EP1575510A4 - Zusammensetzungen und verfahren zur behandlung von krankheiten mit protein-fehlanordnung und aggregation - Google Patents
Zusammensetzungen und verfahren zur behandlung von krankheiten mit protein-fehlanordnung und aggregationInfo
- Publication number
- EP1575510A4 EP1575510A4 EP03785053A EP03785053A EP1575510A4 EP 1575510 A4 EP1575510 A4 EP 1575510A4 EP 03785053 A EP03785053 A EP 03785053A EP 03785053 A EP03785053 A EP 03785053A EP 1575510 A4 EP1575510 A4 EP 1575510A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- aggregation
- compositions
- treatment
- methods
- exhibiting protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40219802P | 2002-08-07 | 2002-08-07 | |
US402198P | 2002-08-07 | ||
PCT/US2003/024868 WO2004014306A2 (en) | 2002-08-07 | 2003-08-07 | Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1575510A2 EP1575510A2 (de) | 2005-09-21 |
EP1575510A4 true EP1575510A4 (de) | 2007-12-26 |
Family
ID=31715805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03785053A Withdrawn EP1575510A4 (de) | 2002-08-07 | 2003-08-07 | Zusammensetzungen und verfahren zur behandlung von krankheiten mit protein-fehlanordnung und aggregation |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1575510A4 (de) |
JP (1) | JP2006509726A (de) |
KR (1) | KR20050053607A (de) |
CN (1) | CN101123993A (de) |
AU (1) | AU2003259073A1 (de) |
CA (1) | CA2494908A1 (de) |
IL (1) | IL166706A0 (de) |
NO (1) | NO20051159L (de) |
NZ (1) | NZ538145A (de) |
WO (1) | WO2004014306A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2007139120A1 (ja) * | 2006-05-30 | 2009-10-08 | 国立大学法人大阪大学 | アミロイドβクリアランス促進剤 |
KR100982909B1 (ko) * | 2009-07-08 | 2010-09-20 | 고려대학교 산학협력단 | 아탁신-1 유전자 또는 아탁신-1 단백질을 유효성분으로 포함하는 항암용 조성물 및 그를 이용한 항암제 스크리닝 방법 |
WO2011015572A1 (en) * | 2009-08-03 | 2011-02-10 | Galapagos Nv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases |
US11492617B2 (en) | 2017-08-08 | 2022-11-08 | Ionis Pharmaceuticals, Inc | Compositions and methods for modulation of protein aggregation |
WO2021078939A1 (en) | 2019-10-23 | 2021-04-29 | Universität Wien | Rna oligonucleotides for preventing aggregation of proteins |
WO2023205579A1 (en) * | 2022-04-18 | 2023-10-26 | The Regents Of The University Of California | Compositions and methods for disrupting pathological aggregates |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999006545A2 (en) * | 1997-08-01 | 1999-02-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation |
WO1999029891A1 (en) * | 1997-12-09 | 1999-06-17 | Arch Development Corporation | Methods for identifying factors controlling amyloid protein aggregation |
WO2000073501A2 (de) * | 1999-06-01 | 2000-12-07 | LASMÉZAS, Corinne, Ida | Nucleinsäuremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung |
WO2001023412A2 (en) * | 1999-09-27 | 2001-04-05 | Massachusetts Institute Of Technology | Methods of screening for agents which inhibit aggregation of polypeptides |
WO2002054083A2 (en) * | 2001-01-03 | 2002-07-11 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
WO2002065136A2 (en) * | 2001-02-15 | 2002-08-22 | University Of Chicago | Yeast screens for agents affecting protein folding |
WO2003013437A2 (en) * | 2001-08-07 | 2003-02-20 | University Of Delaware | Compositions and methods for the prevention and treatment of huntington's disease |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998001575A1 (en) * | 1996-07-08 | 1998-01-15 | Pioneer Hi-Bred International, Inc. | Transformation of zygote, egg or sperm cells and recovery of transformed plants from isolated embryo sacs |
CA2350212A1 (en) * | 1998-11-05 | 2000-05-11 | Thomas Jefferson University | Treatment of parkinson's disease with oligonucleotides |
JPWO2003044197A1 (ja) * | 2001-11-21 | 2005-03-24 | 独立行政法人科学技術振興機構 | ハンチントン病遺伝子転写因子 |
