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EP1257650A4 - POLYMERASE COMPOSITIONS AND METHODS OF USE THEREOF - Google Patents

POLYMERASE COMPOSITIONS AND METHODS OF USE THEREOF

Info

Publication number
EP1257650A4
EP1257650A4 EP00983732A EP00983732A EP1257650A4 EP 1257650 A4 EP1257650 A4 EP 1257650A4 EP 00983732 A EP00983732 A EP 00983732A EP 00983732 A EP00983732 A EP 00983732A EP 1257650 A4 EP1257650 A4 EP 1257650A4
Authority
EP
European Patent Office
Prior art keywords
methods
polymerase compositions
polymerase
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00983732A
Other languages
German (de)
French (fr)
Other versions
EP1257650A1 (en
Inventor
James B Flanegan
Sushma Ogram
Barbara J Morasco
Linda Barone
Siu-Chi Chang Sun
James M Groarke
Marc S Collett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Viropharma Biologics LLC
Original Assignee
University of Florida
Viropharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida, Viropharma Inc filed Critical University of Florida
Publication of EP1257650A1 publication Critical patent/EP1257650A1/en
Publication of EP1257650A4 publication Critical patent/EP1257650A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241Nucleotidyltransferases (2.7.7)
    • C12N9/127RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
EP00983732A 1999-11-23 2000-11-21 POLYMERASE COMPOSITIONS AND METHODS OF USE THEREOF Withdrawn EP1257650A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16706899P 1999-11-23 1999-11-23
US167068P 1999-11-23
PCT/US2000/031909 WO2001038538A1 (en) 1999-11-23 2000-11-21 Polymerase compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
EP1257650A1 EP1257650A1 (en) 2002-11-20
EP1257650A4 true EP1257650A4 (en) 2004-03-24

Family

ID=22605803

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00983732A Withdrawn EP1257650A4 (en) 1999-11-23 2000-11-21 POLYMERASE COMPOSITIONS AND METHODS OF USE THEREOF

Country Status (4)

Country Link
EP (1) EP1257650A4 (en)
JP (1) JP2003514562A (en)
AU (1) AU2044701A (en)
WO (1) WO2001038538A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018191275A1 (en) * 2017-04-10 2018-10-18 The Penn State Research Foundation Compositions and methods comprising viral reverse transcriptase
CN108976972B (en) * 2018-06-19 2020-06-02 太原理工大学 A kind of application method of metal nozzle anti-corrosion device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1272179B (en) * 1994-02-23 1997-06-16 Angeletti P Ist Richerche Bio METHODOLOGY TO REPRODUCE IN VITRO THE PROTEOLITHIC ACTIVITY OF THE NS3 PROTEASE OF THE VIRUS HCV.
IT1278077B1 (en) * 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio METHODOLOGY TO REPRODUCE IN VITRO THE ACTIVITIES OF RNA-DEPENDENT RNA POLYMERASE AND OF TERMINAL NUCLEOTIDYLTRANSPHERASE CODED BY THE
AU768177B2 (en) * 1998-04-02 2003-12-04 Viropharma Incorporated Hepatitis C virus NS5B compositions and methods of use thereof
EP1071454A1 (en) * 1998-04-24 2001-01-31 Washington University Chimeras of hepatitis c virus and bovine viral diarrhea virus

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOOBAR-LARSSON L ET AL: "Intracellular hepatitis C virus RNA-dependent RNA polymerase activity", ARCHIVES OF VIROLOGY, vol. 146, no. 8, August 2001 (2001-08-01), pages 1553 - 1570, XP002267951, ISSN: 0304-8608 *
LIN C ET AL: "HEPATITIS C VIRUS NS3 SERINE PROTEINASE", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 68, no. 12, 1 December 1994 (1994-12-01), pages 8147 - 8157, XP002018452, ISSN: 0022-538X *
See also references of WO0138538A1 *
TOMEI L ET AL: "NS3 IS A SERINE PROTEASE REQUIRED FOR PROCESSING OF HEPATITIS C VIRUS POLYPROTEIN", JOURNAL OF VIROLOGY, NEW YORK, US, US, vol. 67, no. 7, 1 July 1993 (1993-07-01), pages 4017 - 4026, XP000561255, ISSN: 0022-538X *

Also Published As

Publication number Publication date
AU2044701A (en) 2001-06-04
EP1257650A1 (en) 2002-11-20
WO2001038538A1 (en) 2001-05-31
JP2003514562A (en) 2003-04-22

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