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EP1364004A4 - Administration of nucleic acid sequence to female animal - Google Patents

Administration of nucleic acid sequence to female animal

Info

Publication number
EP1364004A4
EP1364004A4 EP01997073A EP01997073A EP1364004A4 EP 1364004 A4 EP1364004 A4 EP 1364004A4 EP 01997073 A EP01997073 A EP 01997073A EP 01997073 A EP01997073 A EP 01997073A EP 1364004 A4 EP1364004 A4 EP 1364004A4
Authority
EP
European Patent Office
Prior art keywords
administration
nucleic acid
acid sequence
female animal
ghrh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01997073A
Other languages
German (de)
French (fr)
Other versions
EP1364004A2 (en
Inventor
Robert J Schwartz
Robert H Carpenter
Ruxandra Draghia-Akli
Douglas R Kern
Roy G Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Advisys Inc
Original Assignee
Baylor College of Medicine
Advisys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine, Advisys Inc filed Critical Baylor College of Medicine
Publication of EP1364004A2 publication Critical patent/EP1364004A2/en
Publication of EP1364004A4 publication Critical patent/EP1364004A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Growth is improved by utilizing growth enhancement potential methodology to administer a nucleic acid sequence, such as GHRH or an analog, to a female animal, preferably through a parenteral route of administration. Piglets born from sows injected with DNA encoding GHRH are larger, and effects ae demonstrated in subsequent pregnancies without additional administration(s) of the vector.
EP01997073A 2000-12-12 2001-12-12 Administration of nucleic acid sequence to female animal Ceased EP1364004A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25502100P 2000-12-12 2000-12-12
US255021P 2000-12-12
PCT/US2001/048726 WO2002061037A2 (en) 2000-12-12 2001-12-12 Administration of nucleic acid sequence to female animal

Publications (2)

Publication Number Publication Date
EP1364004A2 EP1364004A2 (en) 2003-11-26
EP1364004A4 true EP1364004A4 (en) 2005-11-09

Family

ID=22966509

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01997073A Ceased EP1364004A4 (en) 2000-12-12 2001-12-12 Administration of nucleic acid sequence to female animal

Country Status (10)

Country Link
EP (1) EP1364004A4 (en)
KR (1) KR20040039187A (en)
CN (1) CN1575301A (en)
AR (1) AR035671A1 (en)
AU (1) AU2002248194B2 (en)
BR (1) BR0116472A (en)
CA (1) CA2430921C (en)
MX (1) MXPA03005236A (en)
PL (1) PL366116A1 (en)
WO (1) WO2002061037A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR037038A1 (en) * 2001-10-26 2004-10-20 Baylor College Medicine A COMPOSITION AND METHOD TO ALTER THE MAGRA BODY MASS AND THE OSEAS PROPERTIES IN A SUBJECT
CA2475273A1 (en) * 2002-02-07 2003-08-14 Baylor College Of Medicine Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy
DE60336736D1 (en) 2002-07-16 2011-05-26 VGX Pharmaceuticals LLC CODON-OPTIMIZED SYNTHETIC PLASMIDE
DE10240418A1 (en) * 2002-09-02 2004-03-11 Avontec Gmbh Formulation for introducing nucleic acids into eukaryotic cells
AU2003295366B2 (en) * 2002-11-04 2011-11-24 Advisys, Inc. Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells
CA2513743C (en) * 2003-01-28 2013-06-25 Advisys, Inc. Reducing culling in herd animals growth hormone releasing hormone (ghrh)
CN102127545A (en) * 2010-11-24 2011-07-20 山东农业大学 Skeletal muscle specificity CKM (Creatine Kinase Muscle) promoter and applications thereof
CN104031930B (en) * 2014-05-30 2017-09-22 华南农业大学 A kind of method of nutrition and immune substance content in raising sow milk
CN105219774B (en) * 2015-10-10 2019-04-30 广西大学 Pork insulin specific expressing promoter PIP2 and its application
CN105617404A (en) * 2016-01-27 2016-06-01 广州市科虎生物技术研究开发中心 Application of GRF (growth hormone releasing factor) expression plasmid in preparation of medicines for reducing rate of weak piglets
DE202018105142U1 (en) * 2018-04-29 2018-10-08 Kalmarna Limited - CCS Trustees Limited Compositions for oral administration for influencing the progeny of mammals
CN115044666B (en) * 2022-06-13 2024-06-25 天津市农业科学院 SNP molecular marker for predicting sow binary syndrome and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317387A1 (en) * 1987-11-04 1989-05-24 Institut National De La Recherche Agronomique Method for enhancing the milk production of mamals and/or increasing the weight of the litter and improving the post-birth growth
WO1992000095A1 (en) * 1990-06-29 1992-01-09 Hoffmann-La Roche Inc. Histidine substituted growth hormone releasing factor analogs
WO1999005300A2 (en) * 1997-07-24 1999-02-04 Valentis, Inc. Ghrh expression system and methods of use
WO2001006988A2 (en) * 1999-07-26 2001-02-01 Baylor College Of Medicine Super-active porcine growth hormone releasing hormone analog

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165755A (en) * 1997-01-23 2000-12-26 University Of Victoria Innovation And Development Corporation Chicken neuropeptide gene useful for improved poultry production

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317387A1 (en) * 1987-11-04 1989-05-24 Institut National De La Recherche Agronomique Method for enhancing the milk production of mamals and/or increasing the weight of the litter and improving the post-birth growth
WO1992000095A1 (en) * 1990-06-29 1992-01-09 Hoffmann-La Roche Inc. Histidine substituted growth hormone releasing factor analogs
WO1999005300A2 (en) * 1997-07-24 1999-02-04 Valentis, Inc. Ghrh expression system and methods of use
WO2001006988A2 (en) * 1999-07-26 2001-02-01 Baylor College Of Medicine Super-active porcine growth hormone releasing hormone analog

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DRAGHIA-AKLI R ET AL: "ENHANCED GROWTH BY ECTOPIC EXPRESSION OF GROWTH HORMONE RELEASING HORMONE USING AN INJECTABLE MYOGENIC VECTOR", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 15, no. 12, November 1997 (1997-11-01), pages 1285 - 1289, XP002060954, ISSN: 1087-0156 *
DRAGHIA-AKLI RUXANDRA ET AL: "Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 12, December 1999 (1999-12-01), pages 1179 - 1183, XP002159711, ISSN: 1087-0156 *
KHAN A S ET AL: "GHRH GENE DELIVERY TO PREGNANT RATS INCREASES SOMATOTROPH POPULATION AND GROWTH OF PUPS.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 74.3 URL - http://sf, XP009053813 *

Also Published As

Publication number Publication date
KR20040039187A (en) 2004-05-10
BR0116472A (en) 2005-04-05
WO2002061037A2 (en) 2002-08-08
WO2002061037A3 (en) 2003-10-02
CA2430921A1 (en) 2002-08-08
CN1575301A (en) 2005-02-02
EP1364004A2 (en) 2003-11-26
CA2430921C (en) 2016-06-07
AR035671A1 (en) 2004-06-23
PL366116A1 (en) 2005-01-24
AU2002248194B2 (en) 2007-04-05
WO2002061037B1 (en) 2004-01-15
MXPA03005236A (en) 2005-04-08

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