Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N2/00—Magnetotherapy
  • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Definitions

• the present invention relates to a method of ion movement activation, especially through cell membranes and capillary walls in living organisms, and apparatus for application of this method.
• Known ion movement methods are based on pulsed very low frequency electromagnetic field impact on living organisms. Magnetic fields with negligible electric component are generated by electric current pulses.
• a method and apparatus for ion movement through cell membranes is known from EP 0407006 European Patent Application.
• a method disclosed is based on a simultaneous activation of different ionic species, Ca ++ and Mg ++ in particular, using magnetic cyclotron resonance frequency. An effect of uniform very low frequency magnetic fields generated by sinusoidal electric current pulses of non-zero average value is used for this purpose, when field lines are parallel to the axis on which a part of the living organism is located.
• An apparatus for using the method according the above patent application comprises a generator of sinusoidal electric pulses which is connected to a constant and defined direct current circuit and to an amplifier, outputs of both are controlled with the switch controlling a pair of Helmholtz coils which operate as electrical pulse to magnetic signal converter.
• a basic current pulse consisting of a square wave superimposed onto an exponentially increasing current is used for ion transportation, then an interruption as long as at least pulse duration follows.
• Pulses and interruptions form a 100 to 1000 Hz wave.
• Pulse amplitude is modulated with a 0,5 to 35 Hz signal, modulation envelope is triangular (close to an isosceles triangle).
• Modulated basic pulse string of constant polarisation forms a packet 0,3 to 1 second long, then a 0,7 to 5,0 seconds interruption follows.
• Pulse packets are converted into alternating magnetic field signals, electrodynamically and magnetomechanically influencing ions and especially protons to cause their transport through cell membranes.
• An apparatus for ion transport as described in the patent discussed consists of a control desk connected to a microprocessor control unit and then, by an amplifier, with a transmitting coil which converts current pulses into magnetic signals.
• a control circuit consists of microprocessor, clock generator, memory, address generator and analog-to-digital converter.
• a method of ion transport activation through cell membranes and capillary walls in live organisms is based on the effects of pulsed very low frequency electromagnetic field generated by electric current pulses.
• Two types of signals are used, as well as their combinations into consecutive packets, packet groups, packet group series, sets of packet group series, combined sets of packet groups series. They magnetomechanically and electrodynamically influence ions of different elements, giving rise to ion cyclotron resonance in live organisms cells.
• Field intensity E depends upon induction change rate dB/dt according to the equation
• Magnetomechanical effect on a biological system consists in the creation of magnetomechanical force F, causing the movement of particles and atoms with non-compensated spins.
• Magnetomechanical force F is a result of magnetic field induction B gradient dB/dx and can be expressed as the equation
• V - is the volume of uncompensated spins
• ⁇ is the relative magnetic permeability of a biological system
• ⁇ 0 - is the magnetic permeability of vacuum.
• the characteristic of the first type of signal is an open polygon line consisting of seven sections of 3,0 to 9,4 ms total duration. Within its first section, induction increases linearly from zero to 1/3 B max during 0,5 to 1 ,6 ms. Within its second section, which is parallel to f axis, induction has constant value of 1/3 B max during 0,5 to 1 ,2 ms then, within its third section it increases linearly from 1/3 B max to 2/3 B max during 0,4 to 1 ,5 ms.
• induction is kept constant on the 2/3 B max value during 0,1 to 0,5 ms.
• induction increases linearly to B max during 0,5 to 1,5 ms.
• induction sharply decreases to zero during 0,1 ms or less, remaining at zero value within its seventh section during 0,5 to 1 ,5 ms.
• the characteristic of the second type of signal is shaped as an open polygon line consisting of five sections of 5.0 to 9,4 ms total duration.
• induction increases linearly to 1/2 B max value during 0,7 to 1 ,3 ms.
• Alternating magnetic field frequencies are ion resonance frequencies f c of different elements.
• Ratios of f c to induction B of alternating magnetic field are equal to the ratio of a particular element's ion electric charge to ion mass.
• signals of both types are combined into packets, each of which consists of consecutive particular signals string, an interruption is included between consecutive packets, duration of the interruption between consecutive first type signals is longer than duration ot the interruption between consecutive second type signals.
