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EP1287159A4 - ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS - Google Patents

ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS

Info

Publication number
EP1287159A4
EP1287159A4 EP01933181A EP01933181A EP1287159A4 EP 1287159 A4 EP1287159 A4 EP 1287159A4 EP 01933181 A EP01933181 A EP 01933181A EP 01933181 A EP01933181 A EP 01933181A EP 1287159 A4 EP1287159 A4 EP 1287159A4
Authority
EP
European Patent Office
Prior art keywords
hypertension
treatment
mammals
peptides
products obtained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01933181A
Other languages
German (de)
French (fr)
Other versions
EP1287159A1 (en
Inventor
Martin E Davis
Anand Rao
Sylvie Gauthier
Yves Pouliot
Line Gourley
Ann Francoise Allain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Davisco Foods International Inc
Original Assignee
Davisco Foods International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/567,283 external-priority patent/US6630320B1/en
Priority claimed from US09/702,068 external-priority patent/US6998259B1/en
Application filed by Davisco Foods International Inc filed Critical Davisco Foods International Inc
Publication of EP1287159A1 publication Critical patent/EP1287159A1/en
Publication of EP1287159A4 publication Critical patent/EP1287159A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Peptides Or Proteins (AREA)
EP01933181A 2000-05-08 2001-05-08 ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS Withdrawn EP1287159A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US702068 1991-05-17
US09/567,283 US6630320B1 (en) 2000-05-08 2000-05-08 Treatment of hypertension in mammals with hydrolyzed whey proteins
US567283 2000-05-08
US09/702,068 US6998259B1 (en) 1999-05-20 2000-10-30 Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
PCT/US2001/014797 WO2001085984A1 (en) 2000-05-08 2001-05-08 Enzymatic treatment of whey proteins for the production of antihypertensive peptides, the resulting products and treatment of hypertension in mammals

Publications (2)

Publication Number Publication Date
EP1287159A1 EP1287159A1 (en) 2003-03-05
EP1287159A4 true EP1287159A4 (en) 2005-02-09

Family

ID=27074429

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01933181A Withdrawn EP1287159A4 (en) 2000-05-08 2001-05-08 ENZYMATIC TREATMENT OF LACTOSERUM PROTEINS FOR OBTAINING ANTI-HYPERTENSION PEPTIDES, PRODUCTS OBTAINED AND TREATMENT OF HYPERTENSION IN MAMMALS

Country Status (7)

Country Link
EP (1) EP1287159A4 (en)
JP (1) JP2004519204A (en)
AU (1) AU2001259625A1 (en)
CA (1) CA2415688A1 (en)
MX (1) MXPA02011018A (en)
NZ (1) NZ523036A (en)
WO (1) WO2001085984A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69920219T2 (en) 1998-06-17 2005-09-22 New Zealand Dairy Board BIOACTIVE WHEY BULB HYDROLYSATES
WO2004002241A1 (en) 2002-07-01 2004-01-08 Unilever N.V. Satiety inducing composition
US7718171B2 (en) 2003-04-07 2010-05-18 Chr. Hansen A/S Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
EP1466529A1 (en) * 2003-04-07 2004-10-13 Chr. Hansen A/S Composition with heart rate reducing properties
US20060216330A1 (en) * 2003-05-05 2006-09-28 Janssen Johannes G Peptides having an ace inhibiting effect
ES2253036B1 (en) 2003-07-31 2007-07-16 Consejo Sup. Investig. Cientificas BIOACTIVE PEPTIDES DERIVED FROM PROTEINS OF THE EGG CLEAR BY ENZYMATIC HYDROLYSIS.
ZA200604248B (en) * 2003-12-15 2007-11-28 Unilever Plc Peptides having an ace inhibiting effect
EP1685764A1 (en) 2005-01-27 2006-08-02 Globus Egg Sciences B.V. Anti-hypertensive functional food products
NL1026931C2 (en) * 2004-08-31 2006-03-01 Friesland Brands Bv ACE-inhibiting whey hydrolysates.
CN101035433B (en) 2004-09-03 2011-09-07 科·汉森有限公司 Fermented milk or vegetable proteins comprising receptor ligand and uses thereof
FR2876389B1 (en) * 2004-10-13 2007-05-25 Viridis Sa HYDROLYSATS OF WHITE PROTEINS FROM LUZERNE
ES2319475B1 (en) 2005-06-08 2010-02-16 Consejo Superior Investig. Cientificas BIOACTIVE PEPTIDES IDENTIFIED IN ENZYMATIC HYDROLYZES OF LACTEE CASEINS AND PROCEDURE OF OBTAINING.
DE102008032828A1 (en) 2008-07-02 2010-01-07 Technische Universität Dresden Tryptophan-containing peptides from alpha-lactalbumin with hypotensive and vasoprotective action for biofunctional foods
PE20151867A1 (en) 2013-04-25 2016-01-07 Crucell Holland Bv SOLUBLE AND STABILIZED RESPIRATORY SYNCITIAL VIRUS (RSV) PREFUSION POLYPEPTIDES F
CN107847581B (en) 2015-07-07 2022-03-22 扬森疫苗与预防公司 Stabilized soluble pre-fusion RSV F polypeptides
DK3319633T3 (en) 2015-07-07 2021-02-01 Janssen Vaccines & Prevention Bv VACCINE MOD RSV
KR102491447B1 (en) 2016-04-05 2023-01-20 얀센 백신스 앤드 프리벤션 비.브이. Vaccine against RSV
PE20190420A1 (en) 2016-04-05 2019-03-19 Janssen Vaccines And Prevention B V SOLUBLE AND STABILIZED RESPIRATORY SYNCITIAL VIRUS (RSV) PREFUSION PROTEINS F
DK3464331T3 (en) 2016-05-30 2021-01-18 Janssen Vaccines & Prevention Bv STABILIZED PREFUSION RSV F PROTEINS
CA3061278A1 (en) 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against rsv infection
WO2018210871A1 (en) 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against rsv infection
JP2020533367A (en) 2017-09-15 2020-11-19 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． Safe method of inducing immunity to RSV

