 アムジェン インコーポレイテッド PAC1 antibody and uses thereof
CN108658984A (en) * 2018-04-16 2018-10-16 刘洁 A kind of pharmaceutical composition and its preparation method and application for treating rheumatoid arthritis
CN113402467B (en) * 2021-06-18 2022-05-13 山东汇海医药化工有限公司 Synthetic method of flibanserin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006031491A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirolactam cgrp receptor antagonists
WO2007061694A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2709306B1 (en) * 1993-07-20 1995-10-20 Adir New benzospiroalcene derivatives, process for their preparation and pharmaceutical compositions containing them.
US6638941B1 (en) * 1997-05-28 2003-10-28 Osi Pharmaceuticals, Inc. Conformationallly constrained peptidomimetics as β-turn templates and modulators of SH3 domains
US6548710B2 (en) * 2000-10-31 2003-04-15 Akzo Nobel N.V. Process for preparing 1-indanones
EP1608627B1 (en) 2003-03-14 2008-05-07 Merck & Co. Inc. Bicyclic anilide spirohydantoin cgrp receptor antagonists
ATE509019T1 (en) 2003-03-14 2011-05-15 Merck Sharp & Dohme BENZODIAZEPINE PIROHYDANTOINS AS CGRP RECEPTOR ANTAGONISTS
AU2004222328B2 (en) * 2003-03-14 2009-10-08 Merck Sharp & Dohme Corp. Aryl spirohydantoin CGRP receptor antagonists
AU2004221891B2 (en) * 2003-03-14 2009-11-19 Merck Sharp & Dohme Corp. Monocyclic anilide spirohydantoin CGRP receptor antagonists
AU2005282466B2 (en) 2004-09-08 2011-03-10 Merck Sharp & Dohme Corp. Monocyclic anilide spirolactam CGRP receptor antagonists
EP1794133B1 (en) 2004-09-09 2011-12-14 Merck Sharp & Dohme Corp. Aryl spirolactam cgrp receptor antagonists
CN101018781A (en) * 2004-09-13 2007-08-15 默克公司 Bicyclic N-anilide spirolactam CGRP receptor antagonists
US7750010B2 (en) 2004-09-13 2010-07-06 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantion CGRP receptor antagonists
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
US7384931B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
EP1951228B1 (en) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Bicyclic spirohydantoin cgrp receptor antagonists
AU2006316646A1 (en) 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam bicyclic CGRP receptor antagonists
JP2009515971A (en) 2005-11-18 2009-04-16 メルク エンド カムパニー インコーポレーテッド Spirohydantoin aryl CGRP receptor antagonist
US7851464B2 (en) 2005-11-18 2010-12-14 Merck Sharp & Dohme Corp. Spirolactam aryl CGRP receptor antagonists
CA2629415A1 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam tricyclic cgrp receptor antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006031491A2 (en) * 2004-09-09 2006-03-23 Merck & Co., Inc. Tricyclic anilide spirolactam cgrp receptor antagonists
WO2007061694A2 (en) * 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists

Also Published As

Publication number Publication date
JP2009515973A (en) 2009-04-16
AU2006316642A1 (en) 2007-05-31
EP1951042A2 (en) 2008-08-06
EP1951042B1 (en) 2012-10-10
US7947677B2 (en) 2011-05-24
CA2629415A1 (en) 2007-05-31
WO2007061692A3 (en) 2007-11-29
US20090105219A1 (en) 2009-04-23
WO2007061692A2 (en) 2007-05-31

