EP1601337A1 - Oral and dental care agent - Google Patents
Oral and dental care agentInfo
- Publication number
- EP1601337A1 EP1601337A1 EP04719419A EP04719419A EP1601337A1 EP 1601337 A1 EP1601337 A1 EP 1601337A1 EP 04719419 A EP04719419 A EP 04719419A EP 04719419 A EP04719419 A EP 04719419A EP 1601337 A1 EP1601337 A1 EP 1601337A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- oral
- dental care
- active ingredient
- tartar
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- the invention relates to oral and dental care products which, on the basis of a special combination of active ingredients, can contribute to the reduction and inhibition of discoloration on human teeth and to the inhibition of tartar and plaque.
- Modern oral and dental care products are primarily used to clean and remove food residues, discoloration and firmly adhering dental plaque from the tooth surface.
- plaque is the basis for the formation of tartar, which in turn leads to the development and progression of gingivitis, bleeding (gingivitis) and caries.
- a mouth and dental care product should even completely inhibit the formation of plaque and tartar through special additives.
- chlorhexidine has long been known as a very effective antibacterial agent.
- the effect of chlorhexidine is based on its high retention rate in the oral cavity, which is associated with a certain depot effect or a long-term effect.
- chlorhexidine has so far been the formation of discoloration in the oral cavity, which is caused by chlorhexidine-related deposits primarily from polyphenols of various luxury foods such as tea, coffee or red wine. These discolorations particularly affect the toughness are unaesthetic and are generally not accepted by consumers. Therefore, long-term use is usually not practiced despite the high effectiveness of chlorhexidine in oral and dental care products.
- a mouth and dental care product which not only has a discolouration-reducing and -preventing effect due to a special combination of active ingredients, but also a high tartar-inhibiting effect and an anti-plaque effect.
- the invention therefore relates to oral and dental care compositions containing an active ingredient combination
- A at least one cationic, antibacterial component
- B at least one anti-tartar active ingredient selected from the group of azacycloalkane diphosphonic acids or their physiologically tolerable salts
- bisbiguanide derivatives are understood as cationic, antibacterial components.
- the compounds chlorhexidine and alexidine are particularly preferred. These two compounds are preferably used in the oral and dental care products in the form of their water-soluble, physiologically tolerable salts.
- Such salts are, for example, the acetates, gluconates, hydrochlorides, hydrobromides, citrates, bisulfites, fluorides, sorbates, salicylates, maleate, tartrates, fumarates, ethylenediaminotetraacetates, iminodiacetates, cinnamates, thiocyanates, arginates, benzoates and glutaride deschlorates.
- antibacterial biguanide compounds are for example obtained from the polyhexamethylene type Vantocil ® IB (ICI) which is known from DE-A-1964196 known 1, 6-bis (4- chlorbenzylbiguanido) hexane (fluorhexidine), and further known antibacterial biguanide compounds from documents US-A-2,684,924, US-A-2,990,425, US-A-3,468,898, US-A-4,022,834, US-A-4,053,636 and US-A-4, 198,392.
- ICI polyhexamethylene type Vantocil ® IB
- chlorhexidine digluconate as an antibacterial component in the oral and dental care products.
- the antibacterial component (A) is used in the oral and dental care compositions according to the invention in amounts of 0.001 to 3% by weight, based on the total weight of the composition.
- a preferred amount of the antibacterial component is from 0.01 to 1% by weight and in particular from 0.01 to 0.2% by weight, based on the total weight of the agent.
- compounds of the formula are used as anti-tartar active ingredient (B)
- n stands for integers between 3 and 5
- R stands for hydrogen or a CrC r alkyl group
- X stands for hydrogen, ammonium, substituted ammonium salts such as mono-, di- or triethanolammonium salts or alkali ions such as sodium or potassium ions, with a maximum of 3 groups X simultaneously represent hydrogen.
- the 2,2-diphosphono-1-azacycloalkanes are excellent sequestering agents for polyvalent metal ions, especially for 2- and 3-valent metal ions. They are particularly suitable as complexing agents for alkaline earth metal ions.
- aza-cycloheptane-2,2-diphosphonic acid as an anti-tartar active ingredient or a physiologically acceptable salt, for example the sodium salt of azacycloheptane-2,2-diphosphonic acid, in the oral and dental care products.
- the anti-tartar active ingredient (B) is used in the oral and dental care compositions according to the invention in amounts ranging from 0.001 to 5% by weight, based on the total weight of the composition.
- An amount of component (B) is preferably used in a quantity range of 0.01 to 3% by weight, in particular 0.05 to 2% by weight.
- the third, mandatory component (C) of the active ingredient combination according to the invention is the binder.
- Binders that can be used in the context of the invention are xanthan gum and carboxymethyl cellulose. They are usually used in amounts of min at least 0.01% by weight and in particular in amounts of 0.05 to 2% by weight, based on the total weight of the agent.
