EP1490382A4 - Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein - Google Patents

Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein

Info

Publication number: EP1490382A4
Authority: EP; European Patent Office
Prior art keywords: homoerythromycin; deoxo; aza; crystalline; hydrate used
Prior art date: 2002-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP02717187A

Other languages

German (de)

French (fr)

Other versions

EP1490382A1 (en

Inventor

Gi Jeong Kim

Mi Ra Seong

Sang Min Yun

Kwee Hyun Suh

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hanmi Pharmaceutical Co Ltd

Hanmi Pharmaceutical Industries Co Ltd

Original Assignee

Hanmi Pharmaceutical Co Ltd

Hanmi Pharmaceutical Industries Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-03

Filing date

2002-04-03

Publication date

2007-09-12

2002-04-03 Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd

2002-04-03 Priority claimed from PCT/KR2002/000588 external-priority patent/WO2003082889A1/en

2004-12-29 Publication of EP1490382A1 publication Critical patent/EP1490382A1/en

2007-09-12 Publication of EP1490382A4 publication Critical patent/EP1490382A4/en

Status Withdrawn legal-status Critical Current

Links

HRKNNHYKWGYTEN-HOQMJRDDSA-N (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)NC[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 HRKNNHYKWGYTEN-HOQMJRDDSA-N 0.000 title 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title 1
229960004099 azithromycin Drugs 0.000 title 1

EP02717187A 2002-04-03 2002-04-03 Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein Withdrawn EP1490382A4 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/KR2002/000588 WO2003082889A1 (en)	2001-03-21	2002-04-03	Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein

Publications (2)

Publication Number	Publication Date
EP1490382A1 EP1490382A1 (en)	2004-12-29
EP1490382A4 true EP1490382A4 (en)	2007-09-12

Family

ID=33411531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP02717187A Withdrawn EP1490382A4 (en)	2002-04-03	2002-04-03	Process of preparing azithromycin and crystalline 9-deoxo-9a-aza-9a-homoerythromycin a hydrate used therein

Country Status (3)

Country	Link
EP (1)	EP1490382A4 (en)
JP (1)	JP2005522470A (en)
CN (1)	CN1276919C (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101624412B (en) *	2008-07-10	2012-07-04	刘力	Derivative of macrolides, method for preparing same and application thereof
CN101724000B (en) *	2008-10-29	2012-05-30	广东东阳光药业有限公司	A kind of crystallization method of erythromycin
CN103159811A (en) *	2011-12-10	2013-06-19	山东方明药业集团股份有限公司	Preparation method for azithromycin intermediate 9a-deoxo-9a-aza-9a-homoerythromycin A
CN102417531B (en) *	2011-12-20	2014-06-11	浙江国邦药业有限公司	Method for preparing azithromycin monohydrate
CN105315316A (en) *	2014-07-21	2016-02-10	常州制药厂有限公司	Preparation method for azithromycin intermediate
CN106632543A (en) *	2016-12-20	2017-05-10	宁夏启元药业有限公司	Synthesis method of azithromycin
CN109293719A (en) *	2018-10-12	2019-02-01	浙江国邦药业有限公司	A kind of dihydro homoerythromycin crystal compound and preparation method thereof
CN114516895A (en) *	2020-11-19	2022-05-20	江苏威奇达药业有限公司	Azithromycin amine crystallization method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0827965A2 (en) *	1996-07-11	1998-03-11	Astur-Pharma, S.A.	Synthesis of 9-deoxo- 9a-aza 11,12-deoxy- 9a-methyl-9a-homoerythromycin A 11,12- hydrogenorthoborate dihydrate
EP0941999A2 (en) *	1998-03-13	1999-09-15	Hovione Inter Ltd.	Preparation of azithromycin dihydrate
WO2001000640A1 (en) *	1999-06-29	2001-01-04	Biochemie S.A.	Macrolides
WO2002015842A2 (en) *	2000-08-23	2002-02-28	Wockhardt Limited	Process for preparation of anhydrous azithromycin

2002
- 2002-04-03 CN CN02828700.2A patent/CN1276919C/en not_active Expired - Fee Related
- 2002-04-03 JP JP2003580353A patent/JP2005522470A/en active Pending
- 2002-04-03 EP EP02717187A patent/EP1490382A4/en not_active Withdrawn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0827965A2 (en) *	1996-07-11	1998-03-11	Astur-Pharma, S.A.	Synthesis of 9-deoxo- 9a-aza 11,12-deoxy- 9a-methyl-9a-homoerythromycin A 11,12- hydrogenorthoborate dihydrate
EP0941999A2 (en) *	1998-03-13	1999-09-15	Hovione Inter Ltd.	Preparation of azithromycin dihydrate
WO2001000640A1 (en) *	1999-06-29	2001-01-04	Biochemie S.A.	Macrolides
WO2002015842A2 (en) *	2000-08-23	2002-02-28	Wockhardt Limited	Process for preparation of anhydrous azithromycin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO03082889A1 *

Also Published As

Publication number	Publication date
CN1276919C (en)	2006-09-27
CN1625560A (en)	2005-06-08
EP1490382A1 (en)	2004-12-29
JP2005522470A (en)	2005-07-28

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Legal Events

Date	Code	Title	Description
2004-11-12	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2004-12-29	17P	Request for examination filed	Effective date: 20040903
2004-12-29	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2005-03-23	RIN1	Information on inventor provided before grant (corrected)	Inventor name: SEONG, MI RA Inventor name: KIM, GI JEONG Inventor name: SUH, KWEE HYUN Inventor name: YUN, SANG MIN
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: KIM, GI JEONG Inventor name: YUN, SANG MIN Inventor name: SUH, KWEE HYUN Inventor name: SEONG, MI RA
2007-09-12	A4	Supplementary search report drawn up and despatched	Effective date: 20070813
2007-09-12	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/7048 20060101ALI20070807BHEP Ipc: A61P 31/04 20060101ALI20070807BHEP Ipc: C07H 17/08 20060101AFI20031015BHEP
2007-11-14	17Q	First examination report despatched	Effective date: 20071016
2010-03-26	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2010-04-28	18D	Application deemed to be withdrawn	Effective date: 20091102