EP1129108A4 - Caspases and apoptosis - Google Patents

Caspases and apoptosis

Info

Publication number: EP1129108A4
Authority: EP; European Patent Office
Prior art keywords: caspases; apoptosis
Prior art date: 1998-10-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP99953073A

Other languages

German (de)

French (fr)

Other versions

EP1129108A1 (en

Inventor

Dennis Lee

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-06

Filing date

1999-10-06

Publication date

2002-01-09

1999-10-06 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2001-09-05 Publication of EP1129108A1 publication Critical patent/EP1129108A1/en

2002-01-09 Publication of EP1129108A4 publication Critical patent/EP1129108A4/en

Status Pending legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Crystallography & Structural Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP99953073A 1998-10-06 1999-10-06 Caspases and apoptosis Pending EP1129108A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US10342898P	1998-10-06	1998-10-06
US103428P		1998-10-06
PCT/US1999/023271 WO2000020440A1 (en)	1998-10-06	1999-10-06	Caspases and apoptosis

Publications (2)

Publication Number	Publication Date
EP1129108A1 EP1129108A1 (en)	2001-09-05
EP1129108A4 true EP1129108A4 (en)	2002-01-09

Family

ID=22295125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99953073A Pending EP1129108A4 (en)	1998-10-06	1999-10-06	Caspases and apoptosis

Country Status (3)

Country	Link
EP (1)	EP1129108A4 (en)
JP (1)	JP2003524603A (en)
WO (1)	WO2000020440A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0513310A (en) *	2004-07-12	2008-05-06	Idun Pharmaceuticals Inc	tetrapeptide analogs
US7709370B2 (en)	2007-09-20	2010-05-04	International Business Machines Corporation	Spin-on antireflective coating for integration of patternable dielectric materials and interconnect structures
US8618663B2 (en)	2007-09-20	2013-12-31	International Business Machines Corporation	Patternable dielectric film structure with improved lithography and method of fabricating same
US8084862B2 (en)	2007-09-20	2011-12-27	International Business Machines Corporation	Interconnect structures with patternable low-k dielectrics and method of fabricating same
WO2012019003A1 (en)	2010-08-06	2012-02-09	Bristol-Myers Squibb Company	Substituted indole and azaindole oxoacetyl piperazinamide derivatives
CN110759966B (en) *	2019-11-22	2021-01-26	中国药科大学	caspase-3 inhibitors and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995005192A1 (en) *	1993-08-13	1995-02-23	Merck & Co., Inc.	SUBSTITUTED KETONE DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1995035308A1 (en) *	1994-06-17	1995-12-28	Vertex Pharmaceuticals Incorporated	INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
GB2292149A (en) *	1994-08-09	1996-02-14	Ferring Res Ltd	Peptide inhibitors of pro-interleukin-1beta converting enzyme
WO1998016505A1 (en) *	1996-10-11	1998-04-23	Warner-Lambert Company	SULFONAMIDE INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS
WO1998036057A1 (en) *	1997-02-18	1998-08-20	Dana Farber Cancer Institute	Thymocyte caspase activity and negative selection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5055451A (en) *	1986-12-22	1991-10-08	Syntex Inc.	Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors

1999
- 1999-10-06 EP EP99953073A patent/EP1129108A4/en active Pending
- 1999-10-06 JP JP2000574551A patent/JP2003524603A/en not_active Ceased
- 1999-10-06 WO PCT/US1999/023271 patent/WO2000020440A1/en not_active Application Discontinuation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995005192A1 (en) *	1993-08-13	1995-02-23	Merck & Co., Inc.	SUBSTITUTED KETONE DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
WO1995035308A1 (en) *	1994-06-17	1995-12-28	Vertex Pharmaceuticals Incorporated	INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME
GB2292149A (en) *	1994-08-09	1996-02-14	Ferring Res Ltd	Peptide inhibitors of pro-interleukin-1beta converting enzyme
WO1998016505A1 (en) *	1996-10-11	1998-04-23	Warner-Lambert Company	SULFONAMIDE INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS
WO1998036057A1 (en) *	1997-02-18	1998-08-20	Dana Farber Cancer Institute	Thymocyte caspase activity and negative selection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0020440A1 *

Also Published As

Publication number	Publication date
WO2000020440A1 (en)	2000-04-13
EP1129108A1 (en)	2001-09-05
JP2003524603A (en)	2003-08-19

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Legal Events

Date	Code	Title	Description
2001-07-20	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-09-05	17P	Request for examination filed	Effective date: 20010413
2001-09-05	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-01-09	A4	Supplementary search report drawn up and despatched	Effective date: 20011122
2002-01-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-01-09	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07K 5/08 A, 7C 07K 5/02 B, 7A 61P 25/28 B
2002-09-25	18D	Application deemed to be withdrawn	Effective date: 20020129
2002-10-02	D18D	Application deemed to be withdrawn (deleted)
2002-11-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2003-01-02	R18D	Application deemed to be withdrawn (corrected)	Effective date: 20020108