- binders or thickeners to the oral and dental care products, which have a consistency-regulating effect and furthermore prevent the separation of the liquid and solid components.
- compositions according to the invention are 0.1-5% by weight, preferably 0.1-3% by weight and in particular 0.5-2% by weight.
- natural and / or synthetic water-soluble polymers such as alginates, carrageenans, agar-agar, guar gum, arabic gum, succinoglycan gum, guar flour, locust bean gum, tragacanth, karaya gum, pectins, hydroxyethyl cellulose or methylhydroxypropyl cellulose, hydrophobically modified Cellulose, starch and starch ether.
- Water-soluble carboxyvinyl polymers eg Carbopol ® types
- polyvinyl alcohol polyvinylpyrrolidone
- higher molecular weight polyethylene glycols in particular those with molecular weights of 10 2 to 10 6 D
- Layered silicates and finely divided silicas can also fulfill this function.
- Water-insoluble, non-derivatized celluloses which are offered, for example, by J. Rettenmaier & Sons under the names Arbocel ® and Vitacel ® , are particularly suitable as further binding or thickening agents.
- water-insoluble is understood to mean a solubility of less than 1% by weight in water at 20 ° C., ie less than 1% by weight of the cellulose is dissolved in 100 g of a saturated solution at 20 ° C.
- Arbocel ® CGP 5000 a highly viscous paste made of powder cellulose with thixotropic properties, is a particularly effective thickener that has strong consistency properties even at low concentrations, against ionic see components is inert and can be easily combined with other thickeners.
- the oral and dental care compositions further contain surface-active surfactants or surfactant mixtures to improve the cleaning effect and the foaming. They promote the rapid, complete dissolution and distribution of oral and dental care products in the oral cavity and at the same time support the mechanical removal of dental plaque, especially in areas that are difficult to access with a toothbrush. In addition, they promote the incorporation of water-insoluble substances, such as aromatic oils, stabilize the polishing agent dispersion and support the anti-caries effect of fluorides.
- anionic surfactants zwitterionic and ampholytic surfactants, nonionic surfactants, cationic surfactants or mixtures of these compounds can be used as surfactants in toothpaste formulations.
- toothpastes preferably contain at least one surfactant from the group of anionic surfactants, while mouthwashes preferably contain at least one surfactant from the group of nonionic surfactants.
- the surfactant or the surfactant mixture is usually present in an amount of 0.1-10% by weight, preferably 0.3-7% by weight and in particular 1-5% by weight, based on the total weight of the Composition used.
- Suitable surfactants with good foaming action are anionic surfactants, which also have a certain enzyme-inhibiting effect on the bacterial metabolism of the plaque.
- alkali or ammonium salts in particular sodium salts, of C 8 -C 8 -alkane carboxylic acids, of alkyl polyglycol ether sulfates with 12-16 C atoms in the linear alkyl group and 2-6 glycol ether groups in the mole cool, of linear alkane (C ⁇ 2 -C ⁇ 8 ) sulfonates, sulfosuccinic acid monoalkyl (C ⁇ 2 - Ci 8 ) esters, sulfated fatty acid monoglyceride, sulfated fatty acid alkanolamides, sulfoacetic acid alkyl (Ci 2 -Ci 6 ) esters, acyl sarcosines, Acyl taurides and acyl isethionates each with 8 - 18 carbon atoms in the acyl group.
- alkali or ammonium salts in particular sodium salts
- At least one anionic surfactant in particular a sodium laurylalkyl sulfate with 12-18 C atoms in the alkyl group.
- a surfactant is sodium lauryl sulfate which is commercially available for example under the name Texapon.RTM ® K1296 commercially.
- Zwitterionic and / or ampholytic surfactants are surface-active compounds that contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule.
- Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example the trimethylammonium glycinate, cocoalkyldimethylam onium glycinate, N-acylamino-propyl-N, N-dimethylammoniumglycinate, for example the cocoacylaminopropyldimethyl and ammoniumglycine 2-alkyl-3-carboxylmethyl-3-hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the cocoacylaminoethylethylethylcarboxymethylglycinate.
- betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example the trimethylammonium glycinate, cocoalkyldimethylam onium glycinate, N-acylamino
- the fatty acid amide derivative known under the CTFA name Cocamidopropyl Betaine is particularly preferred.
- Such products are commercially available, for example, under the names Tego-Betain ® BL 215 and ZF 50 and Genagen ® CAB.
- Ampholytic surfactants are surface-active compounds which, in addition to a Cs-C-j ⁇ -alkyl or acyl group, contain at least one free amino group and at least one -COOH or -S0 3 H group in the molecule and are capable of forming internal salts.
