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EP1807527A4 - High arachidonic acid producing strains of yarrowia lipolytica - Google Patents

High arachidonic acid producing strains of yarrowia lipolytica

Info

Publication number
EP1807527A4
EP1807527A4 EP05851406A EP05851406A EP1807527A4 EP 1807527 A4 EP1807527 A4 EP 1807527A4 EP 05851406 A EP05851406 A EP 05851406A EP 05851406 A EP05851406 A EP 05851406A EP 1807527 A4 EP1807527 A4 EP 1807527A4
Authority
EP
European Patent Office
Prior art keywords
arachidonic acid
yarrowia lipolytica
acid producing
producing strains
high arachidonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP05851406A
Other languages
German (de)
French (fr)
Other versions
EP1807527B1 (en
EP1807527A2 (en
Inventor
Howard G Damude
Peter John Gillies
Daniel Joseph Macool
Stephen K Picataggio
Dana M Walters Pollak
James John Ragghianti
Zhixiong Xue
Narendra S Yadav
Hongxiang Zhang
Quinn Qun Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Priority to DK12152258.5T priority Critical patent/DK2458000T3/en
Priority to EP12152258.5A priority patent/EP2458000B1/en
Publication of EP1807527A2 publication Critical patent/EP1807527A2/en
Publication of EP1807527A4 publication Critical patent/EP1807527A4/en
Application granted granted Critical
Publication of EP1807527B1 publication Critical patent/EP1807527B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
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EP05851406.8A 2004-11-04 2005-11-03 High arachidonic acid producing strains of yarrowia lipolytica Not-in-force EP1807527B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DK12152258.5T DK2458000T3 (en) 2004-11-04 2005-11-03 STARES OF YARROWIA LIPOLYTICA, PRODUCING GREAT QUANTITIES OF ARACHIDONIC ACID
EP12152258.5A EP2458000B1 (en) 2004-11-04 2005-11-03 High arachidonic acid producing strains of yarrowia lipolytica

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62481204P 2004-11-04 2004-11-04
PCT/US2005/040306 WO2006055322A2 (en) 2004-11-04 2005-11-03 High arachidonic acid producing strains of yarrowia lipolytica

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP12152258.5 Division-Into 2012-01-24

Publications (3)

Publication Number Publication Date
EP1807527A2 EP1807527A2 (en) 2007-07-18
EP1807527A4 true EP1807527A4 (en) 2009-08-19
EP1807527B1 EP1807527B1 (en) 2013-07-17

Family

ID=36337096

Family Applications (5)

Application Number Title Priority Date Filing Date
EP05818267A Withdrawn EP1807526A4 (en) 2004-11-04 2005-11-03 High eicosapentaenoic acid producing strains of yarrowia lipolytica
EP13161757.3A Not-in-force EP2649887B1 (en) 2004-11-04 2005-11-03 High eicosapentaenoic acid producing strains of Yarrowia lipolytica
EP05818385.6A Not-in-force EP1809756B1 (en) 2004-11-04 2005-11-03 Docosahexaenoic acid producing strains of yarrowia lipolytica
EP05851406.8A Not-in-force EP1807527B1 (en) 2004-11-04 2005-11-03 High arachidonic acid producing strains of yarrowia lipolytica
EP12152258.5A Not-in-force EP2458000B1 (en) 2004-11-04 2005-11-03 High arachidonic acid producing strains of yarrowia lipolytica

Family Applications Before (3)

Application Number Title Priority Date Filing Date
EP05818267A Withdrawn EP1807526A4 (en) 2004-11-04 2005-11-03 High eicosapentaenoic acid producing strains of yarrowia lipolytica
EP13161757.3A Not-in-force EP2649887B1 (en) 2004-11-04 2005-11-03 High eicosapentaenoic acid producing strains of Yarrowia lipolytica
EP05818385.6A Not-in-force EP1809756B1 (en) 2004-11-04 2005-11-03 Docosahexaenoic acid producing strains of yarrowia lipolytica

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP12152258.5A Not-in-force EP2458000B1 (en) 2004-11-04 2005-11-03 High arachidonic acid producing strains of yarrowia lipolytica

Country Status (9)

Country Link
US (8) US7588931B2 (en)
EP (5) EP1807526A4 (en)
JP (3) JP5139806B2 (en)
KR (3) KR20070085649A (en)
CN (4) CN101437952A (en)
CA (3) CA2585178C (en)
DK (4) DK1807527T3 (en)
NO (3) NO20072517L (en)
WO (3) WO2006052870A2 (en)