Similar Documents

Publication Publication Date Title
EP1951042A4 (en) SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
FR22C1044I1 (en) CGRP RECEPTOR ANTAGONISTS
ZA200809275B (en) Substituted spirocyclic CGRP receptor antagonists
DK1973886T3 (en) PROKINETICIN-1 Receptor Antagonists
EP1954135A4 (en) SPIROLACTAM ARYL RECEPTOR CGPR RECEPTOR ANTAGONIST
EP1954268A4 (en) SPIROLACTAM BICYCLIC BCRP RECEPTOR ANTAGONISTS
DK1740177T3 (en) Antagonists for muscarinic-sensitive acetylcholine receptors
EP1981902A4 (en) NOGO RECEPTOR ANTAGONISTS
EP1959959A4 (en) MORPHOLINE-carboxamide-Prokineticin Receptor Antagonists
ATE413400T1 (en) CGRP RECEPTOR ANTAGONISTS
DK1720859T3 (en) Chemokine receptor antagonists
DK2009992T3 (en) IL-8 RECEPTOR ANTAGONISTS
ATE505467T1 (en) 2-AZA-BICYCLOÄ3.1.0UHEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
ZA200708067B (en) Spirocyclic thrombin receptor antagonists
DK2081951T3 (en) Progesterone receptor antagonists
EP1765805A4 (en) Cgrp receptor antagonists
EP1951051A4 (en) TRICYCLIC CGRP RECEPTOR ANTAGONISTS OF SPIROHYDANTOIN
ATE429428T1 (en) INDANDERIVATES AS ANTAGONISTS OF THE MCH RECEPTOR
EP1641781A4 (en) BENZODIAZEPINE CGRP RECEPTOR ANTAGONISTS
DE602005004011D1 (en) HYDROISOINDOLIN tachykinin receptor antagonists
ATE537151T1 (en) PYRAZOLINE COMPOUNDS AS MINERALOCORTICOID RECEPTOR ANTAGONISTS
IL195807A0 (en) Cgrp receptor antagonists
EP2254413A4 (en) CGRP RECEPTOR ANTAGONISTS OF THE IMIDAZOBENZAZEPINE TYPE
BRPI0817835A2 (en) CGRP ANTAGONISTS
EP1951228A4 (en) SPIROHYDANTOIN BICLYCLIC CGRP RECEPTOR ANTAGONISTS

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080618

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MERCK SHARP & DOHME CORP.

A4 Supplementary search report drawn up and despatched

Effective date: 20101004

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/06 20060101ALI20100928BHEP

Ipc: A61K 31/4747 20060101ALI20100928BHEP

Ipc: C07D 519/00 20060101AFI20100928BHEP

Ipc: A61K 31/499 20060101ALI20100928BHEP

Ipc: A61K 31/4985 20060101ALI20100928BHEP

Ipc: A61K 31/551 20060101ALI20100928BHEP

Ipc: A61K 31/4355 20060101ALI20100928BHEP

Ipc: A61K 31/55 20060101ALI20100928BHEP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 602006032444

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: A01N0035000000

Ipc: C07D0519000000

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 25/06 20060101ALI20120315BHEP

Ipc: A61K 31/551 20060101ALI20120315BHEP

Ipc: A61K 31/4985 20060101ALI20120315BHEP

Ipc: A61K 31/4355 20060101ALI20120315BHEP

Ipc: A61K 31/55 20060101ALI20120315BHEP

Ipc: A61K 31/499 20060101ALI20120315BHEP

Ipc: A61K 31/4747 20060101ALI20120315BHEP

Ipc: C07D 519/00 20060101AFI20120315BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

DAX Request for extension of the european patent (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SCHERING CORPORATION

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MERCK SHARP & DOHME CORP.

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 578927

Country of ref document: AT

Kind code of ref document: T

Effective date: 20121015

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602006032444

Country of ref document: DE

Effective date: 20121206

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20121228

Year of fee payment: 7

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 578927

Country of ref document: AT

Kind code of ref document: T

Effective date: 20121010

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130121

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130210

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130111

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130211

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20121228

Year of fee payment: 7

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20130110

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

26N No opposition filed

Effective date: 20130711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121114

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602006032444

Country of ref document: DE

Effective date: 20130711

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20121010

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121114

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20140601

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20061114

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131130

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20131130

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20140601

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 10

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 11

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 12

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602006032444

Country of ref document: DE

Owner name: MERCK SHARP & DOHME LLC, RAHWAY, US

Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20220908 AND 20220914

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20231013

Year of fee payment: 18

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20231010

Year of fee payment: 18

Ref country code: DE

Payment date: 20231010

Year of fee payment: 18