- ampholytic surfactants are N-alkyl glycines, N-alkyl propionic acids, N-alkyl aminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamido propylglycine, N-alkyl taurine, N-alkylisarcosine, 2-alkylaminopropionic acid and alkylaminoacetic acid, each with about 8 to 18 carbon atoms in the alkyl group.
- Particularly preferred ampholic surfactants are N-coconut alkyl aminopropionate, coconut amino amino ethyl propinate and C 12 -C 18 acyl sarcosine.
- quaternary emulsifiers are also suitable, those of the ester quat type, preferably methyl-quaternized difatty acid triethanolamine ester salts, being particularly preferred.
- Non-ionic surfactants are particularly suitable according to the invention for supporting the cleaning action. Those nonionic surfactants which are selected from at least one of the following groups are particularly preferred:
- polyglycerol esters such as. B. polyglycerol polyricinoleate, polyglycerol poly-12-hydroxystearate or polyglycerol dimerate.
- Partial esters based on linear, branched, unsaturated or saturated Ce Gaa fatty acids, ricinoleic acid as well as 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (eg sorbitol), sucrose, alkyl glucosides (e.g. methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (e.g. cellulose);
- alkyl glucosides e.g. methyl glucoside, butyl glucoside, lauryl glucoside
- polyglucosides e.g. cellulose
- the adducts of ethylene oxide and / or of propylene oxide with fatty alcohols, fatty acids, alkylphenols, glycerol mono- and diesters and sorbitan mono- and diesters with fatty acids or with castor oil are known, commercially available products and are preferred according to the invention. These are homolog mixtures whose average degree of alkoxylation corresponds to the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate with which the addition reaction is carried out.
- Ci 2 -C 8 fatty acid mono- and - diesters of addition products of ethylene oxide with glycerol are known from DE-PS 2024051 as refatting agents for cosmetic preparations.
- C 8 -C 8 alkyl mono- and oligoglycosides their preparation and their use are from the prior art, for example from US-A-3,839,318, DE-A-20 36472, EP-A-77 167 or WO-A-93 / 10132 known. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms.
- glycoside residue it applies that both monoglycosides in which a cyclic sugar residue is glycosidically bonded to the fatty alcohol is, as well as oligomeric glycosides with a degree of oligomerization up to preferably about 8 suitable.
- the degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.
- An alkyl (oligo) glycoside is preferably an alkyl (oligo) glycoside of the formula RO (C 6 H 0 O) ⁇ -H, in which R represents an alkyl group having 12 to 14 carbon atoms and x is one Averages from 1 to 4.
- a particularly preferred surfactant which is used in the oral and dental care products according to the invention is the alkyl glycoside sold by the company Cognis under the trade name Plantacare 1200 UP (Ci 2 -i 6 -fatty alcohol-1,4-glucoside).
- the oral and dental care compositions of the invention further contain humectants to protect against drying out and to regulate the consistency and low-temperature stability of the products. However, they can also be used to impart suspensions and to influence taste or gloss.
- Toxicologically acceptable polyols such as, for example, sorbitol, xylitol, glycerol, mannitol, 1, 2-propylene glycol or mixtures thereof, are usually used as humectants, but polyethylene glycols with molecular weights of 200-2000, in particular from 200 to 1500, can also be used as humectant components in Serve toothpastes.
- humectant components are preferred, the combination of glycerol and / or sorbitol containing 1,2-propylene glycol or polyethylene glycol being particularly preferred.
- xylitol with one or both of the humectants glycerol and sorbitol should also be mentioned as a preferred combination, the anticariogenic property of xylitol also being mentioned in addition to the property as a humectant.
- the oral and dental care compositions of the invention can furthermore contain ethanol in amounts of 0 to 10% by weight, preferably in amounts of 1 to 5% by weight, based on the total weight of the composition , contain.
- the humectant or the mixture of humectants is contained in the total composition in an amount of 10-85% by weight, preferably 20-70% by weight and in particular 30-50% by weight.
- the composition according to the invention additionally contains oil / fat and / or wax components.
- oil / fat and / or wax components In particular in combination with surfactants, these give the compositions according to the invention gloss and smoothness.
- natural, chemically modified and synthetic waxes, fats and oils can be used alone or in any combination.
- the oil / fat and wax components are used in an amount of 0.1 to 10% by weight, based on the total compositions, preferably 0.5 to 5% by weight and in particular 0.8 to 3% by weight.
- mono-, di- and triglycerides with liquid to solid consistency as well as hydrocarbons and silicone oils are understood, which can be of natural or synthetic origin. According to the invention, it is preferred to select the oil components from the group of triglycerides and / or paraffin oils. These can be of plant, animal or synthetic origin.
- Mono-, di- and triglycerides are the mono-, di- and triesters of fatty acids with glycerol, ie acylglycerols, where the glycerol can be esterified with the same or with different fatty acids or fatty acid derivatives (eg lecithin).