Families Citing this family (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313911B2 (en) * 2003-05-07 2012-11-20 E I Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
EP2166067B1 (en) 2003-08-01 2015-07-01 BASF Plant Science GmbH Method for producing polyunsaturated fatty acids in transgenic organisms
ES2421440T3 (en) 2004-02-27 2013-09-02 Basf Plant Science Gmbh Method for preparing polyunsaturated fatty acids in transgenic plants
CN103451246B (en) * 2004-04-22 2018-02-16 联邦科学技术研究组织 With recombinant cell synthesis of long-chain polyunsaturated fatty acids
CA2884237C (en) 2004-04-22 2020-09-08 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
CA2568689A1 (en) * 2004-06-04 2005-12-15 Fluxome Sciences A/S Metabolically engineered cells for the production of polyunsaturated fatty acids
US20060094102A1 (en) * 2004-11-04 2006-05-04 Zhixiong Xue Ammonium transporter promoter for gene expression in oleaginous yeast
US7879591B2 (en) 2004-11-04 2011-02-01 E.I. Du Pont De Nemours And Company High eicosapentaenoic acid producing strains of Yarrowia lipolytica
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
GB0503657D0 (en) 2005-02-22 2005-03-30 Fluxome Sciences As Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
US7470532B2 (en) * 2005-10-19 2008-12-30 E.I. Du Pont De Nemours And Company Mortierella alpina C16/18 fatty acid elongase
JP5123861B2 (en) * 2005-11-23 2013-01-23 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Δ9 elongases and their use in the production of polyunsaturated fatty acids
AR059376A1 (en) 2006-02-21 2008-03-26 Basf Plant Science Gmbh PROCEDURE FOR THE PRODUCTION OF POLYINSATURATED FATTY ACIDS
US7465793B2 (en) 2006-04-20 2008-12-16 E.I. Du Pont De Nemours And Company Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
WO2007127377A2 (en) * 2006-04-28 2007-11-08 Resolvyx Pharmaceuticals, Inc. Combinations comprising omega-3 fatty acid compounds for the treatment of cardiovascular disease
US7695950B2 (en) 2006-05-17 2010-04-13 E. I. Du Pont De Nemours And Company Δ5 desaturase and its use in making polyunsaturated fatty acids
US7678560B2 (en) 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
GB0614442D0 (en) 2006-07-20 2006-08-30 Fluxome Sciences As Metabolically engineered cells for the production of pinosylvin
US9029111B2 (en) 2006-08-24 2015-05-12 Basf Plant Science Gmbh Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains
EP2059588A4 (en) 2006-08-29 2010-07-28 Commw Scient Ind Res Org SYNTHESIS OF FATTY ACIDS
US20080095711A1 (en) * 2006-08-31 2008-04-24 Falck John R Modulators of Pulmonary Hypertension
AU2007322223B2 (en) 2006-10-23 2012-12-13 Corteva Agriscience Llc Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7709239B2 (en) * 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
US8846374B2 (en) 2006-12-12 2014-09-30 E I Du Pont De Nemours And Company Carotenoid production in a recombinant oleaginous yeast
US7923223B2 (en) 2006-12-20 2011-04-12 E. I. Du Pont De Nemours And Company Δ-9 desaturase and its use in making polyunsaturated fatty acids
BRPI0806354A2 (en) 2007-02-12 2011-09-06 Du Pont transgender oilseeds, seeds, oils, food or food analogues, medicinal food products or medicinal food analogues, pharmaceuticals, beverage formulas for babies, nutritional supplements, pet food, aquaculture feed, animal feed, whole seed products , mixed oil products, partially processed products, by-products and by-products
US8188338B2 (en) * 2007-04-10 2012-05-29 E. I. Du Pont De Nemours And Company Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US8957280B2 (en) 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
CN101541963B (en) * 2007-05-25 2012-10-31 三得利控股株式会社 Novel lysophosphatidate acyltransferase gene
EP2152849B1 (en) 2007-06-01 2013-02-20 Solazyme, Inc. Production of oil in microorganisms
JP5451387B2 (en) * 2007-06-18 2014-03-26 サントリーホールディングス株式会社 Glycerol-3-phosphate acyltransferase (GPAT) homolog and use thereof
DE112008001989A5 (en) * 2007-07-31 2010-06-10 Basf Plant Science Gmbh Desaturases and methods of producing polyunsaturated fatty acids in transgenic organisms
CN101970638B (en) 2007-10-03 2015-02-11 纳幕尔杜邦公司 Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
DK2198005T3 (en) * 2007-10-03 2014-07-21 Du Pont Peroxisome Biogenesis Factor Protein (PEX) Breakage to Change the Contents of Polyunsaturated Fatty Acids and Total Lipid Content in Oily Eukaryotic Organisms
US8343753B2 (en) * 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
US8486478B2 (en) 2007-11-08 2013-07-16 International Great Brands LLC Structured lipid compositions
US8206772B2 (en) 2007-11-08 2012-06-26 Kraft Foods Global Brands Llc Structured lipid compositions and methods of formulation thereof
US7879384B2 (en) 2007-11-08 2011-02-01 Kraft Foods Global Brands Llc Structured glycerol esters useful as edible moisture barriers
WO2009126548A2 (en) * 2008-04-07 2009-10-15 Rich Products Corporation Method for preparing edible aquatic animals for storage
US20090291479A1 (en) * 2008-05-23 2009-11-26 E. I. Du Pont De Nemours And Company Manipulation of acyl-coa binding protein expression for altered lipid production in microbial hosts
US8168858B2 (en) 2008-06-20 2012-05-01 E. I. Du Pont De Nemours And Company Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids
