EP1501853A4 - DURCH RNA-INTERFERENZ VERMITTELTE HEMMUNG DER GENEXPRESSION DES REZEPTORS DES EPIDERMALEN WACHSTUMSFAKTORS UNTER VERWENDUNG VON siNA (SHORT INTERFERING NUCLEIC ACID) - Google Patents

DURCH RNA-INTERFERENZ VERMITTELTE HEMMUNG DER GENEXPRESSION DES REZEPTORS DES EPIDERMALEN WACHSTUMSFAKTORS UNTER VERWENDUNG VON siNA (SHORT INTERFERING NUCLEIC ACID)

Info

Publication number: EP1501853A4
Authority: EP; European Patent Office
Prior art keywords: nucleic acid; short interfering; sina; rna; gene expression
Prior art date: 2002-02-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP03716093A

Other languages

English (en)

French (fr)

Other versions

EP1501853A2 (de

Inventor

James Mcswiggen

Pamela Pavco

Leonid Beigelman

Kathy Fosnaugh

Sharon Jamison

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sirna Therapeutics Inc

Original Assignee

Sirna Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-20

Filing date

2003-02-20

Publication date

2005-11-16

2002-05-29 Priority claimed from PCT/US2002/016840 external-priority patent/WO2002097114A2/en

2002-09-19 Priority claimed from US10/251,117 external-priority patent/US20030170891A1/en

2002-10-21 Priority claimed from US10/277,494 external-priority patent/US20030186909A1/en

2003-02-20 Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc

2003-02-20 Priority claimed from PCT/US2003/005045 external-priority patent/WO2003070912A2/en

2005-02-02 Publication of EP1501853A2 publication Critical patent/EP1501853A2/de

2005-11-16 Publication of EP1501853A4 publication Critical patent/EP1501853A4/de

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP03716093A 2002-02-20 2003-02-20 DURCH RNA-INTERFERENZ VERMITTELTE HEMMUNG DER GENEXPRESSION DES REZEPTORS DES EPIDERMALEN WACHSTUMSFAKTORS UNTER VERWENDUNG VON siNA (SHORT INTERFERING NUCLEIC ACID) Withdrawn EP1501853A4 (de)

Applications Claiming Priority (25)

Application Number	Priority Date	Filing Date	Title
US277494		1981-06-26
US251117		1988-09-29
US35858002P	2002-02-20	2002-02-20
US358580P		2002-02-20
US36312402P	2002-03-11	2002-03-11
US363124P		2002-03-11
PCT/US2002/016840 WO2002097114A2 (en)	2001-05-29	2002-05-29	Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv
WOPCT/US02/16840		2002-05-29
US38678202P	2002-06-06	2002-06-06
US163552		2002-06-06
US10/163,552 US20030105051A1 (en)	2001-05-29	2002-06-06	Nucleic acid treatment of diseases or conditions related to levels of HER2
US386782P		2002-06-06
US39392402P	2002-07-03	2002-07-03
US393924P		2002-07-03
US40678402P	2002-08-29	2002-08-29
US406784P		2002-08-29
US40837802P	2002-09-05	2002-09-05
US408378P		2002-09-05
US40929302P	2002-09-09	2002-09-09
US409293P		2002-09-09
US10/251,117 US20030170891A1 (en)	2001-06-06	2002-09-19	RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA)
US10/277,494 US20030186909A1 (en)	1997-01-27	2002-10-21	Nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
US44012903P	2003-01-15	2003-01-15
US440129P		2003-01-15
PCT/US2003/005045 WO2003070912A2 (en)	2001-06-06	2003-02-20	RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)

Publications (2)

Publication Number	Publication Date
EP1501853A2 EP1501853A2 (de)	2005-02-02
EP1501853A4 true EP1501853A4 (de)	2005-11-16

Family

ID=56290383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP03716093A Withdrawn EP1501853A4 (de)	2002-02-20	2003-02-20	DURCH RNA-INTERFERENZ VERMITTELTE HEMMUNG DER GENEXPRESSION DES REZEPTORS DES EPIDERMALEN WACHSTUMSFAKTORS UNTER VERWENDUNG VON siNA (SHORT INTERFERING NUCLEIC ACID)