- the fatty acids are preferably C 6 -C 3 o-fatty acids which may be saturated or unsaturated and branched or unbranched. These include a.
- natural fats and oils such as e.g. B. beef tallow, peanut oil, turnip oil, cottonseed oil, soybean oil, sunflower oil, palm oil, palm kernel oil, linseed oil, almond oil, castor oil, corn oil, olive oil, rapeseed oil, sesame oil, cocoa butter and coconut oil and the like.
- the hydrogenated or hardened oils e.g. B. hydrogenated soybean oil, castor oil and peanut oil can be used.
- silicone oils or natural and synthetic hydrocarbons such as, for example, available thin to thick liquid paraffin oils, isohexadecane, isoeicosane or polydecene, for example, under the designation Emery ® 3004, 3006, 3010, Ethylflo ® or Nexbase ® 2004G.
- inverse fats e.g. esters of vicinal tricarboxylic acids with C 6 -C 30 fatty alcohols
- glyceryl trialkyl ether is also conceivable here.
- Waxing is understood to mean naturally or artificially obtained substances with the following properties: they have a solid to brittle hard consistency, coarse to fine crystalline, translucent to opaque, but not glassy, and melt without decomposition above 35 ° C. They are low viscosity and not stringy a little above the melting point and show a strongly temperature-dependent consistency and solubility. From a chemical point of view, the most common representatives from the wax group are esters of fatty acids and higher fatty alcohols, which are of animal and vegetable origin. Natural vegetable waxes, such as, for example, B.
- the natural waxes that can be used according to the invention also include the mineral waxes, such as, for. B. ceresin and ozokerite or the petrochemical waxes such as paraffin waxes (z. B. Vaseline) and micro waxes.
- a wax component are also chemically modified waxes, such as. B. Montanester waxes, Sasol waxes and hydrogenated jojoba waxes can be used.
- the synthetic waxes which can be used according to the invention also include, for example, wax-like polyalkylene waxes and silicone waxes.
- Synthetic waxes can also be used according to the invention, in particular the esters of C ⁇ -Cao fatty acids with C 6 -C 3 o -fatty alcohols, which can be of natural or synthetic origin. Both the fatty acid component and the fatty alcohol component can be straight-chain or branched and saturated or mono- or polyunsaturated.
- the wax component is preferably selected from the group of vegetable or animal and / or paraffin waxes or any mixture of these waxes.
- beeswax and jojoba oil are particularly preferred.
- these can also contain additional active substances such as anti-caries substances, remineralising substances, flavorings or other antimicrobial substances and / or tartar inhibitors, or any combination of these substances.
- fluorine compounds are particularly suitable, preferably from the group of fluorides or monofluorophosphates in an amount of 0.1-0.5% by weight of fluorine.
- Suitable fluorine compounds are e.g. As sodium fluoride, potassium fluoride, tin fluoride, disodium monofluorophosphate (Na 2 P0 3 F), dipotassium monofluorophosphate or the fluoride of an organic amino compound.
- Organic amine fluorides for the purposes of the invention are, for example, ammonium fluoride, cetylamine hydrofluoride and bis (hydroxyethyl) aminopropyl-N-hydroxyethyloctadecylamine dihydrofluoride.
- sodium fluoride, ammonium fluoride or an organic amine fluoride is added to the oral and dental care product.
- antimicrobial components are, for. B. phenols, resorcinols, bisphenols, salicylanilides and amides and their halogenated derivatives, halogenated carabanilides and p-hydroxybenzoic acid esters.
- halogenated diphenyl ethers such as 2,4-dichloro-2'-hydroxydiphenyl ether, 4,4'-dichloro-2'-hydroxydiphenyl ether, 2,4,4'-tribromo-2'-hydroxydiphenyl ether, 2,4,4 '-Trichlor-2'-hydroxy-diphenyl ether (triclosan) suitable as antimicrobial agents.
- phenylsalicylic acid esters and 5-amino-1, 3-bis (2-ethylhexyl) hexa- hydro-5-methylpyrimidine also have zinc and copper ions antimicrobial, whereby synergistic effects occur especially in combination with hexetidine and triclosan .
- Quaternary ammonium compounds such as cetylpyridinium chloride, benzalkonium chloride, domiphen bromide and dequalinium chloride can also be used.
- Octapinol, octenidines and sanguinarine have also proven to be antimicrobial.
- the antimicrobial active ingredients are preferably used in amounts of 0.01-1% by weight in the agents according to the invention. Irgacare ® MP is particularly preferred in an amount from 0.01 to 0.3 wt .-% is used.
- Tartar is mineral deposits that are very similar to natural tooth enamel.
- substances are added to the tooth cleaning agents according to the invention which specifically intervene in the crystal nucleation and prevent existing germs from continuing to grow.