WO2010004784A1 (en) * 2008-07-10 2010-01-14 株式会社Ｊ－オイルミルズ Taste-improving agent for foods and drinks
EP2331695B1 (en) * 2008-08-26 2014-07-23 BASF Plant Science GmbH Nucleic acids encoding desaturases and modified plant oil
BRPI0913138A2 (en) 2008-08-29 2016-05-31 Du Pont transgenic eukaryotic oleaginous host cell, transgenic oleaginous eukaryotic yeast cell, oil or lipids, method for increasing the total lipid content of an oleaginous eukaryotic host cell and method for increasing the total polyunsaturated fatty acid content in the microbial oil
US20100297296A1 (en) * 2008-10-14 2010-11-25 Solazyme, Inc. Healthier Baked Goods Containing Microalgae
US20100303989A1 (en) * 2008-10-14 2010-12-02 Solazyme, Inc. Microalgal Flour
BRPI0921467B1 (en) 2008-11-18 2021-12-14 Commonwealth Scientific And Industrial Research Organisation PROCESS FOR THE PRODUCTION OF OIL COMPRISING EICOSAPENTAENOIC ACID (EPA), DOCOSAPENTAENOIC ACID (DPA) AND DOCOSAHEXAENOIC ACID (DHA)
ES2742527T3 (en) 2008-11-28 2020-02-14 Corbion Biotech Inc Manufacture of customized oils in recombinant heterotrophic microorganisms
WO2010080388A1 (en) 2008-12-18 2010-07-15 E. I. Du Pont De Nemours And Company Reducing byproduction of malonates in a fermentation process
AU2010225738B2 (en) 2009-03-18 2015-01-29 Suntory Holdings Limited Novel acetyl-CoA carboxylase
NZ595271A (en) * 2009-03-19 2013-08-30 Los Angeles Biomed Res Inst Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
CA2755387C (en) * 2009-03-26 2018-06-26 Suntory Holdings Limited Mortierella alpina lysophospholipid acyltransferase
US8399226B2 (en) * 2009-06-16 2013-03-19 E I Du Pont De Nemours And Company High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica
WO2010147904A1 (en) 2009-06-16 2010-12-23 E. I. Du Pont De Nemours And Company Improved optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
WO2010147900A1 (en) 2009-06-16 2010-12-23 E. I. Du Pont De Nemours And Company IMPROVEMENT OF LONG CHAIN OMEGA-3 AND OMEGA-6 POLYUNSATURATED FATTY ACID BIOSYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYLTRANSFERASES
WO2010147907A1 (en) * 2009-06-16 2010-12-23 E. I. Du Pont De Nemours And Company High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica
JP5193371B2 (en) * 2009-09-18 2013-05-08 サントリーホールディングス株式会社 Glycerol-3-phosphate acyltransferase
US8637733B2 (en) 2009-12-24 2014-01-28 E.I. Du Pont De Nemours And Company Plant membrane bound O-acyl transferase (MBOAT) family protein sequences and their uses for altering fatty acid compositions
WO2011087981A2 (en) 2010-01-15 2011-07-21 E. I. Du Pont De Nemours And Company Clinical benefits of eicosapentaenoic acid in humans
MY160121A (en) 2010-01-19 2017-02-28 Dsm Ip Assets Bv Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
CN102947447B (en) * 2010-02-03 2015-05-13 三得利控股株式会社 Glycerol-3-phosphate acyltransferase homologue and use thereof
WO2011133610A1 (en) 2010-04-22 2011-10-27 E. I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
GB201008826D0 (en) 2010-05-26 2010-07-14 Fluxome Sciences As Production of metabolites
WO2011150411A1 (en) 2010-05-28 2011-12-01 Solazyme, Inc. Food compositions comprising tailored oils
US8769868B2 (en) 2010-06-09 2014-07-08 Photonz Corporation Limited Compositions comprising eicosapentaenoic acid suitable for high purification
EP2603092A1 (en) 2010-08-11 2013-06-19 E.I. Du Pont De Nemours And Company Improved aquaculture meat products
US20120040076A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Aquaculture feed compositions
EP2603094A1 (en) 2010-08-11 2013-06-19 E.I. Du Pont De Nemours And Company A sustainable aquaculture feeding strategy
CA2807834C (en) 2010-08-26 2019-06-25 E. I. Du Pont De Nemours And Company Recombinant microbial host cells for high eicosapentaenoic acid production
EP2609202A1 (en) 2010-08-26 2013-07-03 E.I. Du Pont De Nemours And Company Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids
BR112013004356A2 (en) 2010-08-26 2017-06-27 Du Pont isolated polynucleotide, mutant polypeptide, recombinant construct, transformed cell, method for producing a polyunsaturated fatty acid, microbial oil and recombinant microbial host cell.
CN101979622B (en) * 2010-09-13 2012-10-10 北京凯泰新世纪生物技术有限公司 Method for synthesizing fish oil ethyl ester by lipase catalysis
KR102065526B1 (en) 2010-11-03 2020-01-14 테라비아 홀딩스 인코포레이티드 Microbial oils with lowered pour points, dielectric fluids produced therefrom, and releated methods
EP2658962A1 (en) 2010-12-30 2013-11-06 E.I. Du Pont De Nemours And Company Use of saccharomyces cerevisiae suc2 gene in yarrowia lipolytica for sucrose utilization
US8865429B2 (en) 2010-12-30 2014-10-21 E I Du Pont De Nemours And Company Increased oil content by increasing Yap1 transcription factor activity in oleaginous yeasts
EP2670855B1 (en) 2011-02-02 2019-08-21 Corbion Biotech, Inc. Tailored oils produced from recombinant oleaginous microorganisms
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
JP2014510166A (en) 2011-02-11 2014-04-24 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Purification of triglyceride oil from microbial sources using short path distillation
WO2012109545A2 (en) 2011-02-11 2012-08-16 E. I. Du Pont De Nemours And Company Method for obtaining a lipid-containing composition from microbial biomass