• Packets consisting of four first type signals and five second type signals are the most frequently used.
• the first type signal packet duration is 10 to 50 ms and interruption duration is 40 to 60 ms.
• the second type signal packet duration is 20 to 30 ms, interruption duration is 20 to 50 ms.
• a combination of packets formed into packet groups of both signal types is also used.
• Each group consists of a particular type signal packet series, with an interruption between consecutive groups.
• the first type signal packets lasts for 250 to 400 ms, interruption duration is 40 to 60 ms.
• the second type signal packets lasts for 140 to 300 ms, interruption duration is 80 to 200 ms. It is advantageous to use the first type signal packet groups containing at least five packets and the second type signal packet groups containing at least four packets. Moreover, combinations of packet groups into series and then combinations of series into sets is used. Each series consists of a particular signal packet groups sequence, the interruption appears between consecutive packet group series.
• the first type signal packet group series duration is 7 to 10 s, an interruption between series lasts for 3 to 4 s.
• the second type signal packet group series duration is 5 to 9 s, an interruption between series lasts for 2 to 4 s.
• a series of the first type signal packet groups consists usually of twenty to twenty six groups, advantageously - of twenty four groups, when a series of the second type signal packet groups consists twenty to twenty four groups, advantageously
• each set consists of a particular type signal packet group series sequences.
• the duration of first and second type signal packet group series lies between 90 and 240 s.
• Positive and negative polarisation is used for a set of packet group series of particular signal type. It is advantageous when the first type signal packet group series set consists of at least ten series and when the second type signal packet group series set consists of at least twelve series.
• Combinations of the first and the second type signal packet group series sets in a form of at least two first type signal packet groups series sets, after which at least two second type signal packet group sets follow, are the most frequently used. Different set polarisation of neigbouring sets is used.
• An apparatus for ion transport activation consists of control and supervision panel with control pushbuttons and signal lamps, connected to a microprocessor control unit with a generator and memory, as further to an amplifier.
• the amplifier is connected to a converter and dummy load by a symmetrical current source and execution system.
• the execution system is directly connected to the microprocessor control system.
• a current pulse-to-electromagnetic signal converter is usually made as a magnetic applicator containing at least one electromagnetic coil generating the nonuniform magnetic field.
• the control and supervision panel is conected to an infrared radiation receiver, controlled by a remote controller.
• the microprocessor control unit contains a memory, advantageously of RAM type for direct control, and non- volatile EEPROM memory for external apparatus functions programming.
• RAM memory contains shapes of current signals of both types, their sequence of occurence, combinations and forms of packets, packet groups, packet group series, packet group series sets with time relations taken into consideration, and amplitude changes.
• the non-volatile EEPROM memory contains ready-made programs of signals combinations into packets, packet groups, packet group series and sets of packet group series with time relations and amplitude changes taken into consideration.
• the voltage amplifier contains two operational amplifiers. Voltage amplifier input is connected directly to the first operational amplifier non-inverting input and - by a resistor - to the second operational amplifier inverting input. The second operational amplifier, together with four resistors, forms a differential amplifier with its non-inverting imput connected to the first operational amplifier output. Parallel-connected circuits consisting of a resistor in series with a key are connected between ground and first operational amplifier inverting input to create first operational amplifier negative feedback circuit. Voltage amplifier output is the second operational amplifier output.
• Uwy - is amplifier output voltage
• U we - is amplifier input voltage
• a method according to the present invention of ion transport activation through living organisms cell membranes under the influence of nonuniform very low frequency magnetic field ensures an increase in number of transported ions of a particular element and in number of types of elements, ions of which are transported.
• This effect is a result of introduction of two types of magnetic signals with characteristics shaped according to the present invention, resulting in simultaneous occurence of three effect types: electrodynamic effect, magnetomechanical effect and ion cyclotron resonance effect.
• Possibility of combining signals into packets, packet groups, packet group series and packet group series sets, along with a possibility of duration and amplitude changes, enables quantitative and qualitative control of a wide range of ions transported by changing a share of a particular magnetic field influence type.