- These are, for example, condensed phosphates, which are preferably selected from the group of tripolyphosphates, pyrophophates, trimetaphosphates or mixtures thereof. They are used in the form of their alkali or ammonium salts, preferably in the form of their sodium or potassium salts.
- Aqueous solutions of these phosphates typically have an alkaline reaction, so that the pH of the dentifrices according to the invention is adjusted to values of 7.5-9, if necessary by adding acid.
- acids z. B.
- citric acid, phosphoric acid or acidic salts e.g. B. NaH 2 P0 4
- the desired pH of the dentifrice can also be achieved by adding acidic salts of the condensed phosphates, e.g. B. K 2 H 2 P 2 O 7 can be set.
- Tartar inhibitors are usually used in amounts of 0.1-5% by weight, preferably 0.1- 3% by weight and in particular 0.1-2% by weight are used in the agents according to the invention.
- organophosphonates such as 1-hydroxyethane-1, 1-diphosphonate (Na salt) and zinc citrate.
- the agents according to the invention preferably also contain substances which promote re-mineralization of the tooth enamel and are able to close dental lesions. These are usually contained in a total amount of 0.1-10% by weight, preferably 0.1-5% by weight and in particular 0.1-3% by weight. These include e.g. B. fluorides, phosphate salts of calcium such. As calcium glycerol phosphates, calcium hydrogen phosphate, hydroxyapatite, fluoroapatite, F-doped hydroxyapatite, dicaicium phosphate dihydrate and calcium fluoride. But also magnesium salts such as. B. magnesium sulfate, magnesium fluoride or magnesium monofluorophosphate have a remineralizing effect.
- the agents according to the invention preferably contain flavorings, to which e.g. B. sweeteners and / or aromatic oils.
- suitable sweeteners are saccharinates (in particular sodium saccharinate), cyclamates (in particular sodium cyclamate) and sucrose, lactose, maltose or fructose.
- Aromatic oils that can be used are all natural and synthetic aromas that are common for oral and dental care products. Natural flavors can be used both in the form of the essential oils (mixture) isolated from the drugs and in the form of the individual components isolated from them.
- At least one aromatic oil from the group of peppermint oil, spearmint oil, anise oil, star anise oil, caraway oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, geranium oil, sage oil, allspice oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or one or more synthetically isolated or should be preferred produced components of these oils be included.
- the most important components of the oils mentioned are e.g. B.
- menthol carvone, anethole, cineol, eugenol, cinnamaldehyde, caryophyllene, geraniol, citronellol, linalool, salvos, thymol, terpinene, terpinol, methylchavicol and methyl salicylate.
- suitable flavors are e.g. B. menthyl acetate, vanillin, jonone, linalyl acetate, rhodinol and piperiton.
- the oral and dental care products according to the invention are packaged as toothpastes, tooth gels or liquid transparent dentifrices, they contain at least one cleaning body as a further component.
- the cleaning bodies are used for the mechanical removal of the uncalcified dental plaque and should ideally lead to the gloss of the tooth surface (polishing effect) with at the same time minimal abrasion (abrasion effect) and damage to the tooth enamel and dentin.
- the abrasion behavior of the plaster is essentially determined by their hardness, particle size distribution and surface structure.
- Water-soluble inorganic substances are usually used as cleaning bodies or polishing agents.
- the polishing agents according to the invention can be selected from silicas, aluminum hydroxide, aluminum oxide, silicates, organic polymers or mixtures thereof. Furthermore, so-called metaphosphates and calcium-containing polishing components can also be present in the agents according to the invention in amounts of up to 5% by weight. It can be preferred according to the invention to use silicas as polishing agents in toothpastes or liquid tooth cleaning agents. A distinction is basically made between silica polishing agents between gel silicas, hydrogel silicas and precipitated silicas. Precipitated and gel silicic acids are particularly preferred according to the invention because they can be varied widely in their production and are particularly well tolerated with fluoride active ingredients. They are also particularly suitable for the production of gel or liquid toothpastes.
- Gel silicic acids are generated by the reaction of sodium silicate solutions with strong, aqueous mineral acids with the formation of a hydrosol, aging to the hydrogel, washing and subsequent drying. If drying is carried out under gentle conditions to water contents of 15 to 35% by weight, so-called hydrogel silicas are obtained, as are also described, for example, in US Pat. No. 4,153,680. By drying these hydrogel silicas to water contents below 15% by weight there is an irreversible shrinkage of the previously loose structure to the dense structure of the so-called xerogel. Such xerogel silicas are known, for example, from US Pat. No. 3,538,230.
- a second, preferably suitable group of silicic acid polishing agents are the precipitated silicas. These are obtained by precipitating silica from dilute alkali silicate solutions by adding strong acids under conditions in which aggregation to the sol and gel cannot occur. Suitable processes for the preparation of precipitated silicas are described, for example, in DE-OS 25 22 586 and in DE-OS 31 14 493.