WO2012135773A1 (en) 2011-03-31 2012-10-04 E. I. Du Pont De Nemours And Company Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
WO2012135777A1 (en) 2011-04-01 2012-10-04 E. I. Du Pont De Nemours And Company Yarrowia esterase/lipase promoter regions for gene expression in yeast
WO2012138613A1 (en) 2011-04-05 2012-10-11 E. I. Du Pont De Nemours And Company Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
US8609369B2 (en) 2011-04-07 2013-12-17 E I Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
AU2012253803A1 (en) 2011-05-06 2013-12-05 Terravia Holdings, Inc. Genetically engineered microorganisms that metabolize xylose
US8785164B2 (en) * 2011-05-26 2014-07-22 E I Du Pont De Nemours And Company Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein
CN102559710B (en) * 2011-06-27 2013-10-30 中国农业科学院油料作物研究所 Isochrysis sphaerica delta 4-fatty acid desaturase gene and cloning method thereof
CN102373229B (en) * 2011-06-27 2013-09-11 中国农业科学院油料作物研究所 Saccharomyces oleaginosus delta12 and delta15 difunctional fatty acid desaturase gene and cloning method thereof
KR102149068B1 (en) 2011-07-21 2020-08-31 디에스엠 아이피 어셋츠 비.브이. Fatty acid compositions
US20140323569A1 (en) * 2011-07-21 2014-10-30 Krishna Raman Microbial oils enriched in polyunsaturated fatty acids
KR102036389B1 (en) 2011-10-19 2019-10-24 메사추세츠 인스티튜트 오브 테크놀로지 Engineered microbes and methods for microbial oil production
JP5685783B2 (en) * 2012-01-19 2015-03-18 国立大学法人名古屋大学 Novel Yarrowia microorganism, oil decomposing agent and oil decomposing / removing method using the same
CN104364386A (en) 2012-04-18 2015-02-18 索拉兹米公司 Tailored oils
US9719114B2 (en) 2012-04-18 2017-08-01 Terravia Holdings, Inc. Tailored oils
NZ631702A (en) 2012-06-15 2017-01-27 Grains Res & Dev Corp Production of long chain polyunsaturated fatty acids in plant cells
WO2013192007A1 (en) 2012-06-19 2013-12-27 E. I. Du Pont De Nemours And Company MUTANT ACYL-CoA:LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASES
SG11201501013PA (en) 2012-08-10 2015-04-29 Opx Biotechnologies Inc Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN105121646B (en) * 2012-10-30 2020-07-21 农业研究有限公司 Novel acyltransferase polynucleotides, polypeptides, and methods of use thereof
JP6064573B2 (en) * 2012-12-12 2017-01-25 栗田工業株式会社 Feed additives and mixed feed
JP2016502852A (en) 2012-12-21 2016-02-01 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ Recombinant microbial cells that produce at least 28% eicosapentaenoic acid by dry cell weight
US9005940B2 (en) 2012-12-21 2015-04-14 E I Du Pont De Nemours And Company Down-regulation of a polynucleotide encoding a Sou2 sorbitol utilization protein to modify lipid production in microbial cells
PT2934505T (en) 2012-12-24 2021-07-02 Qualitas Health Inc Eicosapentaenoic acid (epa) formulations
US10098371B2 (en) 2013-01-28 2018-10-16 Solazyme Roquette Nutritionals, LLC Microalgal flour
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
US20150057465A1 (en) 2013-03-15 2015-02-26 Opx Biotechnologies, Inc. Control of growth-induction-production phases
BR112015026948A8 (en) 2013-04-26 2017-10-03 Solazyme Inc "COMPOSITIONS, LUBRICANT, SURFACE, SOLVENT, CLEANING FORMULATION, RETICULABLE OR RETICULATED RUBBER COMPOSITION, TIRE STRIP, POLYURETHANE FOAM AND ITS PREPARATION METHOD
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
FR3009619B1 (en) 2013-08-07 2017-12-29 Roquette Freres BIOMASS COMPOSITIONS OF MICROALGUES RICH IN PROTEINS OF SENSORY QUALITY OPTIMIZED
WO2015021352A2 (en) 2013-08-08 2015-02-12 Knipbio Methylotrophs for aquaculture and animal feed
WO2015025920A1 (en) * 2013-08-22 2015-02-26 協和発酵バイオ株式会社 Arachidonic acid-producing polyketide synthase and use thereof
SG11201602638SA (en) 2013-10-04 2016-05-30 Solazyme Inc Tailored oils
US9820484B2 (en) * 2013-12-04 2017-11-21 Nippon Suisan Kaisha, Ltd. Dihomo-γ-linolenic acid-containing microbial oil and dihomo-γ-linolenic acid-containing microbial biomass
WO2015196250A1 (en) * 2014-06-27 2015-12-30 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
KR102535223B1 (en) 2013-12-18 2023-05-30 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 Lipid comprising long chain polyunsaturated fatty acids
BR112016017468A2 (en) 2014-01-31 2017-10-10 Dsm Ip Assets Bv suitable promoters for the expression of heterologous genes in yeast
WO2015123456A1 (en) 2014-02-12 2015-08-20 OmniGen Research, L.L.C. Composition and method for promoting reduction of heat stress in animals
EP3110947B1 (en) 2014-02-24 2019-09-04 Novogy Inc. Diacylglycerol acyl transferase (dga1) polynucleotides, and methods of increasing yeast cell lipid production by overexpression of heterologous dga1
US9394550B2 (en) 2014-03-28 2016-07-19 Terravia Holdings, Inc. Lauric ester compositions
AU2015252916B2 (en) * 2014-05-01 2018-08-09 Ginkgo Bioworks, Inc. Increasing cellular lipid production by increasing the activity of diacylglycerol acyltransferase and decreasing the activity of triacylglycerol lipase
CN106715678A (en) 2014-05-29 2017-05-24 诺沃吉公司 Increasing lipid production in oleaginous yeast
KR102673214B1 (en) * 2014-06-27 2024-06-10 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 Lipid comprising docosapentaenoic acid
