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EP1230394A4 - Lentiviral vector transduction of hematopoietic stem cells - Google Patents

Lentiviral vector transduction of hematopoietic stem cells

Info

Publication number
EP1230394A4
EP1230394A4 EP00978485A EP00978485A EP1230394A4 EP 1230394 A4 EP1230394 A4 EP 1230394A4 EP 00978485 A EP00978485 A EP 00978485A EP 00978485 A EP00978485 A EP 00978485A EP 1230394 A4 EP1230394 A4 EP 1230394A4
Authority
EP
European Patent Office
Prior art keywords
stem cells
hematopoietic stem
lentiviral vector
vector transduction
transduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00978485A
Other languages
German (de)
French (fr)
Other versions
EP1230394A1 (en
Inventor
Wen Yong Chen
Xiaoyun Wu
John C Kappes
Tim M Townes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UAB Research Foundation
Original Assignee
UAB Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UAB Research Foundation filed Critical UAB Research Foundation
Publication of EP1230394A1 publication Critical patent/EP1230394A1/en
Publication of EP1230394A4 publication Critical patent/EP1230394A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16045—Special targeting system for viral vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP00978485A 1999-11-10 2000-11-10 Lentiviral vector transduction of hematopoietic stem cells Withdrawn EP1230394A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16462599P 1999-11-10 1999-11-10
US164625P 1999-11-10
PCT/US2000/030882 WO2001034843A1 (en) 1999-11-10 2000-11-10 Lentiviral vector transduction of hematopoietic stem cells

Publications (2)

Publication Number Publication Date
EP1230394A1 EP1230394A1 (en) 2002-08-14
EP1230394A4 true EP1230394A4 (en) 2002-12-18

Family

ID=22595350

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00978485A Withdrawn EP1230394A4 (en) 1999-11-10 2000-11-10 Lentiviral vector transduction of hematopoietic stem cells

Country Status (5)

Country Link
EP (1) EP1230394A4 (en)
JP (1) JP2003517301A (en)
AU (1) AU784988B2 (en)
CA (1) CA2391129A1 (en)
WO (1) WO2001034843A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7575924B2 (en) 2000-11-13 2009-08-18 Research Development Foundation Methods and compositions relating to improved lentiviral vectors and their applications
WO2003012054A2 (en) 2001-08-02 2003-02-13 Institut Clayton De La Recherche Methods and compositions relating to improved lentiviral vector production systems
RU2305708C2 (en) * 2001-10-02 2007-09-10 Энститю Клейтон Де Ля Решерш Recombinant lentiviral vector, host cell transduced with lentiviral vector, methods for transduction and uses thereof
ATE458047T1 (en) 2002-03-07 2010-03-15 Univ Delaware METHOD FOR ENHANCING OLIGONUCLEOTIDE-MEDIATED NUCLEIC ACID SEQUENCE CHANGE USING COMPOSITIONS CONTAINING A HYDROXYUREA
CN103492406B (en) 2010-12-09 2022-07-26 宾夕法尼亚大学董事会 Use of chimeric antigen receptor-modified T cells for treating cancer
US20140199279A1 (en) * 2011-01-03 2014-07-17 Bluebird Bio, Inc. Methods for enhancing the delivery of gene-transduced cells
UY35468A (en) 2013-03-16 2014-10-31 Novartis Ag CANCER TREATMENT USING AN ANTI-CD19 CHEMERIC ANTIGEN RECEIVER
WO2015157252A1 (en) 2014-04-07 2015-10-15 BROGDON, Jennifer Treatment of cancer using anti-cd19 chimeric antigen receptor
WO2015183885A1 (en) * 2014-05-27 2015-12-03 Dana-Farber Cancer Institute, Inc. Methods and compositions for perturbing gene expression in hematopoietic stem cell lineages in vivo
DK3280729T3 (en) 2015-04-08 2022-07-25 Novartis Ag CD20 TREATMENTS, CD22 TREATMENTS AND COMBINATION TREATMENTS WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) EXPRESSING CELL
EP3512538A4 (en) * 2016-09-13 2020-05-06 Academia Sinica Methods for enhancing lifespan and/or treating cellular proliferative disorders by transplantation
BR112019006781A2 (en) 2016-10-07 2019-07-30 Novartis Ag chimeric antigen receptors for cancer treatment
US11597917B2 (en) 2017-07-06 2023-03-07 The Medical College Of Wisconsin, Inc. In vitro and in vivo enrichment strategy targeting lymphocytes derived from vector transduced HSCs for therapy of disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0134843A1 *

Also Published As

Publication number Publication date
CA2391129A1 (en) 2001-05-17
JP2003517301A (en) 2003-05-27
AU1594401A (en) 2001-06-06
AU784988B2 (en) 2006-08-17
EP1230394A1 (en) 2002-08-14
WO2001034843A1 (en) 2001-05-17

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Legal Events

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18D Application deemed to be withdrawn

Effective date: 20070116