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04282400A (en) * 1991-03-12 1992-10-07 Calpis Food Ind Co Ltd:The Angiotensin converting enzyme inhibitor peptide
JPH06345664A (en) * 1993-06-11 1994-12-20 Takako Tomita New composition for suppressing elevation of blood pressure
EP0671126A1 (en) * 1992-11-30 1995-09-13 Morinaga Milk Industry Co., Ltd. Low-phosphorus whey protein, process for producing the same, hydrolyzate of purified low-phosphorus whey protein, and process for producing the same
EP0821968A2 (en) * 1996-08-02 1998-02-04 The Calpis Food Industry Co., Ltd. Antihypertensive agent and method for preparing same
JPH1033115A (en) * 1996-07-24 1998-02-10 Nouchikusangiyou Shinko Jigyodan Whey beverage and its production

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3149199B2 (en) * 1991-03-12 2001-03-26 カルピス株式会社 Angiotensin converting enzyme inhibitory peptide

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04282400A (en) * 1991-03-12 1992-10-07 Calpis Food Ind Co Ltd:The Angiotensin converting enzyme inhibitor peptide
EP0671126A1 (en) * 1992-11-30 1995-09-13 Morinaga Milk Industry Co., Ltd. Low-phosphorus whey protein, process for producing the same, hydrolyzate of purified low-phosphorus whey protein, and process for producing the same
JPH06345664A (en) * 1993-06-11 1994-12-20 Takako Tomita New composition for suppressing elevation of blood pressure
JPH1033115A (en) * 1996-07-24 1998-02-10 Nouchikusangiyou Shinko Jigyodan Whey beverage and its production
EP0821968A2 (en) * 1996-08-02 1998-02-04 The Calpis Food Industry Co., Ltd. Antihypertensive agent and method for preparing same

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ABUBAKAR A ET AL: "Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion.", JOURNAL OF DAIRY SCIENCE. DEC 1998, vol. 81, no. 12, December 1998 (1998-12-01), pages 3131 - 3138, XP002937027, ISSN: 0022-0302 *
DATABASE WPI Section Ch Week 199248, Derwent World Patents Index; Class B04, AN 1992-392238, XP002311023 *
DATABASE WPI Section Ch Week 199510, Derwent World Patents Index; Class B04, AN 1995-070230, XP002311025 *
DATABASE WPI Section Ch Week 199816, Derwent World Patents Index; Class B04, AN 1998-172040, XP002311024 *
MULLALLY MARGARET M ET AL: "Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins", INTERNATIONAL DAIRY JOURNAL, vol. 7, no. 5, May 1997 (1997-05-01), pages 299 - 303, XP000853725, ISSN: 0958-6946 *
PIHLANTO-LEPPALA ANNE ET AL: "Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins", INTERNATIONAL DAIRY JOURNAL, vol. 8, no. 4, April 1998 (1998-04-01), pages 325 - 331, XP000853723, ISSN: 0958-6946 *
See also references of WO0185984A1 *

Also Published As

Publication number Publication date
CA2415688A1 (en) 2001-11-15
JP2004519204A (en) 2004-07-02
MXPA02011018A (en) 2004-08-19
WO2001085984A1 (en) 2001-11-15
EP1287159A1 (en) 2003-03-05
NZ523036A (en) 2004-04-30
AU2001259625A1 (en) 2001-11-20

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Effective date: 20041209