BR112017000414A2 (en) 2014-07-10 2017-11-07 Terravia Holdings Inc ketoacyl acp synthase genes and their uses
CN104099254B (en) * 2014-07-11 2017-02-15 无锡超科食品有限公司 Bacterial strain for producing polyunsaturated fatty acids and screening method thereof
WO2016014968A1 (en) 2014-07-24 2016-01-28 Solazyme, Inc. Variant thioesterases and methods of use
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3194582A2 (en) 2014-09-18 2017-07-26 TerraVia Holdings, Inc. Acyl-acp thioesterases and mutants thereof
WO2016075314A1 (en) 2014-11-13 2016-05-19 Institut National De La Recherche Agronomique Identification of yarrowia lipolytica transcription factors that affect protein production
FR3028527A1 (en) 2014-11-13 2016-05-20 Pivert IDENTIFICATION OF TRANSCRIPTION FACTORS OF YARROWIA LIPOLYTICA
CN107208088B (en) * 2014-12-10 2022-02-11 银杏生物制品公司 Oleic acid production in yeast
WO2016092071A1 (en) * 2014-12-12 2016-06-16 Dsm Ip Assets B.V. Feed supplement material for use in aquaculture feed
AU2016269143A1 (en) 2015-05-28 2017-11-30 Evolva Sa Biosynthesis of phenylpropanoids and phenylpropanoid derivatives
CN105176848B (en) * 2015-08-19 2017-05-17 江南大学 Mortierella alpine strain overexpressing 3-phosphoglycerol dehydrogenase gene(G3PD1), and construction method and application thereof
WO2017044832A1 (en) * 2015-09-09 2017-03-16 Omnigen Research, Llc A composition and/or combination for aquaculture
EP3370542A1 (en) 2015-10-01 2018-09-12 DSM IP Assets B.V. Supplement material for use in pet food
JP7011590B2 (en) 2015-10-12 2022-02-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Protected DNA template and method of use for increased intracellular gene recombination and homologous recombination
WO2017100158A1 (en) 2015-12-11 2017-06-15 Danisco Us Inc. Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
WO2017105991A1 (en) 2015-12-18 2017-06-22 Danisco Us Inc. Methods and compositions for t-rna based guide rna expression
CN106434416B (en) * 2016-07-28 2019-08-30 中国农业科学院油料作物研究所 A bacterial strain producing eicosapentaenoic acid and its application
JP2020506702A (en) 2017-02-02 2020-03-05 カーギル インコーポレイテッド Genetically modified cells producing C6-C10 fatty acid derivatives
CN107345211A (en) * 2017-04-27 2017-11-14 广州弘宝元生物科技有限公司 Introduce living cells liposome and its application of allogenic polypeptide
US11560583B2 (en) 2017-06-01 2023-01-24 Knipbio, Inc. Heterologous carotenoid production in microorganisms
CN109234216B (en) * 2017-07-10 2022-05-20 上海医药工业研究院 A kind of genetic engineering bacteria for producing squalene and method thereof
CN108467841B (en) * 2018-03-23 2021-08-24 辽宁大学 Vermiculite-immobilized mixed bacteria particles resistant to low temperature degradation of polycyclic aromatic hydrocarbons and their preparation method and application
CN110358692B (en) * 2018-04-09 2021-07-27 中国科学院青岛生物能源与过程研究所 Recombinant yeast strain for producing nervonic acid and its application
WO2019209241A1 (en) 2018-04-23 2019-10-31 Dupont Nutrition Biosciences Aps Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
CN110373437B (en) * 2018-12-11 2022-09-27 山东理工大学 Construction and fermentation technology of a cell factory of stearidonic acid-producing Mucor peregrine
CN109929870B (en) * 2019-02-20 2021-03-16 天津大学 Application of sugar metabolism and lipid metabolism for synergistically improving yield of fatty acid derivatives synthesized by yarrowia lipolytica
CN111685223B (en) * 2019-03-13 2024-02-02 吉态来博(北京)生物科技发展有限公司 Feed containing yarrowia lipolytica, preparation method and application thereof
CN109837256B (en) * 2019-03-21 2020-12-01 江南大学 A kind of diacylglycerol acyltransferase 1 and its application in producing triglyceride
CN110229832A (en) * 2019-06-16 2019-09-13 山东理工大学 A kind of bacterial strain and method improving formula solution rouge yeast bio amount and cell wall yield
CN110499259B (en) * 2019-07-22 2021-07-27 浙江工业大学 A kind of Yarrowia Yarrowia YW100-1 and its application
CN110923261B (en) * 2019-12-20 2021-12-17 江南大学 Method for increasing content of fatty acid C20:0 and/or C22:0 in cell membrane of saccharomyces cerevisiae
WO2021130078A1 (en) 2019-12-23 2021-07-01 Dsm Ip Assets B.V. Aquaculture feed
CN112538438B (en) * 2020-12-11 2023-04-04 南京工业大学 Recombinant yarrowia lipolytica with high oleic acid yield as well as construction method and application thereof
CN116600653A (en) 2020-12-17 2023-08-15 帝斯曼知识产权资产管理有限公司 Aquaculture feed
WO2022178302A1 (en) * 2021-02-18 2022-08-25 Zero Acre Farms Inc. Systems and methods of making oil from microorganisms
CA3210860A1 (en) * 2021-03-03 2022-09-09 Anna EL TAHCHY Production of phospholipids in microbes and uses thereof
CN113388533B (en) * 2021-06-11 2022-09-20 东北农业大学 Debaryomyces hansenii with good fermentation performance and fragrance production function and screening method thereof
WO2023105498A1 (en) * 2021-12-10 2023-06-15 Phycoil Biotechnology International, Inc. Heterotrophic production of essential long-chain polyunsaturated lipids (lcpufa) in auxenochlorella protothecoides
KR20240137096A (en) 2022-02-02 2024-09-19 디에스엠 아이피 어셋츠 비.브이. Yarrowia production method
CN115029257B (en) * 2022-05-05 2023-09-26 南京工业大学 Recombinant Yarrowia lipolytica producing β-carotene and its construction method and application