- a precipitated silica prepared according to DE-OS 31 14 493 with a BET surface area of 15-110 m 2 / g and a particle size of 0.5 to 20 ⁇ m is particularly suitable according to the invention, with at least 80% by weight of the primary particles below 5 ⁇ m should be, and a viscosity in 30% glycerol water (1: 1) dispersion of 30 - 60 Pa s (20 ° C) in an amount of 10 - 20 wt .-% of the toothpaste.
- Precipitated silicas of this type which are preferably suitable also have rounded ones Corners and edges and are available under the trade name Sident ® 12 DS from Degussa.
- the silicas of the type Zeodent ® Huber-Corp., Tixosil® Rhodia and other Sorbosil® types can be used in the agents.
- Zeodent ® 113, Tixosil ® 123 and 73 and Sorbosil ® AC33 are particularly preferred.
- Toothpastes that have a significantly higher viscosity of more than 100 Pa s (25 ° C, D 10 s "1 ), on the other hand, require a sufficiently high proportion of silicas with a particle size of less than 5 ⁇ m, preferably at least 3% by weight. % of a silica with a particle size of 1 to 3 ⁇ m. Toothpastes are therefore preferably added in addition to the precipitated silicas mentioned, more finely divided, so-called thickening silicas with a BET surface area of 150-250 m 2 / g. As examples of commercial products that Sipemat ® 22 LS or Sipernat ® 320 DS from Degussa must be mentioned in particular.
- a weakly calcined alumina with a content of at least 10% by weight of so-called gamma-alumina modifications other than alpha-alumina is preferably suitable as the alumina polishing agent.
- Suitable weakly calcined clays are produced by calcination from aluminum hydroxide.
- Aluminum hydroxide passes through calcination into the ⁇ -Al 2 0 3 which is thermodynamically stable at temperatures above 1200 ° C.
- the thermodynamically unstable, occurring at temperatures between 400 and 1000 ° C len A ⁇ 3 modifications are called gamma forms (cf. Ulimann, Encyclopedia of Industrial Chemistry, 4th edition (1974), volume 7, page 298).
- the degree of calcination ie the conversion into the thermodynamically stable ⁇ -A ⁇ Oa, can be set to any desired level.
- Weak calcination gives an alumina with a ⁇ -A Os content which is lower, the higher the calcination temperature and the longer the caicination time.
- Weakly calcined clays differ from pure 01-Al 2 O 3 in that the agglomerates have a lower hardness, a larger specific surface area and larger pore volumes.
- the dentin abrasion (RDA) of the weakly calcined alumina to be used according to the invention with a proportion of 10-50% by weight ⁇ -Al 2 O 3 is only 30-60% of the dentin abrasion of a strongly calcined, pure CC-Al 2 O 3 (measured in a standard toothpaste with 20% by weight alumina as the only polishing agent).
- ⁇ -Al 2 ⁇ 3 can be the ⁇ -A ⁇ 3 with an aqueous-ammoniacal solution of Alizarin S (1, 2-dihydroxy-9,10-anthraquinone-4-sulfonic acid) stain red.
- the degree of dyeability can be chosen as a measure of the degree of calcination or of the proportion of ⁇ -A ⁇ Os in a calcined clay:
- Suitable, weakly calcined clays with a content of 10-50% by weight of ⁇ -Al 2 O 3 can be colored slightly to deep pink using this process.
- Aluminum oxide polishing agents of various degrees of calcination, fineness and bulk density are commercially available, for example the "polishing clay” from Giulini-Chemie or ALCOA.
- a preferred suitable quality “polishing clay P10 finest” has an agglomerate size of less than 20 ⁇ m, an average primary crystal size of 0.5-1.5 ⁇ m and a bulk density of 500-600 g / l.
- silicates as polishing agent components can also be preferred according to the invention. They are used as cleaning bodies, particularly in modern practice.
- silicates which can be used according to the invention are aluminum silicates and zirconium silicates.
- the sodium aluminum silicate of the empirical formula Nai2 (Al ⁇ 2) i2 (Si ⁇ 2) i2 x 7H2O can be suitable as a polishing agent, such as the synthetic zeolite A.
- water-insoluble metaphosphates are, in particular, sodium metaphosphate, calcium phosphate such as, for example, tricalcium phosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate and calcium pyrophosphate.
- magnesium carbonate, magnesium hydrogen phosphate, trimagnesium phosphate or sodium hydrogen carbonate can be used as the polishing agent, in particular as a mixture with other polishing agents.