Country Status (3)

Country	Link
EP (1)	EP1501853A4 (de)
JP (1)	JP2005517437A (de)
AU (1)	AU2003219818A1 (de)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000044895A1 (de) *	1999-01-30	2000-08-03	Roland Kreutzer	Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
WO2002044321A2 (en) *	2000-12-01	2002-06-06	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Rna interference mediating small rna molecules

2003
- 2003-02-20 EP EP03716093A patent/EP1501853A4/de not_active Withdrawn
- 2003-02-20 AU AU2003219818A patent/AU2003219818A1/en not_active Abandoned
- 2003-02-20 JP JP2003569805A patent/JP2005517437A/ja not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000044895A1 (de) *	1999-01-30	2000-08-03	Roland Kreutzer	Verfahren und medikament zur hemmung der expression eines vorgegebenen gens
WO2002044321A2 (en) *	2000-12-01	2002-06-06	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Rna interference mediating small rna molecules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELBASHIR S M ET AL: "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 20, no. 23, 3 December 2001 (2001-12-03), pages 6877 - 6888, XP002225998, ISSN: 0261-4189 *
PARRISH S ET AL: "Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 6, no. 5, November 2000 (2000-11-01), pages 1077 - 1087, XP002226298, ISSN: 1097-2765 *

Also Published As

Publication number	Publication date
EP1501853A2 (de)	2005-02-02
JP2005517437A (ja)	2005-06-16
AU2003219818A8 (en)	2003-09-09
AU2003219818A1 (en)	2003-09-09

Publication	Publication Date	Title
WO2003070912A3 (en)	2004-11-11	RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003070911A3 (en)	2004-08-26	Rna interference mediated inhibition of type 1 insulin-like growth factor receptor (igf-1r)
WO2003070884A3 (en)	2004-03-25	RNA INTERFERENCE MEDIATED INHIBITION OF MDR P-GLYCOPROTEIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003072705A3 (en)	2003-11-06	Rna interference mediated inhibition of cyclin d1 gene expression using short interfering nucleic acid (sina)
WO2003070918A3 (en)	2004-07-08	Rna interference by modified short interfering nucleic acid
WO2003070895A3 (en)	2004-01-15	RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2005045034A3 (en)	2005-08-11	RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
WO2003070887A3 (en)	2004-01-29	RNA INTERFERENCE MEDIATED INHIBITION OF POLYCOMB GROUP PROTEIN EZH2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003070972A3 (en)	2004-06-03	RNA INTERFERENCE MEDIATED INHIBITION OF CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP1522583A3 (de)	2005-10-12	Durch RNAi bewirkte Hemmung der Expression von dem Placental Growth Factor Gen mittels kleiner interfierender Nukleinsäuren (siNA)
WO2003070888A3 (en)	2004-04-01	Rna interference mediated inhibition of checkpoint kinase-1 (chk-1) gene expression using short interfering nucleic acid
WO2003070896A3 (en)	2004-03-04	RNA INTERFERENCE MEDIATED INHIBITION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
WO2003070197A3 (en)	2004-11-25	RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
EP1710307A3 (de)	2007-06-06	Durch RNA-Interferenz vermittelte Hemmung der Genexpression unter Verwendung von siNA (short interfering nucleic acid)
WO2003070885A3 (en)	2004-11-11	SHORT INTERFERING NUCLEIC ACID INHIBITION OF STEAROYL-CoA DESATURASE (SCD) GENE
EP1501853A4 (de)	2005-11-16	DURCH RNA-INTERFERENZ VERMITTELTE HEMMUNG DER GENEXPRESSION DES REZEPTORS DES EPIDERMALEN WACHSTUMSFAKTORS UNTER VERWENDUNG VON siNA (SHORT INTERFERING NUCLEIC ACID)

Legal Events

Date	Code	Title	Description
2004-12-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2005-02-02	17P	Request for examination filed	Effective date: 20040416
2005-02-02	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
2005-02-02	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO
2005-11-16	A4	Supplementary search report drawn up and despatched	Effective date: 20051006
2008-07-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-08-20	18D	Application deemed to be withdrawn	Effective date: 20080223