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005277A2 (en) * 1978-05-08 1979-11-14 Cpc International Inc. Process for the microbiological production of oil
WO2002008401A2 (en) * 2000-07-24 2002-01-31 Abbott Laboratories Elongase genes and uses thereof
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
WO2003093482A2 (en) * 2002-04-29 2003-11-13 Basf Plant Science Gmbh Method for producing multiple unsaturated fatty acids in plants
WO2004071467A2 (en) * 2003-02-12 2004-08-26 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oilseed plants
WO2004101757A2 (en) * 2003-05-07 2004-11-25 E.I. Dupont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
WO2005047485A2 (en) * 2003-11-12 2005-05-26 E.I. Dupont De Nemours And Company Delta12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2454404A (en) 1942-10-03 1948-11-23 American Cyanamid Co Preparation of piperazine
US2454504A (en) 1946-01-29 1948-11-23 Franz F Ehrenhaft Nonintermittent cinematographic projector
US4670285A (en) 1982-08-06 1987-06-02 The University Of Toronto Innovations Foundation Infant formula
US4880741A (en) 1983-10-06 1989-11-14 Pfizer Inc. Process for transformation of Yarrowia lipolytica
US5071764A (en) 1983-10-06 1991-12-10 Pfizer Inc. Process for integrative transformation of yarrowia lipolytica
GB8407195D0 (en) 1984-03-20 1984-04-26 Cadbury Schweppes Plc Microbial desaturase enzyme inhibitors
US4792523A (en) 1984-08-31 1988-12-20 Cetus Corporation 3'Expression enhancing fragments and method
DD227448A1 (en) 1984-10-18 1985-09-18 Akad Wissenschaften Ddr METHOD FOR THE PRODUCTION OF CITRIC ACID ON MICROBIAL WAYS
JPH075484B2 (en) 1985-03-06 1995-01-25 帝人株式会社 Blood-brain barrier crossing pharmaceutical composition
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
CA1317901C (en) 1986-07-08 1993-05-18 Yoshifumi Shinmen Process for production of bishomo-_-linolenic acid and eicosapentaenoic acid
JP2527340B2 (en) 1986-12-15 1996-08-21 アプライド バイオシステムズ インコーポレイテッド 5- and 6-succinimidyl carboxylate isomers of rhodamine dyes
US5246841A (en) 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
DD259637A1 (en) 1987-04-09 1988-08-31 Adw Ddr PROCESS FOR THE PREPARATION OF ISOZITRATLYASE IN RECOMBINANT MICROORGANISMS
SU1454852A1 (en) 1987-05-19 1989-01-30 Институт Микробиологии Им.Августа Кирхенштейна Strain of jarrowia lipolytical yeast as producer of and nutrient medium for lipase cultivation
JP2582622B2 (en) 1987-10-27 1997-02-19 日東化学工業株式会社 Production of polyunsaturated fatty acids by filamentous fungi
DD267999B5 (en) 1988-01-06 2000-08-10 Akad Wissenschaften Ddr PROCESS FOR THE PREPARATION OF 2-OXOGLUTARIC ACID BY YEAST
US5340742A (en) 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
DD275480A1 (en) 1988-09-15 1990-01-24 Ve Forschungszentrum Biotechno PROCESS FOR THE PREPARATION OF CITRIC ACID BY AEROBE SUBMERSE CULTIVATION OF HEEDS
US5057419A (en) 1988-09-22 1991-10-15 Rutgers University Genetically engineered plasmid and organisms for the production of specialized oils
DD279267A1 (en) 1989-01-05 1990-05-30 Akad Wissenschaften Ddr PROCESS FOR PRODUCING MICROBIAL LIPASE
PL160027B1 (en) 1989-03-23 1993-01-29 Akad Rolnicza Method of simultaneously obtaining citric and isocitric acids
DD285372A5 (en) 1989-06-29 1990-12-12 Ingenieurtechnik,Dd PROCESS FOR IMMOBILIZING MICROORGANISMS OR COIMMOBILIZATION OF MICROORGANISMS AND ENZYMES
DD285370A5 (en) 1989-06-29 1990-12-12 Ingenieurtechnik Im Stammbetrieb Veb Kombinat Suesswaren,Dd PROCESS FOR IMMOBILIZING MICROORGANISMS OR COIMMOBILIZATION OF MICROORGANISMS AND ENZYMES
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
JP3007119B2 (en) 1990-01-12 2000-02-07 紀夫 村田 DNA strand encoding glycerol-3-phosphate acyltransferase
DE69133261D1 (en) 1990-03-16 2003-06-26 Calgene Llc Davis DNAS CODING FOR VEGETABLE DESATURASES AND THEIR APPLICATIONS
US5244921A (en) 1990-03-21 1993-09-14 Martek Corporation Eicosapentaenoic acids and methods for their production
WO1991018985A1 (en) 1990-05-25 1991-12-12 E.I. Du Pont De Nemours And Company Nucleotide sequence of soybean stearoyl-acp desaturase gene
US5658767A (en) * 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
US5246842A (en) 1991-10-30 1993-09-21 The United States Of America As Represented By The Secretary Of Agriculture Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source
AU675923B2 (en) 1991-12-04 1997-02-27 E.I. Du Pont De Nemours And Company Fatty acid desaturase genes from plants
US5246642A (en) * 1992-02-04 1993-09-21 Slaughter Jr Gibbs M Method for resurfacing fiberglass boat hulls
JPH05308978A (en) 1992-05-11 1993-11-22 Onoda Cement Co Ltd Production of docosahexaenoic acid using algae
DE578388T1 (en) 1992-06-25 1995-03-16 Int Flavors & Fragrances Inc Process for the fermentative production of 10-hydroxy-C18-carboxylic acid and gamma-dodecalactone derivatives.
IT1256043B (en) 1992-08-12 1995-11-21 Mutant strain of Yarrowia lipolytica and process for the production of citric acid
AU5407594A (en) 1992-11-17 1994-06-08 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
US5910630A (en) 1994-04-06 1999-06-08 Davies; Huw Maelor Plant lysophosphatidic acid acyltransferases
US6093568A (en) 1994-04-06 2000-07-25 Calgene, Inc. Plant lysophosphatidic acid acyltransferases
WO1996033263A1 (en) 1995-04-17 1996-10-24 JAPAN, represented by DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY Novel microorganisms capable of producing highly unsaturated fatty acids and process for producing highly unsaturated fatty acids by using the microorganisms
FR2734843A1 (en) 1995-06-02 1996-12-06 Centre Nat Rech Scient Bio-conversion of substrate with microbe auxotrophic for cpd. in medium deficient in this cpd.
EP0770683A1 (en) 1995-10-04 1997-05-02 Mitsubishi Chemical Corporation Method for producing erythritol
JPH09252790A (en) 1996-03-21 1997-09-30 Japan Energy Corp Fermentation method for producing pyruvic acid
EP1506996A3 (en) * 1996-03-28 2006-06-14 DSM IP Assets B.V. Preparation of microbial polyunsaturated fatty acid containing oil from pasteurised biomass
WO1997044470A1 (en) 1996-05-21 1997-11-27 Novo Nordisk A/S Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
CA2261231C (en) 1996-07-23 2012-11-27 Nagase Biochemicals, Ltd. Process using ulkenia sp. to prepare docosahexaenoic acid and docosapentaenoic acid
JP3792309B2 (en) * 1996-08-30 2006-07-05 サントリー株式会社 Process for producing unsaturated fatty acid-containing fats and oils
RU2090611C1 (en) 1996-09-27 1997-09-20 Финогенова Татьяна Васильевна Strain of yeast yarrowia lipolytica - producer of citric acid, method of producing citric acid and method of sodium citrate isolation
EP0956013B1 (en) 1996-10-11 2003-04-09 Scarista Limited Pharmaceutical preparation comprising eicosapentaenoic acid and/or stearidonic acid
US6075183A (en) 1997-04-11 2000-06-13 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US5972664A (en) * 1997-04-11 1999-10-26 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