- the oral and dental care products according to the invention can preferably contain a number of further components. These include a .:
- Vitamins e.g. B. retinol, biotin, tocopherol, ascorbic acid and their derivatives (e.g. esters, salts);
- pigments e.g. B. titanium dioxide or zinc oxide
- Colored pigment particles for example colored silica particles such as those e.g. B. are commercially available under the sales name Sorbosil ® BFG 51, BFG 52 and BFG 53 or Sorbosil ® 2352. Mixtures of differently colored pigment particles can also be used.
- Such, e.g. B. strong orange, red or blue colored silica particles can in Quantities of 0.1-1.0% by weight can be contained in the agents according to the invention; o bleach; o dyes; o pH adjusting agents and buffer substances, e.g. B. sodium citrate, sodium bicarbonate or potassium and sodium phosphates, o sodium benzoate;
- Oral and dental care in the sense of the invention is to be understood as a daily cosmetic, non-therapeutic treatment.
- the teeth are cleaned and stains and food residues are removed, which makes their cosmetic appearance more beautiful and attractive.
- a second subject of the invention is therefore a non-therapeutic method for reducing and preventing discoloration on human teeth, in which a mouth and dentifrice containing a combination of active ingredients
- a third subject of the invention is therefore a non-therapeutic method for the inhibition of tartar and plaque, in which a mouth and tooth care product containing a combination of active ingredients
- a fourth object of the invention is the non-therapeutic use of a combination of active ingredients
- a fifth object of the invention is the non-therapeutic use of a combination of active ingredients
- Plastic tub for dye wheel (18 x 5 x 3.5)
- the cattle front teeth are cut in such a way that the flatest possible slabs of the labial sides with 7x7 mm surface are obtained. These slabs are attached to the center of the sample holder with the wax so that only the enamel surface is exposed. The enamel surface is evenly treated with 600 grit sandpaper to remove unevenness and contamination.
- the colorimetric measuring device from Dr. Long used.
- the sample is illuminated with light of the standard illuminant D65 (corresponds to daylight). The entire slab surface is measured in each case. Blinding prevents stray light from entering during the measurement.
- the brightness value L * defined in accordance with DIN 6174 is used as the test barometer.
- Treatment with the active ingredient solution is carried out twice a day in the morning and in the evening.
- Dye bath moves, which is freshly applied twice a day by brewing
- the slabs are rinsed with distilled water and, after the procedure has been completed, additionally wiped dry with cellulose in order to remove loose deposits.
- This treatment regimen was carried out for 10 days.
- the effectiveness of the tartar and PIaque-inhibiting effect was determined by determining the crystal growth of hydroxyapatite.
- the rate of crystal growth which can be influenced by active substances, is determined by titration with an alkali.
- the curve without toothpaste is evaluated as a zero curve with 0% inhibition.
- the consumption of KOH of the zero curve is read after 2 hours and compared with the consumption of the toothpaste solution.
- test mixtures were prepared (unless stated otherwise, all quantities are based on% by weight):
- the formula stability is only from a concentration of 0.1% Keltrol (xanthan
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- Public Health (AREA)
- Veterinary Medicine (AREA)
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Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10311171 | 2003-03-12 | ||
DE2003111171 DE10311171A1 (en) | 2003-03-12 | 2003-03-12 | Oral and dental care composition with antitartar, antiplaque and anti-discoloration action, containing cationic antibacterial agent, aza-cycloalkane-diphosphonic acid and xanthan gum or carboxymethyl cellulose |
PCT/EP2004/002503 WO2004080434A1 (en) | 2003-03-12 | 2004-03-11 | Oral and dental care agent |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1601337A1 true EP1601337A1 (en) | 2005-12-07 |
Family
ID=32892175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04719419A Withdrawn EP1601337A1 (en) | 2003-03-12 | 2004-03-11 | Oral and dental care agent |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060088482A1 (en) |
EP (1) | EP1601337A1 (en) |
JP (1) | JP2006519809A (en) |
CA (1) | CA2518267A1 (en) |
DE (1) | DE10311171A1 (en) |
WO (1) | WO2004080434A1 (en) |
