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EP1620039A4 - Dispositifs a commande magnetique de distribution de medicaments et de genes - Google Patents

Dispositifs a commande magnetique de distribution de medicaments et de genes

Info

Publication number
EP1620039A4
EP1620039A4 EP04750256A EP04750256A EP1620039A4 EP 1620039 A4 EP1620039 A4 EP 1620039A4 EP 04750256 A EP04750256 A EP 04750256A EP 04750256 A EP04750256 A EP 04750256A EP 1620039 A4 EP1620039 A4 EP 1620039A4
Authority
EP
European Patent Office
Prior art keywords
gene delivery
magnetically controllable
controllable drug
delivery stents
stents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04750256A
Other languages
German (de)
English (en)
Other versions
EP1620039A2 (fr
Inventor
Robert J Levy
Michael Chorny
Ilia Fishbein
Ivan Alferiev
Gennady Friedman
Kenneth A Barbee
Benjamin B Yellen
Zachary G Forbes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drexel University
Childrens Hospital of Philadelphia CHOP
Original Assignee
Drexel University
Childrens Hospital of Philadelphia CHOP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drexel University, Childrens Hospital of Philadelphia CHOP filed Critical Drexel University
Priority to EP11003742.1A priority Critical patent/EP2365007B1/fr
Priority to EP15002247.3A priority patent/EP2974699A1/fr
Publication of EP1620039A2 publication Critical patent/EP1620039A2/fr
Publication of EP1620039A4 publication Critical patent/EP1620039A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/10—Acylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/009—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof magnetic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/624—Nanocapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Nanotechnology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
EP04750256A 2003-04-16 2004-04-16 Dispositifs a commande magnetique de distribution de medicaments et de genes Withdrawn EP1620039A4 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11003742.1A EP2365007B1 (fr) 2003-04-16 2004-04-16 Endoprothèse pour administration de gènes et de médicaments contrôlable magnétiquement
EP15002247.3A EP2974699A1 (fr) 2003-04-16 2004-04-16 Stents contrôlables magnétiquement d'administration de médicaments et de gènes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46350503P 2003-04-16 2003-04-16
US54512704P 2004-02-17 2004-02-17
US54623304P 2004-02-20 2004-02-20
PCT/US2004/011861 WO2004093643A2 (fr) 2003-04-16 2004-04-16 Dispositifs a commande magnetique de distribution de medicaments et de genes

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP11003742.1A Division EP2365007B1 (fr) 2003-04-16 2004-04-16 Endoprothèse pour administration de gènes et de médicaments contrôlable magnétiquement
EP15002247.3A Division EP2974699A1 (fr) 2003-04-16 2004-04-16 Stents contrôlables magnétiquement d'administration de médicaments et de gènes

Publications (2)

Publication Number Publication Date
EP1620039A2 EP1620039A2 (fr) 2006-02-01
EP1620039A4 true EP1620039A4 (fr) 2010-08-04

Family

ID=33314244

Family Applications (3)

Application Number Title Priority Date Filing Date
EP15002247.3A Withdrawn EP2974699A1 (fr) 2003-04-16 2004-04-16 Stents contrôlables magnétiquement d'administration de médicaments et de gènes
EP11003742.1A Expired - Lifetime EP2365007B1 (fr) 2003-04-16 2004-04-16 Endoprothèse pour administration de gènes et de médicaments contrôlable magnétiquement
EP04750256A Withdrawn EP1620039A4 (fr) 2003-04-16 2004-04-16 Dispositifs a commande magnetique de distribution de medicaments et de genes

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP15002247.3A Withdrawn EP2974699A1 (fr) 2003-04-16 2004-04-16 Stents contrôlables magnétiquement d'administration de médicaments et de gènes
EP11003742.1A Expired - Lifetime EP2365007B1 (fr) 2003-04-16 2004-04-16 Endoprothèse pour administration de gènes et de médicaments contrôlable magnétiquement

Country Status (4)

Country Link
EP (3) EP2974699A1 (fr)
AU (1) AU2004231992B2 (fr)
CA (2) CA2522625C (fr)
WO (1) WO2004093643A2 (fr)