• the apparatus for application of ion transport activation method fitted with microprocessor control unit connected to an amplifier and converter by the symmetrical current source enables the generation, amplification and transmission of two signal types with characteristics according to the present invention.
• RAM memory of microprocessor control unit permits direct setting of both signals combinations of packets, packet groups, packet group series and sets of packet group series with appropriate durations and amplitude changes, all controlled from control panel. Fitting microprocessor control unit with remote controller and infrared radiation receiver as well as with additional EEPROM memory enables a choice and switching of signal combination sets already created, duration and amplitude changes taken into account,
• An essential merit of such a solution is the possibility of remotely switching the apparatus on with no exposure of personnel on the long-term magnetic field influence.
• the binary-controlled voltage amplifier with parallel-connected resistor and key series circuits guarantees that output amplitude control depends upon program chosen.
• fitting the apparatus with dummy-loaded execution circuit enables the simulation of apparatus operation.
• Fig. 1 illustrates the characteristic of induction B changes as a function of the first type signal duration
• Fig, 2 illustrates the characteristic of induction B changes as a function of the second type signal duration
• Fig. 3 presents the characteristic of induction B changes as a function of time for a packet of four first type signals
• Fig. 4 illustrates the characteristic of induction B changes as a function of time for a packet of five second type signals
• Fig. 5 illustrates the characteristic of induction B changes as a function of time for a group of five first type signal packets
• Fig. 6 presents the characteristic of induction B changes as a function of time for a group of four second type signal packets
• Fig. 7 illustrates the characteristic of induction B changes as a function of time for a series of twenty four first type signal packet groups
• Fig. 8 illustrates the characteristic of induction B changes as a function of time for a series of twenty two second type signal packet groups
• Fig. 9 presents the characteristic of induction B changes as a function of time for two sets of fifteen first type signal packet group series each;
• Fig. 10 illustrates the characteristic of induction B changes as a function of time for two sets of eighteen second type signal packet group series each;
• Fig. 11 illustrates the characteristic of induction B changes as a function of time for two sets of ten first type signal packet group series each;
• Fig. 12 illustrates the characteristic of induction B changes as a function of time for two sets of twelve first type signal packet group series each;
• Fig. 13 illustrates the characteristic of induction B changes as a function of time for a combination of two sets of the first type signal packet group series with two sets of second type signal packet group series;
• Fig. 14 presents the characteristic of induction B changes as a function of time for a combination of two sets of the second type signal packet group series with two sets of the first type signal packet group series;
• Fig. 15 illustrates the characteristic of induction B changes as a function of time for a combination of two sets of the second type signal packet group series and two sets of the first type signal packet group series with amplitude increasing stepwise within each set
• Fig. 16 illustrates the characteristic of induction B changes as a function of time for a combination of two sets of the first type signal packet group series and two sets of the second type packet group series with amplitude increasing stepwise within the first set and decreasing stepwise within the last set
• Fig. 17 is the block schematic of the apparatus for ion transport activation
• Fig. 18 is the schematic drawing of voltage amplifier.
• a method of ion transport activation consists in the application of two signal types and their combinations in a form of consecutive packets, packet groups, packet group series, packet group series sets and combinations of packet group series sets.
• characteristics of induction B changes as a function of time f are shaped as two different open polygon lines.
• Ion cyclotron resonance frequencies f c for selected ions of living organisms body fluids as a function of alternating magnetic field induction are shown in Table 1. Table 1
• Table 2 shows the ratio of electric charge q to ion mass m for elements from the Table 1.
• packets are combined into one type signal groups.
• Packet groups are combined into first type signal packet group series.
• Packet group series are further combined into sets of one signal type.
• Set of the second signal type packet group series as shown in fig. 12 contains twelve series, twenty two groups each.
• Program I of 10 minutes duration as shown in Fig. 13 is used for living organisms. It is the combination of two sets of the first type signal packet group series, three minutes each, and of two sets of the second type signal packet group series, two minutes each. Consecutive sets change their polarisation into a reverse one.
• Example 2 Series of the first and the second type signals as described in Example 1 and combined into sets are used.
• Program II of 10 minutes duration as shown in Fig. 14 is used for living organisms. It is the combination of two sets of the second type signal packet group series, three minutes each, and of two sets of the first type signal packet group series, two minutes each. Consecutive sets change their polarisation into a reverse one.