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CN110927581A (en) * | 2019-11-11 | 2020-03-27 | 国网天津市电力公司电力科学研究院 | Multi-level index evaluation method for operating state of energy storage equipment based on entropy weight method |
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JP4038229B2 (en) * | 2004-09-16 | 2008-01-23 | 和則 草野 | Diagnostic kit and probe / syringe |
GB0505758D0 (en) * | 2005-03-21 | 2005-04-27 | Glaxo Group Ltd | Novel compositions |
EP1762215A1 (en) * | 2005-09-13 | 2007-03-14 | Unilever N.V. | Oral care composition |
US20070138439A1 (en) * | 2005-12-21 | 2007-06-21 | 3M Innovative Properties Company | Denaturant for ethanol |
US10092488B1 (en) | 2006-03-30 | 2018-10-09 | Janet M. Wehrli | System and method for reducing plaque on teeth |
US9498414B1 (en) | 2006-03-30 | 2016-11-22 | Janet M. Wehrli | System and method for reducing plaque on teeth |
US9833386B2 (en) | 2006-03-30 | 2017-12-05 | James D. Welch | Method of, and system for smoothing teeth |
EP2610056B1 (en) * | 2006-06-12 | 2016-09-21 | Solvay USA Inc. | Hydrophilized substrate and method for hydrophilizing a hydrophobic surface of a substrate |
DE102006053693A1 (en) * | 2006-11-13 | 2008-05-15 | Henkel Kgaa | Two-phase mouthwash |
CN101679916B (en) * | 2007-06-12 | 2013-03-20 | 罗迪亚公司 | Mono-di-and polyol phosphate esters in personal care formulations |
WO2008154617A2 (en) | 2007-06-12 | 2008-12-18 | Rhodia Inc. | Hard surface cleaning composition with hydrophilizing agent and method for cleaning hard surfaces |
AU2008261634B2 (en) | 2007-06-12 | 2014-04-24 | Rhodia Inc. | Detergent composition with hydrophilizing soil-release agent and methods for using same |
CN101677933B (en) * | 2007-06-12 | 2013-07-17 | 罗迪亚公司 | Mono-, di- and polyol alkoxylate phosphate esters in oral care formulations and methods for using same |
MX2009013365A (en) * | 2007-07-20 | 2010-01-25 | Rhodia | Method for recovering crude oil from a subterranean formation. |
EP2349191B2 (en) * | 2008-11-25 | 2016-12-21 | The Procter and Gamble Company | Oral care compositions comprising spherical fused silica |
US8551457B2 (en) | 2008-11-25 | 2013-10-08 | The Procter & Gamble Company | Oral care compositions comprising spherical fused silica |
WO2010129795A1 (en) | 2009-05-08 | 2010-11-11 | 3M Innovative Properties Company | Oral care method and kit |
JP2011051927A (en) * | 2009-09-01 | 2011-03-17 | Sunstar Inc | Composition for oral cavity |
AU2011383389A1 (en) * | 2011-12-15 | 2014-08-07 | Alequident Limited | Improvements in oral health, products and methods therefor |
CN104768520B (en) | 2012-11-05 | 2017-06-13 | 宝洁公司 | The precipitated silica of heat treatment |
BR112016005528B1 (en) | 2013-09-13 | 2023-03-28 | 3M Innovative Properties Company | ANTISEPTIC COMPOSITION COMPRISING MULTIVALENT CATIONIC ANTISEPTIC |
DE102014213158A1 (en) * | 2014-07-07 | 2016-01-07 | Henkel Ag & Co. Kgaa | Oral and dental care and cleaning agents with active ingredient deposition |
US11103732B1 (en) | 2015-10-17 | 2021-08-31 | James D. Welch | Method of improving the condition of teeth |
US10342646B2 (en) | 2015-10-17 | 2019-07-09 | James D. Welch | Method of, and system for smoothing teeth |
CN111372555A (en) * | 2017-11-21 | 2020-07-03 | 3M创新有限公司 | Water-in-bag plant-based oil emulsion for oral cavity and use method thereof |
JP7308835B2 (en) * | 2017-12-20 | 2023-07-14 | スリーエム イノベイティブ プロパティズ カンパニー | Oral composition and method of use |
US20230104834A1 (en) * | 2021-09-20 | 2023-04-06 | The Procter & Gamble Company | Jammed Emulsion Toothpaste Compositions |
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2004
- 2004-03-11 EP EP04719419A patent/EP1601337A1/en not_active Withdrawn
- 2004-03-11 WO PCT/EP2004/002503 patent/WO2004080434A1/en active Application Filing
- 2004-03-11 CA CA002518267A patent/CA2518267A1/en not_active Abandoned
- 2004-03-11 JP JP2006504640A patent/JP2006519809A/en active Pending
-
2005
- 2005-09-12 US US11/224,606 patent/US20060088482A1/en not_active Abandoned
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110927581A (en) * | 2019-11-11 | 2020-03-27 | 国网天津市电力公司电力科学研究院 | Multi-level index evaluation method for operating state of energy storage equipment based on entropy weight method |
CN110927581B (en) * | 2019-11-11 | 2022-05-24 | 国网天津市电力公司电力科学研究院 | Multi-level index evaluation method for operating state of energy storage equipment based on entropy weight method |
Also Published As
Publication number | Publication date |
---|---|
US20060088482A1 (en) | 2006-04-27 |
DE10311171A1 (en) | 2004-09-23 |
CA2518267A1 (en) | 2004-09-23 |
WO2004080434A1 (en) | 2004-09-23 |
JP2006519809A (en) | 2006-08-31 |
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