EP1034308A4 (en) 1997-12-04 2002-04-03 Smithkline Beecham Corp Method of generating conditionally expressed mutant cells using expressible antisense sequences
US6344548B1 (en) 1998-06-24 2002-02-05 The Regents Of The University Of California Diacylglycerol o-acyltransferase
US20030167483A1 (en) 1998-06-24 2003-09-04 Farese Robert V. Diacylglycerol O-acyltransferase
US7135617B2 (en) 1998-07-02 2006-11-14 Calgene Llc Diacylglycerol acyl transferase proteins
ATE442435T1 (en) 1998-07-02 2009-09-15 Calgene Llc DIACYLGLYCEROL-ACYLTRANSFERASE PROTEINS
US6403349B1 (en) 1998-09-02 2002-06-11 Abbott Laboratories Elongase gene and uses thereof
US6100077A (en) 1998-10-01 2000-08-08 The Trustees Of Columbia University In The City Of New York Isolation of a gene encoding diacylglycerol acyltransferase
EP0997533A1 (en) 1998-10-24 2000-05-03 Haarmann & Reimer Gmbh Process for the production of gamma-decalactone
FR2785911B1 (en) 1998-11-18 2001-01-26 Agronomique Inst Nat Rech GENE ENCODING A COLZA ACYLTRANSFERASE, AND USES THEREOF
CA2851896C (en) 1998-12-02 2016-05-17 Karlene H. Butler Plant diacylglycerol acyltransferases
EP1147174B1 (en) 1998-12-07 2007-02-14 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
ATE340861T1 (en) * 1998-12-17 2006-10-15 Ca Nat Research Council DIACYLGLYCEROL ACYL TRANSFERASE GENE FROM PLANTS
AU3239900A (en) 1999-02-22 2000-09-04 E.I. Du Pont De Nemours And Company Lysophosphatidic acid acetyltransferases
AU777031B2 (en) 1999-04-01 2004-09-30 Basf Plant Science Gmbh A new class of enzymes in the biosynthetic pathway for the production of triacylglycerol and recombinant DNA molecules encoding these enzymes
KR19990046733A (en) 1999-04-20 1999-07-05 류성구 Manufacturing Method for Docosa Hexaenoic Acid using Pseudomonas sp. YS-180
DE60033311T2 (en) 1999-11-12 2007-10-25 Basf Plant Science Gmbh USE OF AN ENZYME CLASS AND ITS ENCODING GENES TO INCREASE OIL CONTENT IN TRANSGENIC ORGANISMS
KR20020073580A (en) * 2000-02-09 2002-09-27 바스프 악티엔게젤샤프트 Novel Elongase Gene and Method for Producing Multiple-Unsaturated Fatty Acids
AU2000244105A1 (en) 2000-04-28 2001-11-12 Laboratoires Mayoly Spindler Cloning and expressing an acid-resistant extracellular lipase of yarrowia lipolytica
WO2001088144A1 (en) 2000-05-19 2001-11-22 Kaneka Corporation Transformant and process for producing polyester by using the same
US6552250B1 (en) 2000-06-14 2003-04-22 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Diacylglycerol O-acyltransferase
DE10102337A1 (en) * 2001-01-19 2002-07-25 Basf Plant Science Gmbh Preparing ester containing polyunsaturated fatty acids, useful e.g. in animal or human nutrition, by transforming organism with desaturase gene from Phaeodactylum tricornatum
US6635451B2 (en) 2001-01-25 2003-10-21 Abbott Laboratories Desaturase genes and uses thereof
GB2377455A (en) 2001-02-09 2003-01-15 Univ Hull Method of culturing crypthecodinium cohnii
US7045326B2 (en) 2001-02-23 2006-05-16 The Regents Of The University Of California Mono- and diacylglycerol acyltransferases and methods of use thereof
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
JP2002296554A (en) 2001-03-30 2002-10-09 Minebea Co Ltd Faraday rotator
US7045683B2 (en) * 2001-05-04 2006-05-16 Abbott Laboratories Δ4-desaturase genes and uses thereof
US20060206960A1 (en) 2001-09-21 2006-09-14 Jitao Zou Higher plant cytosolic er-based glycerol-3-phosphate acyltransferase genes
US7211656B2 (en) 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
WO2003099216A2 (en) 2002-05-22 2003-12-04 Monsanto Technology Llc Fatty acid desaturases from fungi
EP2333093B1 (en) * 2002-06-19 2020-06-10 DSM IP Assets B.V. Preparation of microbial oil containing polyunsaturated fatty acids
AU2003259682A1 (en) 2002-07-31 2004-02-16 Monsanto Technology, Llc Diacylglycerol acyltransferase nucleic acid sequences and associated products
JP4781817B2 (en) 2002-12-19 2011-09-28 ユニバーシティ オブ ブリストル Process for producing polyunsaturated fatty acids
JP4280158B2 (en) 2002-12-27 2009-06-17 富士フイルム株式会社 Microorganisms capable of producing docosahexaenoic acid and use thereof
EP1599582B1 (en) 2003-02-27 2011-07-27 BASF Plant Science GmbH Method for the production of polyunsaturated fatty acids
EP1613746B1 (en) 2003-03-31 2013-03-06 University Of Bristol Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids
US7214491B2 (en) * 2003-05-07 2007-05-08 E. I. Du Pont De Nemours And Company Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
DE602004022806D1 (en) 2003-06-04 2009-10-08 Nestec Sa BEVERAGE FOR WEIGHT CONTROL
KR100952263B1 (en) 2003-06-04 2010-04-09 세키스이가가쿠 고교가부시키가이샤 Curable Resin Composition
AU2003903058A0 (en) 2003-06-18 2003-07-03 Phytopharm Australia Ltd A process and apparatus for the modification of plant extracts
US7459546B2 (en) * 2003-06-25 2008-12-02 E.I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
US7259255B2 (en) 2003-06-25 2007-08-21 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7267976B2 (en) * 2003-07-02 2007-09-11 E.I. Du Pont De Nemours And Company Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts
EP2166067B1 (en) * 2003-08-01 2015-07-01 BASF Plant Science GmbH Method for producing polyunsaturated fatty acids in transgenic organisms
JP4916886B2 (en) 2003-11-12 2012-04-18 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Δ15 desaturase suitable for altering polyunsaturated fatty acid levels in oily plants and yeast
WO2005049805A2 (en) 2003-11-14 2005-06-02 E.I. Dupont De Nemours And Company Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
US7264408B2 (en) 2004-04-28 2007-09-04 Finisar Corporation Modular optical device package
BRPI0512481A (en) * 2004-06-25 2008-03-11 Du Pont isolated polynucleotide, polypeptide, recombinant construct, cell, transformed yarrowia sp.transformed, methods for transforming a cell, producing a transformed plant, producing yeast, producing polyunsaturated fatty acids and producing at least one polyunsaturated fatty acid, seeds, oils, oilseed plants and food or feed
US7264949B2 (en) * 2004-09-15 2007-09-04 E.I. Du Pont De Nemours And Company Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast
US7198937B2 (en) 2004-11-04 2007-04-03 E. I. Du Pont De Nemours And Company Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US20060094102A1 (en) 2004-11-04 2006-05-04 Zhixiong Xue Ammonium transporter promoter for gene expression in oleaginous yeast
US7189559B2 (en) 2004-11-04 2007-03-13 E. I. Du Pont De Nemours And Company Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US7273746B2 (en) 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US7192762B2 (en) 2004-11-04 2007-03-20 E. I. Du Pont De Nemours And Company Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
US8685679B2 (en) 2004-11-04 2014-04-01 E I Du Pont De Nemours And Company Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms
KR20070101862A (en) 2004-12-14 2007-10-17 아베스타 겐그레인 테크놀로지스 피브이티 리미티드 Recombinant Production of Docosahexaenoic Acid (DHA) in Yeast
US7470532B2 (en) 2005-10-19 2008-12-30 E.I. Du Pont De Nemours And Company Mortierella alpina C16/18 fatty acid elongase

