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EP1656153A2 - Compositions coupe-faim et procedes d'utilisation - Google Patents

Compositions coupe-faim et procedes d'utilisation

Info

Publication number
EP1656153A2
EP1656153A2 EP04778408A EP04778408A EP1656153A2 EP 1656153 A2 EP1656153 A2 EP 1656153A2 EP 04778408 A EP04778408 A EP 04778408A EP 04778408 A EP04778408 A EP 04778408A EP 1656153 A2 EP1656153 A2 EP 1656153A2
Authority
EP
European Patent Office
Prior art keywords
edible composition
dosage form
extract
amount
glycyrrhizin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04778408A
Other languages
German (de)
English (en)
Inventor
Mark A. Pedersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Crave Busters LLC
Original Assignee
Crave Busters LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crave Busters LLC filed Critical Crave Busters LLC
Publication of EP1656153A2 publication Critical patent/EP1656153A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)

Definitions

  • the present invention relates generally to the field of appetite control and, more specifically, to appetite control compositions and methods of use.
  • appetite control compositions have been in use for years. Appetite control compositions are conventionally used to assist in weight control. Typical appetite control compositions include prescription and over-the-counter drugs, e.g., amphetamines, Acutrim®, and Dexatrim®, as well as herbal remedies, e.g., Ephedra sinica, Citrus aurantium, Garcinia cambogia, and Gymnema sylvestre.
  • prescription and over-the-counter drugs e.g., amphetamines, Acutrim®, and Dexatrim®
  • herbal remedies e.g., Ephedra sinica, Citrus aurantium, Garcinia cambogia, and Gymnema sylvestre.
  • the appetite control compositions and methods of use in accordance with the present invention depart substantially from the conventional concepts and designs discussed above and overcome many of the disadvantages of known appetite control compositions.
  • the appetite control compositions according to the invention contain from about 3 mg to about 50 mg of gymnemic acid (an extract of Gymnema sylvestre), from about 10 mg to about 80 mg of glycyrrhizin (an extract of Glycyrrhiza glabra), high impact flavor, and a sweetening agent in a non-traditional dosage form intended to assist in weight control.
  • appetite control compositions according to the invention deliver a relatively small dose of an active ingredient, gymnemic acid, directly to the sweetness taste receptors of the tongue, which blocks the sense of sweetness and thereby produces appetite control.
  • some embodiments according to the invention comprise a slow- dissolving candy or other non-traditional dosage form, whose base may contain sweeteners and high impact flavors for palatability, designed to deliver about 3 mg to about 50 mg of gymnemic acid extracted from Gymnema sylvestre herb and about 10 mg to about 80 mg of glycyrrhizin extracted from Glycyrrhiza glabra root.
  • non-traditional dosage form means a dosage form that provides for the topical application of medicaments to the tissues of the mouth and tongue, more specifically, to the sweetness taste receptors of the tongue. It is advantageous to use a non-traditional dosage form that encourages the user to hold it in his or her mouth for sufficient time to allow the active ingredients to contact the tissues of the mouth and tongue and, more specifically, to contact the sweetness taste receptors of the tongue. Palatability is maximized by incorporating sweeteners and high impact flavors into the base matter of the non- traditional dosage form.
  • suitable non-traditional dosage forms include, but are not limited to, slow-dissolving hard candies or tablets, mouth sprays, toothpastes, gum drops, chocolate bars, lozenges, and pectin or gelatin desserts.
  • the dosage form is preferably large enough not only to facilitate contact between the gymnemic acid and the sweetness taste receptors of the tongue, but it must also be large enough to incorporate about 3 mg to about 50 mg of gymnemic acid and about 10 mg to about 80 mg of glycyrrhizin.
  • Gymnema sylvestre is commonly called Gurmar. It is well known in the art as a
  • Gymnema sylvestre contains the bitter principle gymnemic acid, which is well known for its ability to bind to the sweetness taste receptors on the tongue and to sugar absorption sites in the gut.
  • Gymnema sylvestre and extracts standardized to deliver gymnemic acid have been incorporated into traditional dosage forms to take advantage of its ability to block the absorption of sugar from the gut.
  • the bitter taste of its active constituent, gymnemic acid has previously limited the use of Gymnema sylvestre and its extracts to traditional dosage forms. Such products were designed to slow or reduce sugar absorption from the gut.
  • the dose of gymnemic acid required to provide this "sugar blocking" effect is from 80 mg to 300 mg.
  • Gymnema sylvestre or its extracts are rarely incorporated into non-traditional dosage forms. Gymnemic acid is known to selectively bind to the sweetness receptors of the tongue and eliminate the sense of sweetness for 1 to 2 hours.
  • Glycyrrhiza glabra root is commonly known as licorice root and is well known in the art as a sweetener, expectorant, and demulcent. Glycyrrhizin is an expectorant and demulcent that increases the texture and viscosity of the saliva in the mouth.
  • licorice root or preferably extract of licorice root, is included in the appetite control compositions according to the invention to increase the texture and viscosity of the saliva, allowing for more efficient delivery of gymnemic acid to the taste receptors of the tongue. This reduces the amount of gymnemic acid required to block the sense of sweetness in the mouth and produce appetite control.
  • about 10 mg to about 80 mg of glycyrrhizin is incorporated into the appetite control compositions according to the invention together with gymnemic acid to increase the contact time between the gymnemic acid and the sweetness receptors of the tongue, substantially reducing the quantity of gymnemic acid required to block the sense of sweetness.
  • the present inventor has discovered that relatively small doses between about 3 mg to about 50 mg of gymnemic acid delivered in a slow-dissolving candy or other non- traditional dosage form have the ability to block the sense of sweetness for a period of between 1 to 2 hours, thus discouraging the consumption of food and controlling the appetite.
  • the appetite control compositions according to the invention include Gymnema sylvestre herb or, preferably, an extract of Gymnema sylvestre herb designed to maximize the- quantity of gymnemic acid it contains.
  • Standard potency Gymnema sylvestre extracts are available commercially that contain from 25 to 75% gymnemic acid.
  • the appetite control compositions according to the invention include Glycyrrhiza glabra root or, preferably, an extract of Glycyrrhiza glabra root designed to maximize the quantity of glycyrrhizin it contains.
  • Standard potency Glycyrrhiza glabra root extracts are commercially available that contain from 20 to 50% glycyrrhizin.
  • Glycyrrhizin is an expectorant and demulcent that increases the texture and viscosity of the saliva in the mouth, increasing the contact time between the gymnemic acid and the sweetness receptors of the tongue.
  • the present inventor has found that from about 10 mg to about 80 mg of glycyrrhizin delivered concurrently with gymnemic acid effectively reduces the quantity of gymnemic acid required to block the sense of sweetness for 1 to 2 hours.
  • glycyrrhizin effectively reduces the quantity of gymnemic acid required in the composition by increasing the contact time between the gymnemic acid and the sweetness receptors of the tongue.