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AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US9694103B2 (en) 2003-04-16 2017-07-04 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
US7635734B2 (en) 2004-02-17 2009-12-22 The Children's Hospital Of Philadelphia Photochemical activation of surfaces for attaching biomaterial
DE10350248A1 (de) * 2003-10-28 2005-06-16 Magnamedics Gmbh Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik
US8465453B2 (en) 2003-12-03 2013-06-18 Mayo Foundation For Medical Education And Research Kits, apparatus and methods for magnetically coating medical devices with living cells
US20090118817A1 (en) 2005-06-16 2009-05-07 Mayo Foundation For Medical Education And Research Magnetic Medical Apparatus, Kits, and Methods
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US9028829B2 (en) 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20090216320A1 (en) 2006-04-21 2009-08-27 The Children's Hospital Of Philadelphia Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof
CA2663271A1 (fr) 2006-09-15 2008-03-20 Boston Scientific Limited Endoprotheses biodegradables et procedes de production
US20080086201A1 (en) * 2006-09-15 2008-04-10 Boston Scientific Scimed, Inc. Magnetized bioerodible endoprosthesis
EP2959925B1 (fr) 2006-09-15 2018-08-29 Boston Scientific Limited Dispositifs médicaux et procédés de réalisation desdits dispositifs
EP2066363A2 (fr) * 2006-09-15 2009-06-10 Boston Scientific Limited Endoprothèse contenant des particules d'induction magnétique
ATE488259T1 (de) 2006-12-28 2010-12-15 Boston Scient Ltd Bioerodierbare endoprothesen und herstellungsverfahren dafür
US8182859B2 (en) 2007-03-30 2012-05-22 Boston Scientific Scimed, Inc. Using magnetism to prepare a medical device
DE102007032688A1 (de) 2007-07-13 2009-01-22 Biotronik Vi Patent Ag Implantat und System aus einem Implantat und einer Anregungsvorrichtung
WO2009010303A2 (fr) * 2007-07-18 2009-01-22 Neue Magnetodyn Gmbh Système d'administration de substances actives à un organisme, dispositifs d'utilisation d'un tel système et procédé de fabrication de tels dispositifs
DE102008006402A1 (de) * 2008-01-28 2009-07-30 Magnamedics Gmbh Beschichtete Instrumente für die Invasivmedizin
GB0808090D0 (en) * 2008-05-02 2008-06-11 Iti Scotland Ltd Use of magnetic proteins in medicine
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US20120064142A1 (en) * 2008-11-30 2012-03-15 University Of The Witwatersrand, Johannesburg Polymeric pharmaceutical dosage form in sustained release
EP2403546A2 (fr) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Implants médicaux à tamponnage spontané
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
CN102379762B (zh) * 2011-08-02 2015-03-25 上海微创医疗器械（集团）有限公司 一种带凹槽的生物可降解支架及其制备方法
GB201116879D0 (en) * 2011-09-30 2011-11-16 Magnus Stent Ic Endoprosthesis
ES2855006T3 (es) * 2015-04-01 2021-09-23 Univ Yale Partículas de hierro y platino para la adherencia de productos biológicos en implantes médicos
WO2019006440A1 (fr) * 2017-06-30 2019-01-03 Otomagnetics, Inc. Nanoparticules magnétiques pour l'administration ciblée
US11648135B2 (en) 2017-09-13 2023-05-16 Boston Scientific Scimed, Inc. Coated stent
US11357620B1 (en) * 2021-09-10 2022-06-14 California LASIK & Eye, Inc. Exchangeable optics and therapeutics
WO2024113032A1 (fr) * 2022-12-01 2024-06-06 Dias Maues Chrisiane Système de libération et d'administration de médicaments dirigés vers un tissu cible spécifique par utilisation d'une matrice multifonctionnelle de nanoparticules magnétiques et application destinée à des plateformes et des dispositifs endovasculaires et intraorganiques constitués de graphène

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WO2004069169A2 (fr) * 2003-01-31 2004-08-19 Scimed Life Systems, Inc. Distribution localisee d'un medicament au moyen de nanocapsules chargees de medicament

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Publication number Priority date Publication date Assignee Title
EP0775500A1 (fr) * 1995-11-23 1997-05-28 Cordis Corporation Dispositif médical visible quant on utilise l'imagerie par résonance magnétique
US20020133225A1 (en) * 2001-03-13 2002-09-19 Gordon Lucas S. Methods and apparatuses for delivering a medical agent to a medical implant
US20020133219A1 (en) * 2001-03-15 2002-09-19 Robert Barry Magnetic stent
WO2004069169A2 (fr) * 2003-01-31 2004-08-19 Scimed Life Systems, Inc. Distribution localisee d'un medicament au moyen de nanocapsules chargees de medicament

Also Published As

Publication number Publication date
EP2365007A3 (fr) 2012-05-30
WO2004093643A3 (fr) 2005-04-28
EP2365007B1 (fr) 2015-09-02
AU2004231992B2 (en) 2011-04-21
CA2522625C (fr) 2013-10-01
AU2004231992A1 (en) 2004-11-04
EP2974699A1 (fr) 2016-01-20
CA2821376A1 (fr) 2004-11-04
WO2004093643B1 (fr) 2005-06-16
CA2522625A1 (fr) 2004-11-04
EP2365007A2 (fr) 2011-09-14
WO2004093643A2 (fr) 2004-11-04
EP1620039A2 (fr) 2006-02-01

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