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005277A2 (en) * 1978-05-08 1979-11-14 Cpc International Inc. Process for the microbiological production of oil
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
WO2002008401A2 (en) * 2000-07-24 2002-01-31 Abbott Laboratories Elongase genes and uses thereof
WO2003093482A2 (en) * 2002-04-29 2003-11-13 Basf Plant Science Gmbh Method for producing multiple unsaturated fatty acids in plants
WO2004071467A2 (en) * 2003-02-12 2004-08-26 E. I. Du Pont De Nemours And Company Production of very long chain polyunsaturated fatty acids in oilseed plants
WO2004101757A2 (en) * 2003-05-07 2004-11-25 E.I. Dupont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
WO2005047485A2 (en) * 2003-11-12 2005-05-26 E.I. Dupont De Nemours And Company Delta12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
CHO H P ET AL: "Cloning, expression, and fatty acid regulation of the human delta-5 desaturase.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 24 DEC 1999, vol. 274, no. 52, 24 December 1999 (1999-12-24), pages 37335 - 37339, XP002532310, ISSN: 0021-9258 *
HUANG Y S ET AL: "Cloning of delta12- and delta6-desaturases from Mortierella alpina and recombinant production of gamma-linolenic acid in Saccharomyces cerevisiae.", LIPIDS JUL 1999, vol. 34, no. 7, July 1999 (1999-07-01), pages 649 - 659, XP000908862, ISSN: 0024-4201 *
JURETZEK T ET AL: "VECTORS FOR GENE EXPRESSION AND AMPLIFICATION IN THE YEAST YARROWIA LIPOLYTICA", YEAST, JOHN WILEY & SONS LTD, GB, vol. 18, no. 2, 30 January 2001 (2001-01-30), pages 97 - 113, XP008025954, ISSN: 0749-503X *
LEONARD A E ET AL: "cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid.", THE BIOCHEMICAL JOURNAL 1 MAY 2000, vol. 347 Pt 3, 1 May 2000 (2000-05-01), pages 719 - 724, XP002223219, ISSN: 0264-6021 *
LIN TAO ET AL: "High-frequency codon analysis and its application in codon analysis of tobacco", BIOSIS,, September 2002 (2002-09-01), XP002348320 *
MADZAK C ET AL: "Heterologous Protein Expression and Secretion in the Non-conventional Yeast Yarrowia lipolytica: A Review", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 109, no. 1-2, 1 April 2004 (2004-04-01), pages 63 - 81, XP002995176, ISSN: 0168-1656 *
MARQUARDT A ET AL: "cDNA Cloning, Genomic Structure, and Chromosomal Localization of Three Members of the Human Fatty Acid Desaturase Family", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 66, no. 2, 1 June 2000 (2000-06-01), pages 175 - 183, XP004439352, ISSN: 0888-7543 *
MULLER SVEN ET AL: "Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Kluyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica", YEAST, JOHN WILEY & SONS LTD, GB, vol. 14, no. 14, 1 October 1998 (1998-10-01), pages 1267 - 1283, XP002518099, ISSN: 0749-503X *
PARKER-BARNES J-M ET AL: "Identification and caracterization of an ezyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC.; US, vol. 97, 18 July 2000 (2000-07-18), pages 8284 - 8289, XP002992660, ISSN: 0027-8424 *
SAKURADANI EIJI ET AL: "Gene cloning and functional analysis of a second delta 6-fatty acid desaturase from an arachidonic acid-producing Mortierella fungus.", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY APR 2003, vol. 67, no. 4, April 2003 (2003-04-01), pages 704 - 711, XP002532308, ISSN: 0916-8451 *
See also references of WO2006055322A2 *

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