• Program III of 15 minutes duration as shown in Fig. 15 is used for living organisms. It is a combination of two second type signal packet group series and two first type signal packet group series.
• the second type signal sets duration is six minutes. One set contains twelve series of two minutes total duration and the next set contains twenty four series of four minutes total duration.
• the first type signal sets duration is six minutes. One set contains twenty series and lasts for four minutes and the next set contains ten series and lasts for two minutes.
• the amplitude of each series is changed stepwise within a cycle from minimum induction value to the set B s value, the same cycle is repeated in all sets.
• Program IV of twelve minutes duration as shown in Fig. 16 is used for living organisms. It is a combination of two first type signal packet group series and two second signal type packet group series.
• the first type signal sets duration is six minutes. One set contains ten series of two minutes total duration and the next set contains twenty series of four minutes total duration.
• the second type signal sets duration is six minutes.
• One set contains twenty four series of four minutes total duration and the next set contains twelve series of two minutes total duration.
• series amplitude is changed stepwise from minimum induction value to 0,8 B sk .
• series amplitude is constant and equal to B sk .
• series amplitude changes from 0,8 B sk to minimum induction value.
• the apparatus for ion transport activation as shown in Fig. 17 consists of control and supervision panel PS with control pushbuttons and signal lamps, connected to a microprocessor control unit MUS with a generator as well as with RAM and EEPROM memories, and followed by amplifier W.
• Amplifier W is connected by symmetrical current source IS and execution system UW to the converter PA and dummy load PL.
• Execution system UW is connected directly to the microprocessor control unit MUS.
• the control and supervision panel PS is connected to the infrared radiation receiver IR, controlled with the use of remote controller P.
• Microprocessor control unit MUS contains RAM memory for direct control operations and an additional non-volatile EEPROM memory for equipment functions programming from the outside world.
• RAM memory contains shapes of current signals of two types, their sequence of occurence, combinations of signals into packets, packet groups, packet group series and packet group series sets, taking into consideration their time relations and amplitude changes.
• Non-volatile EEPROM memory contains ready-made programs of packet group series sets combination blocks, time relations and amplitude changes taken into consideration.
• Voltage amplifier as shown in Fig. 18 contains two operational amplifiers W1 and W2.
• Voltage amplifier input WE is direcltly connected to the first operational amplifier W1 non-inverting input (+) and is connected by the resistor R1 to the second operational amplifier inverting input (-).
• Operational amplifier W2 together with four resistors R1 operates as differential amplifier with its non- inverting (+) input connected to the first operational amplifier W1 output.
• U ⁇ is amplifier W output voltage
• the apparatus is started after program is chosen and pushbuttons on control panel PS or remote controller P are switched on.
• Microprocessor control unit MUS generates two pulse types and their combinations into packets, packet groups, packet group series, packet group series sets and combinations of packet group series sets, stored in RAM and EEPROM memories in a digital form.
• Signal amplitude is controlled by binary controlled amplifier W.
• Amplifier output voltage U ⁇ is changed depending upon the status of K1 ,
• Voltage amplifier W drives the symmecthcal current source IS, which enables non-contact polarisation switching of pulses which drive PA converter through execution circuit UW when operated in its basic state. Current pulses are converted in PA converter into signals of alternating magnetic field that effect a living organism.
• execution circuit UW is switched into the second state, in which it is loaded with dummy load PL.

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• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Radiology & Medical Imaging (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Electrotherapy Devices (AREA)
• Radiation-Therapy Devices (AREA)
• Amplifiers (AREA)

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• 1999
  • 1999-06-14 PL PL333729A patent/PL194547B1/pl unknown
  • 1999-09-15 CA CA002409245A patent/CA2409245C/en not_active Expired - Fee Related
  • 1999-09-15 EP EP99941919A patent/EP1299154A1/en not_active Withdrawn
  • 1999-09-15 RU RU2002118595/15A patent/RU2232597C2/ru not_active IP Right Cessation
  • 1999-09-15 WO PCT/PL1999/000031 patent/WO2000076582A1/en not_active Application Discontinuation

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