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions coupe-faim qui contiennent du gymnema sylvestre associé à un expectorant. Dans certains modes de réalisation, ces compositions coupe-faim contiennent entre environ 3 mg à environ 50 mg d'acide gymnemique (un extrait du gymnema sylvestre), entre environ 10 mg à environ 80 mg de glycyrrhizine (un extrait de Glycyrrhiza glabra), un arôme très puissant, ainsi qu'un édulcorant sous forme posologique non traditionnelle. La forme posologique non traditionnelle permet une application topique des médicaments, sur les tissus de la bouche et de la langue, et plus particulièrement, au niveau des récepteurs du goût sucré de la langue. L'administration de l'acide gymnemique aux récepteurs du goût sucré de la langue permet de bloquer la sensation de sucré, et par conséquent, d'exercer un effet coupe-faim.
EP04778408A 2003-07-14 2004-07-14 Compositions coupe-faim et procedes d'utilisation Withdrawn EP1656153A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48689503P 2003-07-14 2003-07-14
PCT/US2004/022872 WO2005007113A2 (fr) 2003-07-14 2004-07-14 Compositions coupe-faim et procedes d'utilisation

Publications (1)

Publication Number Publication Date
EP1656153A2 true EP1656153A2 (fr) 2006-05-17

Family

ID=34079317

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04778408A Withdrawn EP1656153A2 (fr) 2003-07-14 2004-07-14 Compositions coupe-faim et procedes d'utilisation

Country Status (2)

Country Link
EP (1) EP1656153A2 (fr)
WO (1) WO2005007113A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102526397B (zh) * 2012-01-12 2013-06-05 高新华 一种治疗流涎的药剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3885201A (en) * 1999-09-20 2001-04-24 Mastercare Diet and weight control gum and sucker
US6277396B1 (en) * 2000-05-11 2001-08-21 Maximum Human Performance, Inc. Dietary supplement containing a thermogenic substance and an adrenal support substance
US20020136782A1 (en) * 2001-01-18 2002-09-26 Fleischner Albert M. Composition patent for solid-dosage form of weight loss product

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005007113A3 *

Also Published As

Publication number Publication date
WO2005007113A2 (fr) 2005-01-27
WO2005007113A3 (fr) 2005-05-06

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Legal Events

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