US20030235823A1 (en) * | 2002-06-24 | 2003-12-25 | The University Of Alabama | Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation |
-
2003
- 2003-08-07 AU AU2003259073A patent/AU2003259073A1/en not_active Abandoned
- 2003-08-07 WO PCT/US2003/024868 patent/WO2004014306A2/en active Application Filing
- 2003-08-07 CA CA002494908A patent/CA2494908A1/en not_active Abandoned
- 2003-08-07 JP JP2004527888A patent/JP2006509726A/ja active Pending
- 2003-08-07 NZ NZ538145A patent/NZ538145A/en unknown
- 2003-08-07 KR KR1020057002251A patent/KR20050053607A/ko not_active Application Discontinuation
- 2003-08-07 CN CNA038238969A patent/CN101123993A/zh active Pending
- 2003-08-07 EP EP03785053A patent/EP1575510A4/de not_active Withdrawn
-
2005
- 2005-02-06 IL IL16670605A patent/IL166706A0/xx unknown
- 2005-03-04 NO NO20051159A patent/NO20051159L/no not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999006545A2 (en) * | 1997-08-01 | 1999-02-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation |
WO1999029891A1 (en) * | 1997-12-09 | 1999-06-17 | Arch Development Corporation | Methods for identifying factors controlling amyloid protein aggregation |
WO2000073501A2 (de) * | 1999-06-01 | 2000-12-07 | LASMÉZAS, Corinne, Ida | Nucleinsäuremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung |
WO2001023412A2 (en) * | 1999-09-27 | 2001-04-05 | Massachusetts Institute Of Technology | Methods of screening for agents which inhibit aggregation of polypeptides |
WO2002054083A2 (en) * | 2001-01-03 | 2002-07-11 | Ortho-Mcneil Pharmaceutical, Inc. | Alpha synuclein aggregation assays |
WO2002065136A2 (en) * | 2001-02-15 | 2002-08-22 | University Of Chicago | Yeast screens for agents affecting protein folding |
WO2003013437A2 (en) * | 2001-08-07 | 2003-02-20 | University Of Delaware | Compositions and methods for the prevention and treatment of huntington's disease |
Non-Patent Citations (4)
Title |
---|
CORDEIRO Y ET AL: "DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 276, no. 52, 28 December 2001 (2001-12-28), pages 49400 - 49409, XP002196440, ISSN: 0021-9258 * |
KHOSHNAN ALI ET AL: "Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 99, no. 2, 22 January 2002 (2002-01-22), pages 1002 - 1007, XP002401586, ISSN: 0027-8424 * |
LECERF J-M ET AL: "Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 8, 10 April 2001 (2001-04-10), pages 4764 - 4769, XP002323805, ISSN: 0027-8424 * |
PROSKE DANIELA ET AL: "Prion-protein-specific aptamer reduces PrPSc formation.", CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY. 2 AUG 2002, vol. 3, no. 8, 2 August 2002 (2002-08-02), pages 717 - 725, XP002401585, ISSN: 1439-4227 * |
Also Published As
Publication number | Publication date |
---|---|
CN101123993A (zh) | 2008-02-13 |
CA2494908A1 (en) | 2004-02-19 |
KR20050053607A (ko) | 2005-06-08 |
JP2006509726A (ja) | 2006-03-23 |
NO20051159L (no) | 2005-04-26 |
IL166706A0 (en) | 2006-01-15 |
NZ538145A (en) | 2008-05-30 |
AU2003259073A1 (en) | 2004-02-25 |
WO2004014306A2 (en) | 2004-02-19 |
EP1575510A2 (de) | 2005-09-21 |
WO2004014306A3 (en) | 2006-05-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20050224 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12Q 1/68 20060101ALI20060607BHEP Ipc: A61K 48/00 20060101AFI20060607BHEP |
|
PUAK | Availability of information related to the publication of the international search report |
Free format text: ORIGINAL CODE: 0009015 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20070606 |
|
DA4 | Supplementary search report drawn up and despatched (deleted) | ||
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 20071127 |
|
17Q | First examination report despatched |
Effective date: 20080625 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20110301 |